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http://dx.doi.org/10.5352/JLS.2009.19.10.1389

Evaluation of Stability in the Purified Wood Vinegar and Its Hair Growth Effect  

Cho, Young-Ho (Department of Pharmaceutical Engineering, Konynag University)
Lee, Ju-Yeon (Department of medical Beauty, Konyang University)
Lee, Jong-Hwa (Division of Research and Development, Korea Institute of Toxicology)
Cho, Jae-Su (Department of Pharmaceutical Engineering, Konynag University)
Lee, Gye-Won (Department of Pharmaceutical Engineering, Konynag University)
Publication Information
Journal of Life Science / v.19, no.10, 2009 , pp. 1389-1395 More about this Journal
Abstract
Generally, it takes a long time to purify wood vinegar, and it contains toxic compounds such as tar, methanol, phenol and benzopyrene. To reduce the toxicity of wood vinegar itself, we have developed a new purification method of wood vinegar using an oxidation-cohesion reaction and distillation with an active carbon. We have investigated the physico-chemical change (pH, specific gravity, refractive index and dissolved tar), the change of amount of toxic compounds (carbonyl group, phenol, benzopyrene and residual solvents) and organic acids (formic acid (FA), acetic acid (AA), propionic acid (PA)) of the purified wood vinegar under the long term and accelerated storage conditions. Also, we have evaluated the effect of the purified wood vinegar on hair growth using an alopecia model of C57BL/6 mice. As a result, we could find out that the purified wood vinegar was stable and remained without decay under the storage conditions and benzopyrene, a carcinogenic agent, was not detected in the purified wood vinegar. After topical treatment of the purified wood vinegar solution or minoxidil (MXD) for 2 weeks to dorsal skin, the hair regrowth of the mice accelerated faster than that of the control, with no clinical signs. In conclusion, we could suggest a guideline for quality control of process to reduce the toxic compounds in wood vinegar and it might be a useful hair growth promoter in the treatment of baldness or alopecia.
Keywords
Stability test; wood vinegar; hair growth effect;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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