• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.3973-3980
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• 2014

Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg). The present study was undertaken to explore the association of this SNP with susceptibility to prostate adenocarcinoma along with its structural and functional impacts in the Pakistani population in a case-control study. Three-dimensional structure of human TP53 with Pro72Arg polymorphism was predicted through homology modeling, refined and validated for detailed structure-based assessment. We also carried out a HuGE review of the previous available data for this polymorphism. Different genetic models were used to evaluate the genotypes association with the increased risk of PCa (Allelic contrast: OR=0.0.34, 95%CI 0.24-0.50, p=0.000; GG vs CC: OR=0.17, 95%CI 0.08-0.38, p=0.000; Homozygous: OR=0.08, 95%CI 0.04-0.15, p=0.000; GC vs CC: OR=2.14, 95%CI 1.01-4.51, p=0.046; Recessive model: OR=0.10, 95%CI 0.05-0.18, p=0.000; Log Additive: OR=3.54, 95%CI 2.13-5.89, p=0.000) except the Dominant model (OR=0.77, 95%CI 0.39-1.52, p=0.46). Structure and functional analysis revealed that the SNP in the proline rich domain is responsible for interaction with HRMT1L2 and WWOX. In conclusion, it was observed that the Arg coding G allele is highly associated with increased risk of prostate adenocarcinoma in the Pakistani population (p=0.000).

• KIPS Transactions on Software and Data Engineering
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• v.5 no.5
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• pp.243-250
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• 2016

Recently, public interest in virtual reality (VR) and augmented reality (AR) has increased. Therefore, computer graphics-related research has been actively conducted. This has included research on virtual space related to human posture implementation. However, such research has focused on general posture in humans. This paper presents a system with reference to the basic posture in sports climbing and the inverse kinematics method for generating the positions and behavior of virtual characteristics in a three-dimensional virtual space. The simulation based on the inverse kinematics method, produced with an inverse kinematics solver and initial pose animation from motion capture, provides realistic and natural movement. We designed a simulation system to generate correct posture and motions similar to those in sports climbing by applying the basic procedure of sports climbing. The simulation system provides help for producing content about sports climbing, such as learning programs for novice climbers and sports climbing games.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.48 no.1
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• pp.82-90
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• 2012

Four different buildings having various wall construction are analyzed for the effect of wall mass on the thermal performance and inside building air and wall temperature transient and also for calculating the energy consumption load. This analytical study was motivated by the experimental work of Burch et al. An analytical solution of one-dimensional, linear, partial differential equations is obtained using the Laplace transform method, Bromwich and modified Bromwich contour method. A simple dynamic model using steady state analysis as simplified methods is developed and results of energy consumption loads are compared with results obtained using the analytical solution. Typical Meteorological Year data are processed to yield hourly average monthly values. This study is conducted using weather data from two different locations in Korea: Daegu having severe weather in summer and winter and Jeju having mild weather almost all year round. There is a significant wall mass effect on the thermal performance of a building in mild weather condition. Buildings of heavyweight construction with insulation show the highest comfort level in mild weather condition. A proportional controller provides the higher comfort level in comparison with buildings using on-off controller. The steady state analysis gives an accurate estimate of energy load for all types of construction. Finally, it appears that both mass and wall insulation are important factors in the thermal performance of buildings, but their relative merits should be decided in each building by a strict analysis of the building layout, weather conditions and site condition.

• BMB Reports
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• v.45 no.3
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• pp.189-193
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• 2012

Cyst formation is a major characteristic of ADPKD and is caused by the abnormal proliferation of epithelial cells. Renal cyst formation disrupts renal function and induces diverse complications. The mechanism of cyst formation is unclear. mIMCD-3 cells were established to develop simple epithelial cell cysts in 3-D culture. We confirmed previously that Mxi1 plays a role in cyst formation in Mxi1-deficient mice. Cysts in Mxi1 transfectanted cells were showed by collagen or mebiol gels in 3-D cell culture system. Causative genes of ADPKD were measured by q RT-PCR. Herein, Mxi1 transfectants rarely formed a simple epithelial cyst and induced cell death. Overexpression of Mxi1 resulted in a decrease in the PKD1, PKD2 and c-myc mRNA relating to the pathway of cyst formation. These data indicate that Mxi1 influences cyst formation of mIMCD-3 cells in 3-D culture and that Mxi1 may control the mechanism of renal cyst formation.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.1
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• pp.151-160
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• 1994

Recently, terrestrial photogrammetry has been applied effectively to data acquisition in GIS and to monitoring precise machinery for simulation test. Because 3-D coordinates of many object points can be quickly measured with constant accuracy and easy modeling by this method. In this study, the composition concerned with multi-camera system which simultaneously analyzes structure from multi-station using various cameras was developed. The errors of results were analyzed to investigate the accuracy of the system, error of unknown points and control points, convergent and strip adjustment for optimal network design also. As results of this study, the efficiency of multi-camera system developed here was proved through application to monitoring the entire area of the precise model ship. We could also acquire 3-dimensional coordinates with good accuracy by arranging pass points. Therefore, possibility of measurement of instantaneous deformation as well as precision analysis of structures can be suggested.

• Journal of the Korean Society of Propulsion Engineers
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• v.1 no.1
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• pp.104-110
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• 1997

To predict the effect of ring expansion and ring compression on residual stress relief of Al 7175 ring rot]s, 2-D axisymmetric thermal analysis and elastoplastic analysis were performed. The residual stress distributions along the thickness of T73, T7351 and T7352 treated rings were measured using three step sectioning method. The measured results were compared to numerical ones for quenched and stress relieved rings. After quenching, calculated hoop and axial residual stresses were similar to measured ones for T73 treated rings. The residual stresses of T7351 and T7352 treated rings were decreased remarkably compared to T73 treated rings. The effect of axial residual stress relief was superior to that of hoop one, and also ring compression to ring expansion. It was concluded that ring compression is advantageous over ring expansion in view of stress relief effect and practicality, and vice versa in view of dimensional control and press power.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.746-751
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• 2003

A method of measuring the length of defects on the wall of the spent nuclear fuel pool using the image processing and a laser slit beam is proposed. Since the defect monitoring camera is suspended by a crane and hinged to the crane hook, the camera viewing direction can not be adjusted to the orientation that is exactly perpendicular to the wall. Thus, the image taken by the camera, which is horizontally rotated along the axis of the camera supporting beam, is distorted and thus, the precise length can not be measured. In this paper, by using the LASER slit beam generator, the horizontally rotated angle of the camera is estimated. Once the angle is obtained, the distorted image can be easily reconstructed to the image normal to the wall. The estimation algorithm adopts a 3-dimensional coordinate transformation of the image plane where both the laser slit beam and the original image of the defects exist. The estimation equation is obtained by using the information of the beam projected on the wall and the parameters of this equation are experimentally obtained. With this algorithm, the original image of the defect taken at arbitrary rotated angle can be reconstructed to an image normal to the wall. From the result of a series of experiments, the accuracy of the defect is measured within 0.6 and 1.3 % error bound of real defect size in the air and underwater, respectively under 30 degree of the inclined angle of the laser slit beam generator. Also, the error increases as the inclined angle increases upto 60 degree. Over this angle, the defect length can not be measured since the defect image disappears. The proposed algorithm enables the accurate measurement of the defect length only by using a single camera and a laser slit beam.

• Korean Journal of Computational Design and Engineering
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• v.11 no.1
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• pp.49-56
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• 2006

In this study, the modeling support system was developed which can make easy and fast FE-modeling and verify the results of static and durability analysis for the lower arm, one of the important parts in automobile suspension module. It took into account of the whole complicated design processes verifying the durability coefficients evaluated by fatigue analysis, which should be used to satisfy a design criteria. To guide the FE-modeling the drive page was constructed by using HTML and XML, which was based on expert's know-hows. It is able to integrate the processes to design the lower arm in practice, so that the standardization of its FE-Modeling is achieved, consequently. The 3 dimensional CAD's geometrical data were changed automatically into pre-defined shell elements under the concept of mesh-offset technique, and then welding elements were treated to connect between target and basic surfaces constructed by the shell elements. This system has also a user interface to control boundary and load ing conditions applied in performing of the static and durability analysis, in which many load cases can be applied simply with the MPCs driven by just few mouse clicks. These were implemented on the platform of MSC.Patran and utilized ANSYS, MSC.Nastran and MSC.Fatigue as the solver of the analysis performed. The developed system brings not only significant decreasing of man-hours required in FE-modeling process, but also obtaining of satisfied qualities in analyzed results. It will be integrated in a part of virtual prototyping module of the developing e-engineering framework.

• Archives of Plastic Surgery
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• v.44 no.3
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• pp.194-201
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• 2017

Background Platelet-rich plasma (PRP) contains high concentrations of growth factors involved in wound healing. Hydrogel is a 3-dimensional, hydrophilic, high-molecular, reticular substance generally used as a dressing formulation to accelerate wound healing, and also used as a bio-applicable scaffold or vehicle. This study aimed to investigate the effects of PRP and hydrogel on wound healing, in combination and separately, in an animal wound model. Methods A total of 64 wounds, with 2 wounds on the back of each nude mouse, were classified into 4 groups: a control group, a hydrogel-only group, a PRP-only group, and a combined-treatment group. All mice were assessed for changes in wound size and photographed on scheduled dates. The number of blood vessels was measured in all specimens. Immunohistochemical staining was used for the analysis of vascular endothelial growth factor (VEGF) expression. Results Differences in the decrease and change in wound size in the combined-treatment group were more significant than those in the single-treatment groups on days 3, 5, 7, and 10. Analysis of the number of blood vessels through histological examination showed a pattern of increase over time that occurred in all groups, but the combined-treatment group exhibited the greatest increase on days 7 and 14. Immunohistochemical staining showed that VEGF expression in the combined-treatment group exhibited its highest value on day 7. Conclusions This experiment demonstrated improved wound healing using a PRP-hydrogel combined treatment compared to either treatment individually, resulting in a decrease in wound size and a shortening of the healing period.

• International Journal of Industrial Entomology and Biomaterials
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• v.30 no.1
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• pp.6-16
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• 2015

This study established the genetic characterisation of 10 microsporidian isolates infecting non-mulberry silkworms (Antheraea assamensis and Samia cynthia ricini) collected from biogeographical forest locations in the State of Assam, India, using PCR-based markers assays: inter simple sequence repeat (ISSR) and random amplified polymorphic DNA (RAPD). A Nosema type species (NIK-1s_mys) was used as control for comparison. The shape of mature microsporidian spores were observed oval to elongated, measuring 3.80 to $4.90{\mu}m$ in length and 2.60 to $3.05{\mu}m$ in width. Fourteen ISSR primers generated reproducible profiles and yielded 178 fragments, of which 175 were polymorphic (98%), while 16 RAPD primers generated reproducible profiles with 198 amplified fragments displaying 95% of polymorphism. Estimation of genetic distance coefficients based on dice coefficients method and clustering with un-weighted pair group method using arithmetic average (UPGMA) analysis was done to unravel the genetic diversity of microsporidians infecting Indian muga and eri silkworm. The similarity coefficients varied from 0.385 to 0.941 in ISSR and 0.083 to 0.938 in RAPD data. UPGMA analysis generated dendrograms with two microsporidian groups, which appear to be different from each other. Based on Euclidean distance matrix method, 2-dimensional distribution also revealed considerable variability among different identified microsporidians. Clustering of these microsporidian isolates was in accordance with their host and biogeographic origin. Both techniques represent a useful and efficient tool for taxonomical grouping as well as for phylogenetic classification of different microsporidians in general and genotyping of these pathogens in particular.