• Journal of architectural history
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• v.15 no.1 s.45
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• pp.7-27
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• 2006

This study aims to identify and analyze the factors that influenced the construction of London Eye which was led by private groups, including characteristics in progress, differentiated value in design, the combination of technology and design, and construction costs. The results of this study were the followings. 1) London Eye provides a new construction method for a landmark in the downtown in that the architects became the clients of the project which might have been hoarded, procuring the construction costs and completing it by themselves. 2) London Eye presents a space utilization method where undeveloped spaces in the downtown are used in three-dimensions by erecting a structure on the river with a minimum land. 3) The process of design, production and erection is propelled the realization of technical intention design with one system and from at the initial stage, the participation of the engineer where the designer is equal with you must accompany. 4) London Eye is endowed with strong shape by a circle in design concept, which is the simplest geometrical figure, and it provides organic relationship between the past and the present by utilizing historical elements in various ways. 5) The construction was completed through four phases including idea phase, promotion phase, turn-key contract phase, and design-build phase. The most critical factor to the success is derived from the direct contact with Involved companies from the production phase. 6) In a project facing many challenges in terms of technology, the design-build method proves to be a more effective method than turn-key contract in that it may more allocate risks and enable coherent implementation of the core concept in design. The organization for the design-build method was composed of three phases including general affairs, responsible contracting by sector, and cooperative system by sector. Since that was a new concept structure, high-level contractors who hadn't had existing cooperative relationships with one another formed new cooperative relationship, while collaborating companies who had long cooperated led the responsible contracting and sub-cooperative system, which resulted in reduction of risks and time. 7) The major factors to change design were the design characteristics, derived from a technically great combination, and the opening time. 8) A new erection method was applied to London Eye, a structure that overcame the limitation in land and period, and the process of installation demonstrated that it is an important value for the construction of a landmark in the city. 9) In spite of many visitors and tremendous operational income, the factors that London Eye fails to free itself from debts include the construction costs expended double than expected, and interest burden to the investments, which occurred in the course of procuring the costs. Absolute limit in time increased the construction costs, resulting in being a great obstacle in the course of operation.

• Korean Journal of Animal Reproduction
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• v.21 no.4
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• pp.335-343
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• 1997

The effect of thiol compounds on development and intracellular glutathione(GSH) concentrations of bovine embryos produced by in vitro maturation and in vitro fertilization(IVM/IVF) was examined in CRlaa medium with or without $\beta$-mercaptoethanol(0, 10, 25 and 50$\mu$MME) and cysteamine(0, 25, 50 and 75 $\mu$M). Numbers of cells comprising blastocysts were also counted using double fluorescence stain and the total glutathione levels(oxidized and reduced form) of morula and blastocyst embryos were than measured by an enzymatic method. Following routine IVM/IVF procedures oocytes and zygotes were cultured for 40 to 44h in CRlaa medium. Then 2 to 8-cell embyos had cumulus cell removed and were allotted randomly to the experimental medium. In Experiment 1, the proportion of embryos developing to and beyond morulae stages in 0, 10, 25 and 50 $\mu$M $\beta$-ME was 42.9%, 50.0%, 53.7% and 65.6%, respectively. Fifty $\mu$M $\beta$-ME group was significantly higher than those of any other groups (P<0.05). In Experiment 2, the percentages of embryos developed beyond morulae stages in 0, 25, 50 and 75 $\mu$M cysteamine was 42.9%, 40.4%, 60.0% and 59.2%, respectively. Fifty and 75$\mu$M cysteamine groups were significantly higher than in 0 and 25 $\mu$M cysteamine groups, but all of culture medium containing cysteamine(52.6%) was not significantly difference in control group(42.9%). In Experiment 3, the intracellular GSH concentrations of morulae and blastocyst embryos in 0 and 50 $\mu$M $\beta$-ME was 42.4 pM and 44.9 pM, 49.5 pM and 67.8 pM, respectively. Morulae embryos were not difference, but blastocyst embryos were significantly difference between treatments(P<0.05). In Experiment 4, the intracellular GSH concentrations of morulae in CRlaa with or without cysteamine were 39.8 pM and 45.6 pM, and blastocysts were 59.3 pM and 66.8 pM, respectively. Cell numbers of blastocysts were similar to in all experimental groups. These experiments indicate that thiol compounds can increase the proportion of embryos that developing to and beyond morulae stage and the intracellular GSH concentrations.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.65 no.4
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• pp.255-263
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• 2020

In this study, we evaluated the salinity tolerance of five forage rice cultivars (Mogwoo, Mogyang, Miwoo, Jowoo, and Yeongwoo) with respect to germination, seedling growth, productivity, and feed values in a reclaimed paddy field in Muan, Korea. We found that the cultivars Mogwoo, Miwoo, Jowoo, and Yeongwoo showed normal germination and seedling growth, even at saline concentrations of between 0.1% and 0.5%, whereas in contrast, there were significant reductions in the germination and seedling growth of Mokyang with an increase in salt concentration. Among the five cultivars assessed, the seedling growth of Mogwoo and Yeongwoo was relatively higher at different salt concentrations in hydroponic and sand cultivation. Furthermore, cultivation of the five cultivars in the reclaimed paddy field with an initial salt concentration of 0.3% revealed that Yeongwoo was relatively superior in terms of yield and feed value. In conclusion, the germination and early growth of Yeongwoo were relatively good at high salt concentrations, and the yield and forage value of this cultivar in a reclaimed paddy field were also relatively superior to those of the other assessed varieties.

• Journal of Food Hygiene and Safety
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• v.20 no.3
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• pp.185-190
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• 2005

Perilla oil was measured on hygiene state and quality change for oil press condition. All sample .was commercially salted perilla oil, and was tested standard items. The result showed violative rate of $23.1\%$, and violative items were acid value and iodine value. Relationship between D.B.I. and iodine value was 0.78, so that unsuitability of iodine value should be caused of oxidation factor. But acid value was not relationship comparatively. The quality change appeared very small by roasting conditions, but quality of perilla seed gaye many influence on quality of oil. Therefore use of fresh perilla seed is a matter of great importance to quality of perilla oil. Perilla oil was demanded many attention on Quality management for stage and sold period because of high possibility of quality change.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.92-97
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• 2005

Inhibition of inflammatory response, acceleration of basal cell growth, and balanced synthesis of extracellular matrix (ECM) are important in healing of cutaneous open wounds. In order to evaluate the healing effects of water extracts of Radix Astragali (the root of Astragalus membranaceus (Fisch.)) on open wound at early stage, the experimental open wounds were generated on the dorsal sides of SD rats under anesthesia. The boiled-water extracts of Radix Astragali $(100{\mu}l)$, soaked into an occlusive film dressing were applied once a day for eleven consecutive days. The healing process was assessed by measuring macroscopic appearance and wound areas of the open wounds. The molecular aspects of healing process by Radix Astragali extracts were also investigated by Hematoxylin-Eosin (H-E) double staining and immunohistological staining of collagen type I in the healed skin area, implying cell density and linear alignment of the granulation tissue, and ECM synthesis and its remodeling, respectively. The Astragali radix extracts were found to significantly accelerate the cutaneous wound healing by suppressing the inflammation and stimulating the basal cell growth in wounded area, as compared to epidermal growth factor (EGF).

• Journal of Veterinary Clinics
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• v.29 no.6
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• pp.435-440
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• 2012

This study was designed to evaluate the clinical efficacy and safety of Rhubarb extracts ($Rubenal^{(R)}$) in dogs with chronic renal failure (CRF). Client-owned 40 dogs with CRF graded International renal interest Society (IRIS) II-III were enrolled in this study. The dogs were equally allocated and blindly administered with $Rubenal^{(R)}$ or placebo. The following items were evaluated at day 0, 30, 90 and 180: body condition score (BCS), clinical score (appetite, polydipsia/polyuria, quality of life score), hemogram (WBC, RBC, PCV), serum biochemistry (ALT/AST, ALP, Creatinine/BUN, total protein, albumin), serum electrolyte (Na, K, Cl, Ca, P), systolic blood pressure, urinalysis (UPC, USG) and IRIS stage. In this study, we found that the $Rubenal^{(R)}$ preparation was well tolerated by dogs and induced no adverse effects. Statistically significant improvements were observed in clinical score (quality of life score by vet and clients), serum BUN and creatinine levels, serum phosphorus concentration, level of proteinuria, and the IRIS score of CRF in dogs after 6 month of treatment of $Rubenal^{(R)}$. Those findings suggested that the Rhubarb extracts can improve the clinical signs of CRF (i.e. azotemia, hypertension, proteinuria, hyperphosphoremia) and the quality of life (i.e. BCS, clinical score) and can retard the progression of CRF in dogs. Therefore the Rhubarb extracts can be a good supplementary drug for treating dogs with subclinical and clinical renal diseases. However, care should be taken for interpreting our result, because this study is not double-blinded controlled study but pilot study.

• Journal of Bio-Environment Control
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• v.16 no.2
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• pp.89-95
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• 2007

This study was accomplished to compare energy saving effects of several heat insulation materials in greenhouse and to develop new automatic opening and closing equipment which is suitable to the most effective heat insulation material. To find out more effective heat insulation material, the magnitude of heat transfer occurred through aluminum screen (ALS), non-woven fabric (NWF), double-layer aluminum screen with chemical cotton sheet (DAL), and multi-layer fabric screen material quilted with non-woven fabric, chemical cotton, poly foam, and polypropylene (MLF) were compared relatively. The results showed that the relative magnitude of heat transfer occurred through MLF was lower than DAL and ALS by 23.3% and 43.0% respectively. MLF screen material was the most effective compared with other heat insulation materials. But because of thickness, there was a need of new mechanism for automatic operation in greenhouse. Accordingly, new screen system using MLF-thick but profitable for keeping warm in greenhouse-was developed. Opening & closing equipment was designed to roll MLF with pipe axis during opening process and pull MLF with string during closing process with electric motors, clutches, drums, and so on. In hot pepper cultivation and energy saving test during winter time, the early stage yield of pepper under MLF screen system was higher than NWF by 27%, and gasoline consumption of MLF screen system was lower than NWF by 46%.

• Journal of Navigation and Port Research
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• v.30 no.3 s.109
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• pp.173-179
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• 2006

A number of perforated plates are utilized for the passage of the crew and the equipment, reducing weight and the arrangement of piping. Hull girders in double bottom and floor plates are the typical parts which have those plates in a ship structure, and the perforated plate is usually positioned at the place which has less loading without local strength problems. In the case of utilizing the plate inevitably at the place which has large strength, an opening of the plate has large effect on the buckling strength due to in-plane rigidity and ultimate strength. Therefore the assessments of the elastic buckling strength and the ultimate strength for the perforated plate are the essential requirements for determining the dimensions of the parts at the initial design stage. With above reason, a need of the reasonable assessments for the elastic buckling strength and the ultimate strength has evolved. The numerical series analysis with the consideration of the effect due to various aspect ratios and slenderness ratios were performed using finite element method in this research. Simple formulas for the design are also proposed from the above analysis.

• Journal of the Korean Geotechnical Society
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• v.31 no.5
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• pp.23-33
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• 2015

In the present study, a ground heat exchanger was installed for each heat source in the system at the site to evaluate ground heat conductivity, constructability, and economic feasibility; the factors considered in the study included ground heat, groundwater, fillers (such as bentonite and pea pebbles) and the shape of the heat exchange pipe (e.g., U and D-U). The aim was to determine the ground heat exchanger appropriate for the geothermal system in the 3rd-phase construction of Incheon International Airport. A comparative cost analysis of the initial costs based on the above information showed that although the initial costs of the regular vertical closed loop-II and modified vertical closed loop were lower than those of the regular vertical closed loop-I, they could not be expected to deliver high economic efficiency from the viewpoint of constructability (filler injection, heat exchange pipe insertion). The initial costs proved to be higher in the case of Geohil.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3301-3306
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• 2015

Nucleolin (C23) is an important anti-apoptotic protein that is ubiquitously expressed in exponentially growing eukaryotic cells. In order to understand the impact of C23 in radiation therapy, we attempted to investigate the relationship of C23 expression with the radiosensitivity of human non-small cell lung cancer (NSCLC) cells. We investigated the role of C23 in activating the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), which is a critical protein for DNA double-strand breaks (DSBs) repair. As a result, we found that the expression of C23 was negatively correlated with the radiosensitivity of NSCLC cell lines. In vitro clonogenic survival assays revealed that C23 knockdown increased the radiosensitivity of a human lung adenocarcinoma cell line, potentially through the promotion of radiation-induced apoptosis and adjusting the cell cycle to a more radiosensitive stage. Immunofluorescence data revealed an increasing quantity of ${gamma}$-H2AX foci and decreasing radiation-induced DNA damage repair following knockdown of C23. To further clarify the mechanism of C23 in DNA DSBs repair, we detected the expression of DNA-PKcs and C23 proteins in NSCLC cell lines. C23 might participate in DNA DSBs repair for the reason that the expression of DNA-PKcs decreased at 30, 60, 120 and 360 minutes after irradiation in C23 knockdown cells. Especially, the activity of DNA-PKcs phosphorylation sites at the S2056 and T2609 was significantly suppressed. Therefore we concluded that C23 knockdown can inhibit DNA-PKcs phosphorylation activity at the S2056 and T2609 sites, thus reducing the radiation damage repair and increasing the radiosensitivity of NSCLC cells. Taken together, the inhibition of C23 expression was shown to increase the radiosensitivity of NSCLC cells, as implied by the relevance to the notably decreased DNA-PKcs phosphorylation activity at the S2056 and T2609 clusters. Further research on targeted C23 treatment may promote effectiveness of radiotherapy and provide new targets for NSCLC patients.