• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.3
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• pp.259-268
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• 2019

Even if only two ships are encountered, a collision may occur due to the mistaken judgment of the positional relationship. In other words, if an officer does not know a target ship's intention, there is always a risk of collision. In this paper, the experiments are conducted to investigate how the intention affects the action of collision avoidance in cooperative and non-cooperative situations. In non-cooperative situation, each ship chooses a course that minimizes costs based on the current situation. That is, it always performs a selfish selection. In a cooperative situation, the information is exchanged with a target ship and a course is selected based on this information. Each ship uses the Distributed Stochastic Search Algorithm so that a next-intended course can be selected by a certain probability and determines the course. In the experimental method, four virtual ships are set up to analyze the action of collision avoidance. Then, using the actual AIS data of eight ships in the strait of Dover, I compared and analyzed the action of collision avoidance in cooperative and non-cooperative situations. As a result of the experiment, the ships showed smooth trajectories in the cooperative situation, but the ship in the non-cooperative situation made frequent big changes to avoid a collision. In the case of the experiment using four ships, there was no collision in the cooperative situation regardless of the size of the safety domain, but a collision occurred between the ships when the size of the safety domain increased in cases of non-cooperation. In the case of experiments using eight ships, it was found that there are optimal parameters for collision avoidance. Also, it was possible to grasp the variation of the sailing distance and the costs according to the combination of the parameters, and it was confirmed that the setting of the parameters can have a great influence on collision avoidance among ships.

• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.410-418
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• 2021

Helicobacter pylori causes chronic gastritis through cag pathogenicity island (cagPAI), vacuolating cytotoxin A (VacA), lipopolysaccharides (LPS), and flagellin as pathogen-related molecular patterns (PAMPs), which, in combination with the pattern recognition receptors (PRRs) of host cells promotes the expression and secretion of inflammation-causing cytokines and activates innate immune responses such as inflammasomes. To identify useful compounds against H. pylori-associated gastric disorders, the effect of chalcone derivatives to activate the nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome was examined in an H. pylori-infected human monocytic THP-1 cell line in this study. Among the five synthetic structurally-related chalcone derivatives examined, 2'-hydroxy-4',6'-dimethoxychalcone (8) and 2'-hydroxy-3,4,5-trimethoxychalcone (12) strongly blocked the NLRP3 inflammasome in H. pylori-infected THP-1 cells. At 10 μM, these compounds inhibited the production of active IL-1β, IL-18, and caspase-1, and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) oligomerization, but did not affect the expression levels of NLRP3, ASC, and pro-caspase-1. The interruption of NLRP3 inflammasome activation by these compounds was found to be mediated via the inhibition of the interleukin-1 receptor-associated kinase 4 (IRAK4)/IκBα/NF-κB signaling pathway. These compounds also inhibited caspase-4 production associated with non-canonical NLRP3 inflammasome activation. These results show for the first time that certain chalcones could interrupt the activation of the NLRP3 inflammasome in H. pylori-infected THP-1 cells. Therefore, these chalcones may be helpful in alleviating H. pylori-related inflammatory disorders including chronic gastritis.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2637-2641
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• 2016

Tumor necrosis factor ($TNF-{\alpha}$), an inflammatory cytokine that plays an important role in the control of cell proliferation, differentiation, and apoptosis, has previously been used in anti-cancer therapy. However, the therapeutic applications of $TNF-{\alpha}$ are largely limited due to its general toxicity and anti-apoptotic influence. To overcome this problem, the present study focused on the effect of active constituents isolated from a medicinal plant on $TNF-{\alpha}$-induced apoptosis in human colon adenocarcinoma (HT-29) cells. Nimbolide from Azadirachta indica was evaluated for cytotoxicity by methyl tetrazolium 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay and phase contrast microscopy. Effects on apoptotic signaling proteins were investigated using Western blot analysis. Nimbolide showed cytotoxicity against HT-29 cells that was significantly different from the control group (p<0.01), a concentration of $10{\mu}M$ significantly inducing cell death (p<0.01). In combination with $TNF-{\alpha}$, nimbolide significantly enhanced-induced cell death. In apoptotic pathway, nimbolide activated c-Jun N-terminal kinase (JNK) phosphorylation, BH3 interacting-domain death agonist (Bid) and up-regulated the death receptor 5 (DR5) level. In the combination group, nimbolide markedly sensitized $TNF-{\alpha}$-induced JNK, Bid, caspase-3 activation and the up-regulation of DR5. Our findings overall indicate that nimbolide may enhance $TNF-{\alpha}$-mediated cellular proliferation inhibition through increasing cell apoptosis of HT-29 cells by up-reglation of DR5 expression via the JNK pathway.

• Journal of Positioning, Navigation, and Timing
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• v.4 no.1
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• pp.33-41
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• 2015

Compact Network Real-Time Kinematic (RTK) is a method that combines compact RTK and network RTK, and it can effectively reduce the time and spatial de-correlation errors. A network RTK user receives multiple correction information generated from reference stations that constitute a network, calculates correction information that is appropriate for one's own position through a proper combination method, and uses the information for the estimation of the position. This combination method is classified depending on the method for modeling the GPS error elements included in correction information, and the user position accuracy is affected by the accuracy of this modeling. Among the GPS error elements included in correction information, tropospheric delay is generally eliminated using a tropospheric model, and a combination method is then applied. In the case of a tropospheric model, the estimation accuracy varies depending on the meteorological condition, and thus eliminating the tropospheric delay of correction information using a tropospheric model is limited to a certain extent. In this study, correction information modeling accuracy performances were compared focusing on the Low-Order Surface Model (LSM), which models the GPS error elements included in correction information using a low-order surface, and a modified LSM method that considers tropospheric delay characteristics depending on altitude. Both of the two methods model GPS error elements in relation to altitude, but the second method reflects the characteristics of actual tropospheric delay depending on altitude. In this study, the final residual errors of user measurements were compared and analyzed using the correction information generated by the various methods mentioned above. For the performance comparison and analysis, various GPS actual measurement data were collected. The results indicated that the modified LSM method that considers actual tropospheric characteristics showed improved performance in terms of user measurement residual error and position domain residual error.

• Journal of the Society of Naval Architects of Korea
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• v.50 no.5
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• pp.282-290
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• 2013

The effects of the combination of blade number for forward and after propeller on the propeller shaft forces of a contra-rotating propeller (CRP) system are presented in the paper. The research is performed through the numerical simulations based on the Reynolds-Averaged Navier-Stokes equations (RANS). The simulation results of the present method in open water condition are validated comparing with the experimental data as well as the other numerical simulation results based on the potential method for 4-0-4 CRP (3686+3687A) and 4-0-5 CRP (3686+3849) of DTNSRDC. Two sets of CRP are designed and simulated to study the effect of the combination of blade number in behind-hull condition. One set consists of 3-blade and 4-blade, while the other is 4-blade and 4-blade. A full hull body submerged under the free surface is modeled in the computational domain to simulate directly the wake field of the ship at the propeller plane. From the simulation results, the fluctuations of axial force and moment are dominant in the case of same blade numbers for forward and after propellers, whereas the fluctuations of horizontal and vertical forces and moments are very large in the case of different blade numbers.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2005.11a
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• pp.302-305
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• 2005

Recently, many methods to analyze signal have been proposed and representative methods are the Fourier transform and wavelet transform. In these methods, the Fourier transform represents signal with combination cosine and sine at all locations in the frequency domain. However, it doesn't provide time information that particular frequency occurs in signal and denpends on only the global feature of the signal. So, to improve these points the wavelet transform which is capable of multiresolution analysis has been applied to many fields such as speech processing, image processing and computer vision. And the wavelet transform, which uses changing window according to scale parameter, presents time-frequency localization. In this paper, we proposed a new approach using a wavelet of cosine and sine type and analyzed features of signal in a limited point of frequency-time plane.

• 한국공간정보시스템학회:학술대회논문집
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• 2005.11a
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• pp.61-66
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• 2005

Spatiotemporal data mining represents the confluence of several fields including spatiotemporal databases, machine loaming, statistics, geographic visualization, and information theory. Exploration of spatial data mining and temporal data mining has received much attention independently in knowledge discovery in databases and data mining research community. In this paper, we introduce an algorithm Max_MOP for discovering moving sequences in mobile environment. Max_MOP mines only maximal frequent moving patterns. We exploit the characteristic of the problem domain, which is the spatiotemporal proximity between activities, to partition the spatiotemporal space. The task of finding moving sequences is to consider all temporally ordered combination of associations, which requires an intensive computation. However, exploiting the spatiotemporal proximity characteristic makes this task more cornputationally feasible. Our proposed technique is applicable to location-based services such as traffic service, tourist service, and location-aware advertising service.

• Journal of applied mathematics & informatics
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• v.36 no.1_2
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• pp.135-154
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• 2018

In this paper, an almost second order overlapping Schwarz method for singularly perturbed third order convection-diffusion type problem is constructed. The method splits the original domain into two overlapping subdomains. A hybrid difference scheme is proposed in which on the boundary layer region we use the combination of classical finite difference scheme and central finite difference scheme on a uniform mesh while on the non-layer region we use the midpoint difference scheme on a uniform mesh. It is shown that the numerical approximations which converge in the maximum norm to the exact solution. We proved that, when appropriate subdomains are used, the method produces convergence of second order. Furthermore, it is shown that, two iterations are sufficient to achieve the expected accuracy. Numerical examples are presented to support the theoretical results. The main advantages of this method used with the proposed scheme are it reduce iteration counts very much and easily identifies in which iteration the Schwarz iterate terminates.

• Journal of Mechanical Science and Technology
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• v.17 no.10
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• pp.1572-1582
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• 2003

Hybrid rocket combustion has a manifestation of stable response to the perturbations compared to solid propellant combustion. Recently, it has revealed that the low frequency combustion instability about 10 Hz was occurred mainly due to thermal inertia of solid fuel. In this paper, the combustion response function was theoretically derived by use of ZN (Zeldovich-Novozhilov) method. The result with HTPB/LOX combination showed a quite good agreement in response function with previous works and could predict the low frequency oscillations with a peak around 10 Hz which was observed experimentally. Also, it was found that the amplification region in the frequency domain is independent of the regression rate exponent n but showed the dependence of activation energy. Moreover, the response function has shown that the hybrid combustion system was stable due to negative heat release of solid fuel for vaporization, even though the addition of energetic ingredients such as AP and Al could lead to increase heat release at the fuel surface.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.23-27
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• 2007

Many trials have been used to model room impulse responses, all attempting to provide efficient representations of room acoustics. The traditional model designs for room impulse response seem to fail in accuracy, controllability, or computational efficiency. In time domain, a room impulse response is generally considered as the combination of three parts having different acoustic characteristics, initial time delay, early reflection, and late reverberation. This paper introduces new learning hybrid model for the room impulse response. In this proposed model, those three parts are modeled using different models with learning algorithms that determine the length or boundary of each model in the hybrid model. By the simulation with measured room impulse responses, it was examined that the performance of proposed model shows the best efficiency in views of both the parameter numbers and modeling error.