• Journal of Veterinary Science
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• v.21 no.3
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• pp.42.1-42.22
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• 2020

Regenerative medicine using stem cells from various sources are emerging treatment modality in several refractory diseases in veterinary medicine. It is well-known that stem cells can differentiate into specific cell types, self-renew, and regenerate. In addition, the unique immunomodulatory effects of stem cells have made stem cell transplantation a promising option for treating a wide range of disease and injuries. Recently, the medical demands for companion animals have been rapidly increasing, and certain disease conditions require alternative treatment options. In this review, we focused on stem cell application research in companion animals including experimental models, case reports and clinical trials in dogs and cats. The clinical studies and therapeutic protocols were categorized, evaluated and summarized according to the organ systems involved. The results indicate that evidence for the effectiveness of cell-based treatment in specific diseases or organ systems is not yet conclusive. Nonetheless, stem cell therapy may be a realistic treatment option in the near future, therefore, considerable efforts are needed to find optimized cell sources, cell numbers and delivery methods in order to standardize treatment methods and evaluation processes.

• International Journal of Computer Science & Network Security
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• v.22 no.3
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• pp.163-172
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• 2022

The interconnection of an enormous number of devices into the Internet at a massive scale is a consequence of the Internet of Things (IoT). As a result, tasks offloading from these IoT devices to remote cloud data centers become expensive and inefficient as their number and amount of its emitted data increase exponentially. It is also a challenge to optimize IoT device energy consumption while meeting its application time deadline and data delivery constraints. Consequently, Fog Computing was proposed to support efficient IoT tasks processing as it has a feature of lower service delay, being adjacent to IoT nodes. However, cloud task offloading is still performed frequently as Fog computing has less resources compared to remote cloud. Thus, optimized schemes are required to correctly characterize and distribute IoT devices tasks offloading in a hybrid IoT, Fog, and cloud paradigm. In this paper, we present a detailed survey and classification of of recently published research articles that address the energy efficiency of task offloading schemes in IoT-Fog-Cloud paradigm. Moreover, we also developed a taxonomy for the classification of these schemes and provided a comparative study of different schemes: by identifying achieved advantage and disadvantage of each scheme, as well its related drawbacks and limitations. Moreover, we also state open research issues in the development of energy efficient, scalable, optimized task offloading schemes for Fog computing.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.12
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• pp.4385-4399
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• 2021

The Internet of Things (IoT) eHealth systems composed by Wireless Body Area Network (WBAN) has emerged recently. Sensor nodes are placed around or in the human body to collect physiological data. WBAN has many different applications, for instance health monitoring. Since the limitation of the size of the battery, besides speed, reliability, and accuracy; design of WBAN protocols should consider the energy efficiency and time delay. To solve these problems, this paper adopt the end-edge-cloud orchestrated network architecture and propose a transmission based on reinforcement algorithm. The priority of sensing data is classified according to certain application. System utility function is modeled according to the channel factors, the energy utility, and successful transmission conditions. The optimization problem is mapped to Q-learning model. Following this online power control protocol, the energy level of both the senor to coordinator, and coordinator to edge server can be modified according to the current channel condition. The network performance is evaluated by simulation. The results show that the proposed power control protocol has higher system energy efficiency, delivery ratio, and throughput.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.45 no.4
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• pp.240-246
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• 2022

This paper introduces a container loading problem and proposes a theoretical approach that efficiently solves it. The problem is to determine a proper weight of products loaded on a container that is delivered by third party logistics (3PL) providers. When the company pre-loads products into a container, typically one or two days in advance of its delivery date, various truck weights of 3PL providers and unpredictability of the randomness make it difficult for the company to meet the total weight regulation. Such a randomness is mainly due to physical difference of trucks, fuel level, and personalized equipment/belongings, etc. This paper provides a theoretical methodology that uses historical shipping data to deal with the randomness. The problem is formulated as a stochastic optimization where the truck randomness is reflected by a theoretical distribution. The data analytics solution of the problem is derived, which can be easily applied in practice. Experiments using practical data reveal that the suggested approach results in a significant cost reduction, compared to a simple average heuristic method. This study provides new aspects of the container loading problem and the efficient solving approach, which can be widely applied in diverse industries using 3PL providers.

• Journal of Pharmacopuncture
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• v.25 no.4
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• pp.317-325
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• 2022

Polymers are the major constructive material of pharmaceutical formulations that play a prime role in designing effective drug-delivery systems and releasing drugs at their sites of application. Polymers are composed of multiple repeating units of high molecular mass components with attendant properties. Most synthetic polymers are non-biocompatible, expensive, and extremely inclined to deliver adverse impacts. Meanwhile, edible polymers obtained from natural sources have gained remarkable recognition for their promising use in modern medicine. Moreover, polymers derived from natural sources are generally preferred due to certain of their unique features such as abundant availability, biocompatibility, nontoxicity, economical, safe, and effective functions that fit the purpose. Polysaccharides including starch, cellulose, hemicellulose, pectin, and mucilage are identified as a major class of naturally obtained molecules that have a substantial role as functional polymers. This review summarizes the potential role of polysaccharides derived from vegetable sources such as adhesives, anticaking agents, binders, disintegrants, emulsifiers, film-framing agents, and thickeners. This is simply an opportunity to abandon synthetic excipients that hurt our bodies and think back to nature from where we originate.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.1154-1161
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• 2022

Building Information Modelling (BIM) has evolved into a comprehensive, collaborative method in construction project delivery. Most industrialized and developed countries have made BIM mandatory in the government and public projects, whereas developing countries are embracing and catching up BIM technologies to improve their professional's abilities and reduce claims in the construction projects. However, BIM awareness and professional's competence have become critical in implementing BIM in infrastructure projects in Nepal, particularly hydropower projects. The objectives of this study are to find the BIM awareness among hydropower professionals in Nepal and assess their response. The study used a questionnaire survey to assess the awareness. The results showed that only few professionals (12 percentage in this study) are aware of BIM and its application in Hydropower infrastructures. Majority of the respondents (more than 50%) were interested in BIM trainings and believed BIM implementation in future projects. The study indicated that lack of BIM training and lack of BIM awareness were the top factors affecting BIM implementation in hydropower projects in Nepal. The findings showed that about 66 percent of the respondents who used BIM in their projects mainly used during construction phase. More than 80 percent believed that BIM should be mandated for the hydropower projects in Nepal. The findings presented in this study could promote awareness among different professionals, organization, and construction team and encourage BIM implementation in Hydropower projects. The findings could raise awareness of BIM in Nepal's infrastructure sectors and its invaluable benefits in construction.

• Safety and Health at Work
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• v.14 no.1
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• pp.10-16
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• 2023

Whilst Ecological momentary assessment (EMA) can provide important insights over time and across contexts among rotation workers whose work periods alternate with leave at home, it can also be challenging to implement in the resources and construction sectors. This review aimed to provide a summary of the methodological characteristics of EMA studies assessing health outcomes and related behaviors in rotation workers. Systematic searches in PubMed, Medline, EMBASE, CINAHL, PsycINFO, and Scopus were done to include 23 studies using EMA methods in assessing health-related outcomes and behaviors. EMA designs included daily diary: assessments once per day typically fixed at the end of day (47.8%), within day fixed interval time-based design: assessments on multiple times per day at certain times of day (17.4%) and combination of both designs (34.8%). Studies employed paper and pencil diaries (73.9%) and one or more electronic methods (60.9%): wrist-worn actigraphy device (52.2%) and online-based diaries (26.1%) for data collection. Most of the studies (91.3%) did not report prompting -EMAs by schedule alerts or compliance. Daily diary and within day fixed interval dairies designs are common, with the increasing use of electronic EMA delivery techniques. It is unclear how well participants adhere to assessment schedules, as these are inadequately reported. Researchers should report compliance-related information.

• Advances in nano research
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• v.14 no.6
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• pp.591-602
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• 2023

In the present study, capability of nanobiotics in repairing tendon injuries commonly occur in Taekwondo sport is investigated and some approaches are proposed. In this regard, a brief review on the types and application of nanobiotics is presented. Their capabilities and limitation are discussed. Next, different type of tendon injuries in Taekwondo athletes are discussed along with their treatment approaches. Based on the presented data, a nano-scale feasible robot model carrying nanobiotics is proposed for repairing tendons. Finite element simulations is also conducted to show the effectiveness of the repairing process using nanorobots equipped with nanobiotics. This repairing procedure is a combination of mechanical and chemical treatments. The results indicated that using nanobiotics on nanorobots arms in the repair of tendon injuries has many benefits. First, drug delivery is directly injected to the target section. Second, Due to the nanorobots small sizes more acute treatment is possible. Finally, since the control of the nanorobots are assisted with computers, the possibility of human error reduces significantly. The proposed method of the present study could be utilized by other scientists and technological industry in developing final nanorobots with nanobiotics carrying capacity.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.03a
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• pp.837-841
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• 2008

Propulsion of gene coated micro-particles is desired for non-intrusive drug delivery inside biological tissue. This has been achieved by the development of a device that uses high power laser pulses. The present paper looks at the mechanisms of micro-particle acceleration. Initially, a high power laser pulse is focused onto the front side of a thin aluminium foil leading to its ablation. The ablation front drives a compression wave inside the foil, thus leading to the formation of a shock wave, which will later reflect from the rear side of the foil, due to acoustic impedance mismatch. The reflected wave will induce an opposite motion of the foil, characterized by a very high speed, of the order of several millimeters per microsecond. Micro-particles, which are deposited on the rear side of the foil, thus get accelerated and ejected as micro-projectiles and are able to penetrate several hundreds of micrometers inside tissue-like material. These processes have been observed experimentally by using high-speed shadowgraphy and considered analytically.

• Educational Technology International
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• v.6 no.1
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• pp.103-119
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• 2005

This study investigated to designand implement web-based collaborative learning system Co-Net and map out students' learning procedure using the system, based upon Student Team Achievement Division (STAD Slavin, 1990, 1996). There are technical process and instructional considerations to be made during the design process. The former are those that concern equipment requirements and specifications and include Ease of Use, Speed of Access, and Flexibility. On the other hand, instructional considerationsare concerned with the delivery and access of instructional materials and their outcomes on learners. They are cooperative interactions within groups and group heterogeneity, learner control, group incentives, individual accountability, equal opportunity for earning high scores and contributing to group effort, task specialization, and competition among groups. A web site for a virtual learning environment designed and built by the authors and known as Co-Net is then explained along with the whole process learners inside the environment. The main page of Co-Net consists of 15 menus to implement cooperative learning process. The cooperative learning activities using 15 menus are composed of six phases (1) preparation of the new knowledge (2) presentation of the new knowledge (3) knowledge assimilation and application (4) team and individual evaluation (5) team and individual recognition Throughout the five phases, the appropriate use of cooperative learning techniques has been shown to have both academic and social benefits to learners.