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Apoptosis Induction, Cell Cycle Arrest and in Vitro Anticancer Activity of Gonothalamin in a Cancer Cell Lines

  • Alabsi, Aied M.;Ali, Rola;Ali, Abdul Manaf;Al-Dubai, Sami Abdo Radman;Harun, Hazlan;Kasim, Noor H. Abu;Alsalahi, Abdulsamad
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.10
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    • pp.5131-5136
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    • 2012
  • Cancer is one of the major health problems worldwide and its current treatments have a number of undesired adverse side effects. Natural compounds may reduce these. Currently, a few plant products are being used to treat cancer. In this study, goniothalamin, a natural occurring styryl-lactone extracted from Goniothalamus macrophyllus, was investigated for cytotoxic properties against cervical cancer (HeLa), breast carcinoma (MCF-7) and colon cancer (HT29) cells as well as normal mouse fibroblast (3T3) using MTT assay. Fluorescence microscopy showed that GTN is able to induce apoptosis in HeLa cells in a time dependent manner. Flow cytometry further revealed HeLa cells treated with GTN to be arrested in the S phase. Phosphatidyl serine properties present during apoptosis enable early detection of the apoptosis in the cells. Using annexin V/PI double staining it could be shown that GTN induces early apoptosis on HeLa cells after 24, 48 and 72 h. It could be concluded that goniothalamin showing a promising cytotoxicity effect against several cancer cell lines including cervical cancer cells (HeLa) with apoptosis as the mode of cell death induced on HeLa cells by Goniothalamin was.

An Analysis Of Optimized Super Tall Building Tower Crane Selection Which Related With Project Construction Period (프로젝트 공사기간과 연계된 극 초고층 타워크레인 최적화 선정에 관한 연구)

  • Cho, Ji-Hun;Cho, Heung-Goo
    • Journal of the Korea Institute of Building Construction
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    • v.9 no.6
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    • pp.131-139
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    • 2009
  • It is critical to select the appropriate type of tower cranes for the construction of super tall buildings. However the selection is often made based on subjective personal experiences due to the lack of historical and analytical data. As a result, planning mistakes and efficiency errors sometimes occur. This research is to develop a system of hoisting analysis for appropriate tower crane selection and to provide a flexible statistical model based on the Burj Dubai project. In addition, this system hassupporting functions that can estimate the target construction period per floor, and a decision-making construction period computation method which is based on the characteristic of the selected tower cranes.

Effect of repetitive pecking at working length for glide path preparation using G-file

  • Ha, Jung-Hong;Jeon, Hyo-Jin;Abed, Rashid El;Chang, Seok-Woo;Kim, Sung-Kyo;Kim, Hyeon-Cheol
    • Restorative Dentistry and Endodontics
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    • v.40 no.2
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    • pp.123-127
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    • 2015
  • Objectives: Glide path preparation is recommended to reduce torsional failure of nickel-titanium (NiTi) rotary instruments and to prevent root canal transportation. This study evaluated whether the repetitive insertions of G-files to the working length maintain the apical size as well as provide sufficient lumen as a glide path for subsequent instrumentation. Materials and Methods: The G-file system (Micro-Mega) composed of G1 and G2 files for glide path preparation was used with the J-shaped, simulated resin canals. After inserting a G1 file twice, a G2 file was inserted to the working length 1, 4, 7, or 10 times for four each experimental group, respectively (n = 10). Then the canals were cleaned by copious irrigation, and lubricated with a separating gel medium. Canal replicas were made using silicone impression material, and the diameter of the replicas was measured at working length (D0) and 1 mm level (D1) under a scanning electron microscope. Data was analysed by one-way ANOVA and post-hoc tests (p = 0.05). Results: The diameter at D0 level did not show any significant difference between the 1, 2, 4, and 10 times of repetitive pecking insertions of G2 files at working length. However, 10 times of pecking motion with G2 file resulted in significantly larger canal diameter at D1 (p < 0.05). Conclusions: Under the limitations of this study, the repetitive insertion of a G2 file up to 10 times at working length created an adequate lumen for subsequent apical shaping with other rotary files bigger than International Organization for Standardization (ISO) size 20, without apical transportation at D0 level.

How to Improve Eating Behaviour during Early Childhood

  • Green, Robin John;Samy, Gamal;Miqdady, Mohamad Saleh;Salah, Mohamed;Sleiman, Rola;Abdelrahman, Hatim Mohamed Ahmed;Al Haddad, Fatima;Reda, Mona M.;Lewis, Humphrey;Ekanem, Emmanuel E.;Vandenplas, Yvan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.18 no.1
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    • pp.1-9
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    • 2015
  • Eating behaviour disorder during early childhood is a common pediatric problem. Many terminologies have been used interchangeably to describe this condition, hindering implementation of therapy and confusing a common problem. The definition suggests an eating behaviour which has consequences for family harmony and growth. The recent Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition does not cover the entire spectrum seen by pediatricians. Publications are substantive but level of evidence is most of the time low. This purpose of this review is to clarify terminology of eating behaviour problems during early childhood; including benign picky eating, limited diets, sensory food aversion, selective eating, food avoidance emotional disorder, pervasive refusal syndrome, tactile defensiveness, functional dysphagia, neophobia and toddler anorexia. This tool is proposed only to ease the clinical management for child care providers. Diagnostic criteria are set and management tools are suggested. The role of dietary counselling and, where necessary, behavioural therapy is clarified. It is hoped that the condition will make its way into mainstream pediatrics to allow these children, and their families, to receive the help they deserve.

Feasibility Analysis of the Use of Architectural PC for Improving the Productivity in Apartment Housing Projects (공동주택 공사에서의 생산성 향상을 위한 건축 외관용 PC의 적용 타당성 분석)

  • Lee, Hyun-Seok;Sohn, Young-Jin;Lee, Yoon-Sun;Kim, Jae-Jun
    • Korean Journal of Construction Engineering and Management
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    • v.9 no.3
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    • pp.118-125
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    • 2008
  • In Korea, five days per week system, duration reduction bidding system, and post sale system have recently stimulated an interest in productivity improvement in construction project. However, analysis result of productivity in Korean construction industry found that the productivity is too low. APC (Architectural PC) is alternative of reveal wall and parapet in apartment housing prcjects and is used abroad broadly because of duration reduction for productivity improving. APC is used as external curtain wall in Dubai, North America, and Southeast Asia. Therefore, it is proposed that necessary to Introduce APC in Korea. The objective of this study is to draw up introduction of APC in apartment housing projects. We analysed the feasibility of the use of APC. The survey results reported that APC would be able to improve the productivity in the eight productivity factors.

Development of an Optimal Model for Forecasting Overseas Construction Orders (해외건설수주액 예측을 위한 최적모형 개발)

  • Lee, Kwangwon;Jo, Woonghyeon
    • Korean Journal of Construction Engineering and Management
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    • v.21 no.4
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    • pp.30-37
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    • 2020
  • The purpose of this study is to compare and contrast the amount of overseas construction orders of South Korea and China by using various time series models that measure the overseas construction orders. Based on the analysis we propose better specification (model selection) with much more predictive power and prove the universality of the model developed by applying our findings with respect to the prediction power of overseas construction orders from other countries viewpoints (verification of generalization). The input variables include Dubai crude oil and exchange rates by country from 1981 to 2019. The VAR model is proposed based on the prediction power test, with respect to MAPE, RMSE, and MAE between the estimates and actual measurements from 2016 to 2019. We also conclude the results of the prediction of overseas construction orders time series of China are again consistent with the actual numbers. These analyses suggest the possibility of developing a comprehensive model that predict the potential construction orders of other countries.

Energy Modeling of a Supertall Building Using Simulated 600 m Weather File Data

  • Irani, Ali;Leung, Luke;Sedino, Marzia
    • International Journal of High-Rise Buildings
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    • v.8 no.2
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    • pp.101-106
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    • 2019
  • Assessing the energy performance of supertall buildings often does not consider variations in energy consumption due to the change of environmental conditions such as temperature, pressure, and wind speed associated with differing elevations. Some modelers account for these changing conditions by using a conventional temperature lapse rate, but not many studies confirm to the appropriateness of applying it to tall buildings. This paper presents and discusses simulated annual energy consumption results from a 600 m tall skyscraper floor plate located in Dubai, UAE, assessed using ground level weather data, a conventional temperature lapse rate of $6.5^{\circ}C/km$, and more accurate simulated 600 m weather data. A typical office floorplate, with ASHRAE 90.1-2010 standards and systems applied, was evaluated using the EnergyPlus engine through the OpenStudio graphical user interface. The results presented in this paper indicate that by using ground level weather data, energy consumption at the top of the building can be overestimated by upwards of 4%. Furthermore, by only using a lapse rate, heating energy is overestimated by up to 96% due to local weather phenomenon such as temperature inversion, which can only be conveyed using simulated weather data. In addition, sizing and energy consumption of fans, which are dependent both on wind and atmospheric pressure, are not accurately captured using a temperature lapse rate. These results show that that it is important, with the ever increasing construction of supertall buildings, to be able to account for variations in climatic conditions along the height of the building. Adequately modeling these conditions using simulated weather data will help designers and engineers correctly size mechanical systems, potentially decreasing overall building energy consumption, and ensuring that these systems are able to provide the necessary indoor conditions to maintain occupant comfort levels.

Performance Analysis of Islamic Banks in Indonesia: The Maqashid Shariah Approach

  • MURSYID, Mursyid;KUSUMA, Hadri;TOHIRIN, Achmad;SRIYANA, Jaka
    • The Journal of Asian Finance, Economics and Business
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    • v.8 no.3
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    • pp.307-318
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    • 2021
  • The objective of this study is to analyze the performance of Islamic banks with the Maqashid Shariah approach. The analysis technique used is the Simple Additive Weighting Method (SAW) to solve multi-attribute decision problems. The sampling technique used was purposive sampling while the data came from the annual report of each bank. The results showed that the BTPN Shariah (BTPNS) and Bank Muamalat Indonesia (BMI) are ranked first and second respectively on the Maqashid Shariah Index (MSI) with values of 0.265429 and 0.237110 respectively. Panin Dubai Shariah Bank (PDSB) ranked third with an MSI value of 0.180733, followed by BCA Shariah which ranked fourth with an MSI value of 0.151299. BRI Shariah ranked fifth with an MSI value of 0.128606, followed by BNI Shariah which ranked sixth with an MSI value of 0.124661. Bank Mega Shariah ranked last with an MSI value of 0.087068. Furthermore, there is a relationship (correlation) between ROE, ROA, and OEOI and MSI since each data has a value of 0.000, 0.000, 0.050, and 0.001 respectively, which is smaller than the significance value of 0.05. On the other hand, NPF, TPF, and Asset Growth Rates do not correlate with the MSI since each data has a value of 0.051, 0.252, and 0.215 respectively which is greater than the significance value of 0.05.

Comparison of apical extrusion of intracanal bacteria by various glide-path establishing systems: an in vitro study

  • Dagna, Alberto;El Abed, Rashid;Hussain, Sameeha;Abu-Tahun, Ibrahim H;Visai, Livia;Bertoglio, Federico;Bosco, Floriana;Beltrami, Riccardo;Poggio, Claudio;Kim, Hyeon-Cheol
    • Restorative Dentistry and Endodontics
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    • v.42 no.4
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    • pp.316-323
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    • 2017
  • Objectives: This study compared the amount of apically extruded bacteria during the glide-path preparation by using multi-file and single-file glide-path establishing nickel-titanium (NiTi) rotary systems. Materials and Methods: Sixty mandibular first molar teeth were used to prepare the test apparatus. They were decoronated, blocked into glass vials, sterilized in ethylene oxide gas, infected with a pure culture of Enterococcus faecalis, randomly assigned to 5 experimental groups, and then prepared using manual stainless-steel files (group KF) and glide-path establishing NiTi rotary files (group PF with PathFiles, group GF with G-Files, group PG with ProGlider, and group OG with One G). At the end of canal preparation, 0.01 mL NaCl solution was taken from the experimental vials. The suspension was plated on brain heart infusion agar and colonies of bacteria were counted, and the results were given as number of colony-forming units (CFU). Results: The manual instrumentation technique tested in group KF extruded the highest number of bacteria compared to the other 4 groups (p < 0.05). The 4 groups using rotary glide-path establishing instruments extruded similar amounts of bacteria. Conclusions: All glide-path establishment instrument systems tested caused a measurable apical extrusion of bacteria. The manual glide-path preparation showed the highest number of bacteria extruded compared to the other NiTi glide-path establishing instruments.

A Study on World Energy Outlook and the Optimal Alternatives for Energy Technology Development: Focusing on Coal Utilization Technology (에너지자원 수급 전망 분석 및 최적 기술 개발 대안에 관한 연구: 석탄활용기술 중심)

  • Lee, Seong-Kon;Kim, Jong-Wook;Yoon, Yong-Jin
    • Journal of Energy Engineering
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    • v.15 no.3 s.47
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    • pp.174-180
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    • 2006
  • The trend and outlook of energy supply and demand have an crucial effect on not only energy sector but also korean economy due to the rapid change of energy environments with continuous high oil price such as dubai crude oil price of above $60 a barrel. Specifically, korea is the 9th largest energy consuming nation in the world and the 97 percentages of energy import totally depends on the import of energy resources in korea. Korean economy is influenced directly by the trend and outlook of world energy on account of that. Moreover, Should korea be the annex 1 country having responsibility for reducing its greenhouse gas emissions to 1990 levels by the year 2000, in 2013, The effectuation of united nations framework convention on climate change will affect korean economy severely. In this study, we analyze the supply and demand of primary energy resources such as petroleum, coal, and natural gas. we then suggest the optimal alternatives of energy technology development that play an important part, which will be a temporary bridge, in going forward with hydrogen economy in the aspects of energy policy.