Browse > Article

Temperature-Induced Release of All-trans-Retinoic Acid Loaded in Solid Lipid Nanoparticles for Topical Delivery  

Lee, Chang-Moon (Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Chonbuk National University Medical School)
Jeong, Hwan-Jeong (Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Chonbuk National University Medical School)
Park, Ji-Won (Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University)
Kim, Jin (Department of Advanced Chemicals, Chonnam National University)
Lee, Ki-Young (Faculty of Chemical Engineering, Chonnam National University)
Publication Information
Macromolecular Research / v.16, no.8, 2008 , pp. 682-685 More about this Journal
Abstract
The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at $4^{\circ}C$ and at $37^{\circ}C$ were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.
Keywords
all-trans-retinoic acid; coconut oil; curdlan; solid lipid nanoparticle; topical delivery;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
Times Cited By SCOPUS : 11
연도 인용수 순위
1 S. J. Seo, H. S. Moon, D. D. Guo, S. H. Kim, T. Akaike, and C. S. Cho, Mater. Sci. Eng. C, 26, 136 (2006)   DOI
2 Y. Yamaguchi, T. Nagasawa, N. Nakmura, M. Takenaga, M. Mizoguchi, S. I. Kawai, Y. Mizushima, and R. Igarashi, J. Control. Release, 104, 29 (2005)   DOI   ScienceOn
3 S. C. Han, Y. Z. Kim, K. Y. Lee, and D. W. Kim, Korean J. Biotechnol. Bioeng., 19, 178 (2004)
4 K. A. Shah, A. A. Date, M. D. Joshi, and V. B. Patravale, Int. J. Pharm., 345, 163 (2007)   DOI
5 M. Brisaert and J. A. Plaizier-Vercammen, Int. J. Pharm., 334, 56 (2007)   DOI
6 S. R. Hwang, S. J. Lim, J. S. Park, and C. K. Kim, Int. J. Pharm., 276, 175 (2004)   DOI
7 J. S. Park, Y. S. Koh, J. Y. Bang, Y. I. Jeong, and J. J. Lee, J. Pharm. Sci., 97, Articles online in advance of print (2008)
8 A. M. Klingman, G. L. Grove, R. Hirose, and J. J. Leyden, J. Am. Acad. Dermatol., 15, 836 (1986)   DOI   ScienceOn
9 W. Mehnert and K. Mader, Adv. Drug Deliv. Rev., 47, 165 (2001)   DOI
10 D. G. Kim, C. Choi, Y. I. Jeong, M. K. Jang, J. W. Nah, S. K. Kang, and M. S. Bang, Macromol. Res., 14, 66 (2006)   과학기술학회마을   DOI
11 B. D. Kim, G. Na, and H. K. Choi, Eurp. J. Pharm. Sci., 24, 199 (2005)   DOI   ScienceOn
12 H. Chen, X. Chang, D. Du, W. Liu, J. Liu, T. Weng, Y. Yang, H. Xu, and X. Yang, J. Control. Release, 110, 296 (2006)   DOI   ScienceOn
13 P. A. Lehman, J. T. John, and T. J. Franz, J. Invest. Dermatol., 91, 56 (1990)
14 J. Liu, W. Hu, H. Chen, Q. Ni, H. Xu, and X. Yang, Int. J. Pharm., 328, 191 (2007)   DOI   ScienceOn
15 V. C. Njar, L. Gediya, P. Purushottanmachar, P. Chopra, T. S. Vasaitis, A. Khandelwal, J. Mehta, C. Huynh, A. Belosay, and J. Patel, Bioorg. Med. Chem., 14, 4323 (2006)   DOI   ScienceOn
16 Y. I. Jeong, S. H. Kim, T. Y. Jung, I. Y. Kim, S. S. Kang, Y. H. Jin, H. H. Ryu, H. S. Sun, S. Jin, K. K. Kim, K. Y. Ahn, and S. Jung, J. Pharm. Sci., 95, 2348 (2006)   DOI   ScienceOn
17 K. Na, K. H. Park, S. W. Kim, and Y. H. Bae, J. Control. Release, 69, 225 (2000)   DOI   ScienceOn