• Physical Therapy Korea
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• v.14 no.2
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• pp.11-20
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• 2007

The development of neonatal neuromuscular system is accomplished by the functional interaction between the spinal neurons and its target cells, skeletal muscle cells, and the intrinsic and extrinsic factors affecting this process. The aim of this study was to identify the effect of suspension unloading (SU) and neuromuscular electrical stimulation (NMES) upon the development of the neonatal spinal cord. For this study, the neonatal rats were randomly divided into three groups: a control group, an experimental group I, and an experimental group II. The SU for experimental group I and II was applied from postnatal day (PD) 5 to PD 30, and the NMES for experimental group II was applied from PD 16 to PD 30 using NMES that gave isometric contraction with 10 Hz for 30 minutes twice a day. In order to observe the effect of SU and NMES, this study observed neutrophin-3 (NT-3) and microtubule associated protein 2 (MAP2) immunoreactivity in the lumbar spinal cord (L4-5) at the PD 15 and PD 30. The results are as follows. At PD 15, lumbar spinal cord of experimental group I and II had significantly lower NT-3 and MAP2 immunoreactivity than control group. It proved that a microgravity condition restricted the spinal development. At PD 30, lumbar spinal cord of control group and experimental group II had significantly higher NT-3 and MAP2 immunoreactivity than experimental group I. It proved that the NMES facilitated the spinal development by spinal cord-skeletal muscle interaction. These results suggest that weight bearing during the neonatal developmental period is essential for the development of neuromuscular development. Also, the NMES on its target skeletal muscle can encourage the development of the spinal cord system with a full supplementation of the effect of weight bearing, which is an essential factor in neonatal developmental process.

• Journal of Korean Biological Nursing Science
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• v.22 no.3
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• pp.213-221
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• 2020

Purpose: The purpose of this study was to explore the role performance and related factors of clinical research nurses (CRN) in the process of clinical trials of new drug development. Methods: Study participants were CRN whose affiliation was in non-capital areas and who had been working longer than three months at the time of the data collection. The data collection was conducted with a semi-structured questionnaire development by Hwang & Go, 2011 comprising 16 items of participants' characteristics and 60 items of role performance via in-person and online. Additionally, opinions which would be necessary to establish the CRN role were questioned for the future. A total of 141 questionnaires of 151 questionnaires responses were analyzed using descriptive statistics, t-test, and ANOVA for data analysis as appropriate. Results: The level of overall role performance was above average (5.61±0.90) with the highest in subject care (6.04 ± 0.96) and management and the lowest in self-development (4.39 ± 1.52). The only factor affecting overall role performance was employment status and the only sub-category affected by factors of employment status, and some general characteristics was self-development. Conclusion: From study results, it can be concluded that the CRN seem to perform their proper role. Nonetheless, self-development should be considered as critical aspect for better CRN competency, which is an important aspect toward improving the CRN role performance. Additionally, efforts to improve the level of role performance must be established through stable employment and concrete departmental placement as suggested in this study.

• Food Science and Biotechnology
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• v.18 no.3
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• pp.793-798
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• 2009

The objectives of this present study were to compare the contents and determine optimum extraction conditions for the rosmarinic acid (RA) and caffeic acid (CA) from leaves of Korean Perilla frutescens varieties. RA and CA from leaves of cv. Bora, a breeding line of P. frutescens were isolated and elucidated using various spectroscopic data. On the basis of 2 phenolic acids, optimum extraction conditions were obtained by employing 50% EtOH for 60 min at $25^{\circ}C$. We reported for the first time on the contents of RA and CA from leaves of 32 Korean varieties. Among them, leaves of P. frutescens Brit. var. acuta Kudo I exhibited the highest RA content ($8.53{\pm}0.57$ mg/g) and CA content ($2.33{\pm}0.11$ mg/g) showed the highest in the P. frutescens Brit. var. viridis Makino. Interestingly, average RA content ($2.66{\pm}0.17$ mg/g) showed a markedly higher than that of CA ($1.98{\pm}0.16$ mg/g) in Korean varieties. These results suggest that concentrations of the RA and CA in P. frutescens leaves could be a key factor in the selection process of a high quality species.

• Korean Journal of Pharmacognosy
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• v.45 no.3
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• pp.262-267
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• 2014

Royal jelly composes of many components, especially protein. Protein is a major factor which cause allergy. We focused on water soluble royal jelly (WSRJ) that was removed allergy - inducing protein. 10-hyroxy-2-decenoic acid content of WSRJ is 2.42 g/100 g, which is double compared to that of lypophilized RJ. To further access WSRJ as a cosmetic ingredient and potential external treatment for topical use, we investigated its ability to inhibit tyrosinase activity and melanin biosynthesis on melanogenesis in B16F1 melanoma cells. We found that WSRJ increased the cell viability in B16F1 melanoma cell and WSRJ (1~10 mg/ml) inhibited melanin synthesis in with 10 nM ${\alpha}$-melanocyte-stimulating hormone (${\alpha}$-MSH) for 48 h. WSRJ inhibited direct tyrosinase activity, which decreased melanin synthesis in ${\alpha}$-MSH stimulated B16F1 melanoma cells. Thease findings suggest that WSRJ induces the down regulation of melanogenesis by inhibiting tyrosinase activation.

• Korean Journal of Agricultural Science
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• v.46 no.3
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• pp.579-589
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• 2019

Due to the ban on the use of antibiotics, interest has been increasing for the development of therapeutic agents to treat various diseases using natural resources. Osthole, a natural coumarin compound used in traditional Chinese medicines, exerts an anti-inflammatory effect, but its effects in cows remain unknown. In this study, the effect of osthole on lipopolysaccharide (LPS)- or concanavalin-A (Con-A)- stimulated peripheral blood mononuclear cells (PBMCs) was assessed. Jugular venous blood was collected from Korean calves, and PBMCs were isolated. They were then used to study the immune response of PBMCs to treatment with osthole and LPS or Con-A for 72 h by measuring inflammatory cytokines including tumor necrosis factor-${\alpha}$ ($TNF-{\alpha}$) and interferon-${\gamma}$ ($IFN-{\gamma}$). Osthole significantly inhibited the mRNA secretion of $TNF-{\alpha}$ and $IFN-{\gamma}$ in a dose-dependent manner. Therefore, osthole inhibited LPS- or Con-A- induced $TNF-{\alpha}$ and Con-A-induced $IFN-{\gamma}$ production significantly in dose-dependent manner. These results clearly suggest that osthole inhibited the LPS- or Con-A- stimulated upregulation of pro-inflammatory cytokines in a dose-dependent manner, without causing obvious cytotoxic effects. Osthole could also protect cows from LPS- or Con-A- induced endotoxin shock, possibly by inhibiting the production of pro-inflammatory cytokines, which suggests that osthole might be a novel therapeutic agent for the prevention of inflammatory diseases.

• The Journal of Korean Medical History
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• v.31 no.2
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• pp.53-62
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• 2018

It is known that the development of medical science is influenced by various social environmental factors. Historically, Chinese Medicine developed the most during the Song Yuan dynasty, and the reason for this was known to be due to socio-political factors. According to recent studies, however, this period also had severe changes in climate and environment. Therefore, this study was conducted under the premise that this change in climate and environment influenced medical development. When looking at the coldness of the 11th~12th century and data indicating warming before and after this period, the Song Yuan dynasty went through drastic periods of climate change. Therefore, diseases related to heat such as bubonic plague, measles, and malaria were common. Furthermore, due to occasional wars during the Song Yuan dynasty, social unrest was aggravated and infectious diseases spread due to land development and environmental pollution. As the health of people were threatened due to these factors, the printing and distribution of medical text were encouraged, and during this process, the great 4 doctors of Jin-Yuan appeared. The reason why they studied cures for infectious diseases due to heat was related to climatic environment change. The development in medical science is closely related to socio-political factors, however the change in climatic environments are inevitably related to disease emergence as well. Therefore, it should always be taken into consideration as an important factor that promotes development in medical science.

• International Journal of Computer Science & Network Security
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• v.21 no.9
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• pp.267-274
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• 2021

The article deals with problems of innovation development on a network basis, which require effective mechanisms of innovation communications. In research the organizational aspects of ICT infrastructure development for innovation networks sustainable development based on cooperative marketing principles is considered. The proposed research idea is based on the idea that ICT implementation is based not only on the operational approach for innovation management as a factor of efficiency of internal communications, but also on knowledge economy and post-industrial economy trends. Therefore, the purpose of study is to develop an ICT model of innovation infrastructure to improve its effectiveness (strategic character) and efficiency (operative character) through increasing the efficiency of network communication interactions. Creation of information space and communication tools to support innovation network sustainable development and cooperation activities in research is proposed to be solved with the help of specialized ICT platform. It is shown, that ICT platform of innovation cooperation innovation network is important tool for common work of participants. ICT platform is considered as an integrated information system designed to automate business processes related to the sustainable development of innovation network, segment management and integration with HEI information systems and industrial cooperation. The main factors that determine the need to use a special ICT platform for innovation network cooperation were considered. The main issues of concurrent engineering (C-technology) application in high-technology industries and innovation cooperation for integrated product development were studied.

• Journal of Convergence for Information Technology
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• v.10 no.12
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• pp.175-182
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• 2020

This thesis is to investigate the relationship between college students' beauty YouTube viewing satisfaction and the development impact of K-beauty. University students' beauty YouTube viewing satisfaction showed more than average satisfaction in terms of reviews, makeup techniques, makeup trends, agency empathy, and entertainment motives. In order to study the relationship between beauty YouTube viewing satisfaction and K-beauty, as a result of factor analysis of the K-beauty questionnaire, it was divided into factors affecting development and development of other industries. University students' beauty YouTube viewing satisfaction was found to have a positive (+) effect on the factors affecting K-beauty development, and no relationship with other K-beauty industries. Based on these research results, we expect to use reference materials for the development of K-beauty development plans using media contents along with the development of beauty YouTube contents, and we plan to continue a more extensive research.

• Journal of Industrial Convergence
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• v.20 no.4
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• pp.1-6
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• 2022

In recent years, many global manufacturers such as Mercedes-Benz and BMW have been using augmented reality technology to spread it to various fields such as assembly process, after-sales service, sales stores, and consumer manuals. In this study, the application status of innovation in manufacturing using industrial augmented reality was identified, and the possibility of combining existing ERP and augmented reality was analyzed based on this. In addition, it was empirically analyzed that the selection of a dedicated content development engine is the most important factor in development productivity in the development of industrial augmented reality content. The same content developed with Unity3d was redeveloped with Vuforia Studio, and as a result of comparative analysis of development man-hours by field, the development lead time was shortened by 8 times. This study proves productivity by actually developing industrial augmented reality contents, and it is a study with a difference that is difficult to implement in practice.

• Korean Journal of Organic Agriculture
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• v.30 no.4
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• pp.451-470
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• 2022

Recently, the environment has been recognized as an important factor in increasing competitiveness in the industry. In agriculture and rural areas, the environment is becoming important in terms of the competitive advantage of agricultural products and continued regional development. This study intended to provide farmers with basic data for the continuous development of local agriculture through exploratory studies of environmental behaviors and regional development. In this study, 107 questionnaires were used for analysis of farmers in Jinan County to analyze the impact of farmers' environmental consciousness on regional development, and the research model was verified using a structural equation model. As a result of the analysis, it was analyzed that among the components of the environmental consciousness of farmers, environmental health has a statistically significant positive effect on environmental behaviors, while environmental interest and soil environment do not have an impact. The environmental behaviors of farmers have not been shown to be statistically significant to regional development. As a result of the analysis of this research, first, it is necessary to foster at the local level by establishing a customized fostering system for each village and region, such as education and technical support to vitalize the participation of young farmers and small and medium-sized farmers through the establishment of an Eco-friendly agricultural organization support system. It is necessary to raise public awareness of the public good function of agriculture and expand opportunities for sharing the value of Eco-friendly agriculture.