• Biomolecules & Therapeutics
• /
• v.20 no.2
• /
• pp.234-238
• /
• 2012

Propofol is an anesthetic commonly used to provide sedation or to induce and maintain an anesthetic stated. However, there are reports which indicate propofol may cause psychological dependence or be abused. In the present study, we used various behavioral tests including climbing test, jumping test, conditioned place preference, and self-administration test to assess the dependence potential and abuse liability of propofol compared to a positive control (methamphetamine) or a negative control (saline or intralipid). Among the tests, the conditioned place preference test was conducted with a biased method, and the selfadministration test was performed under a fixed ratio (FR) 1 schedule, 1 h per session. No difference was found in the climbing test and jumping test, but propofol (30 mg/kg, i.p.) increased the rewarding effect in the conditioned place preference test, and it showed a positive reinforcing effect compared to the vehicle. These results indicate that propofol tends to show psychological dependence rather than physical dependence, and it seems not to be related with dopaminergic system.

• Nuclear Engineering and Technology
• /
• v.54 no.3
• /
• pp.1071-1084
• /
• 2022

The present study aims to investigate the dynamic properties of a novel isolation system composed of separate rubber and wire isolators. The testing program comprised pure compressive, pure-shear, compressive-stress dependence, and shear-strain dependence tests that used full-scale test specimens according to ISO 22762-1. A total of 22 test specimens were fabricated and investigated. Among the tests, the pure compressive test was a destructive test that reached up to the failure stage, whereas the others were nondestructive tests before the failure stage. Similar to the pure-shear test, at each compressive-stress level in the compressive dependence test or at each shear-strain level in the shear-strain dependence test, the cyclic loading was conducted for three cycles. In the nondestructive tests, examination of the dynamic shear properties in the X-direction was independent of the Y-direction. The test results revealed that the increase in the shear strain increased the energy dissipation but decreased the damping ratio, whereas the increase in the compressive stress increased the damping ratio. In addition, a macro model was developed to simulate the load-displacement response of the isolation systems, and the prediction results were consistent with the experimental results.

• Journal of the Korean Statistical Society
• /
• v.27 no.2
• /
• pp.205-220
• /
• 1998

Dependence concepts for ordered two-way contingency tables have been of considerable interest. We consider a dependence concept which is less restrictive than likelihood ratio dependence and more restrictive than regression dependence. Maximum likelihood estimation of cell probability under this dependence restriction is studied. The likelihood ratio statistics for and against this dependence are proposed and their large sample distributions are derived. A real data is analyzed to illustrate the estimation and testing procedures.

• Communications for Statistical Applications and Methods
• /
• v.22 no.5
• /
• pp.495-506
• /
• 2015

Volatility is a variation measure in finance for returns of a financial instrument over time. GARCH models have been a popular tool to analyze volatility of financial time series data since Bollerslev (1986) and it is said that volatility is highly persistent when the sum of the estimated coefficients of the squared lagged returns and the lagged conditional variance terms in GARCH models is close to 1. Regarding persistence, numerous methods have been proposed to test if such persistency is due to volatility shifts in the market or natural fluctuation explained by stationary long-range dependence (LRD). Recently, Lee et al. (2015) proposed a residual-based cumulative sum (CUSUM) test statistic to test volatility shifts in GARCH models against LRD. We propose a bootstrap-based approach for the residual-based test and compare the sizes and powers of our bootstrap-based CUSUM test with the one in Lee et al. (2015) through simulation studies.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.17 no.2
• /
• pp.62-70
• /
• 2013

The purpose of this study is the displacement and velocity dependence evaluation of clamped shape metallic damper, which were evaluated superior in energy dissipation capacity than straight type slit damper. For this purpose, 6 metallic damper specimens are prepared and dependence test are performed. Test variables are displacement dependence and velocity dependence. According to displacement dependence test results, larger target displacement (50mm) shows lower cyclic numbers and cumulated energy dissipated area than lower target displacement (25mm). Also it shows higher strength and early failure than short target displacement. In velocity dependence evaluation, fast target velocity (60mm/sec) shows lower cyclic numbers and cumulated energy dissipated area than slow target velocity (40mm/sec). Therefore the hysteresis dependence of metallic damper were evaluated as close relation to the loading displacement and velocity conditions.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.31 no.4
• /
• pp.341-348
• /
• 2007

One of the controversial research issues on nanofluids is the temperature dependence of the thermal conductivity of nanofluids, that is, whether it will increase or decrease according to the temperature rise. To evaluate precisely the thermal conductivity behavior of nanofluids, a systematic way of validation experiments for the measuring instrument has been highly recommended. In this paper, procedure of the validation test for transient hot-wire method using the temperature dependence of the base fluids was explained comprehensively and the comparison of the temperature dependence of water-$Al_2O_3$ nanofluids is made between the present work and that of Das et al.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.1
• /
• pp.343-346
• /
• 2012

Two methods of identifying smokers with high nicotine dependence, the heaviness of smoking index (HSI) and number of cigarettes per day (CPD) were compared with the Fagerstrom test for nicotine dependence (FTND). The HSI, CPD and the FTND were administered to 316 adult Malaysian male, daily smokers aged between 25-64 years old in the Malaysian NCD Surveillance-1 Survey using a two-stage stratified random sampling of enumeration blocks and living quarters, via an interview based on a validated questionnaire. The cut-off point for classification of high nicotine dependence on the HSI was a score of four or higher, and for the heavy smoking category, smoking more than 20 cigarettes per day. Classification using each method was compared with classification by the FTND (score of six or more) as the reference standard. Sensitivity, specificity and kappa statistics for concordance between both measures and the FTND were evaluated. The HSI gave a similar prevalence rate of high nicotine dependence as the FTND. There was substantial agreement between the HSI and the FTND (kappa=0.63.), with moderate sensitivity (69.8%) and high specificity (92.5%). However, prevalence of high nicotine dependence using the CPD was 7% lower than the FTND. The heavy smoking category also showed fair agreement with the FTND (kappa=0.45) and moderate sensitivity (67.0%), but specificity was high (86.9%). The findings indicate that the HSI can be used as an alternative to the FTND in screening for high nicotine dependence among daily smokers in large population-based studies, while CPD may not be a suitable alternative to the FTND.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.18 no.5
• /
• pp.78-86
• /
• 2014

The purpose of this study is the displacement and velocity dependence evaluation of I type and S type metallic dampers. For this purpose, 12 metallic damper specimens are prepared and dependence test are performed. Test variables are strut type, displacement and velocity dependence. From the evaluation results of dependence tests, number of cycles are fully exceeded than minimum 5 cycles described in ASCE 7-10. According to displacement dependence test results, larger target displacement (50mm) shows lower cyclic numbers and cumulated energy dissipated area than lower target displacement (25mm). Also it show higher strength and early failure than short target displacement. In velocity dependence evaluation, fast target velocity (60mm/sec) shows lower cyclic numbers and cumulated energy dissipated area than target velocity (40mm/sec). As a results of basic properties, dependence evaluation and cumulated energy dissipated area evaluation, dependence capacity of S type metallic damper is far superior than I type.

• The Korean Journal of Health Service Management
• /
• v.9 no.3
• /
• pp.145-157
• /
• 2015

Objectives : This study identified factors that influenced social nicotine dependence in university students using descriptive methods. Methods : Data were collected 429 university students from 2 universities in B metropolitan city. The analytical methods were the t-test, ANOVA, Scheffe's test, Pearson's Correlation Coefficient and multiple regression analysis. Results : There were significant differences in social nicotine dependence according to gender (t=3.359, p=.001), smoking status (t=8.915, p=.000), religion (t=3.841, p=.022), economic status (t=3.632, p=.027) and grade (t=8.466, p=.000). Social nicotine dependence was weakly correlated with anxiety (r=.113, p<.05). Meaningful variables that explain social nicotine dependence were anxiety, self-efficacy self-esteem, female, smokers and no religion. Conclusions : It is necessary to develop a comprehensive smoke-free policy that considers social nicotine dependence to improve the cultural and social awareness of the associated health hazards of smoking, and to develop smoking cessation education and smoking prevention programs that improve the self-efficacy and self-esteem of university students.

• Korean Journal of Child Studies
• /
• v.14 no.1
• /
• pp.77-89
• /
• 1993

The purpose of this study was to investigate (1) children's field dependence by age and sex, (2) children's interpersonal problem solving ability by age, sex, and contextual factors, (3) children's interpersonal problem solving ability by field dependence. The subjects were 120 five-, seven-, and nine-year-olds. Children's field-dependence was measured with the Children's Embedded Figures Test (CEFT). Children's interpersonal problem solving ability was measured with the Preschool Interpersonal Problem Solving Test (PIPS Test). Statistical methods adopted for data analysis were frequencies, percentiles, means, standard deviation, t-test, oneway ANOVA. $Scheff{\acute{e}}$ test and Pearson's correlations. Major findings were that (1) The older children were more field-independent than the younger ones (2) The older children suggested more problem solving methods and higher-level problem solving strategies than the younger ones. (3) Children suggested higher-level problem solving strategies in contexts involving familiar as opposed to unfamiliar participants and contexts involving children as opposed to adults. (4) 9-year-olds' field-independence was positively associated with interpersonal problem solving ability.