• Safe Food
• /
• v.7 no.1
• /
• pp.20-25
• /
• 2012

• 대한예방의학회:학술대회논문집
• /
• 2002.10a
• /
• pp.222-223
• /
• 2002

• Laboraroty Animal Research
• /
• v.34 no.4
• /
• pp.160-165
• /
• 2018

Breast cancer remains the second leading cause of cancer death among woman, worldwide, despite advances in identifying novel targeted therapies and the development of treating strategies. Classification of clinical subtypes (ER+, PR+, HER2+, and TNBC (Triple-negative)) increases the complexity of breast cancers, which thus necessitates further investigation. Mouse models used in breast cancer research provide an essential approach to examine the mechanisms and genetic pathway in cancer progression and metastasis and to develop and evaluate clinical therapeutics. In this review, we summarize tumor transplantation models and genetically engineered mouse models (GEMMs) of breast cancer and their applications in the field of human breast cancer research and anti-cancer drug development. These models may help to improve the knowledge of underlying mechanisms and genetic pathways, as well as creating approaches for modeling clinical tumor subtypes, and developing innovative cancer therapy.

• Korean Journal of Social Welfare Studies
• /
• no.39
• /
• pp.395-423
• /
• 2008

This study investigated population characteristics that influencing treatment service use of people who are voluntarily using drug dependency treatment services by using logistic and hierarchical regression analysis. The research model of the current study was driven by the framework of the 'the Behavioral Model of Health Services Use(the Andersen model)' that has been broadly applied to study on health behavior. This study used data from a sample group of 80 adults by using purposive sampling. This study found that some predisposing factors, enabling factors and need factors have direct effects on service use. In detail, individuals who graduated from high school use drug dependency treatment utilities more than those who did not. Further, individuals who were given more support from family, peers, or others, use the treatment utilities more frequently and were more willing to use the utilities continuously. Furthermore, the greater the perceived need felt by the dependent, the greater the tendency to enter hospitals or shelters. The important implications of this study for social work practice and social policy can be summarized as follows: first, this study supports the idea that intervention for drug dependents in Korea should be focused on environment resources rather than population characteristics; and government must support drug dependent treatment systems; the present study was the first to investigate Korean drug dependents through taking a more positive view, as well as the first to apply 'the Behavioral Model of Health Services Use', and as such represents an example of how studies could be productively conducted in the future. Despite these implications, there remain some limitations in this study. These include the following: limitation in generalizability of the results; the cross-sectional nature of the study design; survey research through the questionnaire method; using foreign scales; and the difficulty of classifying treatment settings.

• The Journal of the Korea Contents Association
• /
• v.18 no.11
• /
• pp.98-112
• /
• 2018

In order to find out policy and practical implications to support recovering drug addicts in a holistic way, This study conducted in-depth interviews with five research participants using Giorgi's phenomenological study method to understand the meaning of spiritual experience of recovering drug addicts. According to data analysis, these spirituality experiences appeared as two thematic themes: 'experience of relationship with a divine being' and 'experience of inherent transcendence'. Three sub-themes of 'fear and scary existence', 'hanging object' and 'embracing existence' were derived from the essence theme of 'experience of relationship with a divine being' and 'immanent transcendental experience' was conceptualized into four sub-themes: 'facing existence', 'psychological reconstruction', 'mental maturity', and 'a way to go alone'. Based on this, spiritual experiences of recovery drug addicts showed that religion itself exerted a considerable influence on their spiritual experience and their spiritual experience was closely related to the recovery of humanity. Also, 'intrinsic transcendental experience' suggested that two essential themes of spiritual experience were closely interrelated in a mutual cyclical relationship. Based on the results, We discusses the major intervention plan for the recovery drug addicts that the social welfare system can consider.

• Korean Journal of Food Science and Technology
• /
• v.34 no.5
• /
• pp.762-769
• /
• 2002

As a preliminary test for defining intact yellow croaker pigment, the pigment was analyzed by column chromatography and UV-vis spectrophotometry. All maximum absorbance wavelengths commonly showed three maximum absorbance ranges, similar to those of carotenoid, suggesting that the tested pigment may be carotenoid. We detected total six peak RT values in the chromatogram through PDA-HPLC under gradient mode (behavior A at 10% for initial 2 min and changed to behavior B for 60 min). Most pigments were detected at the peak with 3.27 RT value. Because seven peaks were detected under gradient mode and three under isocratic mode [methanol : methylene chloride (90 : 10, v/v)], gradient mode was determined to be more appropriate for quantitative analysis. By the comparison test of RT values among yellow pigment in croakers and reference pigments, such as zeaxanthine, ${\beta}-cryptoxanthine$, ${\beta}-carotene$, and astaxanthin, only ${\beta}-cryptoxanthine$ was detected in the white croaker, whereas such pigment of yellow croaker having RT value of 31.02 was not detected. Therefore, RT value was found to be applicable for detecting adulterated croaker.

• Health Policy and Management
• /
• v.7 no.1
• /
• pp.125-154
• /
• 1997

The hospital, clinical department and the physician factor in explaining variations of hospital resource use in surgically admitted patients was compared. This analysis was based on 6, 361 discharges in 28 hospitals for three surgical conditions - lens procedures anal and stomal procedures, uterine and ovarian procedures using medical insurnce claim data. The results were as follows: 1. Regression analysis indicated that the hospital and clinical department characteristics, such as hospital ownership and size, were more significant predictors of the resource use indicators than the physician and patients' social characteristics. 2. Regarding to the physician factors, the hospital where the physician received the residency training and the medical shool where he/she graduated had less effect compared to the hospitals where he/she currently works. Between the residency trained hospital and medical school, the is more important than the latter. 3. When the hospital charges were divided into type of service provided i. e. room, drug, laboratory & radiologic, procedure & operation, and anesthesic charges, variance due to the hospital factor was larger than that due to the physician factor in each item. In summary, the hospital and clinical departmental factor played an important role than physician factor ; indicating to reduce the variation in hospital resource use, the policy that affects hospital behavior would be more effective than that targets individual physician behavior.

• Quality Improvement in Health Care
• /
• v.27 no.1
• /
• pp.20-25
• /
• 2021

Purpose: The ability to access clinical trials for cancer treatment is important. This study investigated whether regional differences exist in oncologic clinical trial protocols conducted in South Korea. Methods: Records of all approved oncologic clinical trials conducted in 2019 were downloaded from the Republic of Korea Ministry of Food and Drug Safety. The study covered Seoul, the capital area, other metropolitan cities, and provincial areas. Descriptive statistics summarized the distribution patterns of clinical trials by region. Results: A total of 202 oncologic clinical trials were conducted in 63 institutions in 2019. Of these protocols, 186 (92%) were available in Seoul, 120 (59%) in the capital area, 64 (32%) in metropolitan cities, and 66 (33%) in provincial areas. More regional differences in protocol availability were observed in domestic trials, investigator-initiated trials, phase 1 and 2 trials, and smaller-scale trials. Conclusion: Most oncologic clinical trials were conducted in medical institutions located in Seoul, with the rest conducted in the capital area, metropolitan cities, and provincial areas. The findings reveal clear differences in protocol availability between Seoul and the other regions. Measures designed to improve geographical access to oncologic clinical trials may be needed given their growing importance in cancer treatment.

• Korean Journal of Food Science and Technology
• /
• v.34 no.6
• /
• pp.977-983
• /
• 2002

This study was performed to establish the precise and rapid method to distinguish croakers through the pigment analysis of colored imported white croakers for adultration. We surveyed the coloring behaviors, extraction test by water and organic solvent and using pigments such as targeting, curcumine, and azo dye products. The pigment of yellow croaker is not stained on wet cloth or tissue which is rubbed on epidermis of yellow croaker and was not eluted in water extraction test, while adulterated pigments were easily extracted by water and acetone, but edible diluted yellow, Yellow No. 4 and Yellow No. 5 were not extracted. Reactive pigment was detected easily by extraction with water and dispersed pigment was also detected by extraction test. As a result of discoloring characteristics of carotene having similar structure to yellow croaker and azo dye by oxidation and reduction, azo dyes were not discolored by oxidation with sodium percarbonate or peracetic acid but that were discolored by oxidation with Fenton reagent after 1hr and by hypochlorite promptly. On the other hand, carotenes were not discolored by sodium precarbonate and Fenton reagent but discolored by sodium hypochlorite after 2 hr and by peracetic acid promptly. Azo dyes were discolored by reduction with sodium hydrosulfite and sodium carbonate but carotenes were not discolored by these reagents. This discoloring test was applicable to detect adulterated pigments and other marine product.

• Journal of the Korean Society of School Health
• /
• v.33 no.2
• /
• pp.115-124
• /
• 2020

Purpose: The purpose of this study was to compare the health risk behaviors, mental health and subjective health status of adolescents in multicultural families and monocultural (Korean) families. This study was conducted to prepare basic data for education and policy proposals related to health promotion of adolescents in multicultural families. Methods: The study was a secondary analysis using the raw data of the 15th Youth Risk Behavior Web-based Survey (2019). A complex sample multiple logistic regression analysis was conducted to understand the influence of growing up in a multicultural family on health risk behaviors, mental health and subjective health status by comparing the variables to those of monocultural adolescents. Results: Adolescents from multicultural families had a 3.3 times higher rate of drug use experience, 1.89 times higher rate of sexual experience, and 1.24 times higher rate of not wearing seat belts. In addition, the rate of not washing hands and the rate of suicide attempts were 1.34-1.50 times and 1.62 times higher, respectively, compared to adolescents from monocultural families. Conclusion: This study showed that it is necessary to develop appropriate health promotion programs to solve the problems of drug use, sexual intercourse, not wearing seat belts, not washing hands, and attempting suicides, which are more prevalent among adolescents from multicultural families than from monocultural families. It will serve a basic policy for the long-term development and growth of Korea at this critical time when multicultural adolescents are increasing.