• 한국분말재료학회지
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• 제30권4호
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• pp.324-331
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• 2023

Lithium (Li) is a key resource driving the rapid growth of the electric vehicle industry globally, with demand and prices continually on the rise. To address the limited reserves of major lithium sources such as rock and brine, research is underway on seawater Li extraction using electrodialysis and Li-ion selective membranes. Lithium lanthanum titanate (LLTO), an oxide solid electrolyte for all-solid-state batteries, is a promising Li-ion selective membrane. An important factor in enhancing its performance is employing the powder synthesis process. In this study, the LLTO powder is prepared using two synthesis methods: sol-gel reaction (SGR) and solid-state reaction (SSR). Additionally, the powder size and uniformity are compared, which are indices related to membrane performance. X-ray diffraction and scanning electron microscopy are employed for determining characterization, with crystallite size analysis through the full width at half maximum parameter for the powders prepared using the two synthetic methods. The findings reveal that the powder SGR-synthesized powder exhibits smaller and more uniform characteristics (0.68 times smaller crystal size) than its SSR counterpart. This discovery lays the groundwork for optimizing the powder manufacturing process of LLTO membranes, making them more suitable for various applications, including manufacturing high-performance membranes or mass production of membranes.

• Genomics & Informatics
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• 제21권3호
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• pp.31.1-31.8
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• 2023

Multiple myeloma (MM) is a hematological malignancy. It is widely believed that genetic factors play a significant role in the development of MM, as investigated in numerous studies. However, the application of genomic information for clinical purposes, including diagnostic and prognostic biomarkers, remains largely confined to research. In this study, we utilized genetic information from the Genomic-Driven Clinical Implementation for Multiple Myeloma database, which is dedicated to clinical trial studies on MM. This genetic information was sourced from the genome-wide association studies catalog database. We prioritized genes with the potential to cause MM based on established annotations, as well as biological risk genes for MM, as potential drug target candidates. The DrugBank database was employed to identify drug candidates targeting these genes. Our research led to the discovery of 14 MM biological risk genes and the identification of 10 drugs that target three of these genes. Notably, only one of these 10 drugs, panobinostat, has been approved for use in MM. The two most promising genes, calcium signal-modulating cyclophilin ligand (CAMLG) and histone deacetylase 2 (HDAC2), were targeted by four drugs (cyclosporine, belinostat, vorinostat, and romidepsin), all of which have clinical evidence supporting their use in the treatment of MM. Interestingly, five of the 10 drugs have been approved for other indications than MM, but they may also be effective in treating MM. Therefore, this study aimed to clarify the genomic variants involved in the pathogenesis of MM and highlight the potential benefits of these genomic variants in drug discovery.

• 기술혁신연구
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• 제30권2호
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• pp.29-58
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• 2022

벤처기업은 경쟁력 강화를 위한 내부 역량 구축에는 자원과 인력이 부족하기 때문에 공동연구, 네트워킹 등 외부와의 협력이 중요한 역할을 하고 있다. 이에 본 논문에서는 벤처기업의 산학협력 경험이 조직학습역량과 혁신성과에 미치는 영향에 대하여 살펴보고자 하였다. 지속적으로 확대되고 있는 정부 R&D 투자가 벤처기업과 대학의 협력을 촉진함으로써 조직학습역량을 강화하고 혁신성과를 창출하는 메커니즘을 실증 분석하였으며 연구결과는 다음과 같다. 첫째, 벤처기업의 산학협력 경험은 조직학습역량을 강화시키는 것으로 나타났다. 벤처기업은 대학과의 협력 및 자원 활용을 통해 내부 역량 강화에 중요한 역할을 하고 있음을 실증분석 한 것이다. 둘째, 벤처기업의 조직학습역량은 혁신성과에 유의한 영향을 미쳤다. 조직학습역량이 높은 조직은 새로운 아이디어를 발굴하고 공유하는 문화를 가지게 됨으로써 기업의 혁신성과 창출에도 긍정적인 역할을 하는 것으로 나타났다. 마지막으로 벤처기업 창업자의 배태조직(incubator organization)에 따른 산학협력과 조직학습역량을 분석한 결과 중소(벤처)기업 및 개인 경험 기반의 창업 그룹이 대학과의 협력을 통해 조직학습역량과 혁신성과 창출에 긍정적인 영향을 미치는 것으로 나타났다. 중소(벤처)기업과 개인기반의 창업자는 대기업, 대학 및 연구소 창업자에 비해 상대적으로 더 높은 기술역량을 보유한 대학과 협력함으로써 기업의 조직학습역량 강화에 도움을 받은 것으로 볼 수 있다. 본 연구를 통해 정부는 벤처기업의 R&D 성과를 극대화하기 위해 대학과 협력 유도하는 정책이 필요할 것이다. 물론 벤처기업과 대학에 나눠주기식 지원이 혁신성과를 저해하고 있다는 비판도 존재하지만 정부 투자는 기술 축적, 고급인력 양성, 혁신 네트워크 강화 등 무형자원 확충에 중요한 역할을 한다. 그렇기에 정부는 벤처기업의 성장을 위한 투자 전략성 강화를 위해 정부의 권한을 적절하게 활용해야 할 것이다.

• 한국경제지리학회지
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• 제19권4호
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• pp.782-798
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• 2016

본 논문은 EU의 스마트 전문화 전략과 미국의 제조업 르네상스 정책을 비판적으로 검토하고 한국 지역산업정책의 방향을 제안한다. EU의 스마트 전문화 전략은 기업가적인 자기발견과 전략적 조정, 미국의 제조업 르네상스 정책은 생태계에 기반한 산업공유자산의 구축, 그리고 한국의 지역산업정책은 클러스터에 기반한 지역혁신체제 구축으로 요약된다. EU와 미국 정책 사례는 지역산업정책이 지리적으로 착근되어야 한다는 점을 예증하고 있다. 또한 산업과 기술간 융 복합을 위해 산업정책과 혁신정책을 연계시킴으로써 정책수단 혼합의 적실성을 보여주고 있다. 그리고 국가의 역할도 산업 생태계에서 민주적인 규율을 착근시키는 조정자, 매개자로서 자리매김하고 있다. 이러한 점을 고려하면 향후 지역산업정책은 산업과 기술 간의 연계를 촉진할 수 있는 플랫폼 방식으로 전환되어야 한다.

• 기술혁신학회지
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• 제14권spc호
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• pp.1152-1170
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• 2011

본 연구에서는 기술문서의 인용 정보를 기반으로 직접인용과 간접인용을 고려하여 핵심 문서를 선별하였고 선별된 문서 간의 인용네트워크 트리(citation network tree)를 생성하여 기술진화 경로를 추출하고자 하였다. 활용 예시로 OLED(유기발광다이오드) 분야 특허데이터를 분석하여 핵심문서를 선별한 후 문서간 인용관계 트리 계보도를 생성하였고, 그 중 OLED 원천기술이 어떤 기술진화 경로를 통해 반도체 관련 기술로 전이되었는지 분석하였다. 다른 한편으로 그래핀(graphene) 분야 논문의 인용관계 트리 분석을 통하여 간접인용을 고려한 가중치 계산방법이 직접인용만을 고려한 피인용 회수 계산법보다 현실을 더 잘 반영함을 고찰하였다.

• BMB Reports
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• 제55권11호
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8035-8040
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• 2014

Gastric cancer is the second after lung cause of cancer-related mortality in the world. Early detection and treatment can lead to a long survival time. Recently microarrays and next generation sequencing (NGS) have become very useful tools of comprehensive research into gastric cancer, facilitating the identification of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discovery to practical clinical benefits. Although there are many biomarkers and target agents, only a minority of patients are tested and treated accordingly. Microarray technology with maturity was established more than 10 years ago, and has been widely used in the study of functional genomics, systems biology, and genomes in medicine. Second generation sequencing technology is more recent, but development is very fast, and it has been applied to the genome, including sequencing and epigenetics and many aspects of functional genomics. Here we review insights gained from these studies regarding the technology of microarray and NGS, how to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets, and how to analyse candidate genes. We also discuss the challenges and future directions of such efforts.

• 셀메드
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• 제4권3호
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• pp.15.1-15.14
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• 2014

Andrographis paniculata (Burm. F.) Wall. Ex Nees (Family: Anthaceae) is a traditionally known Ayurvedic medicinal plant. Several well-controlled clinical trials conducted during recent years have consistently reconfirmed that Andrographis paniculata extracts are effective in suppressing cardinal symptoms of diverse inflammatory and infectious diseases. Despite extensive efforts though, many questions concerning bioactive constituents of such extracts and their modes of actions still remain unanswered. Amongst diverse diterpene lactones isolated to date from such extracts, andrographolide is often considered to be the major, representative, or bioactive secondary metabolite of the plant. Therefore, it has attracted considerable attention of several drug discovery laboratories as a lead molecule potentially useful for identifying structurally and functionally novel drug. Critical analysis of available preclinical and clinical information on Andrographis paniculata extracts and pure andrographolide strongly suggest that they are pharmacologically polyvalent and that they possess adaptogenic properties. Aim of this communication is to summarize and critically analyze such data, and to point out some possibilities for more rationally exploiting their adaptogenic properties for discovering novel therapeutic leads, or for obtaining pharmacologically better standardized phyto-pharmaceuticals.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10557-10563
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• 2015

It is well known that conventional chemotherapy and radiation therapy can result in toxicity to both normal cells and tumor cells, which causes limitations in the application of these therapeutic strategies for cancer control. Novel and effective therapeutic strategies for cancers with no or low toxicity for normal cells are a high priority. Therefore, natural products with anticancer activity have gained more and more attention due to their favorable safety and efficacy profiles. Pre-clinical and clinical studies have demonstrated that several representative natural compounds such as resveratrol, epigallocatechin-3-gallate, curcumin, allicin and ginsenosides have obvious anticancer potential. In this article, we summarize autophagy-associated targeting pathways of such natural products for inducing the death of cancer cells, and discuss the core autophagic pathways involved in cancer treatments. Recent advances in the discovery, evaluation and exploitation of natural compounds as therapeutic agents for cancers will provide references and support in pre-clinical and clinical application of novel natural drugs for the treatment of primary and metastatic tumors in the future.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권9호
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• pp.3611-3634
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• 2015

In this paper, we build a theoretical framework for quantitatively measuring and graphically representing the degrees of closeness centralization among performers assigned to enact a workflow procedure. The degree of closeness centralization of a workflow-performer reflects how near the performer is to the other performers in enacting a corresponding workflow model designed for workflow-supported organizational operations. The proposed framework comprises three procedural phases and four functional transformations, such as discovery, analysis, and quantitation phases, which carry out ICN-to-WsoN, WsoN-to-SocioMatrix, SocioMatrix-to-DistanceMatrix, and DistanceMatrix-to-CCV transformations. We develop a series of algorithmic formalisms for the procedural phases and their transformative functionalities, and verify the proposed framework through an operational example. Finally, we expatiate on the functional expansion of the closeness centralization formulas so as for the theoretical framework to handle a group of workflow procedures (or a workflow package) with organization-wide workflow-performers.