• Journal of Digestive Cancer Research
• /
• 제6권2호
• /
• pp.55-58
• /
• 2018

Gastric signet ring cell carcinoma (SRC) is a poorly differentiated or undifferentiated cancer of the stomach. However, early gastric SRC showed lower LN metastasis in many studies, thus some endoscopists now regard early gastric SRC as a candidate for endoscopic treatment. But there are unsolved problems of the validity of endoscopic resection in early gastric SRC. In this review, we will comprehensively review the previous clinical studies and discuss the limitation of current studies and the possibility of endoscopic resection of early gastric SRC.

• Tribology and Lubricants
• /
• 제23권5호
• /
• pp.201-206
• /
• 2007

The bent-axis type piston pump which is driven by the piston rod works on the way that the piston rod drives the cylinder block, so the taper angle of the piston rod and the swivel angle between the cylinder block and the shaft are very important design factors. If the above factors cannot satisfy the conditions of optimum design, the friction loss between the cylinder bore and the piston increases, and the pump can even fail to work under conditions of severe friction and wear. Since the piston reciprocates in the cylinder bore with high velocity, and at the same time it rotates on its own axis and revolves on the center of the cylinder block, the decrease of the volume efficiency generated on account of the leakage between the cylinder bore and the piston. Therefore, to prevent this case, the piston ring is designed at the end of the piston, and the friction characteristics between the piston ring and the cylinder bore are in need of research due to its great influence on the performance of piston pump. Thus, in this paper, the elastic hydraulic oil's lubrication analyses of the film thickness, the pressure distribution, and the friction force, and so on, have been performed, and the lubrication characteristics between the piston ring and the cylinder bore are explored by the results of the numerical analysis, and it is contributed to realize the higher efficiency and the more advanced performance of the bent-axis type piston pump.

• Journal of Applied Biological Chemistry
• /
• 제62권1호
• /
• pp.81-86
• /
• 2019

A yellow resin (gamboge) from Garcinia hanburyi has been widely used as folk medicine due to its antibacterial and antitumor activities. We isolated four ${\alpha}$-glucosidase inhibitory compounds from the methanol extract of gamboge. The compounds (1-4) were identified as gambogoic acid (1), moreollic acid (2), gambogic acid (3), and 10-methoxygambogenic acid (4), respectively through spectroscopic data including 2D-NMR and HREIMS. All compounds were examined in the enzyme inhibition assay against ${\alpha}$-glucosidase to identify their inhibitory potencies and kinetic behavior. All compounds (1-4) showed enzyme inhibition against ${\alpha}$-glucosidase, but the activity was significantly affected by the methoxy group on C-10 of ring A and pentenyl pyran moiety of ring D. For example, compound 1 ($IC_{50}=41.4{\mu}M$) bearing pyran ring eight times effective that 4 ($IC_{50}=350.6{\mu}M$) having geranyl group itself. Most active compound was found out to be gambogoic acid (1) which was analyzed most abundant metabolite in gamboge by LC-ESI-MS/MS. In kinetic study, compounds 1 and 2 were proved as noncompetitive inhibitors.

• Molecules and Cells
• /
• 제39권11호
• /
• pp.814-820
• /
• 2016

FtsZ, a tubulin homologue, is an essential protein of the Z-ring assembly in bacterial cell division. It consists of two domains, the N-terminal and C-terminal core domains, and has a conserved C-terminal tail region. Lateral interactions between FtsZ protofilaments and several Z-ring associated proteins (Zaps) are necessary for modulating Z-ring formation. ZapD, one of the positive regulators of Z-ring assembly, directly binds to the C-terminal tail of FtsZ and promotes stable Z-ring formation during cytokinesis. To gain structural and functional insights into how ZapD interacts with the C-terminal tail of FtsZ, we solved two crystal structures of ZapD proteins from Salmonella typhimurium (StZapD) and Escherichia coli (EcZapD) at a 2.6 and $3.1{\AA}$ resolution, respectively. Several conserved residues are clustered on the concave sides of the StZapD and EcZapD dimers, the suggested FtsZ binding site. Modeled structures of EcZapD-EcFtsZ and subsequent binding studies using bio-layer interferometry also identified the EcFtsZ binding site on EcZapD. The structural insights and the results of bio-layer interferometry assays suggest that the two FtsZ binding sites of ZapD dimer might be responsible for the binding of ZapD dimer to two protofilaments to hold them together.

• 한국균학회지
• /
• 제30권2호
• /
• pp.95-98
• /
• 2002

송이 균환의 생장을 알아보기 위하여 1) 균환 선단의 1년간($1999{\sim}2000$) 생장 길이 측정과 2) 2000년의 균환선단을 기점으로 $1997{\sim}2000$년 송이 발생위치간의 거리를 측정하였다. 65년생 소나무림에서 송이 균환 선단은 1년간 평균 11.3cm 생장하였고 ($1999{\sim}2000$), 연도별 ($1997{\sim}2000$) 송이 자실체 발생위치는 연평균 11.3cm 이동하였다. 또한 송이 균환 선단에서 송이 버섯간 거리는 2000년 경우에는 균환선단 안쪽 13.8cm에서 발생하였다. 따라서 당년의 송이 발생위치는 1년 전에 땅속의 송이균사들이 생장하였던 곳임을 알 수 있었다. 송이는 송이 균환의 보호 차원에서 송이 버섯발생 위치에서 50cm 떨어진 밖에서 채취하는 것이 바람직할 것으로 생각되었다.

• 대한수학회지
• /
• 제45권2호
• /
• pp.425-433
• /
• 2008

Let R be a ring with identity $1_R$ and let U(R) denote the group of all units of R. A ring R is called locally finite if every finite subset in it generates a finite semi group multiplicatively. In this paper, some results are obtained as follows: (1) for any semilocal (hence semiperfect) ring R, U(R) is a finite (resp. locally finite) group if and only if R is a finite (resp. locally finite) ring; U(R) is a locally finite group if and only if U$(M_n(R))$ is a locally finite group where $M_n(R)$ is the full matrix ring of $n{\times}n$ matrices over R for any positive integer n; in addition, if $2=1_R+1_R$ is a unit in R, then U(R) is an abelian group if and only if R is a commutative ring; (2) for any semiperfect ring R, if E(R), the set of all idempotents in R, is commuting, then $R/J\cong\oplus_{i=1}^mD_i$ where each $D_i$ is a division ring for some positive integer m and |E(R)|=$2^m$; in addition, if 2=$1_R+1_R$ is a unit in R, then every idempotent is central.

• Journal of Plant Biotechnology
• /
• 제35권3호
• /
• pp.177-183
• /
• 2008

본 연구는 동진벼 유래의 Ac/Ds 삽입변이집단의 GUS 분석을 통하여 뿌리 및 미숙종자에서 강하게 GUS가 발현한 개체를 선발하여 FST(flanking sequence tag) 분석 한 결과 Ds 전이 인자가 3번 염색체 zinc finger RING-H2 관련 Oszinc626 유전자의 첫 번째 exon 부위에 single copy로 삽입되어 있었으며, 선발변이체는 뿌리 및 종자 발달이 정상인 동진벼에 비해 매우 낮은 것으로 나타났다. Oszinc626 유전자는 RING-H2 type(C3-H2-C3)으로 $Cys-X_2-Cys-X_{28}-Cys-X-His-X_2-His-X_2-Cys-X_{14}-Cys-X_2-Cys$ 배열이 C-terminus 가장 말단에 위치하며, 49 kDa의 분자량을 가지고 있다. 또한 Southern blot 분석에서 Oszinc626 유전자는 벼 게놈상에 single copy로 존재하였다. RT-PCR을 통한 돌연변이 유전자의 발현분석 결과 250 mM의 염과, $4^{\circ}C$ 저온등과 같은abiotic stress에 의해 발현이 증가함을 보였고, 호르몬처리에 있어서 ABA와 IAA의 식물호르몬을 처리했을 경우 24시간까지 계속해서 발현양이 증가하는 것을 보이는 반면, 2,4-D 처리의 경우 30분 후에 발현이 일시적으로 증가되었으나 이후 발현이 급속히 감소한 것을 보였다. 벼의 조직 별 발현 검정에서 미성숙한 종자, 뿌리 분열조직 및 신초 등 주로 생장점 부위에서 강하게 발현되는 것을 보임에 따라 Oszinc626 유전자의 경우 식물의 생장에 관여하는 주동 유전자의 하나로 판단된다.

• 한국해양공학회지
• /
• 제20권1호
• /
• pp.20-25
• /
• 2006

This paper deals with the design and aerodynamic analysis of a so-called 'ring-type' impulse turbine for wave energy conversion. Numerical analysis was performed using the CFD cock, FLUENT. The main idea of the proposed turbine rotor was to minimize the adverse effect of tip clearance of the turbine blade; the design was borrowed from a ducted propeller with connected ring tip for special purpose marine vehicles. Results show that the efficiency increases up to $10\%$, depending on flaw coefficient, with the higher flaw coefficient yielding better efficiency. Decrease of input coefficient CA was the main reason for higher efficiency. Performance of ring-type rotor at various design parameters, as well as flaw conditions, was investigated, and the advantages and the disadvantages of the present impulse turbine were also discussed.

• Bulletin of the Korean Chemical Society
• /
• 제29권1호
• /
• pp.81-84
• /
• 2008

In the present study, we report 1H and 13C NMR data of 19 methoxyflavonol derivatives with different substitution patterns on A- and B-ring. In addition, the influence of the methoxy substituents in A- and B-ring on the 1H and 13C NMR chemical shifts is discussed: the 1H and 13C chemical shifts of and the number of methoxyl groups provided information allowing elimination of many structural isomers from consideration and in certain instances greatly simplified structural elucidation.

• 대한수학회보
• /
• 제20권1호
• /
• pp.45-49
• /
• 1983

If R is ring and M is a right (or left) R-module, then M is called a faithful R-module if, for some a in R, x.a=0 for all x.mem.M then a=0. In [4], R.E. Johnson defines that M is a prime module if every non-zero submodule of M is faithful. Let us define that M is of prime type provided that M is faithful if and only if every non-zero submodule is faithful. We call a right (left) ideal I of R is of prime type if R/I is of prime type as a R-module. This is equivalent to the condition that if xRy.subeq.I then either x.mem.I ro y.mem.I (see [5:3:1]). It is easy to see that in case R is a commutative ring then a right or left ideal of a prime type is just a prime ideal. We have defined in [5], that a chain of right ideals of prime type in a ring R is a finite strictly increasing sequence I$_{0}$.contnd.I$_{1}$.contnd....contnd.I$_{n}$; the length of the chain is n. By the right dimension of a ring R, which is denoted by dim, R, we mean the supremum of the length of all chains of right ideals of prime type in R. It is an integer .geq.0 or .inf.. The left dimension of R, which is denoted by dim$_{l}$ R is similarly defined. It was shown in [5], that dim$_{r}$R=0 if and only if dim$_{l}$ R=0 if and only if R modulo the prime radical is a strongly regular ring. By "a strongly regular ring", we mean that for every a in R there is x in R such that axa=a=a$^{2}$x. It was also shown that R is a simple ring if and only if every right ideal is of prime type if and only if every left ideal is of prime type. In case, R is a (right or left) primitive ring then dim$_{r}$R=n if and only if dim$_{l}$ R=n if and only if R.iden.D$_{n+1}$ , n+1 by n+1 matrix ring on a division ring D. in this paper, we establish the following results: (1) If R is prime ring and dim$_{r}$R=n then either R is a righe Ore domain such that every non-zero right ideal of a prime type contains a non-zero minimal prime ideal or the classical ring of ritght quotients is isomorphic to m*m matrix ring over a division ring where m.leq.n+1. (b) If R is prime ring and dim$_{r}$R=n then dim$_{l}$ R=n if dim$_{l}$ R=n if dim$_{l}$ R<.inf. (c) Let R be a principal right and left ideal domain. If dim$_{r}$R=1 then R is an unique factorization domain.TEX>R=1 then R is an unique factorization domain.