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http://dx.doi.org/10.7314/APJCP.2014.15.19.8035

Microarray and Next-Generation Sequencing to Analyse Gastric Cancer  

Dang, Yuan (Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital))
Wang, Ying-Chao (The United Innovation platform of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University)
Huang, Qiao-Jia (Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital))
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8035-8040 More about this Journal
Abstract
Gastric cancer is the second after lung cause of cancer-related mortality in the world. Early detection and treatment can lead to a long survival time. Recently microarrays and next generation sequencing (NGS) have become very useful tools of comprehensive research into gastric cancer, facilitating the identification of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discovery to practical clinical benefits. Although there are many biomarkers and target agents, only a minority of patients are tested and treated accordingly. Microarray technology with maturity was established more than 10 years ago, and has been widely used in the study of functional genomics, systems biology, and genomes in medicine. Second generation sequencing technology is more recent, but development is very fast, and it has been applied to the genome, including sequencing and epigenetics and many aspects of functional genomics. Here we review insights gained from these studies regarding the technology of microarray and NGS, how to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets, and how to analyse candidate genes. We also discuss the challenges and future directions of such efforts.
Keywords
Gastric cancer; next-generation sequencing; microarray; fusion gene; LncRNAs;
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