Browse > Article
http://dx.doi.org/10.4062/biomolther.2012.20.2.234

Dependence Potential of Propofol: Behavioral Pharmacology in Rodents  

Cha, Hye-Jin (National Institute of Food and Drug Safety Evaluation)
Cha, Ji-Hun (National Institute of Food and Drug Safety Evaluation)
Cho, Hea-Young (Korea Food and Drug Administration)
Chung, Eun-Yong (Korea Food and Drug Administration)
Kwon, Kyoung-Jin (National Institute of Food and Drug Safety Evaluation)
Lee, Jun-Yeon (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Jeong, Ho-Sang (National Institute of Food and Drug Safety Evaluation)
Kim, Hye-Soo (Korea Food and Drug Administration)
Chung, Hye-Joo (Korea Food and Drug Administration)
Kim, Eun-Jung (National Institute of Food and Drug Safety Evaluation)
Publication Information
Biomolecules & Therapeutics / v.20, no.2, 2012 , pp. 234-238 More about this Journal
Abstract
Propofol is an anesthetic commonly used to provide sedation or to induce and maintain an anesthetic stated. However, there are reports which indicate propofol may cause psychological dependence or be abused. In the present study, we used various behavioral tests including climbing test, jumping test, conditioned place preference, and self-administration test to assess the dependence potential and abuse liability of propofol compared to a positive control (methamphetamine) or a negative control (saline or intralipid). Among the tests, the conditioned place preference test was conducted with a biased method, and the selfadministration test was performed under a fixed ratio (FR) 1 schedule, 1 h per session. No difference was found in the climbing test and jumping test, but propofol (30 mg/kg, i.p.) increased the rewarding effect in the conditioned place preference test, and it showed a positive reinforcing effect compared to the vehicle. These results indicate that propofol tends to show psychological dependence rather than physical dependence, and it seems not to be related with dopaminergic system.
Keywords
Propofol; Psychological dependence; Physical dependence; Animal behavioral test;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bardo, M. T., Rowlett, J. K. and Harris, M. J. (1995) Conditioned place preference using opiate and stimulant drugs: a meta-analysis. Neurosci. Biobehav. Rev. 19, 39-51.   DOI   ScienceOn
2 el-Kadi, A. O. and Sharif, S. I. (1994) The infl uence of various experimental conditions on the expression of naloxone-induced withdrawal symptoms in mice. Gen. Pharmacol. 25, 1505-1510.   DOI   ScienceOn
3 Gorelick, D. A., Gardner, E. L. and Xi, Z. X. (2004) Agents in development for the management of cocaine abuse. Drugs. 24, 1547-1573.
4 Iwersen-Bergmann, S., Rosner, P., Kuhnau, H. C., Junge, M. and Schmoldt, A. (2001) Death after excessive propofol abuse. Int. J. Legal. Med. 114, 248-251.   DOI   ScienceOn
5 Kest, B., Palmese, C. A., Hopkins, E., Adler, M. and Juni, A. (2001) Assessment of acute and chronic morphine dependence in male and female mice. Pharmacol. Biochem. Behav. 70, 149-156.   DOI   ScienceOn
6 Kim, D. K. (2011) Propofol use for sedation or sedation for propofol use? J. Anesth. (Epub ahead of print)
7 Kim, H. S., Jang, C. G., Oh, K. W., Oh, S., Rheu, H. M., Rhee, G. S., Seong, Y. H. and Park, W. K. (1998) Effects of ginseng total saponin on morphine-induced hyperactivity and conditioned place preference in mice. J. Ethnopharmacol. 60, 33-42.   DOI   ScienceOn
8 Koob, G. F. (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends. Pharmacol. Sci. 13, 177-184.   DOI
9 Koob, G. F. (1996) Drug addiction: the yin and yang of hedonic homeostasis. Neuron. 16, 893-896.   DOI   ScienceOn
10 Le Foll, B. and Goldberg, S. R. (2005) Nicotine induces conditioned place preferences over a large range of doses in rats. Psychopharmacology (Berl). 178, 481-492.   DOI
11 LeSage, M. G., Stafford, D. and Glowa, J. R. (2000) Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fi xed-ratio schedules of drug delivery. Psychopharmacology (Berl). 153, 148-154.   DOI
12 Mucha, R. F., van der Kooy, D., O'Shaughnessy, M. and Bucenieks, P. (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res. 243, 91-105.   DOI   ScienceOn
13 Narita, M., Akai, H., Nagumo, Y., Sunagawa, N., Hasebe, K., Nagase, H., Kita, T., Hara, C. and Suzuki, T. (2004) Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats. Neuroscience 127, 941-948.   DOI   ScienceOn
14 Nguyen, H. T., Li, K. Y., daGraca, R. L., Delphin, E., Xiong, M. and Ye, J. H. (2009) Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. Anesthesiology 110, 326-332.
15 Pain, L., Gobaille, S., Schleef, C., Aunis, D. and Oberling, P. (2002) In vivo dopamine measurements in the nucleus accumbens after nonanesthetic and anesthetic doses of propofol in rats. Anesth. Analg. 95, 915-919.
16 Roussin, A., Montastruc, J. L. and Lapeyre-Mestre, M. (2007) Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature. Fundam. Clin. Pharmacol. 21, 459-466.   DOI   ScienceOn
17 Pain, L., Oberling, P., Sandner, G. and Di Scala, G. (1996) Effect of propofol on affective state as assessed by place conditioning paradigm in rats. Anesthesiology 85, 121-128.   DOI   ScienceOn
18 Picetti, R., Caccavo, J. A., Ho, A. and Kreek, M. J. (2011) Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats. Psychopharmacology (Berl). (Epub ahead of print)
19 Ritzmann, R. F. (1981) Opiate dependence following acute injections of morphine and naloxone: the assessment of various withdrawal signs. Pharmacol. Biochem. Behav. 14, 575-577.   DOI   ScienceOn
20 Saelens, J. K., Granat, F. R. and Sawyer, W. K. (1971) The mouse jumping test--a simple screening method to estimate the physical dependence capacity of analgesics. Arch. Int. Pharmacodyn. Ther. 190, 213-218.
21 Smits, S. E. (1975) Quantitation of physical dependence in mice by naloxone-precipitated jumping after a single dose of morphine. Res. Commun. Chem. Pathol. Pharmacol. 10, 651-661.
22 Sneyd, J. R. (1994) Propofol at a subanesthetic dose may have abuse potential in healthy volunteers. Anesth. Analg. 78, 1032-1033.   DOI   ScienceOn
23 Ward, A. S., Li, D. H., Luedtke, R. R. and Emmett-Oglesby, M. W. (1996) Variations in cocaine self-administration by inbred rat strains under a progressive-ratio schedule. Psychopharmacology (Berl). 127, 204-212.   DOI
24 Way, E. L., Loh, H. H. and Shen, F. H. (1969) Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167, 1-8.
25 Wischmeyer, P. E., Johnson, B. R., Wilson, J. E., Dingmann, C., Bachman, H. M., Roller, E., Tran, Z. V. and Henthorn, T. K. (2007) A survey of propofol abuse in academic anesthesia programs. Anesth. Analg. 105, 1066-1071.   DOI   ScienceOn
26 Weeks, J. R. (1972). Long term intraveneous infusion. (R. D. Myers, Ed.), pp. 155-168. Academic Press, New York.
27 Weerts, E. M., Ator, N. A. and Griffi ths, R. R. (1999) Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons. Drug. Alcohol. Depend. 57, 51-60.   DOI   ScienceOn
28 Wilson, C., Canning, P. and Caravati, E. M. (2010) The abuse potential of propofol. Clin. Toxicol (Phila). 48, 165-170.   DOI   ScienceOn