• Journal of Microbiology and Biotechnology
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• 제28권11호
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• pp.1771-1781
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• 2018

The emergence of multidrug-resistant microorganisms, as well as fungal infectious diseases that further threaten health, especially in immunodeficient populations, is a major global problem. The development of new antifungal agents in clinical trials is inferior to the incidence of drug resistance, and the available antifungal agents are restricted. Their mechanisms aim at certain characteristics of the fungus in order to avoid biological similarities with the host. Synthesis of the cell wall and ergosterol are mainly targeted in clinical use. The need for new approaches to antifungal therapeutic agents or development alternatives has increased. This review explores new perspectives on mechanisms to effectively combat fungal infections and effective antifungal activity. The clinical drug have a common feature that ultimately causes caspase-dependent cell death. The drugs-induced cell death pathway is associated with mitochondrial dysfunction, including mitochondrial membrane depolarization and cytochrome c release. This mechanism of action also reveals antimicrobial peptides, the primary effector molecules of innate systems, to highlight new alternatives. Furthermore, drug combination therapy is suggested as another strategy to combat fungal infection. The proposal for a new approach to antifungal agents is not only important from a basic scientific point of view, but will also assist in the selection of molecules for combination therapy.

• 경영과학
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• 제26권1호
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• pp.37-51
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• 2009

Korean IT industry has been given much weight in national R&D management. A negative side of this fact is that Korean economy is likely to become vulnerable to a condition of the export business in certain items of IT industry which has a serious influence on the national economy. A customized investment strategy through the analysis of technology competitiveness and R&D status in each technology of IT field is required in order to rectify the structural vulnerability and pursue a continuous growth. In this research, a strategic direction to set up an efficient investment strategy is presented. In this process, it draws a portfolio analysis with two axes of technology level and technology life cycle. It also derives a priority order of the national investment considering the degree of technological impact, marketability, and adequacy of public support from AHP (Analytic Hierarchy Process) method by a survey of IT experts. A portfolio analysis in the prior stage helps the respondents in AHP become more familiar with the alternatives' characteristics so that their decision making process more corresponds with national R&D strategies.

• 한국환경복원기술학회지
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• 제26권3호
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• pp.43-55
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• 2023

The railway project is an essential green transportation tool that is considered suitable for the domestic and foreign policy direction of carbon neutrality, but there are some limitations, such as damaging important carbon absorption sources during construction. This study analyzed the environmental impact assessment related to carbon absorption sources of greenhouse gas evaluation items conducted during the railway project, and limitations and implications were derived. The analysis of environmental impact assessment guidelines related to railway projects and carbon absorption sources dealt with prediction and reduction methods related to carbon absorption sources, but guidelines, including environmentally friendly railway construction guidelines, lacked descriptions. Since the greenhouse gas environmental impact assessment, 83 railway project environmental impact assessments have been reviewed, but in some cases, carbon absorption-related predictions have not been implemented, or carbon absorption-related reduction measures have been insufficient. In addition, there were cases where there was a limit to calculating emissions and reduction or where the reduction value was insignificant compared to emissions. In order to supplement the environmental impact assessment in the field of carbon absorption sources related to railway construction projects, alternatives such as quantitative emission and low reduction calculation, review of the no net loss system using the total environmental resource system, and linkage with climate change impact assessment are needed.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1991년도 하계학술대회 논문집
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• pp.363-365
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• 1991

This paper presents a method for feeder reconfiguration in order to operate distribution systems efficiently using heuristic rules. The reconfiguration method presented here not only eliminates various abnormal states but also achieves minimum power loss and optimum load balance of the distribution feeders under normal operating condition transfering loads from one feeder to anoter applying the experiences of the experts. To implement the method effectively, a best-first tree searching strategy based on heuristics is used to evaluate the various load transfer alternatives. The development of a rule-based system aimed at the reduction of the search space is presented as a means of implementing the best-first searching strategy. The results of the computer simulation of the above procedure are as follows; 1) achieving minimum power loss of the distribution feeder adopting the optimum load transfer alternative. 2) Enhencing system reliability and achieving load balance through rational allocation of the feeder loads.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2014년도 제50차 하계학술대회논문집 22권2호
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• pp.99-100
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• 2014

Even though many projects of new development and redevelopment for information systems are invested, they are not taken care of from the perspective of administration and evaluation. Also, decision makers fall short of not only support the process to check alternatives and select an alternative for investment and but also provide necessary information so as to maximize the effects of investments. That is to say, the suggestion of general direction toward IT investment is debatable. Against this backdrop, we propose a value measurement model to manage information systems.

• 유통과학연구
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• 제3권1호
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• pp.91-111
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• 2005

As the environments of world economy have been changed so rapidly, the conditions of marketing and distribution also have been altered. In korea distribution industry has been changed according to the introduction of various patterns of distribution and marketing. Among them the emerging of network marketing, same meaning with multi-level marketing in this research, is a important phenomenon of distribution industry in Korea. Not only it contributes the progress of national economy, especially distribution industry, but also it includes some limitations and criticism from the dissenters. In this paper, the clear definitions and characteristics of network marketing are suggested. And the current situations of network marketing in this country has been analyzed and compared, The future perspectives and problems of this network marketing have been diagnosed and classified for the future development and contribution for national economy. The various alternatives for the future development of network marketing have been studied and suggested in terms of each role of this industry such as distributers, consumers and government. Though this paper has a small contribution, it contains many limitations for research. Therefore it suggest future directions for further research.

• 농촌계획
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• 제5권1호
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• pp.66-75
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• 1999

The study intends to find out contents and impacts of rural development projects implemented by government in Ucheon myon-center village (Hoingseong-county) between 1989-1995. The projects in concern are Rural Industrial Estate Project(1989-90) and Rural Collective Village Project(1992-93), The restructuring of village plan introduced new construction and renewal of buildings that are required for a myon-center in general has to be. The study reveals some morphological patterns the village has and needs to be adjusted. As a conclusion, it proposes a conception of self-containment for a myon-center development. It is necessary that a project plan strategy should be based upon harmonious exploitation between old and new, flexible planning, and sense of technological alternatives.

• 한국주거학회논문집
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• 제18권5호
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• pp.143-150
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• 2007

The purpose of this research is to example the general trend of the service environment evaluation of the silver town and classify based on the service environment evaluation to suggest a effective method and alternatives fur development companies. The survey population of this study focused on 40s and 50s' middle aged both genders living in the Seoul and national capital region, we used random sampling method. The analytical methods used in this study were frequency, mean, standard deviation, factor analysis, Chi-Squae analysis, ANOVA, cluster Analysis, post-hoc estimation (Duncan test), To verify the reliability of each measure, Cronbach's alpha coefficient was used. As a result of classifying the environment evaluation elements, it was classified into 5 groups for the differentiating strategy on each group. The groups are: life support service type, medical and health support service type, cultural support service type, indifference type, and food support service type.

• 한국지구과학회지
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• 제41권5호
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• pp.437-446
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• 2020

전기차, 에너지저장시스템의 수요급증으로 에너지 저장장치에 대한 관심이 세계적으로 증가해 왔다. 에너지 저장장치의 핵심원료인 리튬과 바나듐 등과 같은 에너지저장광물 자원을 안정적으로 공급하기 위하여 새로운 기술적 대안이 필요하다. 이미 리튬과 바나듐을 직접 확보할 수 있는 기술에 대한 여러 국가들의 연구개발 활동이 이루어지고 있다. 이에 따라 효과적인 연구개발 전략을 수립하기 위해서 특허 및 논문 분석을 통해 각 국의 기술동향을 분석하고 향후 기술발전방향을 설정하는 것이 중요하다. 본 연구는 1970년부터 2019년 10월까지 출원 공개 또는 출원 등록된 한국, 미국, 유럽, 일본의 특허자료와 2000년 1월부터 2019년 10월까지의 논문을 대상 검색된 자료를 통해 신기술 개발동향 및 국내외 연구개발 현황을 분석하였다. 분석결과, 현재 에너지저장광물과 관련된 기술의 성장단계는 태동기 단계에 있는 것으로 분석되었다. 따라서 기술시장 선도와 기술 경쟁력 강화를 위해 새로운 기술의 개발과 개발된 기술에 대한 실증을 병행하여 빠르게 기술을 고도화 하는 전략이 필요하다고 사료된다.

• 신재생에너지
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• 제4권1호
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• pp.19-24
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• 2008

Energy environment has been changing rapidly such as high oil prices and the effectuation of UNFCCC. Oil prices have continued to rise and Dubai crude prices recorded about 90 dollars per barrel in 2007. In addition, the effectuation of UNFCCC will affect Korean economy and national energy security. Korea is the 9th $CO_2$ emissions country and takes the 1st place related to the increase rate of $CO_2$ emissions globally. Energy technology development is a key breakthrough and one of the optimal alternatives to cope with national energy security. In this study, we prioritize energy technologies in the sectors of high oil prices and UNFCCC related to ETRM for well focus R&D and efficiency of finite resources allocations. We applied to the extended method of AHP, fuzzy AHP reflecting the fuzziness of human thoughts and perception, for prioritizing the relative importance among energy technologies in ETRM for the first time as we make an energy policy in Korea.