• Asian-Australasian Journal of Animal Sciences
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• v.26 no.10
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• pp.1437-1445
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• 2013

This study was conducted to investigate the effects of feeding increasing proportions of corn grain on concentration of lipopolysaccharide (LPS) in the rumen fluid and the subsequent alterations in immune responses as reflected by plasma concentrations of serum amyloid A (SAA) and haptoglobin (Hp) in goats. Nine goats were assigned to three diets (0%, 25%, and 50% corn grain) in a $3{\times}3$ Latin square experimental design. The results showed that as the proportion of dietary corn increased, the ruminal pH decreased (p<0.001), and the concentrations of propionate (p<0.001), butyrate (p<0.001), lactic acid (p = 0.013) and total volatile fatty acid (p = 0.031) elevated and the ruminal LPS level increased (p<0.001). As the proportion of dietary corn increased, the concentration of SAA increased (p = 0.013). LPS was detectable in the blood of individual goats fed 25% and 50% corn. A real-time PCR analysis showed that the copy number of phylum Bacteroidetes (p<0.001) was reduced ($4.61{\times}10^9$ copies/mL to $1.48{\times}10^9$ copies/mL) by the increasing dietary corn, and a correlation analysis revealed a significant negative correlation between the number of Bacteroidetes and rumen LPS levels. Collectively, these results indicated that feeding goats high proportions (50%) of corn grain decreased the ruminal pH, increased LPS in the rumen fluid and tended to stimulate an inflammatory response.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2008.04a
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• pp.288-293
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• 2008

The standard prestressed concrete I-girder bridge (PSC I-girder bridge) is one of the most prevalent types for small and medium bridges in Korea. When determining the member forces in a section to assess the safety of girder in this type of bridge, the general practice is to use the simplified practical equations or the live load distribution factors proposed in design standards rather than the precise analysis through the finite element method or so. Meanwhile, the live load distribution factors currently used in Korean design practice are just a reflection of overseas research results or design standards without alterations. Therefore, it is necessary to develop an equation of the live load distribution factors fit for the design conditions of Korea, considering the standardized section of standard PSC I-girder bridges and the design strength of concrete. In this study, to develop an equation of the live load distribution factors, a parametric analysis and sensitivity analysis were carried out on the parameters such as width of bridge, span length, girder spacing, width of traffic lane, etc. Then, an equation of live load distribution factors was developed through the multiple linear regression analysis on the results of parametric analysis. When the actual practice engineers design a bridge with the equation of live load distribution factors developed here, they will determine the design of member forces ensuring the appropriate safety rate more easily. Moreover, in the preliminary design, this model is expected to save much time for the repetitive design to improve the structural efficiency of PSC I-girder bridges.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1693-1698
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• 2015

The heterogeneous nature of lung cancer has become increasingly apparent since introduction of molecular classification. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations. In light of the tsunami of new biomarkers and targeted agents, next generation sequencing testing strategies will be more appropriate in identifying the patients for each therapy and enabling personalized patients care. The challenge now is how best to interpret the results of these genomic tests, in the context of other clinical data, to optimize treatment choices. In genomic era of cancer treatment, the traditional one-size-fits-all paradigm is being replaced with more effective, personalized oncologic care. This review provides an overview of lung cancer genomics and personalized treatment.

• Korean Journal of Human Ecology
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• v.10 no.1
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• pp.93-100
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• 2001

The purpose of this study is to investigate the fitness and its problems related in clothing fitness and to get basic data to develop fit ready-to-wear garment, total 352 subjects were surveyed during the period of November, 1998. The major results of this study were as follows ; 1. Both men and women felt fitter in upper clothes than lower clothes. As compared with women, men became more aware of proper fit except coat. 2. Men had lest fitting problems in blouse and shirts while women in coat. Also, the clothes stated which had most fitting problems were trousers by men and women. 3. A variety of fitting problems in ready-to wear garments were identified including sleeve length, skirt length, and pants length. 4. The most frequent alterations were shortening or lengthen of skirt and pants.

• Electrical & Electronic Materials
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• v.7 no.2
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• pp.123-129
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• 1994

SONOS EEPROM chips, containing several SONOSFET nonvolatile memories of various channel size, have been fabricated on the basis of the existing n-well CMOS processing technology for 1 Mbit DRAM ($1.2\mu\textrm{m}$.m design rule). All the SONOSFET memories have the triple insulated-gate consisting of 30.angs. tunneling oxide, 205.angs. nitride and 65.angs. blocking oxide. The miniaturization of the devices for the higher density EEPROM and their characteristics alterations accompanied with the scaling-down have been investigated. The stabler operating characteristics were attained by increasing the ratio of the channel width to length. Also, the transfer, switching, retention and degradation characteristics of the most favorable performance devices were presented and discussed.

• ETRI Journal
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• v.40 no.1
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• pp.133-145
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• 2018

Robustness, payload, and imperceptibility of audio watermarking algorithms are contradictory design issues with high-level security of the watermark. In this study, the major issue in achieving high payload along with adequate robustness against challenging signal-processing attacks is addressed. Moreover, a security code has been strategically used for secure transmission of data, providing tamper detection at the receiver end. The high watermark payload in this work has been achieved by using the complementary features of third-level detailed coefficients of discrete wavelet transform where the human auditory system is not sensitive to alterations in the audio signal. To counter the watermark loss under challenging attacks at high payload, Daubechies wavelets that have an orthogonal property and provide smoother frequencies have been used, which can protect the data from loss under signal-processing attacks. Experimental results indicate that the proposed algorithm has demonstrated adequate robustness against signal processing attacks at 4,884.1 bps. Among the evaluators, 87% have rated the proposed algorithm to be remarkable in terms of transparency.

• BMB Reports
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• v.50 no.7
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• pp.355-360
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• 2017

Mutations in Ras GTPase are among the most common genetic alterations in human cancers. Despite extensive research investigating Ras proteins, their functions still remain a challenge over a long period of time. The currently available data suggests that solving the outstanding issues regarding Ras could lead to development of effective drugs that could have a significant impact on cancer treatment. Developing a better understanding of their biochemical properties or modes of action, along with improvements in their pharmacologic profiles, clinical design and scheduling will enable the development of more effective therapies.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1495-1506
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• 2023

For the safe disposal of high-level radioactive waste using Engineered Barrier Systems (EBS), bentonite buffer is used by its high swelling capability and low hydraulic conductivity. When the bentonite buffer is contacted to heated pore water containing ions by radioactive decay, chemical alterations of minerals such as illitization reaction occur. Illitization of bentonite indicates the alteration of expandable smectite into non-expandable illite, which threatens the stability and integrity of EBS. This study intends to provide a thorough review on the information underlying in the illitization of bentonite, by covering basic clay mineralogy, smectite expansion, mechanisms and observation of illitization, and illitization in EBS. Since understanding of smectite illitization is crucial for securing the safety and integrity of nuclear waste disposal systems using bentonite buffer, this thorough review study is expected to provide essential and concise information for the preventive EBS design.

• Fashion & Textile Research Journal
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• v.25 no.3
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• pp.324-332
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• 2023

Consumers are addressing the issue of dimensional dissatisfaction by repairing clothes, experimenting with style changes, and looking for cost-effective solutions that result in better-fitting garments. This study investigated the repair status by type of clothing, analyzed the method and frequency of repair by type of clothing category and season, and analyzed consumer redesign activities. The findings revealed that upper garments, such as T-shirts, jumpers, jackets, dress shirts, and dresses, were frequently repaired. The common modifications to upper garments included(in order of frequency) shortening sleeve length, shortening overall length, reducing garment width, zipper repair, and adjusting sleeve width. Lower garments, such as pants, jeans, skirts, and training pants, followed in terms of repair frequency. The modifications to lower garments included(in order of frequency) shortening length, reducing width, adjusting waist width (both narrowing and widening), replacing elastic bands, zipper repair, and lengthening. Repairs were more frequently conducted in the order of autumn, winter, spring, and summer. Repair methods varied depending on the clothing type and alterations involved to the length and width of garments and the replacement or removal of old sections. Redesigning clothing as a recycling method was found to enhance the cost-effectiveness of the collection. The study further confirmed the sustainability aspect of redesigning and reusing clothing.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.06a
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• pp.63-63
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• 2009

In this work, we demonstrate 800V 4H-SiC power DMOSFETs with several structural alterations to observe static DC characteristics, such as a threshold voltage ($V_{TH}$) and a figure of merit ($V_B^2/R_{SP,ON}$). To optimize the static DC characteristics, we consider four design parameters; (a) the doping concentration ($N_{CSL}$) of current spreading layer (CSL) beneath the p-base region, (b) the thickness of p-base ($t_{BASE}$), (c) the doping concentration ($N_J$) and width ($W_J$) of a JFET region, (d) the doping concentration ($N_{EPI}$) and thickness ($t_{EPI}$) of epi-layer. Design parameters are optimized using 2D numerical simulations and the 4H-SiC DMOSFET structure results in high figure of merit ($V_B^2/R_{SP,ON}$>~$340MW/cm^2$) for a power MOSFET in $V_B{\sim}1200V$ range.