• Archives of Plastic Surgery
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• 제48권5호
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• pp.549-552
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• 2021

Clinical applications of stromal cells obtained mechanically from adipose tissue are quite popular methods. However, generally accepted protocols still do not exist. In this study, three new delivery methods using different protocols are presented as innovative methods in accordance with an approach called "Indication-based protocols." In mechanical methods, before cutting the fat tissue with ultra-sharp blades, which we define as "Adinizing," mixing it with different liquids such as saline or plasma provides the stromal cells in liquid form with high number and viability as a final product. At the same time, since stromal cells and extracellular matrix are preserved by mechanical methods, it was deemed appropriate to use the term total stromal cells (TOST) instead of stromal vascular fraction for this final product, unlike the product obtained with the enzyme. TOST can be combined with plasma and used for dermal filling in "solid" form. In addition to this filling effect, it will also cause a change in the tissue regeneratively. Finally, the stromal cells obtained from liquid can be applied clinically in aerosol form with the help of nebulizer. We believe that three innovative delivery methods can be used successfully in the treatment of many clinical situations in the future.

• 무역학회지
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• 제47권3호
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• pp.177-190
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• 2022

This study is designed to identify the differences in the types and importance of trade claims at the national level. For analysis data, abstracts of arbitration and court judgments published on the website of the United Nations Commission on International Trade Law are collected and used. The target countries are China and the United States, with 102 cases from China and 59 cases from the United States. By applying topic modeling techniques to the collection decisions of China and the United States, trade claims are categorized, and the importance of each type is identified using the network centrality index derived through semantic network analysis. The analysis results are as follows. First, the main types of trade claims were the same for both the United States and China: product nonconformity, delivery issues, and payments. However, in China, the order of product nonconformity > delivery issues > payments was important, and in the United States, payments > product nonconformity > delivery issues were found to be important. This study is significant in that it presents a strategic trade claim management plan using a quantitative methodology.

• 산업융합연구
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• 제16권1호
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• pp.15-20
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• 2018

인터넷 쇼핑의 증가와 함께 운송장에 적힌 배송정보를 악용한 범죄가 보이스피싱을 통한 물품 가로채기, 상해, 성범죄에 이르기까지 갈수록 고도화 세분화 되고 있다. 따라서 고객의 배송정보에 대한 익명성을 보장하기 위해서 다수 운송업자 상호간에 제품의 배송 구간에 대한 경로 정보를 비밀로 유지하는 배송추적 방지 시스템이 필요하다. 이를 위해서 인터넷 쇼핑의 대금결제와 개인정보의 연계 분리는 블록체인기반 암호화폐의 익명성 기술을 사용하여 보호하고 운송정보에 포함되는 배송정보를 암호화해서 익명성을 보호하는 배송추적 방지 모델 제안한다. 우리의 제안 모델은 고객의 배송정보에 대한 익명성을 보장함과 동시에 기업에게 고객의 배송정보를 제외한 제품판매에 대한 정보를 동시에 제공함으로서 블록체인 기반 인터넷 쇼핑의 활성화에 기여한다.

• 한국경영과학회지
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• 제31권4호
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• pp.35-47
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• 2006

This paper considers an integrated scheduling problem for consecutive production and delivery stages in a two-stage supply chain. The Production is performed on a single facility and then the finished products are delivered to the customer by capacitated multiple vehicles. The objective of this paper is to obtain job sequencing and delivery batching minimizing the total cost of the associated WIP inventory, finished product inventory and delivery. The inventory cost is characterized by the sum of weighted flowtime. The delivery cost is proportional to the required number of delivery batches. Some polynomial-solvable cases are derived. For the general case, two efficient heuristic algorithms are suggested, and then the heuristics are tested through some numerical experiments.

• 대한산업공학회지
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• 제37권4호
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• pp.331-341
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• 2011

This paper considers an inbound lot-sizing and outbound dispatching problem for a single product in a thirdparty logistics (3PL) distribution center. Demands are dynamic and finite over the discrete time horizon, and moreover, each demand has a delivery time window which is the time interval with the dates between the earliest and the latest delivery dates All the product amounts must be delivered to the customer in the time window. Ordered products are shipped by multiple vehicle types and the freight cost is proportional to the vehicle-types and the number of vehicles used. First, we formulate a mixed integer programming model. Since it is difficult to solve the model as the size of real problem being very large, we design a conventional genetic algorithm with a local search heuristic (HGA) and an improved genetic algorithm called adaptive genetic algorithm (AGA). AGA spontaneously adjusts crossover and mutation rate depending upon the status of current population. Finally, we conduct some computational experiments to evaluate the performance of AGA with HGA.

• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.19-25
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• 2001

The purpose of this study was to use a ternary polymeric matrix system for high drug loading of a highly soluble drug for controlled release delivery. The controlled drug delivery of diltiazem HCl (solubility > 50% in water at $25^{\circ}C$) with high loading dose (the final loading dose of drug was 34%) from a ternary polymeric matrix (gelatin, pectin, HPMC) was successfully accomplished. This simple monolithic system with 240 mg drug loading provided near zero-order release over a 24 hour-period by which time the system was completely dissolved. The release kinetics of diltiazem HCl tablet with high loading dose from the designed ternary polymeric system was dependent on the ratios of HPMC : pectin binary mixture. The release rate increased as pectin : HPMC ratio were increased. Swelling behavior of the ternary system and the ionic interaction of formulation components with cationic diltiazem molecule appear to control drug diffusion and the release kinetics. Comparable release profiles between commercial product and the designed system were obtained. The binding study between gelatin with diltiazem HCl showed the presence of two binding sites for drug interaction with subsequent controlled diffusion upon swelling. This designed delivery system is easy to manufacture and drug release behavior is highly reproducible and offers advantages over the existing commercial product.

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 2007년도 학술발표회 논문집
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• pp.38-40
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• 2007

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• 벤처혁신연구
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• 제7권2호
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• pp.197-216
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• 2024

비대면 서비스가 활성화되면서 배달서비스플랫폼 이용이 활성화되고 있다. 이러한 시점에서 배달서비스 플랫폼의 고객경험이 고객만족 및 고객충성도에 미치는 영향을 실증적으로 분석하였다. 특히 본 연구에서는 고객경험을 4개의 하위요소로 나누어 각각이 고객만족과 고객충성도에 미치는 영향을 세분화하여 분석을 했다. 독립변수로 고객경험을 제품경험(product experience), 진실의순간(moments of truth), 결과지향성(outcome focus), 마음의평화(peace of mind) 4개의 하위변수로 나누었다. 매개변수는 고객만족이며, 종속변수는 재이용의도와 타인추천의향이다. 이를 위해 배달서비스플랫폼 이용경험이 있는 고객을 대상으로 설문조사를 하였으며, 이중 유효한 300개를 분석에 활용하였다. 실증분석결과는 다음과 같다. 제품경험, 진실의순간, 결과지향성, 마음의평화 모두 배달서비스플랫폼 이용만족에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 가장 영향을 미치는 변인은 마음의평화 이었다. 한편 이용만족도는 제품경험, 진실의 순간, 결과지향성, 마음의평화와 재이용의도, 타인추천의향에 매개역할을 하는 것으로 나타났다. 본 연구결과는 고객경험을 4가지로 세분화하여 검정하였다는 점에서 학술적인 의미가 있었다. 또한 실무적으로 고객경험중에서 고객을 안심시켜 고객에게 마음의 평화를 주는 것이 가장 중요한 요인임을 밝혔다는 점에서 의미가 있었다.

• Journal of Microbiology and Biotechnology
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• 제26권5호
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• pp.953-958
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• 2016

Chitosan-based film-forming gel is regarded as a promising vehicle for topical delivery of antimicrobial agents to skin wounds, since it protects from microbial infection and the cationic polymer itself possesses antibacterial activity. In this study, possible synergistic interaction against common skin pathogens between the cationic polymer and tyrothricin (TRC), a cyclic polypeptide antibiotic, was investigated, by determining the concentration to inhibit 90% of bacterial isolates (MIC). The addition of the polysaccharide to TRC dramatically reduced the MIC values of TRC by 1/33 and 1/4 against both methicillin-resistant and methicillin-susceptible Staphylococcus aureus, respectively. The synergism of TRC and chitosan combination against both strains was demonstrated by the checkerboard method, with a fractional inhibitory concentration index below 0.5. Moreover, co-treatment of TRC and chitosan exhibited antibacterial activity against Pseudomonas aeruginosa, due to the antibacterial activity of chitosan, whereas TRC itself did not inhibit the gram-negative bacterial growth. These findings suggested that the use of chitosan-based film for topical delivery of TRC could be an alternative to improve TRC antimicrobial activity against strains that are abundant in skin wounds.

• 디지털산업정보학회논문지
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• 제10권3호
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• pp.261-272
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• 2014

Home appliances go through a couple of packaging stages from the plant to consumers. The primary packaging, inner packaging for each part, happens for protection after products leave the plant. The secondary packaging happens in the unit of product, ensuring cushioning packaging to protect products from movement. The final tertiary packaging is for transportation and delivery. Each stage of product packaging, however, costs a lot of money because of disposable packaging materials used in each stage including vinyl, tapes, Styrofoam, and corrugated cardboards. Discarded packaging materials also cause environmental problems. In an effort to come up with a measure to solve those problems, this study proposed a plan to minimize logistics costs with semi-permanent packaging materials to replace disposable ones including Styrofoam, vinyl, and corrugated cardboards in the stages of inner packaging, cushioning packaging, product unit-based packaging, and transportation. The study also developed a model to cut down logistics costs by reducing various packaging stages including the primary, secondary, and tertiary stage only to the secondary one through module-type products instead of the transportation- and delivery-type ones, as well as demonstrated the excellence of the study through numerical analysis.