• Biomolecules & Therapeutics
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• 제5권3호
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• pp.233-238
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• 1997

The distribution and excretion of radioactivity were examined after intraportal administration of sup 166/Ho-chitosan complex at a dose of 1 mcitg (10 mg chitosan/kg) to rats. Whole body macroautoluminographs showed that the radioactivity after an administration was concentrated in liver and perfused primarily to organs including kidney, spleen, and bone marrow, then to muscle and brain. Similar profiles were observed from 2 hr to 168 hr after the administration. The relative percentage of radioactivity in bone and spinal column increased with time, suggesting that free $^{166}$ Ho, released from chitosan complex deposited in the liver, selectively binds to these tissues. $^{166}$ Ho-chitosan complex administered intraportally was excreted less than 4% through urine (2.7$\pm$0.8%) and feces (0.65 $\pm$ 0.4%) up to seven days. These results demonstrate that the radio-activity of $_{166}$ Ho-chitusan complex when administered intraportally, mainly localizes in liver without affec-ting other tissues and organs. Considering the short half life of $^{166}$ Ho and the localization to the liver, $^{166}$ Ho-chitosan complex might be a useful agent in the treatment of hepatic carcinoma.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2019년도 추계학술발표대회
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• pp.153-155
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• 2019

국방무기체계 분야 중 단일 센터에 대규모 분산시스템을 구성하는 경우 신속한 데이터 처리를 위해 통신 미들웨어로 사용되는 DDS의 패킷을 튜닝하여 사용하고 있다. 하지만 향후 국방무기체계는 생존성 보장을 위해 분산시스템의 장소를 주/예비 센터로 이원화하면서 센터간에도 신속한 데이터 동기화 및 비상시 OO초 내 센터 임무전환까지 함께 요구하고 있다. 따라서 단일 센터에서 적용한 DDS 패킷 전송 방식을 WAN 환경에 적용 시 데이터 송수신간 패킷의 순서가 바뀌는 현상이 발생하여 데이터 공유가 제한될 수 있다. 본 연구에서는 이와같은 제한사항을 극복하기 위해 DDS를 적용한 LAN 구간의 기존 성능을 유지하면서 WAN 구간 데이터의 신뢰성 보장을 위한 TCP/IP 기반의 WAN Sync 설계를 제시하였다.

• 한국기계기술학회지
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• 제13권3호
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• pp.25-30
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• 2011

Flow control of flow field is essential to design efficient elements relating to fluid machineries. In this study, flow characteristics of rectangular prism with center gap through-flow at different aspect ratio was investigated to flow control. It was used a FLUENT 6.3 version to study flow field. It was found that the through-flow disturbs the development of vertical velocity component and decreased the vortex size and critical value of a rapid change in pressure coefficient distribution.

• 대한의용생체공학회:의공학회지
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• 제42권5호
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• pp.225-231
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• 2021

The purpose of this study was to investigate the effect on the activity of the upper trapezius and erector spinae according to the length difference of the backpack using electromyogram (EMG). We also conducted a study comparing the center of pressure (COP) and weight distribution before and after using Wii® balance board. Thirty individuals were randomly assigned to the experimental group (n=14) wearing a backpack with a short right strap length and a control group (n=16) wearing a backpack with the same strap length. Data were collected by dividing into groups, carring a 15% weight backpack and walking for 20 minutes on a treadmill. As a result of analyzing the EMG data, there was no significant change in the upper extremity muscle activity of the control group, but it was significantly decreased in the right upper trapezius activity of the experimental group (p<0.05). In addition, there was a significant change of COP in the experimental group (p<0.05), but there was no significant difference of the weight distribution in both groups. Recognizing mechanical changes in the body that may occur due to the asymmetry of the strap length is thought to be helpful for systematic ergonomic intervention according to changes in the external environment in the future.

• 한국유통학회지:유통연구
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• 제1권2호
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• pp.141-172
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• 1996

This study is to investigate global logistics strategies of Korean electronics companies. in terms of service parts. According to the survey, Korean electronics companies were pursuing multi-level global logistics network such as global, continental, national, regional and service center echelon for improving the efficiency of service parts global logistics. Especially there was a tendency of developing new continental distribution centers. And the companies were exploiting efficiency through inventory control by multi-level echelon, demand forecasting by the product life cycle and supply and service lead time management. But there were some insufficient factors for the efficiency of global logistics operation at the construction of worldwide real time logistics information system and pursuit of the efficiency on the whole network including subcontractors. For the future competitive advantage of the Korean electronics companies, the following are suggested: 1) the establishment of arranged logistics channel adjusting each company's global strategy, 2) the construction of worldwide real time logistics information system, 3) the reengineering of all logistics procedures such as order processing, shipping, inventory control, etc., 4) the enhancement of the ratio of the supply from the external companies and the internal manufacturing subsidiaries at each continent, 5) and the pursuit of operational internalization of external subcontractors.

• 한국의료질향상학회지
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• 제27권1호
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• pp.20-25
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• 2021

Purpose: The ability to access clinical trials for cancer treatment is important. This study investigated whether regional differences exist in oncologic clinical trial protocols conducted in South Korea. Methods: Records of all approved oncologic clinical trials conducted in 2019 were downloaded from the Republic of Korea Ministry of Food and Drug Safety. The study covered Seoul, the capital area, other metropolitan cities, and provincial areas. Descriptive statistics summarized the distribution patterns of clinical trials by region. Results: A total of 202 oncologic clinical trials were conducted in 63 institutions in 2019. Of these protocols, 186 (92%) were available in Seoul, 120 (59%) in the capital area, 64 (32%) in metropolitan cities, and 66 (33%) in provincial areas. More regional differences in protocol availability were observed in domestic trials, investigator-initiated trials, phase 1 and 2 trials, and smaller-scale trials. Conclusion: Most oncologic clinical trials were conducted in medical institutions located in Seoul, with the rest conducted in the capital area, metropolitan cities, and provincial areas. The findings reveal clear differences in protocol availability between Seoul and the other regions. Measures designed to improve geographical access to oncologic clinical trials may be needed given their growing importance in cancer treatment.

• 대한한방내과학회지
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• 제21권5호
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• pp.765-771
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• 2000

Objectives : To evaluate the pain control effect of combination treatment of Oriental Medicine on patients who suffered from thalamic pain syndrome caused by thalamic stroke. Methods : We reviewed the medical records and brain imaging data of all patients with thalamic stroke from September 1998 to August 2000 who visited to Department of Oriental Internal Medicine, National Medical Center. We evaluated clinical features of thalamic pain syndrome, including incidence, onset interval from stroke, nature, pain distribution, and assessed the pain control effect of combination treatment by Visual Analog Scale(VAS). Results : 64 cases were selected under the inclusion criteria, and 17 patients(26.5%) with thalamic pain syndrome were identified from 64 thalamic strokes. VAS proved combination treatment effective to control pain of thalamic pain syndrome. In 12 cases(70.5%), pain onset was within the first week poststroke. The patients with allodynia were 6(35.3%). In 12 cases(70.5%), the lesion was mainly located in the posterolateral areas of thalamus. Conclusion : We conclude that combination treatment of the Oriental Medicine modalities have pain control effectiveness on thalamic pain syndrome.(t=-5.47, p=0.0001)

• 산경연구논집
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• 제11권9호
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• pp.37-47
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• 2020

Purpose: This study examined how interpersonal relationship abilities in the elderly affected anger control abilities, as well as the mediating effects of generativity in the relationships between interpersonal relationships, anger control abilities, and self-integration. Research design, data and methodology: The study consisted of randomly selected 300 elderly people currently residing in welfare centers for the elderly, senior citizens colleges, social welfare facilities and other centers in the Seoul or Gyeonggi area. SPSS 23.0 was utilized for this study. Results: Through this research, the effect of interpersonal relationships on anger control ability and self-integration was observed. Not only that, the effects of interpersonal relationship abilities on anger control and self-integration and the mediating role of generativity, was also closely examined. Conclusion: Anger control ability was found to have a direct positive effect on interpersonal relationship abilities. Anger control ability had a direct and positively correlated effect on self-integration. Additionally, ability to control anger was found to have a positive effect on generativity, and generativity was found to have a positive effect on interpersonal relationship ability, but it was not statistically significant. Anger control ability had a positive effect on generativity, and generativity had a positive effect on self-integration.

• 생태와환경
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• 제52권1호
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• pp.21-27
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• 2019

본 연구에서는 영농기간 동안 비강우시에 영농형태에 따른 논에서 유출되는 T-N, T-P, COD, SS의 적정 확률분포를 분석하기 위해 2016년 전라북도 부안군 논 유역에서 모니터링을 수행하였다. 확률분포모형 선정을 위해 Kolmogorov-Smirnov 검정방법을 적용한 결과 Weibull 분포모형에서 대조구, 완효성비료처리구, 물꼬관리처리구의 모든 수질 항목에서(T-N, T-P, COD, SS) 적합성이 있는 것으로 나타났다. 이는 강우시에 모든 수질 항목에서 Log-Normal 분포모형과 Gamma 분포모형에서 적합성이 있는 것으로 보고한 선행연구 결과와는 다른 특성을 보였다. 따라서, 하천의 수질관리를 위해서는 시기별 적합한 확률분포모형을 적용해야 한다. 본 연구 결과에서 분석된 비강우시 영농형태별 (대조구, 완효성비료처리구, 물꼬관리처리구) 확률분포모형에 의해 선정된 수질 항목별 중앙값과 하천의 수질을 연계 분석한다면 논에서 유출되는 수질이 하천에 미치는 영향을 분석할 수 있을 것으로 판단된다.

• 전력전자학회논문지
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• 제24권4호
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• pp.229-236
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• 2019

This study proposes a DC-DC converter topology of solid-state transformer for low-voltage DC distribution. The proposed topology consists of a voltage balancer and bipolar DC-DC converter. The voltage and current equations are obtained on the basis of switching states to design the controller. The open-loop gain of the controller is achieved using the derived voltage and current equations. The controller gain is selected through the frequency analysis of the loop gain. The inductance and capacitance are calculated considering the voltage and current ripples. The prototype is fabricated in accordance with the designed system parameters. The proposed topology and designed controller are verified through simulation and experiment.