• Title/Summary/Keyword: Double Cycle

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Celecoxib, a COX-2 Selective Inhibitor, Induces Cell Cycle Arrest at the G2/M Phase in HeLa Cervical Cancer Cells

  • Setiawati, Agustina
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.1655-1659
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    • 2016
  • Celecoxib, a selective inhibitor of COX-2, showed cytotoxic effects in many cancer cell lines including cervical cancer cells. This study investigated the effect of celecoxib on cell cycle arrest in HeLa cervical cancer cells through p53 expression. In vitro anticancer activity was determined with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. A double staining method was applied to investigate the mechanism of cell death, cell cycling was analyzed by flow cytometryand immunocytochemistry was employed to stain p53 expression in cells. Celecoxib showed strong cytotoxic effects and induced apoptosis with an $IC_{50}$ value of $40{\mu}M$. It induced cell cycle arrest at G2/M phase by increasing level of p53 expression on HeLa cells.

One-Cycle Control Strategy with Active Damping for AC-DC Matrix Converter

  • Liu, Xiao;Zhang, Qingfan;Hou, Dianli
    • Journal of Power Electronics
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    • v.14 no.4
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    • pp.778-787
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    • 2014
  • This study presents an input filter resonance mitigation method for an AC-DC matrix converter. This method combines the advantages of the one-cycle control strategy and the active damping technique. Unnecessary sensors are removed, and system cost is reduced by employing the grid-side input currents as feedback to damp out LC resonance. A model that includes the proposed method and the input filter is established with consideration of the delay caused by the actual controller. A zero-pole map is employed to analyze model stability and to investigate virtual resistor parameter design principles. Based on a double closed-loop control scheme, the one-cycle control strategy does not require any complex modulation index control. Thus, this strategy can be more easily implemented than traditional space vector-based methods. Experimental results demonstrate the veracity of theoretical analysis and the feasibility of the proposed approach.

Efficient Yard Tractor Control Method for the Dual Cycling in Container Terminal (효율적인 듀얼 사이클을 위한 야드 트랙터 통제 방법)

  • Chung, Chang-Yun;Shin, Jae-Young
    • Journal of Navigation and Port Research
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    • v.36 no.1
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    • pp.69-74
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    • 2012
  • Recent global supply chain, improving the efficiency of container shipping process is very important. In the overseas shipping of goods, the voyage of super containership is common to overcome amount of increasing cargo. Thus, container terminal managers make an experiment on the double cycle and dual cycle operation, which ship loading and unloading were carried out simultaneously, for maximizing the productivity of quay side. Yard Tractors(YTs) pooling methods also are introduced for increasing the efficiency of assignment of YTs. In this paper, we analyzed the efficiency of dual cycling through comparing existing pooling methods with the modified method for the dual cycling. We developed a simulation model using simulation analysis software, Arena. The result of experiment shown that the more dual cycling don't always increase the gross crane rate(GCR), which means productivity of quay cranes(QCs) per hour.

The Design of long cantilever beam using post-tensioned tendons in Kumjung Stadium (포스트텐션을 이용한 장스팬 켄틸레버보의 설계)

  • 최동섭;김동환;김종수
    • Proceedings of the Korea Concrete Institute Conference
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    • 2002.10a
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    • pp.619-624
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    • 2002
  • A prestressed/precast concrete system was used to build the new Asian Olympic Stadium Project in Pusan, Korea. The stadium(mainly intended for cycle racing) is designed for the 2002 Asian Olympic Games and has a seating capacity of 20,000 spectators plus a few private suites. More than 1300 prestressed/precast components were used and they include single columns, primary beams, cantilever beams, double riser stands, and double tees. Especially, a total of 24 cantilever beams is used on the fourth story for the stands and double tees. These 8m long beams are post-tensioned to prevent cracking, to increase their durability and to serve serviceability by vibration. A cantilever section with cast-in-place topping is 800mm wide and 1500mm deep. Cantilever beams are connected to the column with the corbel by cast-in place concrete. Bonded post-tensioning tendons were assembled at the job site. Dead-end anchorages were installed in the end of cantilever beams and live-end anchorage is the opposite of them. This article presents the geometric layouts, design features and so on.

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PARAMETRIC INVESTIGATIONS ON THE DOUBLE DIFFUSIVE CONVECTION IN TRIANGULAR CAVITY

  • Kwon, SunJoo;Oh, SeYoung;Yun, Jae Heon;Chung, Sei-Young
    • Journal of the Chungcheong Mathematical Society
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    • v.20 no.4
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    • pp.419-432
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    • 2007
  • Double-diffusive convection inside a triangular porous cavity is studied numerically. Galerkin finite element method is adopted to derive the discrete form of the governing differential equations. The first-order backward Euler scheme is used for temporal discretization with the second-order Adams-Bashforth scheme for the convection terms in the energy and species conservation equations. The Boussinesq-Oberbeck approximation is used to calculate the density dependence on the temperature and concentration fields. A parametric study is performed with the Lewis number, the Rayleigh number, the buoyancy ratio, and the shape of the triangle. The effect of gravity orientation is considered also. Results obtained include the flow, temperature, and concentration fields. The differences induced by varying physical parameters are analyzed and discussed. It is found that the heat transfer rate is sensitive to the shape of the triangles. For the given geometries, buoyancy ratio and Rayleigh numbers are the dominating parameters controlling the heat transfer.

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Thermal Analysis and Optimum Design of Water-Cooled, Series-Flow Type, Double-Effect Absorption Heat Pump (수냉형 직렬방식 2중효용 흡수식 냉방기의 열해석과 최적 설계)

  • Oh, M.D.;Kim, Y.L.;Kim, S.C.;Kim, Y.I.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.4 no.4
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    • pp.332-341
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    • 1992
  • An absorption heat pump cycle has been modeled and simulated to analyze the system performance of water-cooled, series-flow, double-effect absorption heat pump, which can be applied to a direct gas fired cooling system with the medium range of cooling capacity (15RT level). Effect of absorption cooling system parameters, such as concentration difference, inlet temperature of cooling water, 1st generator temperature, leaving temperature differences of condenser and evaporator and efficiency of solution heat exchanger, has been investigated in the view of system cooling performance.

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Cost-effective Power System with an Electronic Double Layer Capacitor for Reducing the Standby Power Consumption of Consumer Electronic Devices

  • Park, Kyung-Hwa;Yi, Kang-Hyun
    • Journal of Power Electronics
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    • v.13 no.3
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    • pp.362-368
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    • 2013
  • Commercial home appliances using remotely controlled systems consume electric power while in standby mode to prepare for receiving a remote turn-on signal. The proposed power system can significantly reduce standby power consumption without increasing cost. Furthermore, since a Electronic Double Layer Capacitor (EDLC) is used as an auxiliary power storage element, the life cycle is longer and system reliability can be better than with existing approaches. When the energy of the EDLC is not sufficient for turning on the appliance, the power system charges the EDLC without affecting the main system. The proposed power system is verified with a commercial LCD TV and a 3.93mW standby consumption is obtained. This standby consumption can be regarded as zero standby equipment according to the IEC-62031 standard.

A Study of Sensorless Driving for The Axial Type Double Rotor Brushless DC Motor (축방향 이중 회전자 브러시리스 직류 전동기의 센서리스 구동에 관한 연구)

  • Won, Jae-Son;Kang, Tae-Sam;Hong, Sun-Ki
    • Proceedings of the KIEE Conference
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    • 1998.11a
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    • pp.168-170
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    • 1998
  • In this paper a driving method using the microcomputer in safe driving the axial type double rotor brushless DC motor without shaft position sensor is studied. The rotor position is determined from the back-EMF passed though special filter. Starting technique which uses the motor as a synchronous motor at standstill are explained. The motor speed is controlled by changing the duty cycle of PWM. The test motor has Y-connected three-phase stator and 8-pole axial type double rotor. From the experiments, we got good performences of the proposed control system.

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Electrochemical Properties of Trimethylammonium Tetrafluoroborate in Electrochemical Double-Layer Capacitors

  • Lee, Sooyeon;Lee, Kyung Min;Kim, Ketack
    • Journal of Electrochemical Science and Technology
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    • v.13 no.2
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    • pp.254-260
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    • 2022
  • Trimethylammonium tetrafluoroborate (TriMA BF4), consisting of the smallest trialkylammonium ion, was investigated for use in electrochemical double-layer capacitors. Despite the presence of a proton in TriMA+, cycle life tests in acetonitrile (AN) and -butyrolactone (GBL) showed a good capacity retention with a 1.8 V cut-off voltage. The rate of electrolysis of TriMA BF4 in GBL was lower than that in AN because of the lower conductivity in GBL. As a consequence, the cells based on GBL achieved a higher capacitance and longer life than those with AN. TriMA BF4 had a higher conductivity and lower viscosity than the quaternary salt tetraethylammonium tetrafluoroborate in GBL, as well as higher ionic mobility, these factors resulted in a higher rate capability.

Investigation of cure cycle for co-cured metal/composite hybrid structures without fabricating thermal residual stress (동시경화 하이브리드 금속/복합재료 구조물의 제조 잔류 열응력 제거를 위한 경화사이클에 관한 연구)

  • Kim Hak Sung;Park Sang Wook;Lee Dai Gil
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2004.10a
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    • pp.83-87
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    • 2004
  • In this work, the cure cycle of co-cured metal/composite structure was investigated to decrease fabricating thermal residual stresses between the metal and the composite material. DSC (Differential scanning calorimetry) experiment and static lap shear test of co-cured aluminum/composite double lap joint as well as the curvature experiment of co-cured steel/composite strip were performed to investigate the effect of curing cycle on the thermal residual stress of co-cured hybrid structures. From the experiments, it was found that post curing method after abrupt cooling of co-cured aluminum/composite hybrid structure at certain point of degree of cure during curing process could eliminate fabricating the thermal residual stresses.

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