• Journal of the Korean Magnetic Resonance Society
• /
• v.20 no.3
• /
• pp.95-101
• /
• 2016

Apolipoprotein B-100 (Apo-B100) is a major component of low density lipoprotein (LDL). Apo B-100 protein has 4,536 amino acid sequence and these amino acids are classified into peptide groups A to G with subsequent 20 amino acids (P1-P302). The peptide groups were act as immunoglobulin (Ig) antigens which oxidized via malondialdehyde (MDA). The mimetic peptide P1 (EEEMLENVSLVCPKDAT RFK) out of D-group peptides carrying the highest value of IgG antigens were selected for structural studies that may provide antigen specificity. Circular Dichroism (CD) spectra were measured for peptide secondary structure in the range of 190-250 nm. Experimental results show that P1 exhibit partial of ${\beta}-sheet$ and random coil structure. Homonuclear (COSY, TOCSY, NOESY) 2D-NMR experiments were carried out for NMR signal assignments and structure determination for P1. On the basis of these completely assigned NMR spectra and distance data, distance geometry (DG) and Molecular dynamics (MD) were carried out to determine the structures of P1. The proposed structure was selected by comparisons between experimental NOE spectra and back calculated 2D NOE results from determined structure showing acceptable agreement. The total Root-Mean-Square-Deviation (RMSD) value of P1 obtained upon superposition of all atoms was in the range $0.33{\AA}$. The solution state P1 has mixed structure of ${\beta}-sheet$ (Glu[1] to Cys[12]) and random coil (Pro[13] to Lys[20]). These NMR results are well consistent with secondary structure from experimental results of circular dichroism. Structural studies based on NMR may contribute to the studies of atherosclerosis and observed conformational characteristics of apo B-100 in LDL using monoclonal antibodies.

• Journal of KIISE:Computer Systems and Theory
• /
• v.32 no.8
• /
• pp.418-425
• /
• 2005

3D surface reconstruction is to make the original geometry of 3D objects from 2D geometric information. Barequet's algorithm is well known and most widely used in surface reconstruction. It tiles matched regions first, then triangulates clefts using dynamic programming. However it takes considerably long processing time while manipulating complex model. Our method tiles a simple region that does not have branches along minimally distant vertex pairs at once. When there are branches, our method divides contour lines into a simple region and clefts. We propose a fast and simple method that calculates medial axes using a minimum distance in cleft region. Experimental results show that our method can produce accurate models than the previous method within short time.

• Journal of Convergence for Information Technology
• /
• v.11 no.11
• /
• pp.166-171
• /
• 2021

An active mount is devised in same geometric constraints with a conventional rubber mount. The proposed mount features the piezoelectric actuator which can be used to reduce the vibration at marine vessels or automotive vehicles. As a first step, a passive rubber mount is adopted and its dynamic characteristics are experimentally evaluated. Based on the geometry of the rubber mount, a rubber element for the active mount is manufactured and integrated with two piezostacks in series, in which the piezostack is operated as an inertial type of actuator. A conventional PID controller featured by the simple and easy implementation, is then designed to attenuate the non-resonant high frequency vibration transmitted from the base excitation. Finally, the control performances of a proposed active mount are evaluated in the wide frequency range and compared with those of the conventional rubber mount.

• Wind and Structures
• /
• v.32 no.2
• /
• pp.127-142
• /
• 2021

Wind load acting on a standalone structure is different from that acting on a similar structure which is surrounded by other structures in close proximity. The presence of other structures in the surrounding can change the wind flow regime around the principal structure and thus causing variation in wind loads compared to a standalone case. This variation on wind loads termed as interference effect depends on several factors like terrain category, geometry of the structure, orientation, wind incident angle, interfering distances etc., In the present study, a three building configuration is considered and the mean pressure coefficients on each face of principle building are determined in presence of two interfering buildings. Generally, wind loads on interfering buildings are determined from wind tunnel experiments. Computational fluid dynamic studies are being increasingly used to determine the wind loads recently. Whereas, wind tunnel tests are very expensive, the CFD simulation requires high computational cost and time. In this scenario, Artificial Neural Network (ANN) technique and Support Vector Regression (SVR) can be explored as alternative tools to study wind loads on structures. The present study uses these data-driven approaches to predict mean pressure coefficients on each face of principle building. Three typical arrangements of three building configuration viz. L shape, V shape and mirror of L shape arrangement are considered with varying interfering distances and wind incidence angles. Mean pressure coefficients (Cp mean) are predicted for 45 degrees wind incidence angle through ANN and SVR. Further, the critical faces of principal building, critical interfering distances and building arrangement which are more prone to wind loads are identified through this study. Among three types of building arrangements considered, a maximum of 3.9 times reduction in Cp mean values are noticed under Case B (V shape) building arrangement with 2.5B interfering distance. Effect of interfering distance and building arrangement on suction pressure on building faces has also been studied. Accordingly, Case C (mirror of L shape) building arrangement at a wind angle of 45º shows less suction pressure. Through this study, it was also observed that the increase of interfering distance may increase the suction pressure for all the cases of building configurations considered.

• Advances in nano research
• /
• v.12 no.5
• /
• pp.467-482
• /
• 2022

In the current work, static and free torsional vibration of functionally graded (FG) nanorods are investigated using Fourier sine series. The boundary conditions are described by the two elastic torsional springs at the ends. The distribution of functionally graded material is considered using a power-law rule. The systems of equations of the mechanical response of nanorods subjected to deformable boundary conditions are achieved by using the modified couple stress theory (MCST) and taking the effects of torsional springs into account. The idea of the study is to construct an eigen value problem involving the torsional spring parameters with small scale parameter and functionally graded index. This article investigates the size dependent free torsional vibration based on the MCST of functionally graded nano/micro rods with deformable boundary conditions using a Fourier sine series solution for the first time. The eigen value problem is constructed using the Stokes' transform to deformable boundary conditions and also the convergence and accuracy of the present methodology are discussed in various numerical examples. The small size coefficient influence on the free torsional vibration characteristics is studied from the point of different parameters for both deformable and rigid boundary conditions. It shows that the torsional vibrational response of functionally graded nanorods are effected by geometry, small size effects, boundary conditions and material composition. Furthermore, for all deformable boundary conditions in the event of nano-sized FG nanorods, the incrementing of the small size parameters leads to increas the torsional frequencies.

• Journal of the Semiconductor & Display Technology
• /
• v.21 no.4
• /
• pp.53-58
• /
• 2022

Shape changes of hard mask play a key role in the aspect ratio dependent etch (ARDE). For etch process using high density and energy ions, deformation of hard mask shape becomes more severe, and high aspect ratio (HAR) etch profile is distorted. In this study, polygonal geometric model for shape-deformation of amorphous carbon layered hard mask is suggested to control etch profile during the process. Mask shape is modeled with polygonal geometry consisting of trapezoids and rectangles, and it provides dynamic information about angles of facets and etched width and height of remained mask shape, providing important features for real-time HAR etch profiling.

• Steel and Composite Structures
• /
• v.49 no.3
• /
• pp.307-323
• /
• 2023

In this research, the study of the thermoelastic flexural analysis of silicon carbide/Aluminum graded (FG) sandwich 2D uniform structure (plate) under harmonic sinusoidal temperature load over time is presented. The plate is modeled using a simple two dimensional integral shear deformation plate theory. The current formulation contains an integral terms whose aim is to reduce a number of variables compared to others similar solutions and therefore minimize the computation time. The transverse shear stresses vary according to parabolic distribution and vanish at the free surfaces of the structure without any use of correction factors. The external load is applied on the upper face and varying in the thickness of the plates. The structure is supposed to be composed of "three layers" and resting on nonlinear visco-Pasternak's-foundations. The governing equations of the system are deduced and solved via Hamilton's principle and general solution. The computed results are compared with those existing in the literature to validate the current formulation. The impacts of the parameters (material index, temperature exponent, geometry ratio, time, top/bottom temperature ratio, elastic foundation type, and damping coefficient) on the dynamic flexural response are studied.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2004.11a
• /
• pp.159-166
• /
• 2004

The beach, a margin between the sea and the land, is an extremely dynamic zone, for it is here that the motion of the sea interacts with the sediment, rock of the land or the artificial barriers. In order to prohibit or retard erosions due to the extreme Typhoon or storm induced waves, man has constructed these of temporary or more permanent nature, but they caused problems of other erosions from the secondary effect of them and a bad influence on the seascape. In considering the energy available to accelerate sediment transport and erosion in the surf zone, where the waves are broken, and offshore beyond the breaker line, the wave height and the wave period should be taken account. Hence, we tried to present an applicability of the submerged artificial Bio-reefs analyzing waves by a numerical model such that they could reduce the wave power without the secondary effect and restoration of marine ecologies. A new technique of beach preservation is by artificial reefs with artificial and/or natural kelps or sea plants. By engineering the geometry of the nearshore reef, the wave attenuation ability of the feature can be optimized Higher, wider and longer reefs provide the greatest barrier against wave energy but material volumes, navigation hazards, placement methods and other factors require engineering considerations for the overall design of the nearshore reefs.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.49 no.9
• /
• pp.251-258
• /
• 2012

Recently, NAND Flash memory structure is evolving from SDR (Single Data Rate) to high speed DDR(Double Data Rate) to fulfill the high performance requirement of SSD and SSS. Accordingly, the proper ways of transferring data that latches valid data stably and minimizing data skew between pins by using PHY(Physical layer) circuit techniques have became new issues. Also, rapid growth of speed in NAND flash increases the operating frequency and power consumption of NAND flash controller. Internal voltage variation margin of NAND flash controller will be narrowed through the smaller geometry and lower internal operating voltage below 1.5V. Therefore, the increase of power budge deviation limits the normal operation range of internal circuit. Affection of OCV(On Chip Variation) deteriorates the voltage variation problem and thus causes internal logic errors. In this case, it is too hard to debug, because it is not functional faults. In this paper, we propose new architecture that maintains the valid timing window in cost effective way under sudden power fluctuation cases. Simulation results show that the proposed technique minimizes the data skew by 379% with reduced area by 20% compared to using PHY circuits.

• Journal of Biomedical Engineering Research
• /
• v.25 no.4
• /
• pp.295-300
• /
• 2004

Coil embolization technique has been used recently to treat cerebral aneurysms. When a giant or a multilobular aneurysm are treated by roils, filling an aneurysm sac completely with coils is difficult and partial blocking of an aneurysm sac is inevitable. Blood flow characteristics, which nay affect the embolization process of an aneurysm sac, are changed by the locations of coils for the Partially blocked aneurysms. Blood flow fields are also influenced by the geometry of a parent vessel. In order to suggest the coil locations effective for aneurysm embolization, the blood flow fields of lateral aneurysm models were analyzed for the different coil locations and parent vessel geometries. Three dimensional pulsatile flow fields are analyzed by numerical methods considering non-Newtonian viscosity characteristics of blood. Flow rate into the aneurysm sac (inflow rate) and wall shear stress, which are suspected as flow dynamic factors influencing aneurysm embolization, are also calculated. Inflow rates were smaller and the low wall shear stress zones were larger in the neck blocked models compared to the dome blocked models. Smaller inflow and larger low wall shear stress zones in the distal neck blocked model imply that the distal neck should be the effective coil locations for aneurysm embolization.