• BMB Reports
• /
• v.44 no.9
• /
• pp.572-577
• /
• 2011

Elevated phospholipase D (PLD) expression prevents cell cycle arrest and apoptosis. However, the roles of PLD isoforms in cell proliferation and apoptosis are incompletely understood. Here, we investigated the physiological significance of the interaction between PLD2 and protein kinase CKII (CKII) in HCT116 human colorectal carcinoma cells. PLD2 interacted with the CKII${\beta}$ subunit in HCT116 cells. The C-terminal domain (residues 578-933) of PLD2 and the N-terminal domain of CKII${\beta}$ were necessary for interaction between the two proteins. PLD2 relocalized CKII${\beta}$ to the plasma membrane area. Overexpression of PLD2 reduced CKII${\beta}$ protein level, whereas knockdown of PLD2 led to an increase in CKII${\beta}$ expression. PLD2-induced CKII${\beta}$ reduction was mediated by ubiquitin-dependent degradation. The C-terminal domain of PLD2 was sufficient for CKII${\beta}$ degradation as the catalytic activity of PLD2 was not required. Taken together, the results indicate that the C-terminal domain of PLD2 can regulate CKII by accelerating CKII${\beta}$ degradation in HCT116 cells.

• Journal of Advanced Navigation Technology
• /
• v.24 no.1
• /
• pp.28-36
• /
• 2020

Korea augmentation satellite system (KASS) is the Korean satellite based augmentation system (SBAS) developed by ministry of land, infrastructure, and transport (MOLIT) since 2014. Since KASS is the safety critical system that can affect to the safety of airplane, the software of KASS is developed according to the DO178B software level induced from safety analysis. In case of KASS control station (KCS), most of the software of KCS get assigned software level E in DO178B. In that case, ECSS-Q-ST-80C category D is assigned as a software product assurance standard. In this paper, the software related standard ECSS-E-ST-40C, ECSS-Q-HB-80-04A are analyzed to satisfy ECSS-Q-ST-80C and as a result the software product assurance activities regarding software life cycle and the software quality model, metric is proposed for the product assurance of the KCS software.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.26 no.5D
• /
• pp.771-781
• /
• 2006

This Study is about the development of LCC Analysis Model and Evaluation of VE. It was carried out to help the person's intention decision about choosing the pavement construction method that can deal with 'Pavement Life Factor' like Area Character and Traffic Volume efficiently, by considering the total life cycle cost of pavement life cycle happens according to the numbers of public use year. For this, we developed the new LCC Analysis Model by using the Data of Seoul city the representative city in Korea, and carried out VE Evaluation that reflects the opinions of specialists. This Analysis Model consists of cost items that affects directly the choice of pavement construction, except for the common cost items of the various pavement construction. And we investigated the propriety by applying our model to the example line that are used for the public at present. About the base data of cost items that are used for our analysis, we enhanced our model's confidence by using the statistics data of Seoul and the standard data of unit cost calculation.

• The KIPS Transactions:PartD
• /
• v.16D no.1
• /
• pp.105-112
• /
• 2009

Risk management is increasingly seen as one of the main jobs of project managers. It involves anticipating risks that might affect the project schedule or the quality of the software being developed and taking action to avoid these risks. The results of the risk analysis should be documented in the project plan along with an analysis of the consequences of a risk occurring. Effective risk management makes it easier to cope with problems and to ensure that these do not lead to unacceptable budget or schedule slippage. This research provides criteria of analysis of risk items to the estimation of process milestone on software development. Also, In this paper propose to a fixed quantity and transition phase.

• The KIPS Transactions:PartD
• /
• v.17D no.6
• /
• pp.443-452
• /
• 2010

COTS system is increasingly seen as one of the main jobs of reuse development. It involves reliability of COTS that might affect the project schedule or the quality of the software being developed and taking action to avoid these risks. The results of the COTS analysis should be documented in the project plan along with an analysis of the attribute and operation. Effective risk management makes it easier to cope with problems and to ensure that these do not lead to unacceptable budget or schedule slippage. This research provides criteria of analysis of risk items to the estimation of process milestone on COTS development.

• Journal of the Korea Safety Management & Science
• /
• v.15 no.3
• /
• pp.51-60
• /
• 2013

With the recent changes in the environment of weapon systems acquisition, the systems development is becoming more susceptible to a variety of risks. To cope with this situation, US DoD has been emphasizing the importance of constantly applying the test and evaluation (T&E) process throughout the whole life cycle of the weapon systems. In particular, the safety requirements are called for attention while dealing with system risks. To this end, the present paper is aimed at studying the T&E process which incorporates the systems safety in weapon systems development. Analyzing and modeling the relevant processes has made it possible to achieve the objective. As a case study, the model results were applied to the development of unmanned aerial vehicles.

• STI Policy Review
• /
• v.8 no.1
• /
• pp.41-61
• /
• 2017

The literature in research policy extensively addresses the interaction between public R&D and the society. Scholars have paid particular attention to the way science and technology are diffused into the society and industry with the aim of substantiating their potential value. In practice, having recognized the importance of the said interaction, R&D entities and governmental organizations promote scientific and technological innovations that result from their R&D activities. Yet, the nature of news media exposure as their primary channel to promote R&D outcomes has been remarkably understudied. Using the results of R&D projects supported by the National Research Foundation of Korea (NRF), this study examines R&D entities' strategic use of the news media to publicize their outcomes. The empirical results suggest that the scale of an R&D project positively affects the counts of media exposure of its R&D outcomes, whereas the level of technology readiness and the technology life-cycle do not have significant influence. In addition, the results suggest that, compared to senior researchers, young researchers are more likely to publicize their R&D outcomes and that R&D outcomes from highly ranked universities are more likely to be publicized than those from lower-ranking universities despite our control for R&D outcomes. The aforementioned results suggest that in promoting the diffusion of science and technology, especially to the public, policymakers should be concerned about incentives for those who provide techno-scientific information, such as researchers. The social need for the diffusion of techno-scientific information into the public (e.g., technology transfer and diffusion) is an insignificant factor in determining the media exposure of such information, whereas personal benefits and sensitive issues related to a researcher's own R&D activities (e.g., justification for R&D activities) drive researchers to publicize their R&D outcomes. This paper suggests that policymakers, especially those concerned with better diffusion of scientific and technological innovations need to design a proper incentive system to maximize the societal benefits of media exposure.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.32 no.4D
• /
• pp.345-356
• /
• 2012

Road pavement requires repetitive maintenance works to maintain satisfactory service level to the public. However, the repetitive maintenance works upon deteriorated pavement structure make negative effects to deterioration speed. It often leads to inefficient use of limited budget. For that reason, the pavements require reconstruction work to recover their original performance. Recently, construction demands in the Korean national highway have already been reached to maximum level, and the aged pavements start to demand much more reconstruction works. However, in the real world, road agencies have often been confused when they determine maintenance design for such aged road sections due to budget constraint. It is because there is no reliable long-term maintenance strategy that supports their decision making. To support their decision making, this paper aimed to suggest the best maintenance strategy considering changing process of pavement performance by repetitive maintenance works. As an analysis method, probability distribution and hazard function to estimate the life expectancy were adopted, and then the results were used for long-term life cycle cost analysis with deterministic or Monte-Carlo method under various scenarios. As an empirical study, the Korean national highway data that has long-maintenance history data since 1986 has been applied. Last, this paper considered quality assurance of maintenance work to improve maintenance quality. These could be important information as a part of long-term maintenance strategy of pavement.

• Korean Journal of Construction Engineering and Management
• /
• v.12 no.2
• /
• pp.64-71
• /
• 2011

Construction projects are becoming larger in size and higher in complexity. Operation and maintenance, therefore, is an important part in providing the serviceability of the built facility from the perspective of life-cycle. This paper presents a 3D graphic model-integrated data extraction for bridge maintenance. The 3D graphic model environment assigns attributes to the member blocks in CAD, and link the attributes to the data stored in a database. Then, the user can click the member block to extract the data associated with the attributes. A prototype has been developed to test the applicability of the 3D graphic model environment using CAD and web. Application of the system in an actual bridge construction showed that the 3D graphic model environment can help the user find necessary data at a shorter time, thereby increasing the effectiveness of operation and maintenance in bridge structures.

• The Journal of the Korea Contents Association
• /
• v.15 no.8
• /
• pp.37-45
• /
• 2015

With advancement in information technologies and a better mobile environment, the paradigm of service is shifting again from web portals to networked-applications based on individual application programs. Furthermore, as more investment is being made in R&D, the efforts to enhance R&D productivity are becoming important. In this paper, we designed a personalized service model for developing a tool to assist researchers in their R&D activities. To do this, we first compared services and tools in terms of information activities of researchers in R&D. In addition, we also analyzed changes of information environment such as open expansion of information and data, enhancement of personal information protection, popularization of social networking service, very big contents, advances in web platform technology in terms of personalization, and defined some directions of developing a personalized service. Subsequently we designed a personalized service model of research support tool in the views of functions, contents, operation, and defined personalized design goals and principles for implementing it as standard, participation, and open.