Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
권호 표지

Temperature-Induced Release of All-trans-Retinoic Acid Loaded in Solid Lipid Nanoparticles for Topical Delivery

  • Lee, Chang-Moon (Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Jeong, Hwan-Jeong (Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Park, Ji-Won (Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University) ;
  • Kim, Jin (Department of Advanced Chemicals, Chonnam National University) ;
  • Lee, Ki-Young (Faculty of Chemical Engineering, Chonnam National University)
  • Published : 2008.12.31
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Abstract

The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at $4^{\circ}C$ and at $37^{\circ}C$ were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.

Keywords

References

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