• Biomolecules & Therapeutics
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• 제29권4호
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• pp.353-364
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• 2021

The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the GI tract can lead to GI disorders. GI disorders are highly prevalent in the population and account for substantial morbidity, mortality, and healthcare utilization. GI disorders can be functional, or organic with structural changes. Functional GI disorders include functional dyspepsia and irritable bowel syndrome. Organic GI disorders include inflammation of the GI tract due to chronic infection, drugs, trauma, and other causes. Recent studies have highlighted a new explanatory mechanism for GI disorders. It has been suggested that autophagy, an intracellular homeostatic mechanism, also plays an important role in the pathogenesis of GI disorders. Autophagy has three primary forms: macroautophagy, microautophagy, and chaperone-mediated autophagy. It may affect intestinal homeostasis, host defense against intestinal pathogens, regulation of the gut microbiota, and innate and adaptive immunity. Drugs targeting autophagy could, therefore, have therapeutic potential for treating GI disorders. In this review, we provide an overview of current understanding regarding the evidence for autophagy in GI diseases and updates on potential treatments, including drugs and complementary and alternative medicines.

• 정신신체의학
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• 제25권2호
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• pp.185-192
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• 2017

연구목적 최근 남성에서 섭식장애의 유병률이 증가되고 있다. 본 연구에서는 국내 남성 섭식장애 환자의 임상적 특징을 알아보고자 하였다. 방 법 본 연구는 2010년 3월부터 2016년 11월까지 인제대학교 서울백병원 섭식장애 클리닉에 내원한 남성 환자 32명과 대조군인 여성 환자 75명을 대상으로 하였다. 남성 및 여성 환자 간 섭식병리 및 공존정신병리를 비교하였으며, 면담도구로는 섭식장애검사(Eating disorders examination)를 사용하였으며, 설문평가로는 벡 우울 척도(Beck Depression Inventory)와 스필버그 상태-특성 불안 척도(Spielberger State and Trait Anxiety Inventory)를 사용하였고, 체중관련 변수들을 조사하였다. 남성 환자 군을 대상으로 과거 체중감량의 정도와 섭식장애 병리 간의 연관성을 탐색하였다. 결 과 남녀 환자 간 내원 연령, 발병 연령, 이환 기간, 내원 시의 체질량지수는 유의한 차이가 없었다. 남성 섭식장애 환자에서 여성 환자들에 비하여 병전 과체중 및 비만의 기왕력이 더 높게 나타났다(${\chi}^2=4.692$, p=0.03). 남녀 간 동반되는 불안 증상의 정도는 차이가 없었으나, 남성 환자군에서 우울 증상의 정도가 낮았다(d=0.63). 남성 환자들에서 과거 체중감량 정도와 현재의 섭식장애 병리간 관련 있었다. 결 론 본 연구는 한국인 남성을 대상으로 섭식장애의 임상적 특징을 탐색한 첫 연구라는 데 큰 의의가 있다. 본 연구결과는 남성 섭식장애 환자들의 치료에 대한 접근을 높이고 예방계획을 수립하는 데 중요한 단서가 될 수 있을 것이다.

• 대한안전경영과학회지
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• 제11권4호
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• pp.85-91
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• 2009

While musculoskeletal disorders increased, its prevention efforts were rather decreased or its operation was insufficient. This study aims to examine the actual conditions of musculoskeletal disorders at Electronics Company in Korea, analyze occupational danger factors related to musculoskeletal disorders through analysis of components of wrong workplaces and works, evaluate degree of danger of factors examined, analyze association between danger factors and musculoskeletal disorders, accumulate data of musculoskeletal disorders which are not enough in Korea and further prepare the foundation of improving working environment and developing prevention/management program of musculoskeletal disorders.

• 대한불안의학회지
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• 제3권1호
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• pp.15-19
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• 2007

Substantial rates of comorbid anxiety disorders have been found using structured research diagnostic interviews in depressed outpatients. Comorbid anxiety disorders is underrecognized in routine clinical settings, in which clinicians usually use unstructured diagnostic interviews. Recognition of comorbid conditions such as anxiety disorders in patients seeking treatment for depression is clinically important because the presence of these disorders might influence selection of treatment options or predict the chronicity of the depression. A reliable and valid self-report screening questionnaire, such as the Psychiatric Diagnostic Screening Questionnaire (PDSQ), would potentially enhance usual clinical practice as a useful diagnostic aid.

• 생물정신의학
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• 제20권3호
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• pp.74-79
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• 2013

Objectives This paper aims to understand the emotional-biological pathogenesis of eating disorders, and translate the understanding into new brain directed treatments. Methods The first part of the review sets the eating behavior into the context of what is now understood about the central control of appetite and molecular biology. The second part of the review sees how emotion relates to the brain circuit involving eating disorders. Results In general, patients with anorexia nervosa restricting type were less sensitive to reward, whereas patients with bulimia nervosa and anorexia nervosa binge purging type were more sensitive to it. The emotional life of people with eating disorders centers on food, weight, and shape. The abnormalities in social and emotional functioning both precede and persist outside of eating disorders. Conclusions Research into understanding the biological framework of the brain in eating disorders suggests that abnormalities may exist in emotional and information processing. This aspect can be translated into novel brain-directed treatments, particularly in anorexia nervosa.

• 대한불안의학회지
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• 제5권1호
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• pp.3-7
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• 2009

In this article, we review research on how normal personality traits and personality disorder traits may relate to anxiety disorders ; as predisposing factors, 2) as complications, 3) as pathoplastic factors, and 4) as manifestations of common underlying etiologies. Based on current literatures, we draw a conclusion as follows : 1) Normal personality traits such as high neuroticism and low extraversion and personality disorder traits, especially cluster C traits, are at least risk factors for certain anxiety disorders ; 2) Anxiety disorders in early life might influence a later development of personality disorder ; 3) Personality disorder traits may have negative influence on the outcome of anxiety disorders ; 4) Personality and anxiety disorders may be manifestations of common genetic and environmental etiologies.

• Journal of mucopolysaccharidosis and rare diseases
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• 제4권1호
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• pp.1-6
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• 2018

Lysosomal storage disorders are a group of rare inherited metabolic disorders with protean manifestations and variable severity ranging from attenuated forms to severe ones. It is necessary to diagnose and manage these disorders timely before irreversible damage occurs. Prior to the era of enzyme replacement therapy and newer therapeutics, only treatment option available was palliative care. Over the past two decades, extensive research in the lysosomal storage disorders has led to substantial expansion of our understanding about them. This mini review focusses on the spectrum, challenges faced in the diagnosis and therapy and remedial actions taken so far in lysosomal storage disorders in resource constrained country like India.

• 한국임상수의학회지
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• 제15권2호
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• pp.358-363
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• 1998

These studies were performed to investigate what genital diseases could be diagnosed by ultrasonography in the mares associated with infertility. Of 159 thoroughbred breeders(4 to 18 years old), 31 mares which had been considered as the mares with reproductive disorders were examined by ultrasonography during the breeding season. 1. Hematoma in ovarian disordersl endometritis and pyometra in uterine disorders could be diagnosed by ultrasonography. 2.The rate of infertility was 19.5% out of 159 breeders and the rate of uterine disordres was 71.0% among the whole reproductive disorders. 3.Of 31 mares considered as the mares with infertilityi 26 mares were diagnosed by ultrasonography denoting 83.9% of diagnosis rate. 4.The highest average age of mares among the mares with reproductive disorders was 11.7 years in the mares with uterine disorders. The average age of the mares diagnosed as concepted was 7.5 years, which was much lower than that of the mares with reproductive disorders.5.Crushing one of twin vesicles was confirmed by ultrasonography. In conclusions ultrasonography was feasible for diagnosis of the mares with reproductive problems.

• 대한안전경영과학회지
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• 제9권4호
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• pp.29-38
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• 2007

We adapted association rules of data mining in order to investigate the relation among the factors of musculoskeletal disorders and proposed the method of preventing the musculoskeletal disorders associated with multiple logistic regression in previous study. This multiple logistic regression was difficult to establish the method of preventing musculoskeletal disorders in case factors can't be managed by worker himself, i.e., age, gender, marital status. In order to solve this problem, we devised association rules of factors of musculoskeletal disorders and proposed the interactive method of preventing the musculoskeletal disorders, by applying association rules with the result of multiple logistic regression in previous study. The result of correlation analysis showed that prevention method of one part also prevents musculoskeletal disorders of other parts of body.

• 말소리와 음성과학
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• 제3권1호
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• pp.111-116
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• 2011

The purpose of this study was to analyze the association between self-reported voice problems and voice disorders in the Korean adult population. Data were collected from the 4th Korea National Health and Nutritional Examination Survey (2008) from 3,135 subjects (1,310 men and 1,825 women) aged 19 years and older. Multi-nominal logistic regression analyses were used to examine the association between self-reported voice problems and voice disorders in the Korean adult population. Adjusting for covariates (age, sex, education level, job, smoking, alcohol drinking, thyroid disorders, pain and discomfort during the last 2 weeks), self-reported voice problems included independently associated functional voice disorders (OR=4.70, 95% CI: 3.14-7.03) and organic voice disorders (OR=3.89, 95% CI: 1.57-9.65). The results of the present study verified that self-reported voice problems are valuable indicators for voice disorders. Further research is needed to ascertain the effect of self-reported voice problems on voice disorder in adults.