• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1322-1323
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• 2008

기존의 펨토 초 레이저를 이용하여 발생시킨 테라 헤르츠 광원의 한계를 극복하기 위하여 대용량의 가속기를 이용한 테라 헤르츠 광원의 발생에 관한 연구가 활발히 진행되고 있다. 포항방사광 가속기연구소에서도 펨토 초 테라 헤르츠 빔을 이용한 분광학적인 방법을 사용하여 단백질 접힘과 DNA-단백질 간 상호작용, 화학적, 생물학적인 반응 동력학 등에 관한 연구와 영상 기술개발 등을 할 계획을 가지고 펨토초 테라 헤르츠 빔 라인을 건설 중에 있다. 펨토 초-테라 헤르츠 빔 라인의 마이크로웨이브를 가속하는 장치에 사용되는 전원장치의 설계와 제작 및 시험과정을 외국기술에 의존하지 않고 순수 국내기술로 실현하였다. 본 논문에서는 펄스 모듈레이터의 설계와 실험결과를 보이고자 한다.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10c
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• pp.51-53
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• 1998

3개 이상의 DNA 혹은 단백질의 염기서열을 정렬하는 복수 염기서열 정렬(multiple sequence alignment)방법은 염기서열들 사이의 진화관계, gene regulation, 단백질의 구조와 기능에 관한 연구에 필수적인 도구이다. 복수 염기서열 정렬문제는 NP-complete 문제군에 속하며, 이 문제를 해결하기 위하여 가장 유용하게 사용되는 알고리즘으로는 dynamic programming이 있다. Dynamic programming은 주어진 입력 염기서열 군들에 대한 최적의 정렬을 생산할 수 있다. 그러나 dynamic programming의 단점은 오랜 실행시간이 요구되며, 때로는 dynamic programming의 속성 때문에 이 알고리즘을 사용하여도 주어진 입력 염기서열 군들에 대한 최적의 정렬을 얻어내지 못하는 경우가 있다. 본 연구에서는 이러한 dynamic programming의 문제를 해결하기 위하여 genetic algorithm을 복수 염기서열 정렬문제에 적용하였다. 본 논문에서는 genetic algorithm의 design과 적용방법을 기술하였다. 본 연구에서 제안된 genetic algorithm을 사용하여 dynamic programming의 단점이었던 오랜 실행시간을 줄일 수 있었으며, dynamic programming이 제공하지 못하는 최적의 염기서열 정렬을 제공할 수 있었다.

• Proceedings of the Korea Society of Poultry Science Conference
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• 2003.11a
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• pp.135-137
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• 2003

The analyses of relationship between specific genes and economic traits were performed on the basis of the genetic characterization of Korean native chicken in this study. Three generation reference pedigree was established from the several lines of Korean native chicken and cornish breed for the linkage analysis and many economic traits were collected for QTL(quantitative trait loci) detection. The experimental design were planed to detect QTLs of meat quality and laying performance from those two distinctive breeds.

• Current Optics and Photonics
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• v.3 no.4
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• pp.275-284
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• 2019

Chirality is ubiquitous in physics and biology from microscopic to macroscopic phenomena, such as fermionic interactions and DNA duplication. In photonics, chirality has traditionally represented differentiated optical responses for right and left circular polarizations. This definition of optical chirality in the polarization domain includes handedness-dependent phase velocities or optical absorption inside chiral media, which enable polarimetry for measuring the material concentration and circular dichroism spectroscopy for sensing biological or chemical enantiomers. Recently, the emerging field of non-Hermitian photonics, which explores exotic phenomena in gain or loss media, has provided a new viewpoint on chirality in photonics that is not restricted to the traditional polarization domain but is extended to other physical quantities such as the orbital angular momentum, propagation direction, and system parameter space. Here, we introduce recent milestones in chiral light-matter interactions in non-Hermitian photonics and show an enhanced degree of design freedom in photonic devices for spin and orbital angular momenta, directionality, and asymmetric modal conversion.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.174.1-174.1
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• 2003

We have previously reported the synthesis and cytotoxic activities of a series of azaanthraquinone derivatives using doxorubicin as a lead compound. Doxorubicin is known to intercalate into DNA and to inhibit topoisomerase II activity. But in the case of quinone compounds like Dox, its use is limited because of systemic toxicities, primarily cardiotoxicity and myelosuppression. In this study, we discuss the synthesis of isoindolobenzoquinoxaline derivatives. The quinone group of the azaanthraquinone derivatives were removed in the target compounds. (omitted)

• Design & Manufacturing
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• v.16 no.3
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• pp.34-38
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• 2022

Regular expression pattern matching is widely used in applications such as computer virus vaccine, NIDS and DNA sequencing analysis. Hardware-based pattern matching is used when high-performance processing is required due to time constraints. ReCPU, SMPU, and REMP, which are processor-based regular expression matching processors, have been proposed to solve the problem of the hardware-based method that requires resynthesis whenever a pattern is updated. However, these processor-based regular expression matching processors inefficiently handle repetitive operations of regular expressions. In this paper, we propose a new instruction set to improve the inefficient repetitive operations of ReCPU and SMPU. We propose REMPi, a regular expression matching processor that enables efficient iterative operations based on the REMP instruction set. REMPi improves the inefficient method of processing a particularly short sub-pattern as a repeat operation OR, and enables processing with a single instruction. In addition, by using a down counter and a counter stack, nested iterative operations are also efficiently processed. REMPi was described with Verilog and synthesized on Intel Stratix IV FPGA.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.11a
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• pp.713-716
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• 2007

오늘날 인간 프로젝트와 같은 종합적인 연구의 궁극적 목적을 달성하기 위해서는 이들 연구로부터 획득한 대량의 관련 데이터에 대해 새로운 현실적 의미를 부여할 수 있어야 한다. 따라서 현재의 마이크로어레이 기술을 이용해서 효과적으로 종양을 분류하기 위해서는 특정 종양 분류와 밀접하게 관련이 있는 정보력 있는 유전자를 선택하는 과정이 필수적이다. 본 논문에서는 암에 걸린 흰쥐 외피 기간 세포 분화 실험에서 얻어진 3840 유전자의 마이크로어레이 cDNA를 이용해 데이터의 정규화를 거쳐 유사성 척도 방법으로 정보력 있는 유전자들을 추출한 후, DT, NB, SVM, MLP 알고리즘을 이용하여 클래스 분류 모델을 구축하고, 성능을 비교분석하였다. 피어슨 적률 상관 계수를 이용하여 선택된 50 유전자들을 멀티퍼셉트론 분류기로 분류한 결과 94.8%의 정확도를 보여 가장 최적의 조합을 보였다.

• Nutrition Research and Practice
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• v.11 no.2
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• pp.121-129
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• 2017

BACKGROUND/OBJECTIVES: The study was conducted to evaluate the effects of dietary leucine supplementation on mitochondrial biogenesis and energy metabolism in the liver of normal birth weight (NBW) and intrauterine growth-retarded (IUGR) weanling piglets. MATERIALS/METHODS: A total of sixteen pairs of NBW and IUGR piglets from sixteen sows were selected according to their birth weight. At postnatal day 14, all piglets were weaned and fed either a control diet or a leucine-supplemented diet for 21 d. Thereafter, a $2{\times}2$ factorial experimental design was used. Each treatment consisted of eight replications with one piglet per replication. RESULTS: Compared with NBW piglets, IUGR piglets had a decreased (P < 0.05) hepatic adenosine triphosphate (ATP) content. Also, IUGR piglets exhibited reductions (P < 0.05) in the activities of hepatic mitochondrial pyruvate dehydrogenase (PDH), citrate synthase (CS), ${\alpha}$-ketoglutarate dehydrogenase (${\alpha}$-KGDH), malate dehydrogenase (MDH), and complexes I and V, along with decreases (P < 0.05) in the concentration of mitochondrial DNA (mtDNA) and the protein expression of hepatic peroxisome proliferator-activated receptor-${\gamma}$ coactivator $1{\alpha}$ (PGC-$1{\alpha}$). Dietary leucine supplementation increased (P < 0.05) the content of ATP, and the activities of CS, ${\alpha}$-KGDH, MDH, and complex V in the liver of piglets. Furthermore, compared to those fed a control diet, piglets given a leucine-supplemented diet exhibited increases (P < 0.05) in the mtDNA content and in the mRNA expressions of sirtuin 1, PGC-$1{\alpha}$, nuclear respiratory factor 1, mitochondrial transcription factor A, and ATP synthase, $H^+$ transporting, mitochondrial F1 complex, ${\beta}$ polypeptide in liver. CONCLUSIONS: Dietary leucine supplementation may exert beneficial effects on mitochondrial biogenesis and energy metabolism in NBW and IUGR weanling piglets.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.3
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• pp.202-213
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• 2020

Although technological advances have allowed the efficient collection of large amounts of microbiome data for microbiological studies, proper analysis tools for such big data are still lacking. Additionally, analyses of microbial communities using poor databases can lead to misleading results. Hence, this study aimed to design an appropriate method for the analysis of big microbial databases. Bacteria were collected from the fingertips and personal belongings (mobile phones and laptop keyboards) of individuals. The genomic DNA was extracted from these bacteria and subjected to next-generation sequencing by targeting the 16S rRNA gene. The accuracy of the bacterial matching percentage between the fingertips and personal belongings was verified using a formula and an environment-related and human-related database. To design appropriate analysis, the bacterial matching accuracy was calculated based on the following three categories: comparison between qualitative and quantitative analysis, comparisons within same-gender participants as well as all participants regardless of gender, and comparison between the use of a human-related bacterial database (hDB) and environment-related bacterial database (eDB). The results showed that qualitative analysis, comparisons within same-gender participants, and the use of hDB provided relatively accurate results. This study provides an analytical method to obtain accurate results when conducting studies involving big microbiological data using human-derived microorganisms.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.196-201
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• 2004

In biometric and biomedical applications, a special transporting mechanism must be designed for the ${\mu}$TAS (micro total analysis system) to move samples and reagents through the microchannels that connect the unit procedure components in the system. An important issue for this miniaturization and integration is microfluid management technique, i.e., microfluid transportation, metering, and mixing. In view of this, this study presents an optimal fuzzy sliding-mode control (OFSMC) design based on the 8051 microprocessor and implementation of a complete microfluidic manipulated system implementation of biochip system with a pneumatic pumping actuator, a feedback-signal photodiodes and flowmeter. The new microfluid management technique successfully improved the efficiency of molecular biology reaction by increasing the velocity of the target nucleic acid molecules, which increases the effective collision into the probe molecules as the target molecules flow back and forth. Therefore, this hybridization chip was able to increase hybridization signal 6-fold and reduce non-specific target-probe binding and background noises within 30 minutes, as compared to conventional hybridization methods, which may take from 4 hours to overnight. In addition, the new technique was also used in DNA extraction. When serum existed in the fluid, the extraction efficiency of immobilized beads with solution flowing back and forth was 88-fold higher than that of free-beads.