• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8019-8026
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• 2014

The promyelocytic leukemia (PML) gene is a gene known to be a tumor suppressor, although recent data suggest that it has a dual function in tumorigenesis. It was initially discovered in acute promyelocytic leukemia (APL) in which a t(15; 17) chromosomal translocation fused it to the retinoic acid receptor alpha ($RAR{\alpha}$). It has been shown to be involved in various types of cancer. It has at least 6 nuclear isoforms and a cytoplasmic type with different characteristics. Its multiple functions in growth inhibition, apoptosis induction, replicative senescence, inhibition of oncogenic transformation, and suppression of migration and angiogenesis have made it a therapeutic target for cancer therapy. However, its dual role in the process of tumorigenesis has made this field challenging. In this review, we discuss PML structure, functions and expression in tumors.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.1
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• pp.13-18
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• 2015

This study presents the structure design of antenna to have the dual band characteristics in a desired frequency band through the structural modification of an antenna structure. For the experiment, a wideband crossed planar monopole antenna was used. The target frequency band was set to ISM 2.45GHz/5.8GHz. To give the properties, an additional antenna element was added to the crossed planar monopole antenna, which is a main body of the antenna. And then structural adjustment parameter was set to change the length(shape) of the antenna. Various simulations were conducted to find the dual band characteristics in the desired frequency band. The simulations brought forth the antenna bandwidth above the normal values for ISM 2.45GHz/5.8GHz. The structural adjustment parameter introduced in this study for structural modification of an antenna can be useful in developing an antenna featured with dual band(multiband) characteristics.

• Journal of the Korea Society of Computer and Information
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• v.25 no.9
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• pp.63-69
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• 2020

Image-image translation is a technology that creates a target image through input images, and has recently shown high performance in creating a more realistic image by utilizing GAN, which is a non-map learning structure. Therefore, there are various studies on image-to-image translation using GAN. At this point, most image-to-image translations basically target one attribute translation. But the data used and obtainable in real life consist of a variety of features that are hard to explain with one feature. Therefore, if you aim to change multiple attributes that can divide the image creation process by attributes to take advantage of the various attributes, you will be able to play a better role in image-to-image translation. In this paper, we propose Multi CycleGAN, a dual attribute transformation structure, by utilizing CycleGAN, which showed high performance among image-image translation structures using GAN. This structure implements a dual transformation structure in which three domains conduct two-way learning to learn about the two properties of an input domain. Experiments have shown that images through the new structure maintain the properties of the input area and show high performance with the target properties applied. Using this structure, it is possible to create more diverse images in the future, so we can expect to utilize image generation in more diverse areas.

• Earthquakes and Structures
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• v.15 no.4
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• pp.383-393
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• 2018

In this study, seismic performance of low and medium-rise RC buildings with wide-beam and ribbed-slab were evaluated numerically. Moment resisting systems consisting of moment and dual frame were selected as structural system of the buildings. Sufficiency of moment resisting wide-beam frames designed with high ductility requirements were evaluated. Upon necessity frames were stiffen with shear-walls. The buildings were designed in accordance with the Turkish Earthquake Code (TEC 2007) and were evaluated by using the strain-based nonlinear static method specified in TEC. Second order (P-delta) effects on the lateral load capacity of the buildings were also assessed in the study. The results indicated that the predicted seismic performances were achieved for the low-rise (4-story) building with the high ductility requirements. However, the moment resisting frame with high ductility was not adequate for the medium-rise building. Addition of sufficient amount of shear-walls to the system proved to be efficient way of providing the target performance of structure.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.2
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• pp.264-270
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• 2011

This paper focuses on possibility to design and fabrication new combination of bullet core to substitute current toxic material of heavy metal such as lead by environment-friendly ones. The core is designed as dual structure to manipulate the core center of gravity easily by combining materials, which of basis is tungsten of low cost and easily acquired. Those combinations are W-M series such as W-Cu, W-Sn, W-Cu-Sn, and W-Cu-Ni to target the density of lead, $11.34g/cm^3$ through powder-metallurgy. Out of four, combination of W-Cu-Ni shows the highest compression density of 96% and is confirmed as the most suitable substitution for lead due to the excellent property of matter and sintering. All combination samples is simulated on the PRODAS software for designing and structure analysis by adjusting the center of gravity of dual core samples forward and backward. The simulations confirm the similarity of current bullet core with respect to properties of mass, aero dynamics, and flying stability.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.60-61
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• 2007

IAZO (indium aluminium zinc oxide) anode films were co-sputtered on glass substrate using a dual target DC magnetron sputtering system. For preparation of IATO films, at constant DC power of IZO (indium zinc oxide) target of 100 W, the DC power of AZO (Aluminum zinc oxide) target was varied from 0 to 100 W. To analyze electrical and optical properties of IAZO anode, Hall measurement examination and UV/V is spectrometer were performed, respectively. In addition, structure of IAZO anode film was examined by X-ray diffraction (XRD) method. Surface smoothness was investigated by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). From co-sputtered IAZO anode, good conductivity($2.32{\times}10^{-4}{\Omega}.cm$) and high transparency(approximately 80%) in the visible range were obtained even at low temperature deposition. Finally, J-V-L characteristics of phosphorescent OLED with IAZO anode were studied by Keithley 2400 and compared with phosphorescent OLED with conventional ITO anode.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.233-236
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• 2000

The acoustical response of fish depends on size and physical structure na, most important, on the presence or absence of a swimbladder. Acoustic scattering models for swimbladdered fish represent a fish by an ideal pressure-release surface having the size and shape as the swimbladder. Target strength experiments of red seabream (Chrysophrys major) have been conducted using 38 (split-beam), 120 (split-beam) and 200kHz (dual-beam) frequencies. At each start of each experiment, the live fish are placed in the cage at the surface, then the cage is lowed to about $4{\cal}m$ depth where it remains during the measurements. To test the acoustic models, predictions of target strength based on swimbladder morphometries of 10 red seabream offish total length from $103{\cal}mm{\;}to{\;}349{\cal}mm$ ($3 <$TL/\lambda$ < 45)are compared with conventional target strength measurements on the same, shock-frozen immediately after caged experiments. X-ray was projected along dorsal aspect to know the morphological construction of swimbladder. and fish body. At high frequencies, Helmholtz-kirchhoff(HK) approximation would greatly enhance swimbladdered fish modeling. Sound scattering model [HK-ray approximation model] for comparison to experimental target strength data was used to model backscatter measurements from individual fish. The scattering data can be used in the inverse method along with multiple frequency sonar systems to investigate the adequacy of classification and identification of fish

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.1
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• pp.68-75
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• 2007

A single chip NFC transceiver supporting not only NFC active and passive mode but also 13.56MHz RFID reader and tag mode was designed and fabricated. The proposed NFC transceiver can operate as a RFID tag even without external power supply which has dual antenna structure for initiator and target. The area increment due to additional target antenna is negligible because the target antenna is constructed by using a shielding layer of initiator antenna. The analog front end circuit of the proposed NFC transceiver consists of a transmitter and receiver of reader/writer block supporting NFC initiator or RFID reader mode, and a tag circuit for target of passive NFC mode or RFID tag mode. The maximum baud rate of the proposed NFC device is 212kbps by using UART serial interface. The chip has been designed and fabricated using a Magnachip's $0.35{\mu}m$ double poly 4-metal CMOS process, and the effective area of the chip is 2200um by 3600um.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.4
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• pp.819-825
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• 2016

In this paper, a phase locked loop structure with parallel dual loop which have a different bandwidth has been proposed. The bandwidths depending on transfer functions are obtained through dual loops. Two different bandwidths of each loop are used to suppress noise on the operating frequency range. The proposed phase locked loop has two different voltage controlled oscillator gains to control two different wide and narrow loop filters. Furthermore, it has the locking status indicator to achieve an accurate locking condition. The phase margin of $58.2^{\circ}$ for wide loop and $49.4^{\circ}$ for narrow loop is designed for stable operation and the phase margin of $45^{\circ}$ is maintained during both loops work together. It has been designed with a 1.8V 0.18um complementary metal oxide semiconductor (CMOS) process. The simulation results show that the proposed phase locked loop works stably and generates a target frequency.

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.397-404
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• 2020

Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.