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A useful material isolation from the Bombycis corpus (Beauveria bassiana) growing of the silkworm, Bombyx mori L.  

정이연 (농업과학기술원 잠사곤충부)
남성희 (농업과학기술원 잠사곤충부)
홍인표 (농업과학기술원 잠사곤충부)
유승헌 (충남대학 농과대학)
권학철 (성균관대학교 약학대학)
이강노 (성균관대학교 약학대학)
Publication Information
Journal of Sericultural and Entomological Science / v.45, no.1, 2003 , pp. 25-30 More about this Journal
Abstract
This study was carried out to investigate active constituents of Bombysis corpus on the neurite outgrowth from PC 12 cells led to isolate three new and a known sphingolipids from the n-hexane soluble portion and five amines from the butanol soluble portion of its methanol extract. On the basis of spectroscopic data, their structures have been elucidated as (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine, (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine,(4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine,(4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine,(4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine, 1,7-dimethyl-xanthine, uracil, urea, betaine and tyrosine, respectively. The neurite outgrowth activities of these compounds were examined in PC12 cells by measuring the length of neurites. These compounds promoted neurite outgrowth in PC12 cells significantly.
Keywords
Bombycis corpus; PC12 cells; Silkworm; Beauveria bassiana;
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Times Cited By KSCI : 1  (Citation Analysis)
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