• 대한핵의학회지
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• 제37권4호
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• pp.207-218
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• 2003

Myocardial perfusion imaging has been increasingly used to provide prognostic data and guidance on the choice of appropriate management of patients with known or suspected coronary artery disease. The electrocardiogram gated myocardial SPECT program is corning into wide use with an advent of $^{99m}Tc-labeled$ tracers and an improvement of SPECT machines. The gated technique permits measurement of important cardiac prognostic indicators without any further discomforts or radiation burden in patients underwent standard myocardial perfusion SPECT. In addition, gated study significantly improves diagnostic yield by reducing the number of borderline interpretations and could find myocardial stunning and viable myocardium. Gated single photon emission computed tomography (SPECT) imaging allows the automated calculation of end-diastolic volume, end-systolic volume, ejection fraction, myocardial mass and the assessment of regional wall motion and thickening, and it have dramatically improved assessment of coronary artery disease in routine nuclear practice. This allows the simultaneous assessment of both perfusion and function within the same acquisition, and serves as a cost-effective technique for providing more diagnostic data with fewer diagnostic tests. Because the diagnostic and prognostic power derived from knowledge of left ventricular function can be added to that provided by assessing myocardial perfusion, gated SPECT imaging has rapidly gained widespread acceptance and is now used on a routine clinical basis in a growing number of laboratories, including South Korea. The gated SPECT technique for measurement of left ventricular parameters has been validated against a variety of well established techniques. In this work, overview of gated myocardial perfusion SPECT focus on functional parameters is presented.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.329-334
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• 2019

Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague-Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.

• 대한의용생체공학회:의공학회지
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• 제26권2호
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• pp.87-93
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• 2005

A new method for real-time estimating left ventricular relaxation time constant (T) from the left ventricular (LV) pressure waveform, based on the isovolumic relaxation model, is proposed. The presented method uses a recursive least squares (RLS) algorithm to accomplish real-time estimation. A new criterion to detect the end-point of the isovolumic relaxation period (IRP) for the estimation of T is also introduced, which is based on the pattern analysis of mean square errors between the original and reconstructed pressure waveforms. We have verified the performance of the new method in over 4,600 beats obtained from 70 patients. The results demonstrate that the proposed method provides more stable and reliable estimation of τ than the conventional 'off-line' methods.

• Journal of Chest Surgery
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• 제23권6호
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• pp.1090-1106
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• 1990

This study was undertaken to investigate whether adenosine administered during cardioplegic arrest could enhance myocardial protection and improve recovery of function after ischemia. Isolated Langendorff-perfused rat hearts were subjected to 40 minutes of normothermic [37oC] ischemia. Control hearts [n=10] received modified St. Thomas’ cardioplegic solution, and the remaining hearts received modified St. Thomas’ cardioplegic solution with either 20 \ulcornerM [n=10], 200 \ulcornerM [n=10] adenosine. After ischemia of 40 minutes and 30 minutes of reperfusion, left ventricular contractility was superior in all groups of adenosine-treated hearts compared with control hearts. Furthermore, there was a significant incremental increase in functional recovery with increasing dose of adenosine. Post-ischemic diastolic stiffness was significantly better in all adenosine groups compared with controls. No differences were noted in coronary flow or myocardial water content between adenosine-treated and control hearts. These data demonstrate that adenosine administered in these concentrations provides myocardial protection, preservation of myocardial ATP and creatine phosphokinase and improved post-ischemic functional hemodynamic recovery after normothermic ischemia, presumably metabolically by reducing depletion of adenosine triphosphate, inducing rapid cardiac arrest and enabling improved post-ischemic recovery.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1999-2000
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• 2008

In this study, pulse wave parameters changes were verified between normotensive and hypertensive group. To measure pulse wave in radial artery, non-invasive tonometric pulse wave measurement device (SphygmoCor PX, AtCor, Austrailia) was used. 136 subjects participated in this study. Among 20 parameters, 16 parameters changes were analysed(p < 0.05) between normotensive(n=104) and hypertensive group(n=32). As a results, several parameters related with pulse pressure, reflective pulse wave, systolic and diastolic function of heart showed significant difference between normotensive and hypertensive group.

• 재활간호학회지
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• 제6권2호
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• pp.173-182
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• 2003

Purpose: This study was conducted to evaluate the effects of aerobic exercise on health status with essential hypertension. Method: A non-equivalent control group design was used. For the experimental group, aerobic exercise was given by researcher at one health center in Daegu. Test for hypothesis was done by $X^2$-test t-test, paired t-test, and unpaired t-test. Result: There were significant differences in systolic, diastolic, and MAP between two groups. There were significant differences in body weight, BMI, and body composition between two groups. Hypothesis 3 was partially supported that the score of health status and physical function of experimental group were significantly higher than that of control group. Conclusion: Findings indicated that this study would contribute to application of aerobic exercise as nursing intervention for the people with high blood pressure.

• 한국콘텐츠학회논문지
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• 제9권7호
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• pp.225-232
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• 2009

연구는 심박수, 수축기 혈압, 이완기 혈압, 말초혈관 산소포화도 알아보고자 바닥과 스위스 볼상에서 요부안정화운동(LSE)에 따른 심혈관기능에 미치는 연구를 하였다. 대상자는 K 산업체 재활센타를 이용한 근골격계 근로자 중 선정기준에 적합한 남성 18명을 실험1군 바닥 적용군에 9명, 실험군 2군 스위스볼 적용군에 9명으로 분류하여 심박수, 수축기 혈압, 이완기 혈압, 말초혈관 산소포화도를 비교하였다. 심박수는 휴대용 심박 측정계(RS400sd, Finland)로, 혈압은 혈압계((FC-110, Japan)로, 말초혈관 산소포화도는 누리텍 체력 측정장치((TF-300-5, Korea)로 측정하고 분석하였다. 두군 모두 운동실시 후에 말초혈관 산소농도가 점차 통계학적으로 유의하게 증가하였으며, 수축기혈압이 통계학적으로 유의하게 감소하였다. 요부안정화운동에 따른 자세변동이 심혈관기능에 영향을 미치지만 지변의 상태에 따른 차이는 크게 영향을 받지 않는다는 결론을 얻었다.

• Investigative Magnetic Resonance Imaging
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• 제21권1호
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• pp.20-27
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• 2017

Purpose: To evaluate quantification results of single breath-hold (SBH) magnetic resonance (MR) cine imaging compared to results of conventional multiple breath-hold (MBH) technique for left ventricular (LV) function in patients with cardiac arrhythmia. Materials and Methods: MR images of patients with arrhythmia who underwent MBH and SBH cine imaging at the same time on a 1.5T MR scanner were retrospectively reviewed. Both SBH and MBH cine imaging were performed with balanced steady state free precession. SBH scans were acquired using temporal parallel acquisition technique (TPAT). Fifty patients ($65.4{\pm}12.3years$, 72% men) were included. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), myocardial mass, and LV regional wall motion were evaluated. Results: EF, myocardial mass, and regional wall motion were not significantly different between SBH and MBH acquisition techniques (all P-values > 0.05). EDV, ESV, and SV were significant difference between the two techniques. These parameters for SBH cine imaging with TPAT tended to lower than those in MBH. EF and myocardial mass of SBH cine imaging with TPAT showed good correlation with values of MBH cine imaging in Passing-Bablok regression charts and Bland-Altman plots. However, SBH imaging required significantly shorter acquisition time than MBH cine imaging ($15{\pm}7sec$ vs. $293{\pm}104sec$, P < 0.001). Conclusion: SBH cine imaging with TPAT permits shorter acquisition time with assessment results of global and regional LV function comparable to those with MBH cine imaging in patients with arrhythmia.

• 대한핵의학회지
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• 제14권1호
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• pp.29-36
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• 1980

Most of clinical morbidity in cardiology are associated with abnormalities of the left ventricle. Several methods have been developed to measure the left ventricular function, including cardiac catheterization with cineangiography, echocardiography, and systolic time interval. But these methods have many limitations. ECG gated cardiac blood pool scan provides a safe, noninvasive, repeatable method for determining the left ventricular function. Utilizing the cardiac blood pool scan, we measured the left ventricular function in 165 cardiac patients, and in 26 normal subject. 1. Left ventricular ejection fractions were measured by cardiac blood pool scan, and compared in 20 patients with that measured by x-ray cineangiography. Correlation coefficient was 0.885. 2. Ejection fractions were classified by funtional class made in New York Heart Association. Ejection fractions well represented the functional status. 3. Ejection fractions decreased in cardiomyopathy ($20.1{\pm}4.8%$) and ischemic heart disease ($34.4{\pm}16.7%$). Impaired ejection fractions in myocardial infarction were associated with the extent of infarction. 4. Regional left ventricular wall motion was evaluated from the end-diastolic and end-systolic images. In cardiomyopathy diffuse hypokinesia was noted and in myocardial infarction akinesia was noted on the infarcted areas.

• 한국산학기술학회논문지
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• 제12권7호
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• pp.3088-3095
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• 2011

본 연구는 건강한 정상인의 필라테스 운동에 참여가 심혈관 및 호흡 변인에 미치는 영향을 분석하여, 필라테스 운동이 심폐계에 미치는 영향을 규명하고자 하였다. 건강한 정상인 36명을 무작위로 필라테스 운동에 참여하는 실험군과 대조군으로 나누었다. 필라테스 운동은 8주간 주 3회, 1회당 60분 동안 실시되었고 운동 전과 후에 혈압, 최대산소섭취량, 산소이용률, 그리고 무산소성 역치 등 심혈관 및 호흡계와 관련된 변인들을 측정하였다. 8주의 필라테스 운동을 시행한 실험군의 이완기 혈압을 제외한 나머지 심혈관 및 호흡 변인들이 필라테스 운동전에 비해 통계적으로 유의하게 상승되었으며, 대조군과의 비교에서도 수축기 혈압, 최대산소섭취량, 산소이용률, 그리고 무산소성역치가 통계적으로 유의한 차이가 나타났다. 본 연구의 결과에서 필라테스 운동은 심혈관 및 호흡 변인에 효과가 있으며 필라테스 운동이 유연성, 통증조절 및 재활 치료의 효과 이외에도 유산소 운동의 효과를 나타내는 것을 알 수 있다.