• Journal of Pharmaceutical Investigation
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• v.41 no.2
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• pp.103-109
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• 2011

The objective of the study was to prepare self-microeulsifying drug delivery system (SMEDDS) incorporating atorvastatin calcium and evaluate its properties and oral bioavailability. Solubility of atorvastatin in various vehicles was determined. Pseudo-ternary phase diagrams were constructed to identify the good self-emulsification region. The droplet size distributions of the resultant emulsions were determined by dynamic light scattering measurement. The mean droplet size of chosen formulation (20% ethyl oleate, 40% tween-80, 40% Carbitol$^{(R)}$) was $23.4{\pm}1.3$ nm. The SMEDDS incorporating atorvastatin calcium appeared to be associated with better performance in dissolution and pharmacokinetic studies, compared with raw atorvastatin calcium. In dissolution test, the release percentage of atorvastatin from SMEDDS mixture could rapidly reach more than 95% within 3 min. Oral $AUC_{0{\rightarrow}8hr}$ values in SD rats was $1994{\pm}335\;ng{\cdot}hr/mL$, which significantly increased (P<0.05) compared with raw atorvastatin calcium. The SMEDDS formulation was relatively stable when stored at $4^{\circ}C$ during 3 months. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin, by the oral route.

• Journal of Conservation Science
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• v.30 no.4
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• pp.335-343
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• 2014

This study classified the result of non-metallic inclusion analysis and result of microstructure investigation on the ironware excavated in the Baekje region into Han River, Geum River, and Yeongsan River to estimate the iron making temperature and study the characteristics of regional and temporal characteristics of the heat treatment technology and steel making technology. Regardless of era, bloom iron and sponge iron are judged to be the major method for making as a directreduction process in all three regions. The result of the reinterpretation of the non-metallic inclusion by the oxide ternary constitutional diagram suggest that the temperature inside of the furnace is estimated to be between $1,100{\sim}1,300^{\circ}C$ while making the steel. The magnetic iron ores are the major raw material of steel ore and irons with high $TiO_2$ are estimated to use iron sands. Ironware with $CaO/SiO_2$ rate higher than 0.4% are considered to have artificially added the flux of calcareous materials. It was found that the iron making method is the solid caburizing-steel which caburizes low-carbon steels by the CO gas and $CO_2$ gas created when heating the forging furnace with charcoal. Also, the ironware manufacturers in the Baekje during 3rd century recognized the heat treatment technology as they performed carburizing process and quenching to intentionally increase the strength of necessary parts.

• Journal of the Korean Institute of Landscape Architecture
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• v.43 no.6
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• pp.138-149
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• 2015

In order to search for the reasonable planning directions for representing traditional landscape, this study conducted the comparative analysis of the designs on the panels and their constructions from both winners of "The Landscape Design Competitions for City Infrastructure of Minlak(2) District in Uijeongbu" and "The Design Competition for Dongtan(2) District Land Development Phase 1". The representing targets and views, the composition and placement of representing space, the design of representing facilities and landscape planting were examined based on the text, master plans, elevations and cross sections, diagrams, images, and perspective drawings proposed from the competition panels. Then, the landscape constructions were reviewed. The results are as follows: First, the types of the representing targets and views are the agricultural landscape, as the local landscape of target area, which are divided into the life space of a traditional village, the traditional water space, and the traditional culture. Second, as to the composition and placement of representing space, the traditional theme spaces are formulated considering the surrounding land use and the local cultural heritage. However, some spaces were changed to the exercise space or convenient facility spaces required in a neighborhood park. Third, in the case of the representing facilities, a round island in the square pond, a traditional pavilion and Hwagye(terraced flower bed) were made without the facilities designed creatively. Fourth, the application of traditional planting techniques was focused on planting trees in the village forest on an island in the square pond and on Hwagye. Fifth, the traditional representing work has gradually advanced with the selection of subject and experimental facility designs based on the professional references. Sixth, the choice of the realizable subject, the expertise for information analysis and the creative design of the traditional facility are required in the future.

• Korean Journal of Construction Engineering and Management
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• v.19 no.6
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• pp.124-134
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• 2018

Despite the many advantages of modular housing, low preference for modular housing for consumers who are familiar with RC structure leads to high construction cost of modular housing. The cost of modular buildings is about 130% of that of RC structures, so it is urgent to secure economical efficiency of modular buildings. Therefore, in this study, after calculating the savings amount of modular housing by type of construction work, economic analysis was conducted from a long - term perspective. In order to carry out the research, the authors compiled and analyzed the material cost, labor cost, and expenses incurred by each type of work by reclassifying the statement of the modular housing into the factory production and the site installation. After that, Pareto diagrams were created to find a core work that is included in the cost ratio of about 80%, and selected it as a cost reduction subject. Based on the assumption that the market size of domestic modular housing is similar to the level of modular advanced countries such as Japan and European countries, six cost reduction methods were set up that reflects the characteristics of the modular construction method and used for the expert interviews. Cost saving potentials in percentage from the interview were converted to the amount of savings that can be achieved by each type of method when applying the method. Finally, the findings of the study are expected to suggest long-term directions for technical development for modular construction and cost savings.

• Polymer(Korea)
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• v.25 no.3
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• pp.399-405
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• 2001

Poly[3-octylthiophene-co-3-(4-fluorophenyl)thiophene]s were synthesized in 2:1, 1:1, and 1:2 mole ratios, and organic electroluminescent devices were fabricated using the copolymers. The opto-electrical properties of the copolymers were studied by PL, EL spectra, I-V, and V-L curves of the organic electroluminescent devices in conjunction with the energy band diagrams which were obtained from the cyclic voltammogram and the electronic absorption spectra. The LUMO energy level of P(OT/FPT)(1:1) is the lowest as -3.35 eV. In the copolymers P(OT/FPT)(2:1) and P(OT/FPT)(1:1) the ${\lambada}_{max}$ in the PL and EL spectra red-shifted as the mole ratio of fluorophenyl group increased while in P(OT/FPT)(1:2) it showed a blue-shift. This indicates that the backbone chain is twisted due to the steric hinderance of the fluorophenyl group leading to shorter ${\pi}$-conjugation length. P(OT/FPT)(1:1) showed the highest EL intensity and the highest power efficiency among the three copolymers. In P(OT/FPT)(1:2) the roughness of the film surface causes unusually high local leakage current leading to the low efficiency of electroluminescence.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.6 no.3
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• pp.57-66
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• 2007

Weaving is defined as the crossing of two or more traffic streams traveling in the same general direction along a significant length of highway without the aid of traffic control devices. Compared with other freeway sections, perturbation is easy to happen at weaving section. Because there are a lot of lane-changing maneuvers at the weaving section, traffic is subject to turbulence in excess of that normally presents on freeway basic section. This turbulence causes operational problems and its impact must be considered. The purpose of this paper is to perform a basic study on flow characteristics by lane, which can be achieved through analyzing breakdown phenomenon in the microscopic approach. The study made use of data derived from the aerial photography for the microscopic analysis. This research produced the 30-second interval data such as flows, speeds, and densities for the macroscopic analysis and derived the vehicular data to draw time-space diagram for the microscopic analysis. The paper analyzed the traffic characteristics using flows, speeds and densities variation and investigated the conditions of breakdown occurrence with the time-space diagrams. The breakdown phenomenon was identified at weaving section and the propagation from free flow to synchronized flow was observed in this study. In the future, the findings help develop the traffic operational algorithm to manage the traffic congestion under ubiquitous circumstance since the conditions of breakdown Phenomenon can be understood more.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.37 no.6
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• pp.1-11
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• 2000

In this paper, we propose a novel control signaling protocol that efficiently controls connection setup and increases the utilization of network resources. The proposed protocol, Separated Control Signaling Protocol(SCSP), separates bearer control from call control lot WDM optical networks. The main function of call control is to check the availability of network resources such as wavelengths and receivers at destination node. Bearer control is to reserve and assign wavelengths. The signaling architecture of this protocol consists of call controller and hearer controller The call controller handles call setup and release, activates the beater controller, and manages the status of call and bearer. The bearer controller reserves wavelengths, sets up bearer, tears down bearer. and notifies the status of beater to call controller. The state transition diagrams of each controller are designed. Using control messages and related primitives, the information flows for call setup and bearer setup, hearer teardown and call release, and reaction for setup failures are described to evaluate the performance. The simulation results show that the separated control signaling protocol is superior to conventional one in terms of call blocking probability and resource utilization.

• Communications of Mathematical Education
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• v.32 no.3
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• pp.407-433
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• 2018

In order to analyze textbooks from a discursive approach, the purpose of this study is to structuralize an analytic framework based on previous literature review and apply it to analyzing the meanings and their syntheses developed by words and visual mediators appeared in the definition of graph in first-year middle school textbooks. The discursive approach consists of the communicational approach developed by Sfard(2008) and the systemic functional linguistics developed by Halliday(1985/2004). In this study, ideational meta-functions for ideational meanings and interpersonal meta-functions for interpersonal meanings were employed to analyze the meanings produced by words and visual mediators in textbooks, whereas textual meta-functions for textual meanings were used for analyzing the synthesized relationships between words and visual mediators. Results show that first, density in mathematical discourse was very high and subjects in mathematical activities were ambiguous in the ideational meanings of words, and behavior aspect was more emphasized than thinking aspect in the interpersonal meanings of words which request student participations. In the case of ideational meanings of visual mediators, there was a lack of narrative diagrams, whereas there were qualitative differences in the case of offer. Second, there was a need for promoting a wide range of diverse synthetic relationships between words and visual mediators for developing enriched mathematical meanings through the varying uses like specification, explanation, similarity, and complement. These results are so important that they provide a new analytic framework from a discursive approach to textbook analysis because not only words, but also visual mediators are analyzed as tools for producing meanings in mathematics textbooks and their synthetic relationships are also examined.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.2
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• pp.181-188
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• 2012

The present study on nitrogen-diluted non-premixed counterflow flames with finite burner diameters experimentally investigates the important role of the outer edge flame in flame extinction. Flame stability diagrams mapping the flame extinction response of nitrogen-diluted non-premixed counterflow flames to varying global strain rates in terms of the burner diameter, burner gap, and velocity ratio are explored. There exists a critical nitrogen mole fraction beyond which the flame cannot be sustained, and also the curves of the critical nitrogen mole fraction versus the global strain rate have C-shapes in terms of burner diameter, burner gap, and velocity ratio. In flames with sufficiently high strain rates, the curves of the critical nitrogen mole fractions versus global strain rate collapse into one curve, and the flames can have the 1-D flame response of typical diffusion flames. Three flame extinction modes are identified: flame extinctions through the shrinkage of the outer edge flame with and without an oscillation of the outer edge flame prior to the extinction and flame extinction through a flame hole at the flame center. The measured flame surface temperature and a numerical evaluation of the fractional contribution of each term in the energy equation show that the radial conductive heat loss at the flame edge destabilizes the outer edge flame, and the conductive and convection heat addition to the outer edge from the trailing diffusion flame stabilizes the outer edge flame. The radial conductive heat loss at the flame edge is the dominant extinction mechanism acting through the shrinkage of the outer edge flame.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.325-330
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• 2009

In Korea, medical diagnostic equipments and biochemical examination can not be used in order for diagnosing sub-healthy state or ante-disease state in oriental medicine clinic. So morphic analogical method used in oriental medicine can be a good tool as a disease-predictable signs in order to enable preventive diagnosis and therapy. Therefore the four geometrical subjects; Essence, Pneuma, Spirit, Blood(四科;精氣紳血) and the four taxonomical species; Pisces, Quadruped, Aves, Carapaces(四類;魚走鳥甲) are chosen as morphic models in this paper. The differences of two classifying methods with four subjects and four species were as follows. The diagnostic category was meta-medical and synthetic against medical specific. The diagnostic object was body in contrast with face. They were able to be applicant in psychology and classification of characteristics against diagnostics and therapeutics directly in oriental medicine. The theoretical basis was basic diagrams of four unit-fluids of body and morphological analogy with four animal species respectively. And the therapeutic aims were systemic pathogenesis following five phase theory against congestion and deficiency of Essence, Pneuma, Spirit, Blood. The four subjects and four species are mixed each other practically in clinic. But it should be used limitedly because of the above reasons described and must divide the principal and secondary factors and follow the pathology of principal shape factor. In order to improve the diagnostic value of ante-disease state, the discriminable standards, measurement methods, limit of interrelating interpretation and the criteria of abnormal disproportion were needed to be defined more clearly in advance.