• Genomics & Informatics
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• 제19권4호
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• pp.47.1-47.12
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• 2021

Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few human oncogenic viruses, which causes a variety of malignancies, including Kaposi's sarcoma, multicentric Castleman disease, and primary effusion lymphoma, particularly in human immunodeficiency virus patients. The currently available treatment options cannot always prevent the invasion and dissemination of this virus. In recent times, siRNA-based therapeutics are gaining prominence over conventional medications as siRNA can be designed to target almost any gene of interest. The ORF57 is a crucial regulatory protein for lytic gene expression of KSHV. Disruption of this gene translation will inevitably inhibit the replication of the virus in the host cell. Therefore, the ORF57 of KSHV could be a potential target for designing siRNA-based therapeutics. Considering both sequence preferences and target site accessibility, several online tools (i-SCORE Designer, Sfold web server) had been utilized to predict the siRNA guide strand against the ORF57. Subsequently, off-target filtration (BLAST), conservancy test (fuzznuc), and thermodynamics analysis (RNAcofold, RNAalifold, and RNA Structure web server) were also performed to select the most suitable siRNA sequences. Finally, two siRNAs were identified that passed all of the filtration phases and fulfilled the thermodynamic criteria. We hope that the siRNAs predicted in this study would be helpful for the development of new effective therapeutics against KSHV.

• Journal of Korea Trade
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• 제25권4호
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• pp.108-127
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• 2021

Purpose - On the basis of knowledge transfer theory, we empirically explored how three types of human resource (HR) innovation knowledge exchange within a Chaebol drive the global subsidiary performance of the headquarters (HQ) of a Chaebol's globally affiliated companies. Design/methodology - Using a sample of 176 Korean HQ firms of the top 53 Chaebols and 1,061 of their foreign manufacturing subsidiaries (n = 1,061), we tested the relationship between the exchange of explorative and exploitative sustainable HR innovation knowledge among HQ firms of Chaebols, their subsequent transfer of technical HR knowledge via technical schemas, and the subsequent impact on the global subsidiary performance. Findings - The Chaebols' decisions about the three strategic knowledge management options (i.e., the degree of exchange of explorative and exploitative technological HR innovation knowledge and the extent of HQ-subsidiary HR knowledge transfer) have highly significant relationships with the global subsidiary performance. The results help explains the conditions under which the explorative versus exchange of exploitative sustainable HR innovation knowledge pays off by showing the moderating role of the degree of HQ-to-subsidiary technical HR knowledge transfer, at least in the case of the Chaebol as one representative type of the emerging-market business groups. Originality/value - As the first of its kind in the field of sustainable HR innovation knowledge management at the business group level, the present study makes a clear contribution in demonstrating how the performance of Chaebols' manufacturing subsidiaries depends greatly on their strategy for management of knowledge, as reflected in the choices they make about sharing both explorative and exploitative sustainable HR innovation knowledge among HQ firms and the subsequent transfer of HQ's sustainable HR innovation knowledge to the foreign subsidiaries.

• Journal of Korea Trade
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• 제24권1호
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• pp.1-34
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• 2020

Purpose - In this study, we investigate determinants of hedging with derivatives and its effect on firm value and firm risk for Korean firms. Design/methodology - To avoid the endogeneity problem pointed out in previous studies, we use a two-stage analysis by using gains and losses from derivatives as instrument variable for hedging with derivatives. Findings - Our analysis on the determinants of hedging shows that firms that are more leveraged and less profitable, and with more growth opportunities are likely to hedge through derivatives. Additionally, large firms, firms less diversified into industry, and firms more diversified geographically are likely to use derivatives. Our two-stage analysis shows that indicators of hedging with derivatives have an insignificant effect on firm value, and the indicator of futures/forwards use and of swaps use have significant negative effect on firm value. Whereas, the extent of hedging with derivatives has positive effect on firm value for all types of foreign currency derivatives, which suggests that moderately low hedgers use derivatives inefficiently, but extensive hedgers use derivatives properly. With regard to firm risk, hedging with derivatives increases market-based risk, but decreases accounting-based risk. Thus, we conclude that Korean firms use derivatives to manage operational volatility rather than to manage market risk, and accounting-based risk reduction through hedging is not directly translated into higher firm value. Originality/value - This is not the first study to investigate hedging behavior of Korean firms, but the sample period that that this study analyzed is the longest and various method are used to control the endogeneity problem. We investigate not only total foreign currency derivatives but also by types of derivatives, including futures/forwards, options, and swaps.

• Earthquakes and Structures
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• 제22권2호
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• pp.169-184
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• 2022

The importance of seismicity in developing countries and the strengthening of buildings is a topic of major importance. Therefore, the study of several solutions with the development of new technologies is of great importance to investigate the damage on retrofitted structures by using probabilistic methods. The Federal Emergency Management Agency considers three types of performance levels by considering different scenarios, intensity and duration. The selection and scaling of ground motions mainly depends on the aim of the study. Intensity-based assessments are the most common and compute the response of buildings for a specified seismic intensity. Assessments based on scenarios estimate the response of buildings to different earthquake scenarios. A risk-based assessment is considered as one of the most effective. This research represents a practical method for developing countries where exists many active faults, tall buildings and lack of good implementable approaches. Therefore, to achieve the main goal, two high-rise steel buildings have been modeled and assessed. The contribution of buckling-restrained braces in the elastic design of both buildings is firstly verified. In the nonlinear static range, both buildings presented repairable damage at the central top part and some life safety hinges at the bottom. The nonlinear incremental dynamic analysis was applied by 15 representative/scaled accelerograms to obtain levels of performance and fragility curves. The results shown that by using probabilistic methods, it is possible to estimate the probability of collapse of retrofitted buildings by buckling-restrained braces and tuned mass dampers, which are practical retrofitting options to protect existing structures against earthquakes.

• 아태비즈니스연구
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• 제12권3호
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• pp.155-173
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• 2021

Purpose - Previous research points out that South Korean perceive their happiness less than Chinese and Japanese, although the three nations belong to the same Northeast Asia cultural sphere. This study aims to find out the reasons for the relatively low perception of happiness in South Korea and develop policy options to improve the relatively low perceived happiness in South Korea. Design/methodology/approach - For the analyses, analysis of variance (ANOVA) and regression analysis were performed based on the World Values Survey data (Wave 7). Findings - First, South Korean perceived happiness less than Chinese due to 'satisfaction with the financial situation of household' and 'in-group trust'. More specifically, although there was no difference in the impact of 'satisfaction with the financial situation of household' on perceived happiness in South Korea and China, South Korean evaluated 'satisfaction with the financial situation of household' lower than Chinese. In addition, the impact of 'in-group trust' on happiness in South Korea was less than that in China, where the level of 'in-group trust' was also lower in South Korea than China. Second, South Korean perceived happiness less than Japanese due to 'in-group trust'. Although South Korean had a higher level of 'in-group trust' than Japanese, the impact of 'in-group trust' on perceived happiness was less in South Korea than Japan. The contribution of 'in-group trust' to perceived happiness, calculated with the regression coefficient of 'in-group trust' multiplied by the mean of 'in-group trust', was evaluated lower in South Korea than Japan. Research implications or Originality - This study identifies the mechanism leading to low perception of happiness in South Korea, based on the World Values Survey data.

• Journal of Periodontal and Implant Science
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• 제52권6호
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• pp.496-508
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• 2022

Purpose: This study aimed to compare the long-term survival rate and peri-implant marginal bone loss between different types of dental implant-abutment connections. Methods: Implants with external or internal abutment connections, which were fitted at Gangneung-Wonju National University Dental Hospital from November 2011 to December 2015 and followed up for >5 years, were retrospectively investigated. Cumulative survival rates were evaluated for >5 years, and peri-implant marginal bone loss was evaluated at 1- and 5-year follow-up examinations after functional loading. Results: The 8-year cumulative survival rates were 93.3% and 90.7% in the external and internal connection types, respectively (P=0.353). The mean values of marginal bone loss were 1.23 mm (external) and 0.72 mm (internal) (P<0.001) after 1 year of loading, and 1.20 mm and 1.00 mm for external and internal abutment connections, respectively (P=0.137) after 5 years. Implant length (longer, P=0.018), smoking status (heavy, P=0.001), and prosthetic type (bridge, P=0.004) were associated with significantly greater marginal bone loss, and the use of screw-cement-retained prosthesis was significantly associated (P=0.027) with less marginal bone loss. Conclusions: There was no significant difference in the cumulative survival rate between implants with external and internal abutment connections. After 1 year of loading, marginal bone loss was greater around the implants with an external abutment connection. However, no significant difference between the external and internal connection groups was found after 5 years. Both types of abutment connections are viable treatment options for the reconstruction of partially edentulous ridges.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권3호
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• pp.775-793
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• 2023

Human decision-making is a complex behavior. A replication of human decision making offers a potential to enhance the capacity of intelligent systems by providing additional user assistance in decision making. By reducing the effort and task complexity on behalf of the user, such replication would improve the overall user experience, and affect the degree of intelligence exhibited by the system. This paper explores individuals' decision-making processes when using recommender systems, and its related outcomes. In this study, human decision-making (HDM) refers to the selection of an item from a given set of options that are shown as recommendations to a user. The goal of our study was to identify IS constructs that contribute towards such decision-making, thereby contributing towards creating a mental model of HDM. This was achieved through recording Electroencephalographic (EEG) readings of subjects while they performed a decision-making activity. Readings from 16 righthanded healthy avid readers reflect that reward, theory of mind, risk, calculation, task intention, emotion, sense of touch, ambiguity and decision making are the primary constructs that users employ while deciding from a given set of recommendations in an online bookstore. In all 10 distinct brain areas were identified. These brain areas that lead to their respective constructs were found to be cingulate gyrus, precentral gyrus, inferior parietal lobule, posterior cingulate, medial frontal gyrus, anterior cingulate, postcentral gyrus, superior frontal gyrus, inferior frontal gyrus, and middle frontal gyrus (also referred to as dorsolateral prefrontal gyrus (DLPFC)). The identified constructs would help in developing a design theory for enhancing user assistance, especially in the context of recommender systems.

• 아태비즈니스연구
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• 제14권1호
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• pp.93-112
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• 2023

Purpose - Due to the outbreak and spread of COVID-19, companies have reduced their hiring needs in the short term, reducing employment opportunities for most university students and putting pressure on their employment since 2019. This study aims to improve university students' employment options and increase the possibility of entrepreneurship. Design/methodology/approach - In this study, a research survey is conducted on 4-year Chinese university students who have received entrepreneurship education courses, and statistical tests are conducted using SPSS 26.0 and PROCESS 3.3 model 1. The main focus of the study is on the effects of risk perception and five personality factors on entrepreneurial intentions of Chinese university students and the effect of entrepreneurship education on the moderation of entrepreneurial intentions. Findings - The results of the study show that the risk perception of Chinese university students have a significant effect on the will to start a business. Five personality factors have a significant effect on entrepreneurial intentions. Entrepreneurship education has a moderating role in the relationship between risk perception and entrepreneurial intention, and the entrepreneurship education support has a moderating role in the relationship between the influence of five personality factors and entrepreneurial intentions. Research implications or Originality - The results of the study reveal that Chinese university students' exposure to entrepreneurship education support positively influenced entrepreneurial intentions. Such results imply that university students gain information and knowledge related to entrepreneurship through the entrepreneurship education support, which leads to positive perceptions and motivation towards entrepreneurship.

• Clinics in Shoulder and Elbow
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• 제27권1호
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• pp.88-107
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• 2024

The aim of this systematic review was to collect evidence on the following 10 technical aspects of glenoid baseplate fixation in reverse total shoulder arthroplasty (rTSA): screw insertion angles; screw orientation; screw quantity; screw length; screw type; baseplate tilt; baseplate position; baseplate version and rotation; baseplate design; and anatomical safe zones. Five literature libraries were searched for eligible clinical, cadaver, biomechanical, virtual planning, and finite element analysis studies. Studies including patients >16 years old in which at least one of the ten abovementioned technical aspects was assessed were suitable for analysis. We excluded studies of patients with: glenoid bone loss; bony increased offset-reversed shoulder arthroplasty; rTSA with bone grafts; and augmented baseplates. Quality assessment was performed for each included study. Sixty-two studies were included, of which 41 were experimental studies (13 cadaver, 10 virtual planning, 11 biomechanical, and 7 finite element studies) and 21 were clinical studies (12 retrospective cohorts and 9 case-control studies). Overall, the quality of included studies was moderate or high. The majority of studies agreed upon the use of a divergent screw fixation pattern, fixation with four screws (to reduce micromotions), and inferior positioning in neutral or anteversion. A general consensus was not reached on the other technical aspects. Most surgical aspects of baseplate fixation can be decided without affecting fixation strength. There is not a single strategy that provides the best outcome. Therefore, guidelines should cover multiple surgical options that can achieve adequate baseplate fixation.

• 한국ITS학회 논문지
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• 제22권6호
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• pp.49-65
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• 2023

최근 전세계적으로 환경에 대한 관심이 커지고, 국제사회가 '탄소중립'을 선언하면서 '탄소'를 고려한 다양한 수단선택모형 연구가 실시되고 있으나, 탄소에 대한 개인성향을 반영한 연구는 미비한 실정이다. 따라서, 본 연구에서는 탄소저감형 이동수단(전동킥보드 등)을 포함한 대중교통 서비스로 SPT(Sustainable Public Transit)라는 새로운 수단을 제시하고, 수도권 통근자를 대상으로 실시한 SP(Stated Preference)조사를 활용하여 요인분석을 통해 응답자의 탄소에 대한 개인성향을 분석한 후, 다항로짓모형을 활용하여 SPT에 대한 수단선택모형을 구축하였다. 분석 결과, SPT 잠재선호에 영향을 미치는 요인으로 성별, 소득, 개인성향('새로운경로 탐색에 대한 열정', '수단간 환승 선호', '탄소저감지식', '탄소저감실천') 변수가 유의한 것으로 나타났다. 따라서, 본 연구는 수단선택모형 구축시 수단의 속성변수로 탄소배출량을 선정하거나, 탄소저감과 관련한 개인성향 변수를 구축했다는 부분에서 의의가 있다.