Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Dependence Potential of Propofol: Behavioral Pharmacology in Rodents

  • Cha, Hye-Jin (National Institute of Food and Drug Safety Evaluation) ;
  • Cha, Ji-Hun (National Institute of Food and Drug Safety Evaluation) ;
  • Cho, Hea-Young (Korea Food and Drug Administration) ;
  • Chung, Eun-Yong (Korea Food and Drug Administration) ;
  • Kwon, Kyoung-Jin (National Institute of Food and Drug Safety Evaluation) ;
  • Lee, Jun-Yeon (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Jeong, Ho-Sang (National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Hye-Soo (Korea Food and Drug Administration) ;
  • Chung, Hye-Joo (Korea Food and Drug Administration) ;
  • Kim, Eun-Jung (National Institute of Food and Drug Safety Evaluation)
  • Received : 2011.07.19
  • Accepted : 2012.02.07
  • Published : 2012.03.31
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Abstract

Propofol is an anesthetic commonly used to provide sedation or to induce and maintain an anesthetic stated. However, there are reports which indicate propofol may cause psychological dependence or be abused. In the present study, we used various behavioral tests including climbing test, jumping test, conditioned place preference, and self-administration test to assess the dependence potential and abuse liability of propofol compared to a positive control (methamphetamine) or a negative control (saline or intralipid). Among the tests, the conditioned place preference test was conducted with a biased method, and the selfadministration test was performed under a fixed ratio (FR) 1 schedule, 1 h per session. No difference was found in the climbing test and jumping test, but propofol (30 mg/kg, i.p.) increased the rewarding effect in the conditioned place preference test, and it showed a positive reinforcing effect compared to the vehicle. These results indicate that propofol tends to show psychological dependence rather than physical dependence, and it seems not to be related with dopaminergic system.

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References

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