• Macromolecular Research
• /
• v.16 no.8
• /
• pp.682-685
• /
• 2008

The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at $4^{\circ}C$ and at $37^{\circ}C$ were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.

• Journal of Oral Medicine and Pain
• /
• v.37 no.2
• /
• pp.113-123
• /
• 2012

To evaluate the treatment outcome of occlusal stabilizing splint in patients with TMJ osteoarthritis, the 76 subjects were chosen among the patients who presented to the Department of Oral medicine of Pusan National University Hospital, diagnosed as TMJ osteoarthritis by cone beam computed tomography, x-ray and clinical exam, and treated with occlusal stabilizing splint from 2009 to 2011. They were treated with physical therapy and medication before occlusal stabilizing splint delivery and checked monthly after occlusal stabilizing splint delivery. Subjective symptoms and clinical findings were investigated to evaluate and compare the subjects' status at the first visit, splint delivery visit and the last visit. The results were as follows; 1. Pain, noise, LOM and MCO were significantly improved between the first visit and occlusal stabilizing splint delivery visit, and between occlusal stabilizing splint delivery and the last visit. 2. In the acute group, pain and noise were significantly improved between the first visit and occlusal stabilizing splint delivery visit. Pain, LOM and MCO were significantly improved between splint delivery visit and the last visit 3. In the chronic group, pain, noise and LOM were significantly improved between occlusal stabilizing splint delivery visit and the last visit.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.6 no.4
• /
• pp.212-230
• /
• 2001

Recent advances in recombinant DNA technology have resulted in development of many new protein drugs. Due to the unique properties of protein druges, they have to be delivered by parenteral injection Although delivery of protein drugs by other routes, such as pulmonary and nasal routes, has shown some promises, to date most protein drugs are administered by par-enteral routs. For long-term delivery of protein drugs by parenteral administration, they have been formulated into biodegradable microspheres. A number of microencapsulation methods have been developed, and the currently used microencapsulation methods are reviewed here, The microen-capsulation methods have been divided based on the method used. They are: solvent evapora-tion/extraction; phase separation (coacervation);spray drying; ionotropic gelation/polyelectrolyte complexation; interfacial polyumerization and supercritical fluid precipitation. Each method is de-scribed fro its applications, advantages, and limitations.

• Journal of Biomedical Engineering Research
• /
• v.7 no.2
• /
• pp.109-110
• /
• 1986

Polymers are widely applied in bioseparation processes as well as in drug delivery systems. These two fields have a certain commonality, in that they involve either removal or delivery of specific biomolecules from or to an aqueous environment It is also to be noted that therapeutic toxin renloval is an example of a bioseparation process. This presentation will focus on the use of polys!ors in physical as well as biospecific separations and delivery of biomolecules. Several new systems will also be described.

• Journal of the Korea Safety Management & Science
• /
• v.16 no.2
• /
• pp.131-138
• /
• 2014

Auto part industry supplies production for auto manufacturer and after market. These company have inventory for delivery. High inventory level can be good for delivery, but cost will be increase. Low inventory level can be customer unsatisfaction for delivery late. Low inventory level also is reason of low productivity by decreasing product batch size. These article suggest model for calculation a proper inventory level and prove a effect by simulation of some company.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2016.04a
• /
• pp.168-170
• /
• 2016

Drone package delivery routing problem is realistic problem used to find efficient route of drone package delivery service. In this paper, we present an approach for solving drone routing problem for package delivery service using two different heuristics algorithms, genetic and nearest neighbor. We implement and analyze both heuristics algorithms for solving the problem efficiently with respect to cost and time. The respective experimental results show that for the range of customers 10 to 50 nearest neighbor and genetic algorithms can reduce the tour length on average by 34% and 40% respectively comparing to FIFO algorithm.

• The Korean Journal of Applied Statistics
• /
• v.28 no.5
• /
• pp.977-990
• /
• 2015

Food delivery services are well developed in the Republic of Korea, The increase of one person households and the success of app applications influence delivery services these days. We consider a prediction model for the food delivery service based on weather and dates to predict the number of food delivery services in 2014 using various data mining techniques. We use linear regression, random forest, gradient boosting, support vector machines, neural networks, and logistic regression to find the best prediction model. There are four categories of food delivery services and we consider two methods. For the first method, we estimate the total number of delivery services and the posterior probabilities of each delivery service. For the second method, we use different models for each category and combine them to estimate the total number of delivery services. The neural network and linear regression model perform best in the first method, this is followed by the neural network which is the best for the second method. The result shows that we can estimate the number of deliveries accurately based on dates and weather information.

• 대한예방의학회:학술대회논문집
• /
• 2001.10a
• /
• pp.210-211
• /
• 2001

• Perinatology
• /
• v.29 no.4
• /
• pp.159-164
• /
• 2018

Objective: To compare neonatal respiratory morbidity of twins according to birth order related to gestational age and mode of delivery. Methods: We performed the retrospective research of the medical records of 3,224 neonates (1,612 twin pairs) born in a single center from January 2011 to December 2015. Subjects were classified into four gestational age groups: very (<32 weeks), moderate (32-33 weeks), late (34-36 weeks) preterm, and term (${\geq}37weeks$) groups. We investigated clinical characteristics and respiratory morbidity according to birth order related to gestational age group and mode of delivery. Results: We found increased risk of respiratory morbidity in second-born twin than first-born twin (P=0.039). Second-born twin was associated with increased risk of respiratory distress syndrome (RDS) in late preterm group (odds ratio [OR] 2.8, 95% confidence interval [CI] 1.30-5.95), and transient tachypnea of newborn in term group (OR 1.4, 95% CI 1.03-1.81). In vaginal delivery mode, there was no difference of respiratory morbidity between first and second-born twin in each group, but in cases of Cesarean delivery, second-born twin was related with a greater risk of RDS in late preterm group (OR 2.3, 95% CI 1.07-5.09). Birth order and Cesarean section independently increased the risk of RDS (adjusted OR [aOR] 1.69, 95% CI 1.12-2.54; aOR 2.14, 95% CI 1.25-3.66, respectively). Conclusion: Second-born twin and Cesarean delivery are associated with increased risk of RDS, especially in late preterm twins.

• Journal of Microbiology and Biotechnology
• /
• v.20 no.4
• /
• pp.821-827
• /
• 2010

Gene delivery that provides targeted delivery of therapeutic genes to the cells of a lesion enhances therapeutic efficacy and reduces toxic side effects. This process is especially important in cancer therapy when it is advantageous to avoid unwanted damage to healthy normal cells. Incorporating cancer-specific ligands that recognize receptors overexpressed on cancer cells can increase selective binding and uptake and, as a result, increase targeted transgene expression. In this study, we investigated whether a peptide capable of homing to hepatocellular carcinoma (HCC) could facilitate targeted gene delivery by cationic liposomes. This homing peptide (HBP) exhibited selective binding to a human hepatocarcinoma cell line, HepG2, at a concentration ranging from 5 to 5,000 nM. When conjugated to a cationic liposome, HBP substantially increased cellular internalization of plasmid DNA to increase the transgene expression in HepG2 cells. In addition, there was no significant enhancement in gene transfer detected for other human cell lines tested, including THLE-3, AD293, and MCF-7 cells. Therefore, we demonstrate that HBP provides targeted gene delivery to HCC by cationic liposomes.