Browse > Article
http://dx.doi.org/10.5483/BMBRep.2018.51.6.111

Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans  

Kwon, Sujeong (Department of Life Sciences, Pohang University of Science and Technology)
Kim, Eun Ji E. (Department of Life Sciences, Pohang University of Science and Technology)
Lee, Seung-Jae V. (Department of Life Sciences, Pohang University of Science and Technology)
Publication Information
BMB Reports / v.51, no.6, 2018 , pp. 274-279 More about this Journal
Abstract
Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response ($UPR^{mt}$), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals.
Keywords
Caenorhabditis elegans; Immunity; Mitochondria; Pathogen; Surveillance;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Yang W and Hekimi S (2010) A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans. PLoS Biol 8, e1000556   DOI
2 Tang H and Pang S (2016) Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans. Cell Rep 17, 2837-2844   DOI
3 Chavez V, Mohri-Shiomi A and Garsin DA (2009) Ce-Duox1/BLI-3 generates reactive oxygen species as a protective innate immune mechanism in Caenorhabditis elegans. Infect Immun 77, 4983-4989   DOI
4 van der Hoeven R, McCallum KC, Cruz MR and Garsin DA (2011) Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans. PLoS Pathog 7, e1002453   DOI
5 McCallum KC and Garsin DA (2016) The Role of Reactive Oxygen Species in Modulating the Caenorhabditis elegans Immune Response. PLoS Pathog 12, e1005923   DOI
6 Xu S and Chisholm AD (2014) C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Dev Cell 31, 48-60   DOI
7 Koliaki C and Roden M (2016) Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus. Annu Rev Nutr 36, 337-367   DOI
8 Hwang AB and Lee SJ (2011) Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY) 3, 304-310
9 Moehle EA, Shen K and Dillin A (2018) Mitochondrial Proteostasis in the Context of Cellular and Organismal Health and Aging. J Biol Chem [Epub ahead of print]
10 West AP, Shadel GS and Ghosh S (2011) Mitochondria in innate immune responses. Nat Rev Immunol 11, 389-402   DOI
11 Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM and Haynes CM (2012) Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337, 587-590   DOI
12 Cohen LB and Troemel ER (2015) Microbial pathogenesis and host defense in the nematode C. elegans. Curr Opin Microbiol 23, 94-101   DOI
13 Haynes CM, Yang Y, Blais SP, Neubert TA and Ron D (2010) The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell 37, 529-540   DOI
14 Haynes CM, Petrova K, Benedetti C, Yang Y and Ron D (2007) ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell 13, 467-480   DOI
15 Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ and Haynes CM (2014) Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature 516, 414-417   DOI
16 Nargund AM, Fiorese CJ, Pellegrino MW, Deng P and Haynes CM (2015) Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). Mol Cell 58, 123-133   DOI
17 Jeong DE, Lee D, Hwang SY et al (2017) Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling. EMBO J 36, 1046-1065   DOI
18 Van Raamsdonk JM and Hekimi S (2010) Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? Antioxid Redox Signal 13, 1911-1953   DOI
19 Sala AJ, Bott LC and Morimoto RI (2017) Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol 216, 1231-1241   DOI
20 Narendra DP, Jin SM, Tanaka A et al (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8, e1000298   DOI
21 Harper JW, Ordureau A and Heo JM (2018) Building and decoding ubiquitin chains for mitophagy. Nat Rev Mol Cell Biol 19, 93-108   DOI
22 Yang Y, Gehrke S, Imai Y et al (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A 103, 10793-10798   DOI
23 Clark IE, Dodson MW, Jiang C et al (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166   DOI
24 Park J, Lee SB, Lee S et al (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161   DOI
25 Powers ET and Balch WE (2013) Diversity in the origins of proteostasis networks - a driver for protein function in evolution. Nat Rev Mol Cell Biol 14, 237   DOI
26 Kirienko NV, Ausubel FM and Ruvkun G (2015) Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 112, 1821   DOI
27 Jovaisaite V, Mouchiroud L and Auwerx J (2014) The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease. J Exp Biol 217, 137   DOI
28 Hetz C and Papa FR (2018) The Unfolded Protein Response and Cell Fate Control. Mol Cell 69, 169-181   DOI
29 Shpilka T and Haynes CM (2018) The mitochondrial UPR: mechanisms, physiological functions and implications in ageing. Nat Rev Mol Cell Biol 19, 109-120
30 Frakes AE and Dillin A (2017) The $UPR^{ER}$ Sensor and Coordinator of Organismal Homeostasis. Mol Cell 66, 761-771   DOI
31 Prasai K (2017) Regulation of mitochondrial structure and function by protein import: A current review. Pathophysiology 24, 107-122   DOI
32 Mehta MM, Weinberg SE and Chandel NS (2017) Mitochondrial control of immunity: beyond ATP. Nat Rev Immunol 17, 608   DOI
33 Ewbank JJ and Pujol N (2016) Local and long-range activation of innate immunity by infection and damage in C. elegans. Curr Opin Immunol 38, 1-7   DOI
34 Kim DH and Ewbank JJ (2015) Signaling in the innate immune response. WormBook, 1-51
35 Gerwien F, Skrahina V, Kasper L, Hube B and Brunke S (2018) Metals in fungal virulence. FEMS Microbiol Rev 42
36 Chandrangsu P, Rensing C and Helmann JD (2017) Metal homeostasis and resistance in bacteria. Nat Rev Microbiol 15, 338-350   DOI
37 Kang D, Kirienko DR, Webster P, Fisher AL and Kirienko NV (2018) Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. Virulence, 1-41
38 Shore DE and Ruvkun G (2013) A Cytoprotective Perspective on Longevity Regulation. Trends Cell Biol 23, 409-420   DOI
39 Liu Y, Samuel BS, Breen PC and Ruvkun G (2014) Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508, 406-410   DOI
40 Tjahjono E and Kirienko NV (2017) A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa. PLoS Genet 13, e1006876   DOI
41 Pickles S, Vigie P and Youle RJ (2018) Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance. Curr Biol 28, R170-R185   DOI
42 Hwang AB, Ryu EA, Artan M et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A 111, E4458-4467   DOI
43 Mouton-Liger F, Jacoupy M, Corvol J-C and Corti O (2017) PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease. Front Mol Neurosci 10, 120   DOI
44 Kauppila TES, Kauppila JHK and Larsson NG (2017) Mammalian Mitochondria and Aging: An Update. Cell Metab 25, 57-71   DOI
45 Lima A, Burgstaller J, Sanchez-Nieto JM and Rodriguez TA (2018) The Mitochondria and the Regulation of Cell Fitness During Early Mammalian Development. Curr Top Dev Biol 128, 339-363
46 Lee SJ, Hwang AB and Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol 20, 2131-2136   DOI