• International Journal of Oral Biology
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• v.37 no.1
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• pp.1-7
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• 2012

Opioid receptors have been pharmacologically classified as ${\mu}$, ${\delta}$, ${\kappa}$ and ${\varepsilon}$. We have recently reported that the antinociceptive effect of morphine (a ${\mu}$-opioid receptor agonist), but not that of ${\beta}$-endorphin (a novel ${\mu}/{\varepsilon}$-opioid receptor agonist), is attenuated by whole body irradiation (WBI). It is unclear at present whether WBI has differential effects on the antinociceptive effects of ${\mu}-$, ${\delta}-$, ${\kappa}-$ and ${\varepsilon}$-opioid receptor agonists. In our current experiments, male ICR mice were exposed to WBI (5Gy) from a $^{60}Co$ gamma-source and the antinociceptive effects of opioid receptor agonists were assessed two hours later using the hot water ($52^{\circ}C$) tail-immersion test. Morphine and $D-Ala^2$, $N-Me-Phe^4$, Gly-olenkephalin (DAMGO), [$D-Pen^2-D-Pen^5$] enkephalin (DPDPE), trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamide (U50,488H), and ${\beta}$-endorphin were tested as agonists for ${\mu}$, ${\delta}$, ${\kappa}$, and ${\varepsilon}$-opioid receptors, respectively. WBI significantly attenuated the antinociceptive effects of morphine and DAMGO, but increased those of ${\beta}$-endorphin. The antinociceptive effects of DPDPE and U50,488H were not affected by WBI. In addition, to more preciously understand the differential effects of WBI on ${\mu}-$ and ${\varepsilon}$-opioid receptor agonists, we assessed pretreatment effects of ${\beta}$-funaltrexamine (${\beta}$-FNA, a ${\mu}$-opioid receptor antagonist) or ${\beta}$-$endorphin_{1-27}$ (${\beta}$-$EP_{1-27}$, an ${\varepsilon}$-opioid receptor antagonist), and found that pretreatment with ${\beta}$-FNA significantly attenuated the antinociceptive effects of morphine and ${\beta}$-endorphin by WBI. ${\beta}$-$EP_{1-27}$ significantly reversed the attenuation of morphine by WBI and significantly attenuated the increased effects of ${\beta}$-endorphin by WBI. The results demonstrate differential sensitivities of opioid receptors to WBI, especially for ${\mu}-$ and ${\varepsilon}$-opioid receptors.

• The Journal of the Korea Contents Association
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• v.21 no.5
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• pp.465-476
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• 2021

This study considers both causal and control factors for explaining both contact and distribution of sexually explicit material and tests their interaction effects for examining buffering effects of control factors in causal process. This study examines the effect of low self-control, differential association with peers and patriarchy family environmental factor as causal factors. It also considers three control factors such as morality. legal punishment, and lack of opportunity and test interaction effect between causal and control factors in both contact and distribution cases. Using data from college students in Seoul, results show that the effects of all causal factors are significant in both contact and distribution of sexually explicit material and the effect of differential association is the most significant. However, their interaction effects between causal and control factors are different across contact and distribution cases. In the contact case, all interaction effects are not significant. It means that causal factors have independent effects and control factors have no buffering effects. However, in the distribution case, the interaction effects between low self-control and morality, between differential association and morality, between patriarchy family and punishment, and between patriarchy family and lack of opportunity are significant. Empirical implications are discussed.

• Journal of the Korea Institute of Building Construction
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• v.5 no.4 s.18
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• pp.145-152
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• 2005

Long-term axial shortening of the vertical elements of tail buildings results in differential movements between two elements and may lead to the additional moments of connection beam and slab elements, and other secondary effects, such as cracks of partitions or curtain walls. Accurate prediction of time-dependent column shortening is essential for tall buildings from both strength and serviceability aspects. The compensation method is different from reinforced concrete and SRC(Steel Reinforced Concrete) members. The SRC columns are usually compensated according to total differential shortening between two vertical elements. In this study, column shortenings of 37-story W building under construction are predicted and compensated. The SRC column shortenings are compared with the actual column shortening by field measurement and the column shortenings are reanalysed and recompensated.

• Journal of the Korean Society of Safety
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• v.17 no.1
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• pp.99-104
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• 2002

DQM(differential quadrature method) is applied to computation of eigenvalues of the equations of motion governing the free in-plane vibration for circular curved beams including mid-surface extension and the effects of rotatory inertia. Fundamental frequencies are calculated for the members with various end conditions and opening angles. The results are compared with numerical solutions by other methods for cases in which they are available. The differential quadrature method gives good accuracy even when only a limited number of grid points is used.

• Structural Engineering and Mechanics
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• v.35 no.2
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• pp.217-240
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• 2010

A semi-analytical method is presented for accurately prediction of the free vibration behavior of generally laminated composite plates with arbitrary boundary conditions. The method employs the technique of separation of spatial variables within Hamilton's principle to obtain the equations of motion, including two systems of coupled ordinary homogeneous differential equations. Subsequently, by applying the laminate constitutive relations into the resulting equations two sets of coupled ordinary differential equations with constant coefficients, in terms of displacements, are achieved. The obtained differential equations are solved for the natural frequencies and corresponding mode shapes, with the use of the exact state-space approach. The formulation is exploited in the framework of the first-order shear deformation theory to incorporate the effects of transverse shear deformation and rotary inertia. The efficiency and accuracy of the present method are demonstrated by obtaining solutions to a wide range of problems and comparing them with finite element analysis and previously published results.

• Steel and Composite Structures
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• v.15 no.1
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• pp.57-79
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• 2013

This paper studies the dynamic instability of laminated composite plates under thermal and arbitrary in-plane periodic loads using first-order shear deformation plate theory. The governing partial differential equations of motion are established by a perturbation technique. Then, the Galerkin method is applied to reduce the partial differential equations to ordinary differential equations. Based on Bolotin's method, the system equations of Mathieu-type are formulated and used to determine dynamic instability regions of laminated plates in the thermal environment. The effects of temperature, layer number, modulus ratio and load parameters on the dynamic instability of laminated plates are investigated. The results reveal that static and dynamic load, layer number, modulus ratio and uniform temperature rise have a significant influence on the thermal dynamic behavior of laminated plates.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.575-578
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• 2008

In this paper, the purpose is to investigate the stability and variation of natural frequency of a Timoshenko cantilever beam subjected to follower force and tip mass. In addition, an analysis of the flutter instability(flutter critical follower force) of a cantilever beam as slenderness ratio is investigated. The governing differential equations of a Timoshenko beam subjected to an end tangential follower force is derived via Hamilton;s principle. The two coupled governing differential equations are reduced to one fourth order ordinary differential equation in terms of the flexural displacement. Finally, the influence of the slenderness ratio and tip mass on the critical follower force and the natural frequency of a Timoshenko beam are investigated.

• Journal of KSNVE
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• v.6 no.2
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• pp.233-244
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• 1996

In this paper chaotic mothions of a straight pipe conveying oscillatory flow and being subjected to external forces such as earthquake are theoretically investigated. The nonlinear partial differential equation of motion is derived by Newton's method. In this equation, the nonlinear curvature of the pipe and the thermal expansion effects are contained. The nonlinear ordinary differential equation transformed from that partial differential equation is a type of Hill's equations, which have the parametric and external exciation term. This original system is transfered to the averaged system by the averaging theory. Bifurcation curves of chaotic motion of the piping system are obtained in the general case of the frequency ratio, n by applying Melnikov's method. Numerical simulations are performed to demonstrate theorectical results and show strange attactors of the chaotic motion.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.34D no.7
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• pp.23-29
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• 1997

The performance degradation of CMOS differential amplifiers due to hot carrier effect has been measured and analyzed. Two-state CMOS amplifiers whose input transistors are PMOSFETs were designed and fabriacted using the ISRC CMOS 1.5.mu.m process. It was observed after the amplifier was hot-carrier stressed that the small-signal voltage gain and the input offset voltage increased and the phase margin decreased. The performance variation results from the increase of the transconductances and gate capacitances of the PMOSFETs used as input transistors in the differential input stage and the output stage and also resulted from the decrease of their output conductances. After long-term stress, the amplifier became unstable. The reason might be that its phase margin was reduced due to hot carrier effect.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.961-966
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• 2008

In this paper, the purpose is to investigate the stability and variation of natural frequency of a Timoshenko cantilever beam subjected to Subtangential follower force and tip mass. In addition, an analysis of the flutter instability(flutter critical follower force) of a cantilever beam as slenderness ratio is investigated. The governing differential equations of a Timoshenko beam subjected to an end tangential follower force is derived via Hamilton;s principle. The two coupled governing differential equations are reduced to one fourth order ordinary differential equation in terms of the flexural displacement. Finally, the influence of the slenderness ratio and tip mass on the critical follower force and the natural frequency of a Timoshenko beam are investigated.