• Journal of the Earthquake Engineering Society of Korea
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• v.27 no.1
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• pp.25-35
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• 2023

Considering the non-linear behavior of structure and soil when evaluating a nuclear power plant's seismic safety under a beyond-design basis earthquake is essential. In order to obtain the nonlinear response of a nuclear power plant structure, a time-domain SSI analysis method that considers the nonlinearity of soil and structure and the nonlinear Soil-Structure Interaction (SSI) effect is necessary. The Boundary Reaction Method (BRM) is a time-domain SSI analysis method. The BRM can be applied effectively with a Perfectly Matched Layer (PML), which is an effective energy absorbing boundary condition. The BRM has a characteristic that the magnitude of the response in far-field soil increases as the boundary interface of the effective seismic load moves outward. In addition, the PML has poor absorption performance of low-frequency waves. For this reason, the accuracy of the low-frequency response may be degraded when analyzing the combination of the BRM and the PML. In this study, the accuracy of the analysis response was improved by adjusting the PML input parameters to improve this problem. The accuracy of the response was evaluated by using the analysis response using KIESSI-3D, a frequency domain SSI analysis program, as a reference solution. As a result of the analysis applying the optimal PML parameter, the average error rate of the acceleration response spectrum for 9 degrees of freedom of the structure was 3.40%, which was highly similar to the reference result. In addition, time-domain nonlinear SSI analysis was performed with the soil's nonlinearity to show this study's applicability. As a result of nonlinear SSI analysis, plastic deformation was concentrated in the soil around the foundation. The analysis results found that the analysis method combining BRM and PML can be effectively applied to the seismic response analysis of nuclear power plant structures.

• 한국HCI학회:학술대회논문집
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• 2009.02a
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• pp.140-145
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• 2009

Significant attention has recently been drawn to human robot interaction system that uses face detection technology. The most conventional face detection methods have applied under pixel domain. These pixel based face detection methods require high computational power. Hence, the conventional methods do not satisfy the robot environment that requires robot to operate in a limited computing process and saving space. Also, compensating the variation of illumination is important and necessary for reliable face detection. In this paper, we propose the illumination invariant face detection that is performed under the compressed domain. The proposed method uses color balancing module to compensate illumination variation. Experiments show that the proposed face detection method can effectively increase the face detection rate under existing illumination.

• Journal of The Korean Society of Agricultural Engineers
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• v.48 no.6
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• pp.45-56
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• 2006

The finite element method is a practical tool to compute the response of the irregularly layered soil deposit to the base-rock motions. The method is useful not only in estimating the interaction between the structure and the surrounding soil as a whole and the local behavior of the contacting area in detail, but also in predicting the resulting behavior of the superstructure affected by such soil-structure interactions. However, the computation of finite element analysis is marched in the time domain (TD), while the site response analysis has been carried out mostly in the frequency domain (FD) with equivalent linear analysis. This study is intended to compare the results of the TD and FD analysis with focus on the peak response accelerations and the predominant frequencies, and thus to evaluate the applicability and the validity of the finite element analysis in the site response analysis. The comparison shows that one can obtain the results very close to that of FD analysis, from the finite element analysis by including sufficiently large width of foundation in the model and further by applying partial mode superposition. The finite element analysis turned out to be well agreeing with FD analysis in their computed results of the peak acceleration and the acceleration response spectra, especially at the surface layer.

• Journal of the Korean Magnetic Resonance Society
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• v.11 no.1
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• pp.24-29
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• 2007

[ ${\beta}ig-h3$ ] is an extracellular matrix protein that mediates cell adhesion through interaction with integrins. The 18 residue YH motifs within each fas-1 domain are known to be responsible for the interaction with the ${\alpha}_v{\beta}_5$ integrin, and the synthetic YH motif peptides are known to inhibit endothelial tube formation and reduces the number of blood vessels, and so expected to be an effective inhibitor of angiogenesis. In this study, we solved the 3D structure of the 18 residue YH motif peptide (EALRDLLNNHILKSAMCA; D2 peptide) within the second fas-1 domain of ${\beta}ig-h3$ using NMR. The Peptide has ${\alpha}-helix$ structure at the C terminal region but the N terminal region is flexible. The present structural information may be helpful for developing more effective peptide drug candidate for the treatment of diseases dependent on angiogenesis.

• BMB Reports
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• v.47 no.9
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• pp.488-493
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• 2014

Adaptor protein FADD forms the death inducing signaling complex (DISC) by recruiting the initiating caspases-8 and -10 through homotypic death effector domain (DED) interactions. Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of death ligand-induced apoptosis downstream of death receptors, and FADD competes with procaspase-8/10 for recruitment for DISC. However, the mechanism of action of FADD and c-FLIP proteins remain poorly understood at the molecular level. In this study, we provide evidence indicating that the death effector domain (DED) of FADD interacts directly with the death effector domain of human c-FLIP. In addition, we use homology modeling to develop a molecular docking model of FADD and c-FLIP proteins. We also find that four structure-based mutants (E80A, L84A, K169A and Y171A) of c-FLIP DEDs disturb the interaction with FADD DED, and that these mutations lower the stability of the c-FLIP DED.

• Structural Engineering and Mechanics
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• v.21 no.4
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• pp.437-450
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• 2005

In this study, a complete analysis of soil-structure interaction problems is presented which includes a modelling of the near surrounding of the building (near-field) and a special description of the wave propagation process in larger distances (far-field). In order to reduce the computational effort which can be very high for time domain analysis of wave propagation problems, a special approach based on similarity transformation of the infinite domain on the near-field/far-field interface is applied for the wave radiation of the far-field. The near-field is discretised with standard Finite Elements, which also allows to introduce non-linear material behaviour. In this paper, a new approach to calculate the involved convolution integrals is presented. This approximation in time leads to a dramatically reduced computational effort for long simulation times, while the accuracy of the method is not affected. Finally, some benchmark examples are presented, which are compared to a coupled Finite Element/Boundary Element approach. The results are in excellent agreement with those of the coupled Finite Element/Boundary Element procedure, while the accuracy is not reduced. Furthermore, the presented approach is easy to incorporate in any Finite Element code, so the practical relevance is high.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.1
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• pp.294-306
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• 2019

On the basis of the Computational Fluid Dynamics technique (CFD) combined with the overlap grid method, this paper establishes a numerical simulation method to study the problem of ice-propeller interaction in viscous flow and carries out a simulation forecast of the hydrodynamic performance of an ice-class propeller and flow characteristics when in the proximity of milling-shape ice (i.e., an ice block with a groove cut by a high-speed revolving propeller). We use a trimmed mesh in the entire calculation domain and use the overlap grid method to transfer information between the domains of propeller rotation calculation and ice-surface computing. The grid is refined in the narrow gap between the ice and propeller to ensure the accuracy of the flow field. Comparison with the results of the experiment reveals that the error of the hydrodynamic performance is within 5%. This confirms the feasibility of the calculation method. In this paper, we calculate the exciting force of the propeller, analyze the time domain of the exciting force, and obtain the curve of the frequency domain using a Fourier transform of the time-domain curve of the exciting force. The existence of milling-shape ice before the propeller can greatly disturb the wake flow field. Unlike in open water, the propeller bearing capacity shows a downward trend in three stages, and fluctuating pressure is more disordered near the ice.

• BMB Reports
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• v.44 no.3
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• pp.199-204
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• 2011

Ephrin signaling is involved in various morphogenetic events, such as axon guidance, hindbrain segmentation, and angiogenesis. We conducted a yeast two-hybrid screen using the intracellular domain (ICD) of EphrinB1 to gain biochemical insight into the function of the EphrinB1 ICD. We identified the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein. Whole-mount in situ hybridization of Xenopus embryos confirmed the co-localization of EphrinB1 and a Xenopus counterpart to TLE1, xTLE4, during various stages of development. The EphrinB1/xTLE4 interaction was confirmed by co-immunoprecipitation experiments. Further characterization of the interaction revealed that the carboxy-terminal PDZ binding motif of EphrinB1 and the SP domain of xTLE4 are required for binding. Additionally, phosphorylation of EphrinB1 by a constitutively activated fibroblast growth factor receptor resulted in loss of the interaction, suggesting that the interaction is modulated by tyrosine phosphorylation of the EphrinB1 ICD.

• Journal of Information Processing Systems
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• v.8 no.3
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• pp.459-470
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• 2012

Recently, high-throughput technologies such as the two-hybrid system, protein chip, Mass Spectrometry, and the phage display have furnished a lot of data on protein-protein interactions (PPIs), but the data has not been accurate so far and the quantity has also been limited. In this respect, computational techniques for the prediction and validation of PPIs have been developed. However, existing computational methods do not take into account the fact that a PPI is actually originated from the interactions of domains that each protein contains. So, in this work, the information on domain modules of individual proteins has been employed in order to find out the protein interaction relationship. The system developed here, WASPI (Web-based Assistant System for Protein-protein interaction Inference), has been implemented to provide many functional insights into the protein interactions and their domains. To achieve those objectives, several preprocessing steps have been taken. First, the domain module information of interacting proteins was extracted by taking advantage of the InterPro database, which includes protein families, domains, and functional sites. The InterProScan program was used in this preprocess. Second, the homology comparison with the GO (Gene Ontology) and COG (Clusters of Orthologous Groups) with an E-value of $10^{-5}$, $10^{-3}$ respectively, was employed to obtain the information on the function and annotation of each interacting protein of a secondary PPI database in the WASPI. The BLAST program was utilized for the homology comparison.

• Journal of the Earthquake Engineering Society of Korea
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• v.7 no.6
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• pp.1-7
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• 2003

This paper presents a novel hybrid time-frequency-domain method for nonlinear soil-structure interaction(SSI) analysis. It employs, in a practical manner, a computer code for equivalent linear SSI analysis and a general-purpose nonlinear finite element program. The proposed method first (calculates dynamic responses on a truncated finite element boundary utilizing an equivalent linear SSI program in the frequency domain. Then, a general purpose nonlinear finite element program is employed to analyze the nonlinear SSI problem in the time domain, in which boundary conditions at the truncated boundary are imposed with the responses calculated in the previous frequency domain SSI analysis, In order to validate the proposed method, seismic response analyses are carried out for a 2-D underground subway station in a multi-layered half-space, For the analyses, a equivalent linear SSI code KIESSI-2D is coupled to ANSYS program. The numerical results indicate that the proposed methodology can be a viable solution for nonlinear SSI problems.