• Biomolecules & Therapeutics
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• 제26권5호
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• pp.425-431
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• 2018

Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, $Ca^{2+}$/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and ${\gamma}$-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an antidepressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression.

• Environmental Analysis Health and Toxicology
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• 제27권
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• pp.7.1-7.7
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• 2012

Objectives: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted to investigate practical use and toxic effects on neuro-immune interaction of modafinil. Methods: This study reviewed the significance of psychoactive drugs, and discussed the benefits and risks of the application of modafinil, which seems to be ideal as an anti-psychotic or anti-fatigue agent. Results: Modafinil is known to have less or no adverse effects than those found in traditional psychostimulants such as amphetamine, methylphenidate or cocaine. It can be applied as an anti-psychotic or anti-fatigue agent. However, the waking mechanism of modafinil is yet to be fully revealed. Recent studies reported that modafinil may be subject to abuse and addiction. In addition prolonged sleeplessness induces stress responses and impairs immune function. Conclusions: Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.

• 한국콘텐츠학회논문지
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• 제18권11호
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• pp.98-112
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• 2018

이 연구는 회복기 마약중독자의 영성 체험의 의미를 총체적으로 이해하여 이들을 지원하기 위한 정책적, 실천적 시사점을 도출하는데 이 연구의 목적이 있다. 이를 위해 Giorgi의 현상학적 연구방법을 활용하여 5명의 연구 참여자를 대상으로 심층 면담을 진행하였다. 자료 분석결과, 이들의 영성 체험은 '신적 존재와의 관계 체험', '내재적 초월 경험'이란 2가지 본질 주제로 나타났다. 그리고 '신적 존재와의 관계 체험'이란 본질 주제는 '두렵고 무서운 존재', '매달리는 대상', '품어주는 존재'란 3가지 하위 주제로 도출되었으며, '내재적 초월 경험'은 '실존의 직면', '심리적 재구성', '정신적 성숙', '혼자서가야 하는 길' 이란 4가지 하위 주제로 개념화되었다. 이를 기반으로 이 연구는 회복기 마약중독자들의 영성 체험은 종교 그 자체가 이들의 영성체험에 상당한 영향력을 발휘하고 있다는 점, 이들의 영성체험은 인간성 회복과 밀접하게 연관되어 있다는 점, 그리고 '신적 존재와의 관계 체험'과 '내재적 초월 경험'이란 영성 체험의 2가지 본질적 주제가 상호 순환적 관계 속에서 서로 유기적으로 영향을 미치고 있다는 점을 시사 받을 수 있었다. 이를 토대로 사회복지계가 숙고해 볼 수 있는 회복기 마약중독자들을 위한 개입 방안에 대해 논의하였다.

• 한국학교보건학회지
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• 제19권2호
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• pp.1-12
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• 2006

Purpose： The purpose of this study was to investigate the current conditions and to analysis the needs of health education contents in school nurses and elementary school children. Methods : The survey was conducted through the questionnaire with school nurses and students. Subjects were 60 school nurse and 1483 elementary school children. Data was collected based on the from Mar to Apr. 2004. Finally, data was analyzed using mean, SD, and t-test. Results : The students need the health education related safety, oral hygiene, visual promotion, scoliosis prevention, cyber addiction prevention, anti-bullying and school violence prevention. School nurses suggest the contents of health education such as sex education, drug misuse and overuse prevention. There was also a difference in the need of health education among the school nurse and students. Conclusion：I suggest that health education should be conducted taking students' demand in each grade into consideration. School nurses need to positively improve the priorities of health education based on the students' demand.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4495-4499
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• 2013

Morinda citrifolia, also known as Great Morinda, Indian Mulberry, or Noni, is a plant belonging to the family Rubiaceae. A number of major chemical compounds have been identified in the leaves, roots, and fruits of the Noni plant. The fruit juice is in high demand in alternative medicine for different kinds for illnesses such as arthritis, diabetes, high blood pressure, muscle ached and pains, menstrual difficulties, headache, heart diseases, AIDS, gastric ulcer, sprains, mental depression, senility, poor digestion, arteriosclerosis, blood vessel problems, and drug addiction. Several studies have also demonstrated anti-inflammatory, antioxidant and apoptosis-inducing effects of Noni in various cancers. Based on a toxicological assessment, Noni juice was considered as safe. Though a large number of in vitro, and, to a certain extent, in vivo studies demonstrated a range of potentially beneficial effects, clinical data are essentially lacking. To what extent the findings from experimental pharmacological studies are of potential clinical relevance is not clear at present and this question needs to be explored in detail before an recommendations can be made.

• 보험의학회지
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• 제31권1호
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• pp.10-14
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• 2012

The importance of the diseases which are differentiated with acute myocardial infarction (AMI) cannot be overemphasized in insurance medicine. Although there are lots of diseases similar with AMI, in this paper, 5 diseases were described; Myocardial bridging, cocaine toxicity, myocarditis, cardiac syndrome X, and Takotsubo syndrome. Costs of the interventions like coronary angiography or echocardiography are relatively low in Korea compared to western countries. Therefore, detection of those diseases has been increased recently and illegal drug addiction also has been increased probably due to globalization. In conclusion, the knowledge of those diseases dealt with this article could be helpful for the person who is related to insurance medicine.

• Biomolecules & Therapeutics
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• 제28권4호
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• pp.293-301
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• 2020

Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the airway obstruction and the colonization of pathogenic microbes. Developing a novel pharmacological agent to regulate the production and/or secretion of pulmonary mucus can be a useful strategy for the effective management of pathologic hypersecretion of mucus observed in COPD and asthma. Thus, in the present review, we tried to give an overview of the conventional pharmacotherapy for mucus-hypersecretory diseases and recent research results on searching for the novel candidate agents for controlling of pulmonary mucus hypersecretion, aiming to shed light on the potential efficacious pharmacotherapy of mucus-hypersecretory diseases.

• Journal of applied mathematics & informatics
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• 제41권6호
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• pp.1377-1391
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• 2023

When sensitive topics such as gambling habits, drug addiction, alcoholism, tax evasion tendencies, induced abortions, drunk driving, past criminal involvement, and homosexuality are the focus of open or direct surveys, it becomes challenging to obtain accurate information due to nonresponse bias and response bias. People often hesitate to provide truthful answers. Warner introduced an ingenious method to address this issue. In this study, a new and unrelated randomized response model is proposed to eliminate misleading responses and nonresponses caused by the stigma associated with the attribute being investigated. The proposed randomized response model allows for the estimation of the population percentage with the sensitive characteristic in an unbiased manner. The characteristics and recommendations of the proposed randomized response model are examined, and numerical examples are provided to support the findings of this study.

• Journal of Yeungnam Medical Science
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• 제40권1호
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• pp.78-85
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• 2023

Background: Poor sleep quality is associated with psychoactive substance abuse/addiction/withdrawal. Auricular acupuncture (AA) is a nonpharmacological method used for the treatment of sleep disturbances. This study aimed to examine the quality of sleep before and after AA in participants with mental and behavioral disorders due to prior multiple drug use in the therapeutic community. Methods: This was a consecutive case series of 27 participants (25 male [92.6%]). The median age was 35.0 years (interquartile range [IQR], 29.0-37.2 years), methadone/buprenorphine were not used, and the participants were treated with AA (median number of treatments, 15.0 [IQR, 12.0-18.0]) during a median period of 51.0 days (IQR, 49.0-51.0 days) according to the National Acupuncture Detoxification Association (NADA)-Acudetox protocol. Sleep quality was determined using the Pittsburgh Sleep Quality Index (PSQI), a self-rated questionnaire that assesses sleep quality and disturbances over a 1-month interval. Results: The global PSQI score dropped (indicating better sleep quality) by a median of 3.0 points (IQR, 0.0-8.0 points) after treatment. In the multivariate logistic regression analysis, with an increase in global PSQI score during AA by 1 point, there was a 0.73-fold reduction in the risk of poor sleep quality post-AA (adjusted odds ratio, 0.73; 95% confidence interval, 0.52-1.01; p<0.055; Nagelkerke's R² =0.66). Conclusion: The results revealed a positive effect of AA (by the NADA-Acudetox protocol) on sleep quality (as measured by PSQI) among participants in a treatment center with mental and behavioral disorders due to multiple drug use.

• 동의신경정신과학회지
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• 제16권2호
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• pp.135-148
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• 2005

Objective : The purpose of this study is to take around the oriental medical treatment about substance related disorder in china. Method : We review the studies which are published by six different journal in China since 1992 to 2002 involved in substance related disorders. Result 1. The kinds of substance which is the subject of each study. It suggest that the narcotics-withdrawal patients in china take kinds of opium many more than phillopon or barbiturate, cocain etc. especially the heroine takes the most portion in the kinds of opium. 2. The type of chinese medicine demonstration which is about the addiction and withdrawal. There are many symptoms in the each period of withdrawal, According to the each period demonstration, the herbal formula must be different. 3. The formula used in treatment and the substance which is used in common Codonopsis radix is widely used, and pinellia ternata, aractylodes japonica, citrus nobilis, vegetable worms, angelica gigas, zizyphus jujuba, panax ginseng, astragalus membranaceus etc are also used in treatment. 4. The methods of acupunture treatment Hapkok(LI-4), Naegwan(PC6), and Sanyinjiao(SP6) are the widely used acu-points. in addition to these acupoints, there are waegwan(TE5) choksamli(ST36) hanggan(LR2)etc. Conclusion : We expect that this review about substance related disorders in TCM help the clinical study of substance related disorders in Korean medicine.