• Radiation Oncology Journal
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• v.9 no.1
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• pp.7-15
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• 1991

Pentoxifylline (PENTO) has been known to improve RBC fluidity, and thus improve the flux of RBC through narrow capillaries. Additionally, PENTO also decreases the $O_2$ affinity of hemoglobin by increasing 2,3-DPG levels, thereby increasing the $O_2$ release from RBC. Nicotinamide (NA) has been reported to decrease the number of acutely hypoxic cells in tumors by temporarily increasing tumor blood flow. Therefore, the purpose of this study was to examine whether the combination of PENTO and NA (PENTO+NA) would reduce the radioresistance of the Fsall murine fibrosarcoma by oxygenating the hypoxic cells. We obsewed a significantly enhanced radiation-induced growth delay of the FSaII tumors by PENTO+NA. Thus the enhancement ratio was between 2.5 and 2.8 in growth delay assay. The $TCD_{50}$ of control tumors was about 57 Gy, but that of PENTO+NA treated tumors was about 32Gy. Thus $TCD_{50}$ was modified by a factor of 1.8. We also observed that PENTO+NA exerted no effect on the radiation-induced skin damage after the legs without bearing tumors were exposed to X-irradiation. In order to clarify radiosensitizing effects of PENTO+ NA, changes in tumor blood flow and intratumor pOf were measured using laser Doppler flowmetry and $O_2$ microelectrode methods. The tumor blood flow significantly increased at 10 min. after injection of PENTO+ NA. Furthermore, we also found that PENTO+ NA significantly increased intratumor $pO_2$ from 8 to 19 mmHg. We concluded that PENTO+MA was far more effective than NA alone or PENTO alone. The increase in the response of tumors in vivo to X-irradiation appeared to be due mainly to an increase in the tumor oxygenation. Further studies using various concentrations of PENTO alone and in combination with NA to obtain better sequencing and maximal radiosensitization are warranted.

• The Journal of the Acoustical Society of Korea
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• v.38 no.1
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• pp.30-38
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• 2019

In recent years, researches on various communication methods have been conducted, particularly on OFDM (Orthogonal Frequency Division Multiplexing) and CDMA (Code Division Multiple Access) methods, as the use of underwater communication increases. While OFDM is, in general, advantageous in that it is resistant to Doppler in the water and it enables a high-speed communication, CDMA is resistant to frequency selective fading in the water and it can reduce energy consumption. Therefore, in this paper, we performed experiments in the shallow water in Western Sea of Korea to analyze the performance of OFDM and CDMA communication systems in the underwater channel environment. The maximum delay spread and Doppler spread were drawn by using the data obtained from the real sea area in order to analyze the underwater channel environment characteristics of the shallow water in Western Sea of Korea. The communication performances of OFDM and CDMA are shown as coded BER (Bit Error Rate) according to the variation of the maximum delay spread and the Doppler spread, respectively. The result of the analysis show that the OFDM method has more resistant performances to the underwater channel environment changes than the CDMA method.

• Journal of the Institute of Convergence Signal Processing
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• v.13 no.4
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• pp.220-232
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• 2012

In this paper, we investigate the correlation result due to the problems of delay tracking and fringe rotation module in the VCS(VLBI Correlation Subsystem). The VCS, FX-type correlator, adopts the delay tracking and fringe rotation module in order to compensate the delay change and fringe phase of wave signal from the radio source by Doppler's effect. The phase of observed data is also compensated by means of delay tracking and fringe rotation in the correlator, but we confirmed that the phase is unstable by applying long integration period of AIPS(Astronomical Image Processing System) rather than correlator. And the delay value of observed data has the errors of several tens nanoseconds than normal case at the analysis of correlation result. In addition, we found that the phase of correlation results is not connected as the unit of FFT-segment because the initial fringe phase at the fringe rotation module is not correctly determined. In this paper, in order to solve these problems, the original direction of 90 degree phase jump is reversely modified when the bit-shift occurred at the delay tracking. And the initial fringe phase at the fringe rotation module is correctly modified by using the initial phase of observed data. In addition, the parameter calculation module was abnormally operated as designed in the fringe rotation. So, the logical program by the VCS is modified so as to calculate the parameters correctly. Through the experiments of correlation processing over the above problems, the modified proposal algorithm is adequately corrected to the data analysis results, so that the experimental results make it clear for us to operate the developed VCS hardware correlator normally.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.1
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• pp.40-47
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• 2009

This paper presents the method of measuring the feedback interference channel, which is developed between the transmit and receive antennas of a wireless repeater by receiving the transmit signal at the receive antenna of the identical repeater, and experiment results obtained by analyzing the measurements. This experiment uses 2 GHz WCDMA signal and is carried out near a highway. The high-speed mobiles on highways cause reflected signals with high Doppler frequencies and large energy. In order to characterize the feedback channel, the power delay profile and the scattering function are estimated by identifying the delay spread, the Doppler spread, the number of fingers, and the attenuation with delay. Since the feedback interference channel is constructed between the fixed TX and RX antennas, which is dependent upon the multipaths developed by moving or fixed objects around the antennas, the channel shows different properties comparing to the conventional channels between the base station and the mobile station. Therefore, the results presented in the paper are expected to provide guidelines for designing and evaluating wireless repeater systems.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.1
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• pp.132-139
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• 2016

This study was carried out near the waters of Jango port, Dangjin-gun, Chungcheongnam-do by utilizing 10kHz carrier frequency, for the purpose of measurement and analysis of underwater channel environment of the Western sea. For the measurement of horizontal channel environment, the separation distance between transmitter and receiver is made differently in the range between 10m and 4000m. Meanwhile, for the measurement of vertical channel environment, transmission and receiving side ships are fixed as contacted each other and measured differently depending on their depth of submergence. In this study, the Coherence Bandwidth and the Coherence Time were estimated by analyzing the Power delay profile of the real sea based on the measured data, and analyzing the doppler frequency through frequency conversion of received tone-signal, respectively. This study is expected to become a base study in carrying out the frame design for underwater communication to improve the communication and secure the reliability of communication in future underwater channel environment.

• The Journal of the Acoustical Society of Korea
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• v.23 no.1
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• pp.24-29
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• 2004

In ocean acoustic tomography (OAT), the pulse compression techniques using M-sequences are employed in the many studies for investigating the ocean structures. M-sequences can provide the good time and Doppler resolution in the process of demodulation using matched-filter. The signal-to-noise (SNR) performance at the output of receiver may be improved by manipulating received signal, i. e. coherently averaging. The processing time can be significantly reduced by using fast hadarmard transform (FHT) or fast Fourier transform (FFT). In this paper, we estimate the multipath arrival structures and delay times using the East Korean Sea experiment data and explore the compensation method for the detrimental effects on performance due to sampling rate error. We also analyze the characteristics of the ocean acoustic channels through scattering function, delay power profile, and time dispersions.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.309-314
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• 2006

In general DGPS system, the correction message is transferred to users by wireless modem. To cover wide area, many DGPS station should be needed. And DGPS users must have a wireless modem that is not necessary in standalone GPS. But SBAS users don't need a wireless modem to receive DGPS corrections because SBAS correction message is transmitted from the GEO satellite by L1 frequency band. SBAS signal is generated in the GUS(Geo Uplink Subsystem) and uplink to the GEO satellite. This uplink transmission process causes two problems that are not existed in GPS. The one is a time delay in the uplink signal. The other is an ionospheric problem on uplink signal, code delay and carrier phase advance. These two problems cause ranging error to user. Another critical ranging error factor is clock synchronization. SBAS reference clock must be synchronized with GPS clock for an accurate ranging service. The time delay can be removed by close loop control. We propose uplink ionospheric error correcting algorithm for C/A code and carrier. As a result, the ranging accuracy increased high. To synchronize SBAS reference clock with GPS clock, I reviewed synchronization algorithm. And I modified it because the algorithm didn't consider doppler that caused by satellites' dynamics. SBAS reference clock synchronized with GPS clock in high accuracy by modified algorithm. We think that this paper will contribute to basic research for constructing satellite based DGPS system.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.9
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• pp.746-756
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• 2017

An algorithm is developed to generate measurement data of deep space network for Korea Pathfinder Lunar Orbiter (KPLO) mission. The algorithm can provide corrected measurement data for the Orbit Determination (OD) module in deep space. This study describes how to generate the computed data such as range, Doppler, azimuth angle and elevation angle. The geometric data were obtained by General Mission Analysis Tool (GMAT) simulation and the corrected data were calculated with measurement models. Therefore, the result of total delay includes effects of tropospheric delay, ionospheric delay, charged particle delay, antenna offset delay, and tropospheric refraction delay. The computed measurement data were validated by comparison with the results from Orbit Determination ToolBoX (ODTBX).

• ETRI Journal
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• v.24 no.6
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• pp.415-428
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• 2002

This paper presents a new satellite radio interface, satellite code division multiple access (SAT-CDMA), for the satellite component of IMT-2000. The SAT-CDMA was proposed by Korea and was based on wideband CDMA (WCDMA) for a high degree of commonality with the terrestrial component of IMT-2000. Because a satellite link has a longer round trip delay and a higher Doppler shift than a terrestrial link, we developed new technologies that would make the satellite component especially efficient. We present the main features of the SAT-CDMA radio interface by focusing on satellite-specific schemes. We also demonstrate with extensive comparison results the performance of the main technologies in the SAT-CDMA radio interface.

• Proceedings of the IEEK Conference
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• 2000.06a
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• pp.53-56
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• 2000

In MC-CDMA systems effects of delay spread of the channel are reduced with increased symbol duration by simultaneously transmitting data symbols on the parallel subcarriers. However, the increased symbol duration causes the system to be more vulnerable to time selective fading. In other words, although MC-CDMA systems are robust against frequency selective fading in a multipath environment, they are sensitive to Doppler spread and hence inter-carrier interference is increased. In this paper, we investigate the effects of time selective fading characteristics of the mobile channel from the viewpoint of desired signal power to inter-carrier interference power ratio at the combiner output of the MC-CDMA receiver.