• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4699-4704
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• 2013

Background: MicroRNAs have been demonstrated to play important roles in the development and progression of colorectal cancer. Several studies utilizing microRNAs as diagnostic biomarkers for colorectal cancer (CRC) have been reported. The aim of this meta-analysis was to comprehensively and quantitatively summarize the diagnostic value of microRNAs for detecting colorectal cancer. Methods: We searched PubMed, Embase and Cochrane Library for published studies that used microRNAs as biomarkers for the diagnosis of colorectal cancer. Summary estimates for sensitivity, specificity and other measures of accuracy of microRNAs in the diagnosis of colorectal cancer were calculated using the bivariate random effects model. A summary receiver operating characteristic (SROC) curve was also generated to summarize the overall effectiveness of the test. Result: Thirteen studies from twelve published articles met the inclusion criteria and were included. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odd ratio of microRNAs for the diagnosis of colorectal cancer were 0.81 (95%CI: 0.79-0.84), 0.78 (95%CI: 0.75-0.82), 4.14 (95%CI: 2.90-5.92), 0.24 (95%CI: 0.19-0.30), and 19.2 (95%CI: 11.7-31.5), respectively. The area under the SROC curve was 0.89. Conclusions: The current evidence suggests that the microRNAs test might not be used alone as a screening tool for CRC. Combining microRNAs testing with other conventional tests such as FOBT may improve the diagnostic accuracy for detecting CRC.

• 대한한의학회지
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• 제15권2호
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• pp.306-320
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• 1994

An account book of medical treatment is a form of collection materials for diagnostic standardization, and it is a basis of standardization, standardization of medical records is a preconsideration of each standardization. But an account book of medical treatment is only a kind of form for recording medical treatment, therefore standardization of medical treatment eventually holds the key to the standardization of recording charts. However until now we have gradually reformed medical records in accordance with individual characters of medical treatment, and didn't have even standard sheme of medical records, also medical terms for medical records had an inconsistency of redescription and reiterative representation for an identical terms in all parts of the East learning, medical terms for medical records didn't unity. To make better this realities, standardization study used orginated system in the process of existing study, it can get ready the basis of discussion between O.M.D and O.M.D. it can make analysis of diagnostic course and can clearly understand usable information by diagnostic course. for that reason we hope that the basis of standardization is accomplished. And in advance of study for this standardization we have to analysis the course of medical treatment with demonstration of roof, first of all we have to study term definition by diagnostic course and prepare basis by diagnostic course. because this study have limits of indivisual study, it needs to long and synthetic investigation in Association levels. Although we cann't completely alternate with methods of measurement which relyed on individual mastery, if we exclude erroes of individual measurement through mechanization and verify results of diagnosis through keynotes, we can realize standardization of medical treatment with demonstration of proof and in this process we can use medical records as a tool collecting exact data, also we can realize standardization of drawing up medical records.

• 대한치과교정학회지
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• 제46권5호
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• pp.331-342
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• 2016

Objective: To evaluate the accuracy and reliability of the diagnostic tools available for assessing maxillary transverse deficiencies. Methods: An electronic search of three databases was performed from their date of establishment to April 2015, with manual searching of reference lists of relevant articles. Articles were considered for inclusion if they reported the accuracy or reliability of a diagnostic method or evaluation technique for maxillary transverse dimensions in mixed or permanent dentitions. Risk of bias was assessed in the included articles, using the Quality Assessment of Diagnostic Accuracy Studies tool-2. Results: Nine articles were selected. The studies were heterogeneous, with moderate to low methodological quality, and all had a high risk of bias. Four suggested that the use of arch width prediction indices with dental cast measurements is unreliable for use in diagnosis. Frontal cephalograms derived from cone-beam computed tomography (CBCT) images were reportedly more reliable for assessing intermaxillary transverse discrepancies than posteroanterior cephalograms. Two studies proposed new three-dimensional transverse analyses with CBCT images that were reportedly reliable, but have not been validated for clinical sensitivity or specificity. No studies reported sensitivity, specificity, positive or negative predictive values or likelihood ratios, or ROC curves of the methods for the diagnosis of transverse deficiencies. Conclusions: Current evidence does not enable solid conclusions to be drawn, owing to a lack of reliable high quality diagnostic studies evaluating maxillary transverse deficiencies. CBCT images are reportedly more reliable for diagnosis, but further validation is required to confirm CBCT's accuracy and diagnostic superiority.

• Parasites, Hosts and Diseases
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• 제58권4호
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• pp.475-479
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• 2020

Tegumental and excretory-secretory proteins are reported as diagnostic antigens for human opisthorchiasis. Rhophilin associated tail protein1-like (OvROPN1L) protein of Opisthorchis viverrini sperm tail showed potential as a diagnostic antigen. The OvROPN1L recombinant fragments were assayed for diagnostic antigenicity for human opisthorchiasis using indirect ELISA. The strongest antigenic region was a N-terminus peptide of M1 - P56. One synthetic peptide (P1, L3-Q13) of this region showed the highest antigenicity to opisthorchiasis. Sera from other parasitic infections including Strongyloides stercoralis, hookworm, Taenia spp, minute intestinal flukes, Paragonimus spp showed lower reactivity to P1. Peptide P1 is located in the disordered N-terminus of ROPN1L supporting its suitability as linear epitope. In the Platyhelminthes the N-terminal sequence of ROPN1L is diverging with taxonomic distance further suggesting that peptide P1 has potential as diagnostic tool in the genus Opisthorchis/Clonorchis. It should be further evaluated in combination with peptides derived from other O. viverrini antigens to increase its diagnostic power.

• 대한불안의학회지
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• 제14권2호
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• pp.127-134
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• 2018

Objective : The aim of this study was to examine the psychometric features of the Korean version of the Eating Disorder Diagnostic Scale-the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (K-EDDS DSM-5). Methods : A total of 72 patients diagnosed with eating disorders participated in the study. The diagnosis was based on the Korean version of the Eating Disorder Examination (KEDE) interview. All participants completed the K-EDDS and the Eating Disorder Examination Questionnaire version 6.0 (EDE-Q 6.0) for this study. The psychometric features of the K-EDDS were examined using exploratory factor analysis, convergent validity of agreement between the K-EDDS and the KEDE, and internal consistency. Results : The exploratory factor analysis initially extracted 6-factor structures which were reconstructed into 4 factors of body dissatisfaction, binge behavior, binge frequency, and compensatory behavior based on appropriateness of the items. The internal consistency of the K-EDDS was fairly acceptable (Cronbach's alpha=0.72). The diagnostic agreement between the K-EDDS and the KEDE was high (98.61%). The 4 factors of the K-EDDS showed significant correlation with the 4 subscales of the EDE-Q 6.0. Conclusion : Our data suggests that the K-EDDS is a reliable and valid tool for the diagnosis of eating disorders based on the DSM-5.

• Imaging Science in Dentistry
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• 제51권4호
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• pp.363-372
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• 2021

Purpose: This systematic review and meta-analysis assessed the diagnostic accuracy of imaging examinations for the detection of peri-implant bone defects and compared the diagnostic accuracy between titanium (Ti) and zirconium dioxide (ZrO₂) implants. Materials and Methods: Six online databases were searched, and studies were selected based on eligibility criteria. The studies included in the systematic review underwent bias and applicability assessment using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool and a random-effect meta-analysis. Summary receiver operating characteristic (sROC) curves were constructed to compare the effect of methodological differences in relation to the variables of each group. Results: The search strategy yielded 719 articles. Titles and abstracts were read and 61 studies were selected for full-text reading. Among them, 24 studies were included in this systematic review. Most included studies had a low risk of bias (QUADAS-2). Cone-beam computed tomography (CBCT) presented sufficient data for quantitative analysis in ZrO₂ and Ti implants. The meta-analysis revealed high levels of inconsistency in the latter group. Regarding sROC curves, the area under the curve (AUC) was larger for the overall Ti group (AUC=0.79) than for the overall ZrO₂ group (AUC=0.69), but without a statistically significant difference between them. In Ti implants, the AUCs for dehiscence defects(0.73) and fenestration defects(0.87) showed a statistically significant difference. Conclusion: The diagnostic accuracy of CBCT imaging in the assessment of peri-implant bone defects was similar between Ti and ZrO₂ implants, and fenestration was more accurately diagnosed than dehiscence in Ti implants.

• Journal of Hospice and Palliative Care
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• 제24권4호
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• pp.214-225
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• 2021

Purpose: This study reviewed screening and assessment tools that are used to measure delirium in patients with cancer in hospice and palliative care settings and examined their psychometric properties. Methods: Four databases were searched for studies using related search terms (delirium, tools, palliative care, cancer, and others). The inclusion criteria were a) studies that included screening/assessment tools for measuring delirium in cancer patients receiving hospice/palliative care, and b) studies published in English or Korean. The exclusion criteria were a) studies that were conducted in an intensive care setting, and b) case studies, qualitative studies, systematic reviews, or meta-analyses. Results: Out of the 81 studies identified, only 10 examined the psychometric properties of tools for measuring delirium, and 8 tools were ultimately identified. The psychometric properties of the Memorial Delirium Assessment Scale (MDAS) were the most frequently examined (n=5), and the MDAS showed good reliability, concurrent validity, and diagnostic accuracy. The Delirium Rating Scale had good reliability and diagnostic accuracy. The Delirium Rating Scale-Revised 98 also showed good reliability and structural validity, but its diagnostic performance was not examined in hospice/palliative care settings. The Nursing Delirium Screening Scale showed relatively low diagnostic accuracy. Conclusion: The MDAS showed evidence of being a valid assessment tool for assessing delirium in patients with cancer in palliative care. Few studies examined the diagnostic performance of delirium tools. Therefore, further studies are needed to examine the diagnostic performance of screening/assessment tools for the optimal detection of delirium in patients with cancer in hospice/palliative care.

• Parasites, Hosts and Diseases
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• 제51권6호
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• pp.651-656
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• 2013

Human schistosomiasis caused by Schistosoma japonicum and Schistosoma mekongi is a chronic and debilitating helminthic disease still prevalent in several countries of Asia. Due to morphological similarities of cercariae and eggs of these 2 species, microscopic differentiation is difficult. High resolution melting (HRM) real-time PCR is developed as an alternative tool for the detection and differentiation of these 2 species. A primer pair was designed for targeting the 18S ribosomal RNA gene to generate PCR products of 156 base pairs for both species. The melting points of S. japonicum and S. mekongi PCR products were $84.5{\pm}0.07^{\circ}C$ and $85.7{\pm}0.07^{\circ}C$, respectively. The method permits amplification from a single cercaria or an egg. The HRM real-time PCR is a rapid and simple tool for differentiation of S. japonicum and S. mekongi in the intermediate and final hosts.

• 산업융합연구
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• 제17권4호
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• pp.87-94
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• 2019

본 연구의 목적은 노인 치매예방을 위해 스마트폰에서 제공되고 있는 치매예방 게임 앱과 치매진단 앱의 이용에 대한 유용성 및 그 기대효과를 예측하는 것이다. 연구방법은 첫째, 치매예방프로그램의 효과성을 검증하기 위하여 사용되고 있는 6개의 치매진단도구를 선정하고 각 진단도구가 검증하고 있는 인지기능영역을 추출하였다. 둘째는 29개의 스마트폰 치매예방 게임 앱과 치매관리 앱을 선정하여 이 앱들을 이용한 이후의 기대효과를 치매진단도구에서 추출된 인지영역과 연계하여 분석하였다. 연구 결과, 스마트폰 치매예방 앱을 이용하여 지속적으로 게임을 하거나 치매관리를 할 경우 특정 영역의 인지기능을 증진함으로써 치매예방 관리에 도움이 될 것으로 기대되었다. 스마트폰 치매예방 앱은 시공간을 초월한 이용의 용이성, 지속적 사용성 그리고 경제성을 통하여 오프라인으로 운영되고 있는 치매예방프로그램의 한계점을 보완함으로써 노인의 인지능력을 증진시키고 치매를 예방하는 데 유용할 것이다.

• 대한방사선기술학회지:방사선기술과학
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• 제39권4호
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• pp.595-600
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• 2016

진단방사선 검사 시 환자선량을 감소하기 위한 목적으로 진단용 다엽콜리메이터를 제작하고자 하며, 제작 전 사전연구로서 진단용 다엽콜리메이터에 사용되는 차폐물질 및 차폐효율에 대한 몬테칼로 시뮬레이션을 수행하였다. 몬테칼로 시뮬레이션 코드(MCNPX, LANL, USA)를 이용하여 진단방사선 기기(ReX-650R, Listem, Korea)을 모델링하기 위하여, SRS-78 프로그램을 이용하여 관전압(80, 100, 120 kVp)에 따라 에너지 스펙트럼을 획득하였다. 진단용 다엽콜리메이터의 제작을 위하여 사용된 재료는 SKD-11(탄소 : 1.6%, 규소 : 0.4%, 망간 : 0.6%, 크롬 : 5%, 몰리브덴 : 1%, 바나듐 : 0.3%, 밀도: $7.87g/cm^3$)이며 이를 진단방사선 기기에 진단용 다엽콜리메이터($10{\times}0.5{\times}0.5cm^3$, 좌우 20개씩) 형태로 전산 모사하였다. 진단용 다엽콜리메이터의 차폐효율을 확인하기 위하여 MCNPX 코드의 tally6을 이용하여 에너지별로 차폐효율을 계산하였다. 에너지에 따른 차폐효율은 80 kVp 일 때, 98.3% 차폐되었으며, 100 kVp는 95.7%, 마지막으로 120 kVp는 93.6%가 차폐되는 것을 확인할 수 있었다. 본 연구결과를 기반으로 MLC형태 및, 누설선량에 대한 연구를 진행하여 진단방사선 기기에서 사용 가능한 진단용 다엽콜리메이터 개발에 필요한 정보를 제공할 수 있을 것이라 사료된다.