• Mass Spectrometry Letters
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• 제13권4호
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• pp.152-157
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• 2022

Schisandra chinensis and its fruits have been used as a traditional herbal medicine to treat liver dysfunction, fatigue, and chronic coughs. Several in vitro and in vivo studies suggested that dibenzocyclooctadiene lignans present in Schisandra fruits strongly inhibit CYP3A4 activity. However, reports on the inhibitory potential of dietary Schisandra supplements against CYP3A activity are limited despite their increasing consumption as dietary supplements. In this study, we evaluated the CYP3A-inhibitory potential of four dietary Schisandra supplements in human liver microsomes. At a concentration of 0.05 mg/mL, Schisandra supplements from Nature's Way, Swanson, Planetary Herbals, and Only Natural inhibited CYP3A activity by 93.9, 70.8, 33.6, and 24.8%, respectively. Nature's Way, which exhibited the strongest inhibition against CYP3A, had the highest contents of gomisin B and gomisin C, which potently inhibit CYP3A activity. The in vivo pharmacokinetics of this product should be examined to determine whether the clinical relevance of inhibiting CYP3A activity by dietary Schisandra supplementation.

• 대한약학회:학술대회논문집
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• 대한약학회 1999년도 PharmWorld
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• pp.30-60
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• 1999

In spite of many studies of The Korean Association of College of Pharmacy for improvement of the Korean pharmacy education and decrearing to change 4 year curriculum for pharmacy education to 6year curriculum from 1998 by The Ministry of Health and Wellfaire, there are many problems right now in view of the student-oriented education in front of the revolution program of The Ministry of Education. So the student-oriented reformation for pharmacy education in Korea was studied not only by observations of worldwide pharmacy education and pharmacy system, but also by 416 questionaires from many kinds of man and women such as pharmacists in drug store and hospital(159), administraters of The Ministry of Health and Wellfaire (59), professors in college of pharmacy (65), researchers in pharmaceutical company (31) and seniors in college of pharmacy(102).It shows that our Korean pharmacy education was a type of teacher-oriented education which is caused by the short time-education, a lots of subjects in the examination for pharmacy license and egoism of professors for their subjects, and so our teacher-oriented education have to change to the student-oriented education for the most function of pharmacist which is the pharmaceutical care for patients. For the preparing the clerkship/externship for one year, we have to change 4 year curriculum to 6 year curriculum for clinical pharmacy edu-cation, and also subjects of pharmacy in the national examination for pharmacy liciense have to reduce within 3-4 subjects of totally non-subject examination. The Korean Association of Collage of Pharmacy of Pan-pharmaceutical Revolution Association must purchase them and their program can be begun right now in spite of loss of the pharmacist supplement for 2 year and preparing the program of 6 years curriculum. Our teaching purposes of departments of pharmacy and manufacturing pharmacy were respectively clinical pharmacy, and development of new drug and compounding of many kinds of commercial drugs, but we have been not gone to their goals, respectively, because of short time-education for pharmacy as compared as world-wide pharmacy education containing the clerkship/externship and same twelve subjects in their examination for pharmacy license. Most function of pharmacist in Korea are the development of new drug, and social and administrative pharmacy in health care for patients, and so we have to teach them in the department of maunfacturing pharmacy.

• Advances in nano research
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• 제15권3호
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• pp.225-237
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• 2023

Combination of novel technologies with traditional physiotherapy in rehabilitation in injured athletes have shown to provide improved time of recovery. In specific, nanodrugs delivery systems are widely utilized as a counterpart to the physiotherapy in injuries in sports. In the present study, we focus on the common injuries in dance-sports, their recovery and the effect combination of nano-particle drug delivery with the physiotherapy practices. In this regard, a comprehensive review on the common injuries in dance sport is provided. Moreover, the researches on the effectiveness of the nano-particle drug delivery in therapy of such injuries and in similar cases are provided. The possibility of using combination of nano-particle drug delivery and physiotherapy is discussed in detail. Finally, using artificial intelligence methods, predictions on the recovery time and after-treatment side-effects is investigated. Artificial Neural Network (ANN) predictions suggested that using nano-particle drug delivery systems along with physiotherapy practices could provide shortened treatment time to recovery in comparison to conventional drugs. Moreover, the post-recover effects are less than the conventional methods.

• 산업융합연구
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• 제20권7호
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• pp.97-105
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• 2022

통풍은 관절염뿐만 아니라 심혈관질환 등을 유발하는 만성염증질환이다. 하지만 대부분의 환자들이 단순히 관절질환으로 인식하고 있어 치료에 장애로 작용한다. 이 연구를 통해 간호사 주도의 통풍환자 대상 교육이 환자의 통풍에 대한 인식 개선 및 질병 경과에 미치는 영향을 확인하고자 하였다. 교육전문 간호사가 상급종합병원 류마티스내과 외래에 내원한 환자를 대상으로 통풍에 대한 일대일 교육을 시행하였고 환자의 만족도 및 복약순응도, 혈중 요산치의 변화 정도를 측정하였다. 교육을 받은 환자군의 진료만족도는 대조군에 비해 유의하게 높았으며 두 번째와 세 번째 외래 방문 시에 측정한 복약순응도와 혈중 요산치는 대조군에 비해 교육군에서 유의하게 개선이 되었다. 결론적으로 간호사 주도 환자교육은 진료 만족도 개선 및 질환 경과의 호전에도 도움이 되는 것으로 확인되었다.

• 한국환경농학회지
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• 제34권2호
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• pp.111-119
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• 2015

BACKGROUND: Ethychlozate (ECZ) is a plant growth regulator of synthetic auxin for agricultural commodities (ACs). Accurate and sensitive method to determine ECZ in diverse ACs on global official purpose is required to legal residue regulation. As the current official method is confined to the limited type of crops with poor validation, this study was conducted to improve and extend the ECZ method using high-performance liquid chromatography (HPLC) in all the registered crops with method verification. METHODS AND RESULTS: ECZ and its acidic metabolite (ECZA) were both extracted from acidified samples with acetone and briefly purified by dichloromethane partition. ECZ was hydrolyzed to form ECZA and the combined ECZA was finally purified by ion-associated partition including hexane-washing. The instrumental quantitation was performed using HPLC/ FLD under ion-suppression of ECZA with no interference by sample co-extractives. The average recoveries of intra- and inter-day experiment ranged from 82.0 to 105.2% and 81.7 to 102.8%, respectively. The repeatability and reproducibility for intra- and inter-day measurements expressed as a relative standard deviation was less than 8.7% and 7.4%, respectively. CONCLUSION: Established analytical method for ECZ residue in ACs was applicable to the nation-wide pesticide residues monitoring program with the acceptable level of sensitivity, repeatability and reproducibility.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3203-3211
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• 2015

This study identified the actual conditions for safe anticancer drug management among nurses and the relationship between level of awareness and performance of anticancer drug safety regulations in terms of preparation, administration, and disposal. The respondents were 236 nurses working with chemotherapy in wards and outpatient clinics in five hospitals in and near Seoul. Safety regulations provided for the anticancer drug the Occupational Safety Health Administration (OSHA, 1999), as modified for an earlier study, were used. The results showed that the level of awareness and performance on the anticancer drug safety regulations indicate their preparation ($3.38{\pm}0.55$, $2.38{\pm}0.98$), administration ($3.52{\pm}0.46$, $3.17{\pm}0.70$), general handling and disposal ($3.33{\pm}0.54$, $2.42{\pm}0.90$) on a scale 0 to 5. Also, there were significant differences in job positions, work experience, type of preparation, and continuing education and a positive relationship between the level of awareness and nursing performance. Thus, nurses should receive continuing education on the handling of anticancer drugs to improve the level of performance following safety regulations.

• 한국학교보건학회지
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• 제34권3호
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• pp.161-169
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• 2021

Purpose: The purpose of the study was to investigate the effect of loneliness on habitual drug use in Korean adolescents. Methods: The study was designed as a cross-sectional study. Using statistics from the 16th (2020) Korea Youth Risk Behavior Web-based Survey, multiple logistic regression analysis was conducted. A total 54,948 adolescents were included in the analysis. Results: Adolescents were more likely to engage in habitual drug use when they were lonely than when they were not (OR: 1.55, 95% CI: 1.20~2.02). As for sociodemographic characteristics, gender, academic achievement, and living with family were factors influencing habitual drug use. As for health behavior characteristics, perceived stress, depression, current drinking, violence, sexual intercourse, and perceived health were identified as factors affecting habitual drug use. Conclusion: Provision of education that includes loneliness as a factor, which was not previously considered important in school education for preventing habitual drug use of adolescents, should be considered.

• 한국학교보건학회지
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• 제19권2호
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• pp.89-104
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• 2006

Purpose： This study was to develop and verify the effects of drug misuse and abuse preventive program for middle school students. Methods：This research was a quasi experimental study under the nonequivalent control group with pretest-post test design which tried to protect children from the detrimental effect of drugs and develop a drug abuse prevention program for middle school students. Data was collected from October 10th to 21th, 2005. Subject consisted of 145 middle school students in Kyeonggi, experimental group-72, control group-73. Dick & Carey's(1996) educational system was applied, based on documents and materials online related to drug abuse in order to develop drug abuse prevention program. It's composed of 4 parts, 45 minute each. The evaluation instrument testing for the knowledge about drugs was a criterion of referenced test items modeled by Dick & Carey. The instrument for attitudes about drugs was modeled by Kim, Soyaja. A pre-test was taken on the knowledge and attitudes to drugs. The experimental students were given four sessions of drug abuse prevention education. A post-test similar to the pre-test questionnaire was given in 1 week, 4 weeks following the last session. Collected data was analyzed by using SAS 9.1 program. Results：Followings are the summarized result of study 1. The experimental group, that attended the drug abuse prevention program will have more knowledgable about drugs than the control group (F=27.31, p<.0001). 2. The experimental group, that attended the drug abuse prevention program displayed greater negativism attitude than the control group (F=0.58, p=0.4477). Conclusion：The results conclude that drug abuse prevention programs increase the knowledge of middle school students but doesn't change their attitude toward drugs. Therefore we need to offer them more systematic education to increase their knowledge so it will also improve their attitudes as well.

• Journal of Ginseng Research
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• 제47권1호
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• pp.1-8
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• 2023

The herbal medication Panax ginseng Meyer has widespread use in China, Korea, and other parts of the world. The main constituents of ginseng are ginsenosides, which include over 30 different triterpene saponins. It has been found that ginsenosides and their metabolites including Rg1, compound K, Rb1, Re, Rg3, and Rg5 exert anti-inflammatory activities by binding to the glucocorticoid receptor, modulating inflammation-related signaling, including NF-κB and MAPK signaling, and reducing levels of proinflammatory cytokines. Here, we review the recent literature on the molecular actions of ginsenosides in sepsis, suggesting ways in which they may be used to prevent and treat the disease.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.62-65
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• 1998