• Archives of Pharmacal Research
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• 제18권3호
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• pp.183-188
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• 1995

Polymeric reinforcement and coatings of alginate beads were carried out to control the release rate of drug from alginate beads. A poorly water-soluble ibuprofen (IPF) was selected as a model drug. A commercially available $Eudragit^{\circledR}$ RS100 was also used as a polymer. Effects of polymeric contents, the presence of plasticizers and amount of drug loading on the release rate of drug were investigated. The release rate of drug from alginate beads in the simulated gastric fluid did not occur within 2 h but released immediately when dissolution media were switched to the simulated intestinal fluid. No significant difference of release rate from polymer-reinforced alginate bead without plasticizers was observed when compared to plain (simple) beads. However, the release rate of drug from polymer-reinforced alginate beads was further sustained and retarded when aluminium tristearate (AT) as a plasticizer was added to polymer. However, polyethylene glycol 400 (PEG400) did not change the release rate of drug from alginate beads although PEG400 was used to improve dispersion of polymer and sodium alginate, and plasticize $Eudragit^{\circledR}$ RS100 polymer. The presence of plasticizer was crucial to reinforce alginate gel matrices using a polymer. As the amount of drug loading increased, the release rate of drug increased as a result of decreasing effects of polymer contents in matrices. The significantly sustained release of drug from polymer-coated alginate beads occurred as the amount of polymer increased because the thickness of coated membrane increased so that cracks and pores of the outer surface of alginate beads could be reduced. The sustained and retarded action of polymer-reinforced and coated beads may result from the disturbance of swelling and erosion (disintegration) of alginate beads. From these findings, polymeric-reinforcement and coatings of alginate gel beads can provide an advanced delivery system by retarding the release rate of various drugs.

• Environmental Engineering Research
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• 제19권3호
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• pp.269-274
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• 2014

On-site sanitation systems are typically installed to treat grey and toilet wastewaters in areas without sewer and centralized treatment systems. It is well known that, due to inappropriate design and operation, treatment performance of these systems in developing countries is not satisfactory in the removal of pathogens and organic matters. This research aimed to investigate the hydraulic conditions occurring in some on-site sanitation systems and the effects of hydraulic retention times (HRTs) on the system performance. The experiments were conducted with a laboratory-scale septic tank (40L in size) and an actual septic tank (600L in size), to test the hydraulic conditions by using tracer study with HRTs varying at 12, 24 and 48 hr. The experimental results showed the dispersion numbers to be in the range of 0.017-0.320 and the short-circuit ratios in the range of 0.014-0.031, indicating the reactors having a high level of sort-circuiting and approaching complete-mix conditions. The removal efficiency of $BOD_5$ was found to be 67% and the $k_{30}$ values for $BOD_5$ was $2.04day^{-1}$. A modified complete-mix model based on the relationship between $BOD_5$ removal efficiencies and HRTs was developed and validated with actual-scale septic tank data having a correlation coefficient ($R^2$) of 0.90. Therefore, to better protect our environment and minimizing health risks, new generation toilets should be developed that could minimize short-circuiting and improving treatment performance.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 1999년도 정기총회 및 춘계 공동 학술발표회
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• pp.149-156
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• 1999

In the United States (U.S.), the monitored natural attenuation (MNA) approach has been used as an alternative remedial option for organic and inorganic compounds retained in soil and dissolved in groundwater. The U.S. Environmental Protection Agency (EPA) defines the MNA as“in-situ naturally-occurring processes include biodegradation, diffusion, dilution, sorption, volatilization, and/or chemical and biochemical stabilization of contaminants and reduce contaminant toxicity, mobility or volume to the levels that are protective of human health and the environment”. The Department of Soil Environment. National Institute Environmental Research (NIER) is in the process for demonstrating the MNA approach as a potential remedial option for the BTEX contaminated site in Uiwang City. The project is charactering the research site in terms of the nature and extend of contamination, biological degradation rate, and geochemical and hydrological properties. The microbial-degradation rate and effectiveness of nutrient and redox supplements will be determined through laboratory batch and column tests. The geochemical process will be monitored for determining the concentration changes of chemical species involved in the electron transfer processes that include methanogenesis, sulfate and iron reduction, denitrification, and aerobic respiration. Through field works, critical soil and hydrogeologic parameters will be acquired to simulate the effects of dispersion, advection, sorption, and biodegradation on the fate and transport of the dissolved-phase BTEX plume using Bioplume III model. The objectives of this multi-years research project are (1) to evaluate the MNA approach using the BTEX contaminated site in Uiwang City, (2) to establish a standard protocol for future application of the approach, (3) to investigate applicability of the passive approach as a secondary treatment remedy after active treatments. In this presentation, the overall picture and philosophy behind the MNA approach will be reviewed. Detailed discussions of the site characterization/monitoring plans and risk-based decision-making processes for the demonstration site will be included.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.75-75
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• 2015

오염원과 취수장이 동일 구간 내에 공존하는 국내하천의 특성상, 하천 평면 내에서 오염물의 거동 및 혼합 특성을 보다 정확하게 해석하기 위해서는 2차원 이송-분산 모형의 적용이 필요하다. 이를 위해서는 2차원 모형의 주요 매개변수인 종분산계수와 횡분산계수의 적절한 입력이 매우 중요하다. 하지만 국내외적으로 횡분산계수에 대한 연구는 많이 진행된 반면, 현재까지 종분산계수에 대한 연구는 충분히 이루어지지 않은 실정이다. 분산계수를 결정하는 방법에는 실측된 농도 자료의 유무에 따라 크게 두 가지로 분류된다. 실측된 농도 자료가 없는 경우, 이론식이나 경험식을 이용하는 방법이 있다. 반면에 추적자 실험 등을 수행하여 실측된 농도 자료가 있는 경우, 모멘트법 또는 추적법을 적용하여 농도-시간 분포 곡선으로부터 분산계수를 계산하는 것이다. 모멘트법은 임의 지점에서 농도의 횡분포를 통해 얻을 수 있는 2차 모멘트의 종방향 변화율이 횡분산계수와 비례한다는 원리를 이용한 것이며, 추적법은 상류부의 관측된 농도를 입력자료로 하여 하류부의 농도를 계산한 후 계산된 농도와 실측된 하류부 농도의 비교를 통해 분산계수를 산정하는 방법이다. 본 연구에서는 불규칙한 단면 형상을 가지는 자연하천에서의 2차원 종 횡분산계수를 산정하기 위해서 Baek & Seo(2010)가 제안한 2차원 유관추적법(2D Stream-tube Routing Procedure)을 적용하였다. 본 연구에서는 국내 자연하천 중 다양한 사행형태를 갖으며 수질오염 사고의 위험이 높은 구간을 선정하고, 추적자로서 Rhodamine WT를 이용하여 현장실험을 수행하였다. 실험에서 수집된 수리량 및 농도자료로부터 추적자의 2차원적 거동을 분석하였으며, 2차원 유관추적법을 적용하여 종분산계수를 산정하였다. 그 결과 하폭 대 수심비(W/H)와 마찰손실관련 무차원변수(U/U*)의 증가에 따라 종분산계수가 증가됨을 확인 할 수 있었다. 본 연구에서 산출된 종분산계수와 선행 연구에서 수집된 자료를 이용하여 추정식을 개발하였다. 차원해석을 통해 무차원 종분산계수에 영향을 미치는 무차원 인자를 선별하고 회귀분석을 이용하여 종분산계수 추정식을 유도하였다. 추정식을 이용하여 산정한 종분산계수의 범위는 Elder (1959)가 제안한 이론값보다 약 10배 정도로 크게 나타났다. 혼합 특성이 밝혀지지 않은 자연하천에 2차원 확산모형을 적용하고자 할 때 본 연구에서 개발된 추정식으로부터 계산된 종분산계수를 사용할 수 있을 것이다.

• Earthquakes and Structures
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• 제10권1호
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• pp.141-161
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• 2016

In seismic fragility and risk analysis, the definition of structural limit state (LS) capacities is of crucial importance. Traditionally, LS capacities are defined according to design code provisions or using deterministic pushover analysis without considering the inherent randomness of structural parameters. To assess the effects of structural randomness on LS capacities, ten structural parameters that include material strengths and gravity loads are considered as random variables, and a probabilistic pushover method based on a correlation-controlled Latin hypercube sampling technique is used to estimate the uncertainties in LS capacities for four typical reinforced concrete frame buildings. A series of ten LSs are identified from the pushover curves based on the design-code-given thresholds and the available damage-controlled criteria. The obtained LS capacities are further represented by a lognormal model with the median $m_C$ and the dispersion ${\beta}_C$. The results show that structural uncertainties have limited influence on $m_C$ for the LSs other than that near collapse. The commonly used assumption of ${\beta}_C$ between 0.25 and 0.30 overestimates the uncertainties in LS capacities for each individual building, but they are suitable for a building group with moderate damages. A low uncertainty as ${\beta}_C=0.1{\sim}0.15$ is adequate for the LSs associated with slight damages of structures, while a large uncertainty as ${\beta}_C=0.40{\sim}0.45$ is suggested for the LSs near collapse.

• 환경영향평가
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• 제28권4호
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• pp.413-426
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• 2019

주거지 내 위치하거나 매우 인접한 곳에 무분별하게 난립된 개별입지 공장들은 궁극적으로는 준 산업단지 또는 새로운 계획입지로의 조정이 필요하다. 본 연구에서는 김포시 환경을 예로 김포시 전역에 난립된 개별입지 공장들을 새로운 지역으로 군집시킴에 따른 대기 $SO_2$ 오염도의 변화를 AERMOD 모형을 이용하여 평가하였다. 평가결과 개별입지 공장들의 공간 재배치를 통해 김포시 자체 배출원에 의한 오염도를 개선할 수 있는 가능성을 확인하였다. 재배치와 더불어 배출 굴뚝의 높이 조정과 같은 배출규제가 병행되는 경우 김포시 자체 배출원에 의한 오염도를 김포시 전체적으로 볼 때 약 70% 감소 가능하며 행정 구역별로는 최대 약 87% 감소 가능함을 정량적으로 확인하였다. 단, 군집지역으로 선정된 해당 행정구역은 김포시 전체 오염도의 변화 폭과 비교했을 때 상대적으로 큰 오염도 증가가 나타날 수 있다.

• 한국항해항만학회지
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• 제44권6호
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• pp.477-487
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• 2020

부산항은 다수의 컨테이너터미널 운영사에 의해 소규모로 분산 운영되고 있어 다양한 운영 비효율이 발생하고 있다. 특히 2016년 선사들의 얼라이언스 재편과 대형화로 인한 물량 분산은 터미널 분산 운영의 비효율을 촉진시켜, 불필요한 타부두 환적 운송과 체선 문제를 유발하고 있다. 이를 해소하기 위한 방안으로 컨테이너터미널 대형화를 위한 통합운영이 고려되고 있다. 그러나 통합운영에 따르는 선결과제들로 인해 실질적인 통합 및 추진 방향이 모호한 실정이다. 따라서, 본 연구에서는 부산 신항의 컨테이너터미널들을 대상으로 통합운영 유형을 단계별로 나누어 모델링하였으며, 선박 대형화 및 터미널 혼잡도에 따른 시나리오 변화를 두어 향후 부산항이 통합화 추진과 함께 겪게 될 상황을 가정하여 시뮬레이션을 실시하였다. 또한, 분석결과를 바탕으로 통합 유형별로 운영적 효과를 해석하고 평가하였다.

• 한국재료학회지
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• 제31권6호
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• pp.345-352
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• 2021

In this study, Ni nanoparticle supported by graphene oxide (GO) (Ni-GO) is successfully synthesized through hydrothermal synthesis and calcination, and Cr(VI) is extracted from aqueous solution. The morphology and structure of Ni-GO composites are characterized by scanning electron microscopy (SEM), trans mission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). High-resolution transmission electron microscopy (HRTEM) and XRD confirms the high dispersion of Ni nanoparticle after support by GO. Loading Ni on GO can obviously enhance the stability of Ni-GO composites. It can be calculated from TGA that the mass percentage of Ni is about 60.67 %. The effects of initial pH and reaction time on Cr(VI) removal ability of Ni-GO are investigated. The results indicate that the removal efficiency of Cr(VI) is greater than that of bared GO. Ni-GO shows fast removal capacity for Cr(VI) (<25 min) with high removal efficiency. Dynamic experiments show that the removal process conforms to the quasi-second order model of adsorption, which indicates that the rate control step of the removal process is chemical adsorption. The removal capacity increases with the increase of temperature, indicating that the reaction of Cr(VI) on Ni-GO composites is endothermic and spontaneous. Combined with tests and characterization, the mechanism of Cr(VI) removal by rapidly adsorption on the surface of Ni-GO and reduction by Ni nanoparticle is investigated. The above results show that Ni-GO can be used as a potential remediation agent for Cr(VI)-contaminated groundwater.

• Wind and Structures
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• 제35권1호
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• pp.21-34
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• 2022

Gust factor is an important parameter for the conversion between peak gust wind and mean wind speed used for the structural design and wind-related hazard mitigation. The gust factor of typhoon wind is observed to show a significant dispersion and some differences with large-scale weather systems, e.g., monsoons and extratropical cyclones. In this study, insitu measurement data captured by 13 meteorological towers during a strong typhoon Morakot are collected to investigate the statistical characteristics, height and wind speed dependency of the gust factor. Onshore off-sea and off-land winds are comparatively studied, respectively to characterize the underlying terrain effects on the gust factor. The theoretical method of peak factor based on Gaussian assumption is then introduced to compare the gust factor profiles observed in this study and given in some building codes and standards. The results show that the probability distributions of gust factor for both off-sea winds and off-land winds can be well described using the generalized extreme value (GEV) distribution model. Compared with the off-land winds, the off-sea gust factors are relatively smaller, and the probability distribution is more leptokurtic with longer tails. With the increase of height, especially for off-sea winds, the probability distributions of gust factor are more peaked and right-tailed. The scatters of gust factor decrease with the mean wind speed and height. AS/NZ's suggestions are nearly parallel with the measured gust factor profiles below 80m, while the fitting curve of off-sea data below 120m is more similar to AIJ, ASCE and EU.

• 한국지반공학회논문집
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• 제38권8호
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• pp.17-27
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• 2022

김해평야 퇴적층의 동적 특성을 결정하기 위해 6개의 위치에서 상시미동 수평-수직비(HVSR)법으로 지반 고유진동수(f₀)를 도출하고 High frequency f-k방법과 Modified Spatial Autocorrelation 방법을 적용하여 상시미동 기반 표면파 분석을 수행하였다. 레일리파 분산곡선과 지반 고유진동수를 바탕으로 역해석을 실시하여 전단파 속도 주상도를 도출하였다. 분석 결과에 의하면 김해평야 퇴적층 지역은 1hz 이상의 진동수 대역에서 상당한 규모의 지반운동 증폭이 예상된다. 천부 퇴적층은 대체로 200m/s 내외의 전단파 속도를 보이고 60m~100m 사이의 깊이에서 기반암이 존재할 것으로 추정되며, 다수의 위치에서 천부 퇴적층과 기반암 사이에 V_s=400m/s 가량의 하성 퇴적층이 존재하는 것으로 나타났다. 역해석 결과를 바탕으로 김해평야 퇴적층의 전단파 속도-깊이 모델을 도출하였으며, 본 연구에 따르면 김해평야 퇴적층 지역에서 내진설계일반(KDS 17 10 00)의 S6지반에 해당하는 위치의 면적은 상당할 것으로 예상된다.