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http://dx.doi.org/10.4196/kjpp.2019.23.5.329

Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models  

Nam, Dae-Hwan (Predictive Model Research Center, Korea Institute of Toxicology)
Park, Jinsook (Corporate R&D, LG Chem, Ltd.)
Park, Sun-Hyun (Predictive Model Research Center, Korea Institute of Toxicology)
Kim, Ki-Suk (Predictive Model Research Center, Korea Institute of Toxicology)
Baek, Eun Bok (Corporate R&D, LG Chem, Ltd.)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.23, no.5, 2019 , pp. 329-334 More about this Journal
Abstract
Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague-Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.
Keywords
Dipeptidyl peptidase-IV; Gemigliptin; Myocardial ischemia-reperfusion injury; Pressure-volume loop; Spontaneously hypertensive rat;
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