• The Journal of the Korean bone and joint tumor society
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• v.11 no.1
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• pp.32-39
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• 2005

Introduction: Currently, F-18 fluorodeoxyglucose positron emission tomography scans (FDG-PET) has been investigated in soft tissue tumor especially for tumor detection and noninvasive grading. However, the validity and the efficacy of FDG-PET are still unclear in clinical evaluation. The purpose of this study is to determine the efficacy of FDG-PET in compared to conventional diagnostic imaging studies currently used in the soft tissue tumor. Methods: Between March 2001 and March 2002, 29 patients (sixteen males, thirteen females, mean age, 47 years; a range from 4 to 73) diagnosed with soft tissue tumor were evaluated by both conventional diagnostic imaging and FDG-PET. Valid reference test of the local lesion was the histopathologic diagnosis, which was measured in all patients. The suspecting metastasis in the imaging studies was validated by pathology or follow up imaging for at least 6 months. Each imaging diagnosis was made independently. The accuracy of each diagnostic method was evaluated. The incremental cost accuracy ratio was determined in each diagnostic method. Results: For detection of local lesion, sensitivity, specificity, and accuracy for MRI and FDGPET scans were 91%, 57%, 83% and 95%, 43%, 83% respectively. For detection of distant lesion, sensitivity, specificity, accuracy for conventional diagnostic methods and FDG-PET scans were 77%, 89%, 87% and 92%, 94%, 93% respectively. The incremental cost accuracy ratio (ICAR) of FDG-PET for detection of distant lesion was 145,000won/%. According to ICAR for each tumor grade, PET strategy is most cost-effective at high grade tumors. Conclusions: For detection of local lesion such as recurrence or remnant tumor, FDG-PET scan was not more accurate than MRI. However, It was more accurate for detection of metastatic lesion than conventional methods. For detection of high grade tumor, PET was most costeffective than for detection of lower grade tumor.

• Journal of the Korean Society of Radiology
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• v.12 no.2
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• pp.217-223
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• 2018

This study to search the diagnostic performance of shear wave elastography(SWE) in breast mass and to compare the biopsy result and stiffness obtained from shear wave elastography. Diagnostic breast ultrasonography and SWE were targeted for 157 patients who had breast ultrasonography was diagnosed mass from June 2017 to September 2017. Pathology results of 157 patients showed a benign 92 patients(Age, $44.54{\pm}11.84$) and a malignancy 65 patients(Age, $51.55{\pm}10.54$). Final evaluation, biopsy result, and quantitative SWE result were obtained and compared with each other according to Breast Imaging Reporting and Data System(BI-RADS) of diagnostic breast ultrasonography. Quantitative SWE value and pathologic result showed the highest diagnostic specificity of 83.70% in Emean and sensitivity of 89.23% in Emin. Quantitative SWE result and biopsy result is statistically significant.(p=0.000). The optimal cut-off value for malignant lesions was 66.3 kPa and 63.7 kPa, respectively, for the sensitivity, specificity, high maximum mean elasticity value(Emax) and mean elasticity value(Emean) and this showed the highest diagnostic area under the ROC curve(Az) value compared to other SWE measurement(p=0.000). The addition of SWE to conventional US in breast mass make a increase diagnostic specificity and reduce unnecessary biopsy. Therefore, it is expected that it will be helpful to analyze the breast mass using the above analysis and apparatus.

• Korean Journal of Veterinary Service
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• v.39 no.2
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• pp.107-116
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• 2016

In the study, we developed and evaluated a uracil N-glycosylase (UNG)-supplemented single-tube nested reverse transcription-polymerase chain reaction (UsnRT-PCR) assay that can carried out first-round RT-PCR and second-round nested PCR in a reaction tube without reaction tube opening and can simultaneously detect EU- and NA-PRRSV. The UsnRT-PCR confirmed to have a preventing ability of mis-amplification by contamination of pre-amplified PRRSV DNA from previous UsnRT-PCR. Primer specificities were evaluated with RNAs extracted from 8 viral strains and our results revealed that the primers had a high specificity for both genotypes of PRRSV. The sensitivity of the UsnRT-PCR was 0.1 $TCID_{50}$/0.1 mL for EU- or NA-PRRSV, respectively, which is comparable to that of previously reported real time RT-PCR (RRT-PCR). Clinical evaluation on 110 field samples (60 sera and 50 lung tissues) by the UsnRT-PCR and the RRT-PCR showed that detection rates of the UsnRT-PCR was 70% (77/110), and was relatively higher than that of the RRT-PCR (69.1%, 76/110). The percent positive or negative agreement of the UsnRT-PCR compared to RRT-PCR was 96.1% (73/76) or 90.9% (30/33), showing that the test results of both assays may be different for some clinical samples. Therefore, it is recommend that diagnostic laboratory workers use the two diagnostic assays for the correct diagnosis for the relevant samples in the swine disease diagnostic laboratories. In conclusion, the UsnRT-PCR assay can be applied for the rapid, and reliable diagnosis of PRRSV without concerns about preamplified DNA carryover contamination that can occurred in PCR process in the swine disease diagnostic laboratories.

• Journal of Electrical Engineering and Technology
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• v.13 no.2
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• pp.936-942
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• 2018

The diagnostic multi-leaf collimator preventing unnecessary dose from entering into patients during the diagnostic examination was made in this study. The movement of the entire 50 leaves was embodied with the group of 25 ones thereof configured in a pair facing each other on the left and right of the median line. Dimensions of the length, width, and height of each shielding leaf were $5{\times}0.5{\times}0.5cm^3$ resulting in the maximum boost field of $10{\times}10cm^2$. The material of multi-leaf collimator had the excellence on the machinability with the use of the SKD-11 alloy tool steel having the high wear resistance against frequent movement, and it was devised to control both-side's shielding leaves by moving 2 motors unlike existing remedial multi-leaf collimator that use as many motors as the number of 50 shielding leaves. Thereafter, the transmission dose of leaves, cross-leaf leakage dose, and inter-leaf leakage dose were measured by the developed multi-leaf collimator attached to X-ray equipment. An ionization chamber was used to detect doses there from, and the comparative analysis was carried out by means of the radiographic film that was easy to detect the dose leakage in between each leaf. Results obtained from the test conducted in comparative analysis yielded approximately 98%, 96%, and 94% of shielding efficiency realized at each level of energy of 80kV, 100kV, and 120kV it was confirmed there was no dose leakage resulted from the varied level of irradiation energy. Thus the multi-leaf collimator to be developed based on this study is thought that it could fully reduce the unnecessary dose to patients in the diagnostic test and the shielding efficiency thereof is expected to be increasing if it is made in a miniaturized form with a way of increasing the thickness of each leaf later for an extended application to general diagnostic purposes.

• Journal of The Korean Association For Science Education
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• v.27 no.4
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• pp.346-353
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• 2007

In order to be efficient in teaching, a teacher should understand the current learner's level through diagnostic evaluation. This study has examined the major issues arising from the noble diagnostic assessment tool based on the theory of knowledge space. The knowledge state analysis method is actualizing the theory of knowledge space for practical use. The knowledge state analysis method is very advantageous when a certain group or individual student's knowledge structure is analyzed especially for strong hierarchical subjects such as mathematics, physics, chemistry, etc. Students' knowledge state helps design an efficient teaching plan by referring their hierarchical knowledge structure. The knowledge state analysis method can be enhanced by computer due to fast data processing. In addition, each student's knowledge can be improved effectively through individualistic feedback depending on individualized knowledge structure. In this study, we have developed a diagnostic assessment test for measuring student's learning outcome which is unattainable from the conventional examination. The diagnostic assessment test was administered to middle school students and analyzed by the knowledge state analysis method. The analyzed results show that students' knowledge structure after learning found to be more structured and well-defined than the knowledge structure before the learning.

• Clinical and Experimental Pediatrics
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• v.48 no.4
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• pp.349-354
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• 2005

Headache is a common complaint in pediatric office practices as well as in children presenting to emergency departments. Children who complain of headache usually are brought to medical attention by their parents, who seek reassurance that the headaches are not a sign of a serious illness. The etiologies of headache range from school problems to brain tumors. A history taking, physical examination, and appropriate diagnostic testing will enable to distinguish primary headaches from those of a secondary etiology. The clinical, neuroimaging, and laboratory evaluation of the child with headache are reviewed here.

• The Journal of the Korean dental association
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• v.50 no.4
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• pp.189-195
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• 2012

Various imaging modalities have been used for dental implant assessment in the different stages of implant treatment. Basic imaging, such as panoramic and periapical radiographs, are generally useful and cost-effective but do not provide the cross-sectional visualization or interactive image analysis that can be obtained with more sophisticated imaging techniques, such as Cone-Beam Computed Tomography(CBCT) imaging. This article includes the applications of CBCT imaging and their diagnostic contribution to presurgical evaluation, treatment planning, and postoperative assessment of dental implants.

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.369-369
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• 2005

• Journal of Biomedical Engineering Research
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• v.12 no.4
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• pp.267-276
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• 1991

This paper describes syntactic pattern recognition algorithm for pattern recognition and diagnostic parameter extraction of ECG signal. ECG signal which is represented linguistic string is evaluated by pattern grammar and its interpreter-LALR(1) parser for pattern recognition. The proposed pattern grammar performs syntactic analysis and semantic evaluation simultaneously. The performance of proposed algorithm has been evaluated using CSE database.

• Proceedings of the Safety Management and Science Conference
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• 2000.05a
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• pp.207-215
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• 2000

This study deals with the application of knowledge-engineering and a methodology for the assessment & measurement of reliability, availability, maintainability, and safety of industrial systems using fault-tree representation. A fuzzy methodology for fault-tree evaluation seems to be an alternative solution to overcome the drawbacks of the conventional approach(insufficient information concerning the relative frequences of hazard events). To improve the quality of results, the membership functions must be approximated based on heuristic considerations. The purpose of this Is to describe the knowlwdge engineering approach, directed to integrate the various sources of knowledge involved in a FTA.