• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제20권3호
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• pp.140-145
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• 2009

Objectives : This study explored the differences in their ego defense mechanisms between adolescents with conduct disorder and normal adolescents. Methods : Subjects were 35 adolescents with conduct disorder and 44 normal adolescents. The Ewha Defense Mechanism Test (EDMT), consisting of 200 items and 20 scales, was administered, to examine the defense mechanisms of both groups of adolescents. Results : Normal adolescents presented statistically significantly higher scores on the reaction formation, controlling, suppression, anticipation, dissociation, and distortion scales than did adolescents with conduct disorder. Zn addition, adolescents with conduct disorder used neurotic defense mechanisms of both neurotic and mature levels less frequently than normal adolescents did. Factor analysis revealed that, normal adolescents had higher scores on ego-expansive factor scales and behavior control factor scales thanadolescents with conduct disorder did. Conclusion : The results suggest adolescents with conduct disorder use mature and ego-expansive defense mechanisms less frequently than do normal adolescents.

• Molecules and Cells
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• 제26권2호
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• pp.107-112
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• 2008

Invasion mechanisms of pathogens and counteracting defense mechanisms of plants are highly diverse and perpetually evolving. While most classical studies of plant defense have focused only on defense-specific factor-mediated responses, recent work is beginning to shed light on the involvement of non-stress signal components, especially growth and developmental processes. This shift in focus links plant resistance more closely with growth and development. In this review, we summarize our current understanding of how pathogens manipulate host developmental processes and, conversely, of how plants deploy their developmental processes for self-protection. We conclude by introducing our recent work on UNI, a novel R protein in Arabidopsis which mediates cross-talk between developmental processes and defense responses.

• 한국연초학회지
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• 제14권2호
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• pp.168-195
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• 1992

Pulmonary system is a target organ and primary defense mechanism against environmental oxidants and polutants. Enzymatic and nonenzymatic antioxdant defense mechanisms undoubtedly protect the lung from oxidants even endogenous oxidative stress. In addition, new ways of augmenting pulmonary antioxidant defenses are developed, which can be used to support the intrinsic antioxidants. Therefore, improved understanding of antioxidant defense mechanisms will increase our knowledge of the cause and will suggest rational approaches for treating and preventing oxidant-induced lung injury. In this review, we discuss the formation and scavenging of free radicals, and the strategies for antioxidant defense of pulmonary system.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제10권2호
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• pp.158-168
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• 1999

본 연구의 목적은 최근 사회적으로 심각한 문제로 대두되고 있는 학교폭력에서 피해 청소년들이 사용하는 방어기제의 특성을 알아보고자 함에 있다. 연구대상은 학교폭력 피해자인 41명의 임상군과 학교폭력 피해 경험이 없는 40명의 정상군이다. 임상군을 다시 19명의 환자군과 22명의 학교군으로 나누어 특성을 살펴보았다. 연구도구는 이화방어기제검사와 분노척도가 사용되었다. 연구를 통해 도출된 결론중 중요한 내용은 다음과 같다. 첫째, 정상군은 임상군에 비하여 허세, 반동형성, 전치, 통제, 합리화, 해리 등으로 구성된 신경증 적 단계의 방어기제와 억제, 예견, 승화, 이타주의, 유우머 등으로 구성된 성숙단계의 방어기제를 유의하게 많이 사용하였다. 둘째, 임상군 내에서 낮병동 환자가 외래환자에 비하여 성숙단계의 방어기제를 더 많이 사용하였으며, 학교군이 입원군에 비하여 허세 방어기제를 더 많이 사용하였다. 셋째, 전치, 행동화 방어기제는 특성분노, 상태분노와 유의미한 정적 관계를 보이며, 신체화 방어기제는 특성분노와, 퇴행 방어기제는 상태분노와 유의미한 정적 관계를 보인다.

• Animal cells and systems
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• 제7권3호
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• pp.213-219
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• 2003

The response of plants to pathogens and wounding is dependent upon very sensitive perception mechanisms. Although genetic approaches have revealed a variety of resistance genes that activate common defense responses, defense-related proteins are not well characterized in plants. Therefore, we used a proteomic approach to determine which defense-related proteins are induced by salicylic acid (SA) and wounding in Chinese cabbage. We found that SA and wounding induce pathogenesis-related protein 1a (PR1a) at both protein and mRNA levels using proteomics and Northern blot analysis, respectively. This indicates that our proteomic approach is useful for identifying defense-related proteins. We also identified several other proteins that are induced by SA or wounding. Among the seven SA-induced proteins identified, four may be defense-related, including defense-related protein, phospholipase D (PLD), resistance protein RPS2 homolog, and L-ascorbate peroxidase. Out of the six wounding-induced proteins identified, three may be defense-related: heat shock cognate protein 70 (HSC70), polygalacturonase, and peroxidase P7. The precise functions of these proteins in plant defense responses await further study. However, identification of the defense-related proteins described in this study should allow us to better understand the mechanisms and signal transduction pathways involved in defense responses in Chinese cabbage.

• 동의신경정신과학회지
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• 제19권3호
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• pp.23-34
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• 2008

Objective: The purpose of this study was to investigate characteristics of the defense mechanism of oriental medicine students by using Ewha Defense Mechanism Test(EDMT) preliminarily. Method: We described the characteristics of the defense mechanism of oriental medicine students and compared the scores of EDMT with standard group. We analysed the differences of defense mechanism by sex (male, female) and age($\leq$29 and $\geq$30 yrs old) within oriental medicine students. The score of EDMT were verified by examination of one sample t-test and unpaired t-test. Results and Conclusions: First, there was no Major Defense Mechanism in oriental medicine students. Second, oriental medicine students had more defensive, passive inclination and used Evasion and Show-off more frequently. Third, the differences within oriental medicine students depended on age rather than sex. The younger students used immature and neurotic defense mechanisms more frequently, and the older students had more defensive and passive inclination.

• BMB Reports
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• 제51권6호
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• pp.274-279
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• 2018

Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response ($UPR^{mt}$), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals.

• The Plant Pathology Journal
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• 제15권1호
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• pp.8-13
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• 1999

Hypersensitive cell death of plants during incompatible plant-pathogen interactions is one of the efficient defense mechanisms of plants against pathogen infections. For better understanding of the molecular mechanisms involved in the plant hypersensitive response (HR), TMV-induced biotic plant cell death and CuSO4-induced abiotic plant cell death were compared in terms of expression patterns of ten different defense-related genes as molecular markers. The genes include five pathogenesis-related protein genes, two plant secondary metabolite-associated genes, two oxidative stress-related genes and one wound-inducible gene isolated from tobacco. Northern blot analyses revealed that a same set of defense-related genes was induced during both biotic and abiotic cell death but with different time and magnitude. The expression of defense-related genes in tobacco plants was temporarily coincided with the time of cell death. However, when suspension cell cultures was used to monitor the expression of defense-related genes, different patterns of the gene expression were detected. This result implies that three are common and, in addition, also different branches of signaling pathways leading to the induced expression of defense-related genes in tobacco during the pathogen- and heavy metal-induced cell death.

• IMMUNE NETWORK
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• 제9권2호
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• pp.46-52
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• 2009

Although tuberculosis poses a significant health threat to the global population, it is a challenge to develop new and effective therapeutic strategies. Nitric oxide (NO) and inducible NO synthase (iNOS) are important in innate immune responses to various intracellular bacterial infections, including mycobacterial infections. It is generally recognized that reactive nitrogen intermediates play an effective role in host defense mechanisms against tuberculosis. In a murine model of tuberculosis, NO plays a crucial role in antimycobacterial activity; however, it is controversial whether NO is critically involved in host defense against Mycobacterium tuberculosis in humans. Here, we review the roles of NO in host defense against murine and human tuberculosis. We also discuss the specific roles of NO in the central nervous system and lung epithelial cells during mycobacterial infection. A greater understanding of these defense mechanisms in human tuberculosis will aid in the development of new strategies for the treatment of disease.

• Journal of Ginseng Research
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• 제35권1호
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• pp.1-11
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• 2011

Korean ginseng is a medicinally important perennial herb from the family Araliaceae. It has been cultivated for its highly valued medicinal properties for over 1,000 years in east Asian countries such as China, Korea, and Japan. Due to its longtime cultivation in shady areas, ginseng is frequently exposed to pathogenic infections. Plants protect themselves from microbial pathogens using an array of defense mechanisms, some of which are constitutively active, while others are activated upon pathogen invasion. These induced defense responses, controlled by defense-related genes, require tradeoffs in terms of plant fitness. We hypothesize that ginseng, as with other plants, possesses regulatory mechanisms that coordinate the activation of attacker-specific defenses in order to minimize fitness costs while attaining optimal resistance. Several classes of defense-related genes are induced by infection, wounds, irradiation, and other abiotic stresses. Both salicylates and jasmonates have been shown to cause such responses, although their specific roles and interactions in signaling and development are not fully understood in ginseng. This review summarizes possible defense-related genes in ginseng based on their expression patterns against biotic and abiotic stresses and describes their functional roles.