• Annals of Clinical Neurophysiology
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• 제19권1호
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• pp.34-39
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• 2017

Background: Automated nerve excitability testing is used to assess various peripheral neuropathies and motor neuron diseases. Comparing these excitability parameters with normal data provides information regarding the axonal excitability properties and ion biophysics in diseased axons. This study measured and compared normal values of axonal excitability parameters in both the distal motor and sensory axons of normal Koreans. Methods: The axonal excitability properties of 50 distal median motor axons and 30 distal median sensory axons were measured. An automated nerve excitability test was performed using the QTRACW threshold-tracking software (Institute of Neurology, University College London, London, UK) with the TRONDF multiple excitability recording protocol. Each parameter of stimulus-response curves, threshold electrotonus, current-voltage relationship, and recovery cycle was measured and calculated. Results: Our Korean normal data on axonal excitability showed ranges of values and characteristics similar to previous reports from other countries. We also reaffirmed that there exist characteristic differences in excitability properties between motor and sensory axons: compared to motor axons, sensory axons showed an increased strength-duration time constant, more prominent changes in threshold to hyperpolarizing threshold electrotonus (TE) and less prominent changes in threshold to depolarizing TE, and more prominent refractoriness and less prominent subexcitability and superexcitability. Conclusions: We report normal data on axonal excitability in Koreans. These data can be used to compare various pathological conditions in peripheral nerve axons such as peripheral neuropathies and motor neuron disease.

• 한국축산시설환경학회지
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• 제18권1호
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• pp.9-18
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• 2012

IT 기술의 발달과 함께 각 분야에서는 IT와 융합한 기술을 개발하고 있으며, 축산분야에서도 구제역발생 이후에 IT를 활용한 가축의 관리에 관심을 가지고 있다. 최근에는 정보통신 기술이 유비쿼터스 기술로 진보하면서 U-축산의 도입이 필요한 시점이다. U-축산의 도입을 위해서는 우선 현재 업무에 대한 분석을 통하여 서비스 모델 도출이 필요하다. 본 연구에서는 축산 부문의 서비스모델을 가축 생애주기별로 구분하여 기존의 국내외 사례들을 기반으로 하여 도출하였다. 이중에는 현재 사업으로 진행되고 있는 것도 있으며, 앞으로 진행되어야 할 것들도 있다. 향후에는 도출된 서비스 모델에 대하여 각 서비스모델별로 목표를 설정하고, 기능을 정의하며, 플랫폼을 정의하는 과정이 필요하며, 단일 서비스모델이 아닌 통합된 서비스모델로서 방향을 진행하여야 할 것이다. 이제 축산업에서도 유비쿼터스기술을 활용한 U-축산 도입을 통하여 첨단화 되고, 효율적인 방식으로 가축관리가 진행되며, 산업 경쟁력 및 생산성을 높일 수 있을 것으로 기대된다.

• 한국식품영양학회지
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• 제33권2호
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• pp.194-203
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• 2020

The purpose of this study was to develop a functional senior mixed soymilk for seniors and to provide functional senior-mixed soymilk to prevent disease outbreaks. The isoflavone content of senior soymilk was 0.15±0.01 mg/g. The β-glucan content of senior soymilk was 9.82±0.01 mg/g. The weight gain of mice were significantly higher in the high-fat diet group than in the other groups. The serum triglyceride content was high at 102.67±40.61 mg/dL in the high-fat diet group, but significantly lower at 83.00±42.43 mg/dL in the 20% senior soymilk group. Thus, the results of this study comprehensively suggest that food intake should be ingested for each life cycle with reference to the dietary reference intakes for Koreans. In particular, the elderly in their 50s and older are deficient in protein and weakened immune capacity, so it is imperative that they maintain their health through various foods such as soymilk, which is evenly nutritious.

• 동의생리병리학회지
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• 제19권5호
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• pp.1427-1432
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• 2005

The purpose of this study is to report the effect of oriental treatments for the abnormal uterine bleeding. We treated 10 outpaients who had abnormal uterine bleeding and visited Dongshin University Oriental Medical Hospital by Herb medication, acupuncture therapy and moxibustion therapy at the same time in accordance with 塞流 ([sailiu]-stanch blood), 澄源([chengyuan]-correct origin) and 復舊([fujiu]-restore) which are principles of treatment of 崩漏 ([benglou]-metrorrhagia) and got good results from them. in herbal medication Yikweseungyang-tanggamibang or Junsaenghwalhyul-tanggamibang was used. In acupuncture therapy, Sp10(Hyulhae, 血海) K10(Umgok, 陰谷) Sp6(Samumgyo, 三陰交) Liv2(Haenggan, 行間) Liv3(Taechung, 太衝) CV3(Chungguk, 中極) were used. In Moxa Therapy, Sp6(Samumgyo, 三陰交) CV6(Qihae, 氣海) CV4(Kwanwon, 關元), CV3(Chungguk, 中極) were used. After the oriental medical treatments, abnormal uterine bleeding was disappeared and 10 outpaients recovered the normal menstrual cycle. This study showed successful orieantal herbal treatment of metrorrhagia. After this, further study and approach will be needed about the disease of the abnormal uterine bleeding.

• 대한수의학회지
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• 제53권1호
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• pp.25-28
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• 2013

The aim of this study was to applicate and evaluate a SYBR Green real-time PCR for the specific detection of Salmonella spp. Specificity of the PCR method was confirmed with 48 Salmonella spp. and 5 non-Salmonella strains using invA gene primer. The average threshold cycle ($C_T$) of Salmonella spp. was $11.83{\pm}0.78$ while non-Salmonella spp. was $30.86{\pm}1.19$. Correlation coefficients of standard curves constructed using $C_T$ versus copy number of Salmonella Enteritidis ATCC 13076 showed good linearity ($R^2=0.993$; slope = 3.563). Minimum level of detection with the method was > $10^2$ colony forming units (CFU)/mL. These results suggested that the SYBR Green real-time PCR might be applicable for the specific detection of Salmonella spp. isolates.

• 한국치위생학회지
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• 제12권4호
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• pp.759-770
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• 2012

Objectives : The purpose of this study was to examine the awareness of implant wearers about periodontal diseases and implant management, which were closely linked to implant durability, in an effort to obtain information on the right directions for oral health education related to implant self-care and specialized care. Methods : The subjects in this study were 217 patients who wore implant and visited 14 different dental hospitals and clinics in the metropolitan area. After a questioaire survey was conducted and collected data were analyed by the statistical package SPSS 18.0. Results : As for the awareness of the subjects on the regeneration of alveolar ridge by general characteristics, there were statistically significant intergroup gaps according to the number of possessed implant, implant satisfaction and subjective gingival health status(p<0.05). Regarding their awareness of implant durability by general characteristics, there were statistically significant gaps according to the number of possessed implant and oral health education experience(p<0.05). Concerning their awareness of the cycle of regular implant checkup by general characteristics, there were statistically significant gaps according to occupation, subjective gingival health status and oral health education experience(p<0.05). Conclusions : The above-mentioned findings suggest that in order to ensure the long-term safe maintenance of implant, the way of looking at periodontal diseases and implant management should be changed. Specifically, more intensive oral health education should be provided for implant wearers to be aware of the importance of self-care and specialized care to change their oral health behavior, and clinical dental hygienists should improve their role performance to make it happen.

• Food Science and Biotechnology
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• 제16권4호
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• pp.531-536
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• 2007

The aerial part of Artemisia iwayomogi Kitamura has traditionally been used for inflammation, infectious disease, cancer, pyretic, diuretic, liver protective effect, and choleretic purposes in Korea. We investigated that the essential oil induces apoptosis in KB cell as evidenced by Hoechst-33258 dye staining, flow cytometry (cell cycles), and DNA fragmentation for nuclear condensation and Western blotting for activation of caspases-3, -8, -9, Bax, Bcl-2, cytochrome c, and poly (ADP-ribose) polymerase (PARP) cleavage. In the present study, we found that the essential oil could induce apoptosis in KB cells, as characterized by DNA fragmentation, activation of caspase-3, -8, and -9, and PARP cleavage. The efficacious induction of apoptosis was observed as a dose-dependent. The essential oil-induced apoptotic cell death was accompanied by up-regulation of Bax and down-regulation of Bcl-2. The essential oil also caused the loss of mitochondrial membrane potential and cytochrome c release from mitochondria to cytosol. These findings indicate that mitochondrial pathways might be involved in the essential oil-induced apoptosis and enhance our understanding of the anticancer function of the essential oil in herbal medicine.

• 대한한의학회지
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• 제26권1호
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• pp.46-58
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• 2005

Objective : This study on Sipimikwanjung-tang was undertaken to evaluate its antioxidant capacities and antiperoxidation activities in rat liver tissues. Sipimikwanjung-tang which has been one of the prescriptions in sasang constitutional medicine is usually applied for the therapy of various liver diseases. It is elucidated that Sipimikwanjung-tang has antioxidants on liver tissue of rat and the cytotoxic effects on human hepatoblastoma Hep G2 cells. Methods: Sipimikwanjung-tang extract in antioxidant effects of Hep G2 cells is evaluated by MTT assay, DAPI staining, DNA fragmentation assays and FACS can analysis. Results: Sipimikwanjung-tang induced apoptosis in Hep G2 cells, and induced G1 and G2M arrest of the cell cycle as well as a significant increase in PARP and caspase-3 activity. It induced an increase in $H_2O_2$ generation and the subsequent $NF-{\kappa}B$ activation and also induced cell apoptosis through the caspase-3-dependent pathways in the low concentration of Sipimikwanjung-tang extracts. However, the high dose of Sipimikwanjung-tang extract in Hep G2 cells inhibited $TGF-{\beta}l-induced$ apoptosis via increase in cellular $H_2O_2$, formation and $NF-{\kappa}B$ activation in human hepatoblastoma Hep G2 cells. Conclusion: From this study, the possibility that Sipimikwanjung-tang extracts apply to antioxidant and apoptotic treatment of disease is revealed.

• 한국산림과학회지
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• 제104권2호
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• pp.332-335
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• 2015

자낭균인 Taphrina wiesneri는 한국의 공원과 도로 주변에 주로 식재되는 왕벚나무에 빗자루병을 발생시킨다. 이 병원균은 생태적 특성이 잘 알려져 있지 않아 방제법 등을 개발하는데 어려움이 있다. 이번 연구에서는 빗자루 병원균의 월동부위를 조사하기 위해 빗자루 병징을 보이는 왕벚나무의 건전가지와 이병가지, 그리고 병징이 나타나지 않은 건전한 왕벚나무 가지에서 종 특이적 primer (TwITSF와 TwITSR)를 사용하여 월동부위를 조사하였다. 그 결과 빗자루병에 감염된 왕벚나무의 이병가지 뿐만 아니라 건전가지에서도 종 특이적인 PCR 증폭산물이 관찰되었으며, 그 이외의 건전한 왕벚나무와 감염목 주변의 다른 식물 종 샘플에서는 PCR 증폭산물이 관찰되지 않았다.

• 한국콘텐츠학회논문지
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• 제15권5호
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• pp.592-606
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• 2015

전 연령층에 걸친 우울증 및 정신질환과 꾸준한 자살률 증가는 정부경쟁력을 크게 떨어뜨리는 심각한 사회문제이다. 정부는 정신건강을 증진시키고 자살을 예방하기 위해 다양한 정책을 실시하고 있으나 시행과정 및 연계 관리 체계 등에서 여러 문제점들이 제기된다. 본 연구는 정신건강분야에 있어 ICT 융합방안의 실태와 방향성을 파악하기 위해 국내외 사례를 살펴보았다. 미국과 영국에서는 ICT를 융합한 원격 정신치료서비스를 지역노인, 소아청소년, 취약계층 등에 제공하고 있다. 국내는 노인자살을 방지하기 위해 독거노인을 대상으로 응급알림 장치를 설치하거나 우울증과 치매 완화를 위한 기술이 개발 중에 있다. 고령화시대에 사회경제적 비용을 줄이고 보편적 복지실현을 위해 ICT 융합 정신건강관리 서비스가 필요하다. 이에 원격정신진료와 관련하여 첨예하게 갈등을 보이는 의료법과 의료기기에 대한 사회적 합의, 생애전주기에 걸쳐 이용자의 정신적 특성을 고려한 효과성 연구, 인구 밀집도와 의료접근성이 낮은 지역 중심의 특화된 정책 등이 제고되어져야한다.