• 대한예방한의학회지
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• 제4권1호
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• pp.1-16
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• 2000

From 1998, Oriental Medical Physicians(OMP) is distributed in Public Health Sector. but long term plan for Oriental Medicine in Public Health is not existed. So, this study is designed for the activation of OMP Subjects in this study were comprised 3 groups of oriental medicine related persons, the group of which are Students of 11 Oriental Medical Schools, Oriental Medical Physicians in Public Health Sector, Specialist Croup of Oriental medicine Policy(total 1,458 persons). Data were collected from July 1st to November 30, 1999. Direct interview with key persons, systematic interview by using of interview protocol, e-mail and facsimile have been conducted. The results of survey were coded by Excel 5.0, and analysed with SAS 6.12 statistical package. Inter-group difference determined by T-test, and descriptive statistics have been examined. Major findings can be epitomized as follows. 1) OMP disposition to multifarious organizations and institutes such as Public Health Centers, Public Health Sub-centers, Public Hospitals, Private Hospitals in Remote-Vulnerable Area, Community Social Welfare Centers, Institutes for Heath Policy Research, etc, will promise an effective use of Oriental Medical Physician. 2) Average number of patients treated by OMP was 22.8, average budget for oriental medical department, in which OMP were affiliated, was 39.6 million Won per year. Direct cost per every patient visit was 7,210.9 Won, which is considered expensive for public health service. Therefore, development and transformation for Oriental Medical Service in Public Health Sector is desirable in economic and political aspects. 3) It is recommended that ${\ulcorner}Advisory\;Committee{\lrcorner},{\ulcorner}Planning\;Commission\;for\; Public\;Health\;in\;Oriental\;Medicine{\lrcorner}$ should be established for the activation and for the support of Oriental Medical Physician in Public Health Sector, 4) Most effective programmes for oriental public health doctor are health service programmes for the elderly, Home health visit, chronic degenerative disease control services(p<0.001). 5) Standard guideline for facilities and equipments of Oriental Medicine Department in Public Health Center is needed for optimal supply of resources and activation of public health activity.

• 생명과학회지
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• 제19권10호
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• pp.1389-1395
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• 2009

천연물 신약으로 응용 가능성이 있는 목초액을 산화응집반응과 활성탄 등을 첨가하여 증류하는 방법으로 제조하였으며, 장기보존과 가속 저장 조건에서 목초액의 이화학적 변화(pH, 비중, 굴절률 및 용해 타르), 유해물질(카르보닐기, 벤조피렌 및 잔류용매) 그리고 유기산(개미산, 초산 및 프로피온산)의 변화를 검토하여 안정성을 평가하였다. 또한, 발모 모델로서 C57BL/6 마우스를 이용하여 모발 성장 효과를 살펴보았다. 보관 기간 중에 어떤 화학 결합이 일어나거나 또는 분해반응이 반복적으로 일어나지 않았다. 또한, 유해성분이나 주성분이 일정하게 유지되었고 특히 발암물질인 벤조피렌은 검출되지 않았다. 정제된 목초액 또는 미녹시딜을 2주 동안 등에 도포한 후, 어떤 임상 증상 없이 음성 대조군인 생리식염수보다 모발 성장을 촉진하였다. 따라서 화장품이나 천연물 신약으로 응용가능성이 높은 목초액을 함유한 제품 개발 시 일정한 양으로 유지되는 주성분을 함유하면서 페놀과 같은 유해물질을 줄일 수 있는 방법이 가능할 뿐만 아니라 모발 성장 촉진 효과가 있어 탈모환자에도 유용하게 사용될 것으로 기대되어진다.

• 한국터널지하공간학회 논문집
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• 제18권5호
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• pp.419-429
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• 2016

국내 도심지 지상교통의 대규모 혼잡으로 발생되는 경제적인 손실을 해소하기 위해 지하 40 m 이상의 대심도 지하도로가 계획되고 있으며, 안전한 장대 지하도로 구축을 위해 국내 지침에 의거하여 1등급 방재시설이 적용되어야 한다. 이러한 방재시설의 일환으로 화재발생시 터널내의 화재확산 방지 및 구조물 붕괴 방지 역할을 하는 물분무 설비가 있으나, 현실적으로 많은 기능적, 기술적인 측면에서 문제점이 발생되어 개선방안이 필요한 실정이다. 국내외적으로 화재초기진압을 위한 자동모니터 소화설비가 다양한 분야에 적용되고 있으며, 최근에는 도로/철도터널분야에 적용을 위한 이론적/실험적인 연구를 통한 개발 및 상용화가 추진되고 있다. 이러한 자동화 소화설비의 우수한 화재진압성능을 바탕으로 현재 적용되고 있는 물분무 시스템에 대한 기술적/경제적 비교분석을 실시하였으며, 화재진압성능 뿐만 아니라 경제적인 측면에서도 우수하다는 분석이 도출되었다. 하지만 본 시스템의 상용화, 제품화를 위해서는 국내 터널의 특성을 반영한 다양한 연구개발이 필요하며, 본 시스템에 따른 제도적인 개선을 통하여 활성화 된다면 독자적인 원천기술개발을 통한 선진화 방재기술 강국으로 도약하기를 기대한다.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2017년도 제55차 동계학술대회논문집 25권1호
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• pp.235-238
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• 2017

This study was to develop a portable digital radiography (PDR) system with a function measuring the X-ray source-with-detector angle (SDA) and to evaluate the imaging performance for the diagnosis of chest imaging. The SDA device consisted of an Arduino, an accelerometer and gyro sensor, and a Bluetooth module. According to different angle degrees, five anatomical landmarks on chest images were assessed using a 5-point scale. Mean signal-to-noise ratio and contrast-to-noise ratio were 182.47 and 141.43. Spatial resolution (10% MTF) and entrance surface dose were 3.17 lp/mm ($157{\mu}m$) and 0.266mGy. The angle values of SDA device were not significant difference as compared to those of the digital angle meter. In chest imaging, SNR and CNR values were not significantly different according to different angle degrees (repeated-measures ANOVA, p>0.05). The visibility scores of the border of heart, 5th rib and scapula showed significant differences according to different angles (rmANOVA, p<0.05), whereas the scores of the clavicle and 1st rib were not significant. It is noticeable that the increase in SDA degree was consistent with the increase of visibility score. Our PDR with SDA device would be useful to be applicable to clinical radiography setting according to the standard radiography guideline at various fields.

• 한국발생생물학회지:발생과생식
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• 제21권2호
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• pp.121-130
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• 2017

4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both $F_0$ and $F_1$. In females, NP decreased the weight of ovary and uterus in $F_0$ but not in pre-pubertal $F_1$ pubs. Fertility of male and female in $F_0$ or $F_1$ was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both $F_0$ and $F_1$. Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in $F_0$, but significantly decreased in NP 50 group of $F_1$. The litter size and sex ratios of offspring in $F_1$ and $F_2$ were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of $F_0$ and $F_1$ but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.

• Journal of Dairy Science and Biotechnology
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• 제34권2호
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• pp.91-98
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• 2016

본 시험은 안전식품인 우유단백질에서 분리되어 영유아 식품 등에 세계적으로 사용되고 있는 GMP 내 기본적으로 7%로 결합되어 있는 지표성분인 sialic acid의 함유량이 높게 제조한 23%-GNANA를 기능성 식품 원료 개발함에 최종 연구 목표를 두었다. 시험물질은 23% sialic acid와 GMP 단백질로 구성(제품명: HELICOBACTROL-23)되어 있으며, (주)한일바이오메드사(한국)에서 공여 받아 미생물복귀돌연변이시험을 실시하였다. 미생물에 대한 돌연변이 유발성 유무를 검색하기 위해 히스티딘 요구성 균주인 Salmonella typhimurium TA98, TA100, TA1535 및 TA1537과 트립토판 요구성 균주인 Escherichia coli WP2uvrA를 이용하였다. 미생물복귀돌연변이시험은 시험물질을 5단계의 농도군(0, 61.7, 185, 556, 1,670, $5,000{\mu}g/plate$)으로 하여 평가하였다. 평가결과로서, 대사활성계 존재 유무와 관계없이 5균주 모두에서 시험물질의 각 농도에 의한 복귀돌연변이 유발원 양성기준인 콜로니 생성수치가 재현성있는 증가를 나타내지 않았으며, 용량의존성도 확인되지 않았다. 결론적으로, 시험물질인 23%-GNANA의 식품첨가물로서 등록을 위하여 수행한 미생물돌연변이시험에서 안전성이 확인되었다.

• 한국산업보건학회지
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• 제19권4호
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• pp.347-362
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• 2009

The United Nation agreed to adopt the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) until 2008 to solve the significant differences enough to result in different labels or MSDS for the same chemical in different jurisdictions. Though the GHS is an ideal solution in the respect of pursuing only one format of a MSDS throughout the world, it may cause confusion at the beginning due to lack of information. So the Korean Ministry of Labor (MOL) revised the Industrial Safety and Health Act (ISHA) and related public notice on the classification & labelling of chemicals according to the GHS in 2006. The transition period for the implementation of the GHS for substances was set until Jun 30, 2010, and for mixtures until Jun 30, 2013. To promote the implementation of the GHS in Korea, we developed an application program for constructing MSDS database and a management program for providing MSDS contents on the web in accordance with the GHS. We analyzed the sixteen sections of MSDS by the GHS guideline, and the result showed the necessity to construct logically connected DB for chemical identifier, hazard classification, label, standard phrases and regulatory information. Each section of a MSDS was divided into sub-databases to update the database efficiently. According to Relational Database Management System (RDBMS), the sub-databases were automatically assembled and subsequently a full MSDS is produced. At present, MSDS database for 6,314 substances has been built and provided through internet as the MSDS Editing program. During the service period from January 1 to March 31, 13,666 users have searched MSDSs for 33,401 substances. During program review, some comments about the classification results and other MSDS element sources were reported but no technical bug reported. We expect that the MSDS DB management system in accordance with GHS will accelerate the implementation of the GHS in Korea.

• 한국언론정보학보
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• 제84권
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• pp.7-27
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• 2017

이 논문은 지역 지상파와 케이블 지역채널의 시너지를 통한 방송 지역성의 극대화 가능성을 모색한다. 이를 위해 4차 산업혁명으로 대별되는 시대적 환경 변화 속에서 지역성 개념이 갖는 유의미성을 검토하고, 방송 지역성의 현재적 상황과 케이블 지역채널에 관한 기존 논의의 지형을 분석한다. 이를 통해 그간 이질적 유형의 사업자로 동떨어져 존재한 지역 지상파와 케이블 지역채널이 지역성 향상을 위해 유기적으로 연계할 수 있는 가능성을 탐색한다. 권역의 규모와 편성시간의 상이성은 두 매체의 시너지를 위한 최적의 조건을 구성한다. 이에 따른 쟁점으로 무료 보편적 성격이 강한 지역 지상파와 유료방송인 케이블 지역채널을 동일한 법체계로 묶는 것의 적합성과 현실성 문제를 논하며, 케이블 지역채널을 공적 범주로 제도화하는 데 있어서 가장 큰 걸림돌이 정서적 거부감에서 비롯함을 밝힌다. 이를 타개하기 위한 당면과제로 현재의 정책기조인 동일 서비스 동일 규제에 입각한 유료방송 일원화와 케이블 SO 지역사업권 폐지의 폐기, 지역채널의 해설 논평 허용, 종합유선방송사업자의 자체 역량 강화를 제시한다.

• 한국가정과교육학회지
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• 제31권2호
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• pp.67-77
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• 2019

본 연구에서는 중학생의 가족식사 및 혼밥 실태를 알아보고, 가족식사횟수에 따라 식생활 지침 실천도와 정서지능, 회복탄력성 및 폭력성에 유의적 차이가 있는지를 알아보았다. 본 연구의 목적을 달성하기 위하여 대구지역 중학생을 대상으로 자기기입식 설문조사를 통하여 수집된 241개의 자료를 분석하였다. 수집된 자료는 SPSS(v25.0)프로그램을 활용하여 빈도, 백분율, 표준편차, 신뢰도, 일원분산분석(one-way ANOVA), Duncan검증을 실행하였다. 중학생의 가족식사횟수에 따라 식생활 지침 실천도, 정서지능, 회복탄력성에 유의적 차이가 있는지 분석한 결과, 가족식사횟수가 많을수록 식생활 지침 실천도, 정서지능, 회복탄력성이 유의적으로 높게 나타났다. 본 연구 결과에 따른 제언은 다음과 같다. 첫째, 가족식사 집단은 혼밥 집단에 비해 식생활 지침실천도, 정서지능, 회복탄력성이 유의적으로 높게 나타났다(p<0.05). 이에 따라 가족식사횟수를 늘리기 위해 개인적 노력 및 사회·제도적 장치의 마련이 적극적으로 요구된다. 둘째, 2015 개정 교육과정에서 요구하는 핵심역량 중 일부는 정서지능 및 회복탄력성의 하위영역과 의미적으로 일치하고 있고, 이는 중학생의 가족식사경험이 핵심역량의 함양과도 관련이 있음을 예측할 수 있다. 즉 가족식사횟수를 늘리는 것은 교육의 시대적 흐름에 부응하는 것이고, 특히 인성교육을 위해 요구되는 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6055-6059
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• 2015

Background: Medication policy development in Thailand is continually promoting rational drug use. Letrozole, an endocrine therapy drug, is usually prescribed for post-menopausal status early and advanced stage breast cancer. After Ministry of Public Health announced Letrozole as compulsory licensed drug in 2009, more breast cancer patients can access to this drug at low cost especially those within universal coverage schemes. To ensure that Letrozole is rationally prescribed, the drug utilization study was conducted. Objectives: The aim of this study was to describe the appropriate use of Letrozole in breast cancer and the relationship between appropriate use and health benefit schemes. Materials and Methods: A retrospective study to evaluate use of Letrozole in breast cancer patients was performed for six months between January - June 2010 in seven regional cancer hospitals, Thailand. All prescriptions of Letrozole were identified from pharmacy dispensing databases and prescription papers. A medical record review was also performed to evaluate appropriate use referring to the drug use evaluation criteria. The approved criterion of this study was referred from the guideline of Thai National Formulary version 2010. Results: There were 681 prescriptions of Letrozole for 254 breast cancer patients with an average age of $58.6{\pm}10.0years$. The patients in universal coverage scheme (UCS), civil servant medication benefit scheme (CSMBS) and social security scheme (SSS) were 77.7%, 18.5% and 8.7% respectively. 10.6% were prescribed Letrozole for the first time. Letrozole were prescribed by oncologists (82.8%). The average number of tablets per prescription was $58{\pm}10$. Calcium supplements were prescribed concomitant with Letrozole for 19.4%. To assess drug use evaluation criteria, 45 prescriptions were excluded because of uncompleted clinical data, 636 prescriptions were evaluated. The study showed 86 prescriptions (13.5%) with inappropriate use including 6 (0.9%) not prescribed for estrogen receptor (ER) and/or progesterone receptor (PR) positive, 31 (4.9%) not prescribed for post-menopausal and 49 (7.7%) not prescribed for an appropriate duration. Appropriate use percentages in different health benefit schemes were similar, 85.7% of CSMBS, 86.4% of SSS and 86.7% of UCS. The relationship between health benefit scheme and appropriate use of Letrozole was not significantly different, ${\chi}^2$ (2, N = 636) = 0.081, p > 0.05. Conclusions: The study showed inappropriate use in breast cancer patients because of non-compliance with duration, menopausal status and hormone receptor requirements. To prescribe appropriate indication did not referred to the appropriate practice along the treatment. Drug use evaluation proved very useful for detecting the sign of inappropriate use and allows immediate feedback to the stakeholder for developing medication policy in the future. Importantly, there was no significantly difference in appropriate use of Letrozole across health benefit schemes.