• Title/Summary/Keyword: Development factor

Search Result 10,324, Processing Time 0.042 seconds

Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1

  • Ruthenborg, Robin J.;Ban, Jae-Jun;Wazir, Anum;Takeda, Norihiko;Kim, Jung-Whan
    • Molecules and Cells
    • /
    • v.37 no.9
    • /
    • pp.637-643
    • /
    • 2014
  • Wound healing is a complex multi-step process that requires spatial and temporal orchestration of cellular and non-cellular components. Hypoxia is one of the prominent microenvironmental factors in tissue injury and wound healing. Hypoxic responses, mainly mediated by a master transcription factor of oxygen homeostasis, hypoxia-inducible factor-1 (HIF-1), have been shown to be critically involved in virtually all processes of wound healing and remodeling. Yet, mechanisms underlying hypoxic regulation of wound healing are still poorly understood. Better understanding of how the wound healing process is regulated by the hypoxic microenvironment and HIF-1 signaling pathway will provide insight into the development of a novel therapeutic strategy for impaired wound healing conditions such as diabetic wound and fibrosis. In this review, we will discuss recent studies illuminating the roles of HIF-1 in physiologic and pathologic wound repair and further, the therapeutic potentials of HIF-1 stabilization or inhibition.

The Analysis of the Priority Order in the Factors Influencing College Choice of Culinary Art Majors using AHP - Focusing on the Colleges and Universities in Chungcheong-do - (AHP 분석기법을 이용한 조리전공자의 대학 선택 영향 요인의 우선 순위 분석 - 충청도에 위치한 대학을 중심으로 -)

  • Na, Tae-Kyun;Kim, Jang-Eix
    • Culinary science and hospitality research
    • /
    • v.14 no.3
    • /
    • pp.123-135
    • /
    • 2008
  • The purpose of this study is to investigate the priority order in the factors influencing college choice of students who are majoring in culinary art in Chungcheong-do. For the study, we set the decision-making factors of upper hierarchies and nineteen bottom hierarchies based on the literature review and employed the analytical hierarchical process(AHP). As a result, the first considering factor among 4 upper hierarchies for college choice was the educational environments of the department(0.378). The next came in the order named as follows: college and university grade(0.263), the educational environments of colleges or universities(0.244), recommendation(0.115). The first considering factor among the educational environments of the department was the aptitude for the major(0.323). The first considering factor in college and university grade was the entrance competitive rate(0.397). The first considering factors among the educational environments of the colleges or universities were scholarships and tuition fees(0.325). The first considering factor in recommendation was the recommendation of a high school teacher(0.295). This results of this study will contribute to the development of colleges and universities under the turbulent changes of educational environments.

  • PDF

A study on economic analysis of new renewable energy power(photovoltaic, wind power, small hydro, biogas) (신재생에너지 발전(태양광, 풍력, 소수력, 바이오가스)의 경제성 분석 연구)

  • Kim, Chong-Min;Kim, Ki-Young
    • Journal of the Korean Solar Energy Society
    • /
    • v.28 no.6
    • /
    • pp.70-77
    • /
    • 2008
  • The purpose of this study evaluates a feasibility and economical efficiency of new renewable energy. According as weather change is serious problem now days, every people make attention to the reduction of greenhouse gas. The revitalization of new renewable energy creates the variety of energy source, stability of energy supply and reduction of greenhouse gas. In this study evaluates a feasibility and economical efficiency from new renewable energy of various photo voltaics, wind power, small hydro and biogas. Feasibility does in standard of technical characteristic, politic support, marketability, establishment present condition and development aim. Economical efficiency does in standard of developmental unit cost, utilization factor, equipment life, politic support cost, interest ratio. The results of this study were as follows photo voltaics, wind, small hydropower, biogas in order feasibility is high. Developmental unit cost, utilization factor, equipment life, politic support cost and analyzed the relationship of interest ratio fluctuation and economical efficiency. From all new renewable energy the utilization factor most is important in economical efficiency but necessary utilization factor is difficult because environmental problem.

Location Selection Factors for International Distribution Center in Port Hinterland - A Review of Busan New Port Hinterland from User's Perspective -

  • Kim, Si Hyun;Shin, Gun Hoon
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
    • /
    • v.64
    • /
    • pp.187-210
    • /
    • 2014
  • As port functions change to act as an economic catalyst and take on a central position in industries engaged in international trade, port hinterland has become a significant component in international shipping. The success of port hinterland as a strategic base of logistic activities critically depends on location selection factor for international distribution center that links elements of global supply chain management. By examining multi-measurement items empirically, this paper analyzed location selection factor for international logistics distribution center in port hinterland, and evaluated Busan new port hinterland from the user's perspective. Employing exploratory factor analysis, the results revealed that the model structured around five factors incorporating geo-location and accessibility, availability, political supports, cost factors, and quality of business environment is valid and reliable in the context of the location selection factors for logistics distribution center in the context of port hinterland operations. The evaluation of Busan new port hinterland provides useful insights for strategic improvement to accommodate the users' expectation. Further, the model offers both a descriptive and diagnostic strategic management tool for port hinterland development and operations, to guide future improvement.

  • PDF

Korean Parents' Child Rearing Attitudes Perceived by their Children: The Influence of Demographic Variables (자녀가 지각한 부모의 양육태도 및 이에 영향을 주는 요인)

  • LEE, Sook;PARK, Seong Yeon
    • Korean Journal of Child Studies
    • /
    • v.9 no.2
    • /
    • pp.61-94
    • /
    • 1988
  • The purpose of this study was to investigate the several types of Korean parent's child rearing attitudes perceived by their children and the related variables. The study included the development of a "Children's Report of Korean Parent's Behavior Inventory"(CKPBI). Subjects were 1722 5th and 6th grade elementary school children from 5 urban cities in Korea. CKPBI and a Home Environment Questionnaire were used to gather data for the study. Stepwise multiple regression analysis, cross-tabulation analysis, Pearson correlation analysis, and factor analysis were conducted for the purpose of the study. A CKPBI which consists of 46 items for father's and 48 items for mother's was found as both a valid and reliable instrument for measuring the child rearing attitudes of Korean parents. A factor analysis resulted in identifying two factors both for mothers and fathers; they were the "Warmth factor" and "Rejection-Authority factor". Eight types of child rearing attitudes were found for Korean parents. The SES of family significantly predicted Korean parent's child rearing attitudes. The SES of the family, and sex of the child determined variations in Korean parents' child rearing attitudes. Maternal religion had a significant correlation with both boys' and girls' perceptions of parental attitudes. The results of this study indicate high inconsistency within each parent and high consistency between both parents.

  • PDF

Development of an Instrument to Measure Risk Factor-related Deviant Behavior for the Elderly in South Korea (노인의 일탈행동과 관련된 위험요인 측정도구 개발 - 노인 범죄 증가와 관련하여 -)

  • Lee, Sook-Kyung;Hong, Chong-Min
    • Journal of Korean Public Health Nursing
    • /
    • v.25 no.2
    • /
    • pp.244-254
    • /
    • 2011
  • Purpose: The study was designed to develop an instrument to measure risk factor-related deviant behavior (RFRDB) for the elderly. Methods: The preliminary instrument including 52 items to measure the risk factor-related deviant behavior for the elderly was developed through conceptual framework based literature review. The items were reviewed by experts to reveal the Content Validity Index (CVI). Then, construct validity and reliability were tested using factor analysis, comparative groups, and Cronbach's alpha with data from 233 elderly. Results: Among 52 items, 27 questions in the RFRDB instrument were selected from content validity and 21 questions in the final RFRDB were developed from testing validity and reliability. Results of empirical analysis(retest) of RFRDB were supported by 70% congruity with conceptual framework through literature review. The RFRDB has been completed by validity testing by known-group technique. The final developed RFRDB of the elderly has 21 questions each with a 4-point Likert Scale. Conclusion: The RFRDB may be utilized as a measurement to assess the risk of elderly deviant behavior.

Improved Torque Calculation of High Speed Permanent Magnet Motor with Compressor Loads Using Measured Power Factor Angle and Analytical Circuit Parameters

  • Choi, Jang-Young;Jang, Seok-Myeong;Lee, Sung-Ho
    • Journal of international Conference on Electrical Machines and Systems
    • /
    • v.2 no.2
    • /
    • pp.159-164
    • /
    • 2013
  • Difficulty of torque measurements in high-speed permanent magnet (HSPM) motors has necessitated the development of improved torque calculations. Hence, this paper presents an analytical torque calculation of a high speed permanent magnet (HSPM) motor based on the power factor angle. On the basis of analytical magnetic field solutions, the equations for circuit parameters such as back-emf and synchronous inductance are derived analytically. All analytical results are validated extensively by non-linear finite element (FE) calculations and measurements. The internal angle (${\delta}$) between the back-emf and the phase current is calculated according to the rotor speed by using analytical circuit parameters and the measured power factor because this angle is not measured but estimated in case of sensorless drive of the HSPM motor, significantly affecting torque calculation. Finally, the validity of the torque analysis method proposed in this paper is confirmed, by showing that the torque calculated on the basis of the internal angle is in better agreement with the measurements.

A Study on the Structural Modelling of National Maritime Power System (국가해양력시스템의 구조모델화에 관한 연구)

  • 임봉택;이철영
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
    • /
    • 1999.10a
    • /
    • pp.153-161
    • /
    • 1999
  • For composing the structure model of national maritime power system by system structural modelling, in this study, the 50 basic factors are selected by survey of the extensive and thorough literatures on maritime, sea, maritime power and sea power. And the basic factors are classified into 36 component factors by cluster method. The 9 attributes are extracted by the application of the principle component analysis method, one of the factor analysis method in system engineering, to component factors. We defined the attributes composing the national maritime power system by integration the result of this study and existed our studies relate to this topic. Which are showed in table 8. and we showed the structure model of national maritime power system in figure 3. In table 8, the 9 attributes are as follows: the fundamental power of maritime, shipping and port power, naval power, fishing power, shipbuilding power, the power of ocean research and development, dependency on seaborne trade, the protection power of ocean environment and the will and inclination of government.

A Relationship between Hydraulic Conductivity and Electrical Properties of Silty Sand on the Riverside of the Nakdong River (낙동강변 실트질 모래의 수리전도도와 전기적 물성과의 관계)

  • Kim, Soo-Dong;Park, Samgyu;Hamm, Se-Yeong;Oh, Yun-Yeong
    • Journal of Soil and Groundwater Environment
    • /
    • v.19 no.3
    • /
    • pp.39-46
    • /
    • 2014
  • Hydraulic conductivity is an important parameter, representing permeable property of the groundwater in aquifers, in the issues of groundwater development, groundwater contamination, and groundwater flow, etc. We estimated a relationship between hydraulic conductivity and electrical properties (formation factor, chargeability, and time constant) of silty sand in the laboratory. For this study, we conducted grain size analysis, constant head permeameter test, and measured electrical resistivity and spectral induced polarization of silty sand samples collected from the riverside alluvium of the Nakdong River in Nogok-ri area, Dasan-myeon, Goryeong-gun in Gyeongbook Province, Korea. In the laboratory test, we used soil samples of approximately uniform porosity with 0.5% error range, and kept the electrical resistivity of pore water with 100 ohm-m. As a result, the relationship between effective particle size and hydraulic conductivity agrees fairly well with the existing empirical formulas. Hydraulic conductivity was correlated with formation factor, chargeability, and time constant: hydraulic conductivity increased with increasing formation factor and time constant as well as with decreasing chargeability.

Development of the Numerical Guide for Cost-Benefit Analysis of Occupational Radiation Exposure In the Korean Next Generation Reactor

  • Sohn, Ki-Yoon;Kang, Chang-Sun
    • Nuclear Engineering and Technology
    • /
    • v.29 no.1
    • /
    • pp.78-84
    • /
    • 1997
  • The specific purpose of this study is to develop the numerical guide for the cost-benefit analysis of ORE ($/person-Sv reduction) to meet the criterion of ALARA in the design stage of the KNGR. In deriving the guide, the risk factor which is defined by the risk to unit collective radiation exposure dose (deaths/person-Sv) and the monetary value of human life ($/death) are required. The risk factor has been estimated from various clinical data accumulated for a number of years and continuously modified. And the monetary value of human life is usually quantified using the human capital approach. In this study, the risk to radiation exposure perceived by a group of people is investigated through an extensive poll survey conducted among university students in order to modify the existing risk factor for radiation exposure. And in evaluating the monetary value of human life, the QOL factor is introduced in order to incorporate the degree of public welfare or quality of life. As a result of study, a value within the range of 151, 000~172, 000 dollars per person-Sv reduction is recommended as the appropriate interim numerical guide for cost-benefit analysis of ORE to meet the criterion of ALARA in the design stage of the KNGR. A poll survey was also conducted in order to see whether the public acceptance cost of nuclear power should be incorporated in developing the guide, and the result of study shooed that such a cost does not need to be considered.

  • PDF