• The Korean Journal of Physiology and Pharmacology
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• v.22 no.1
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• pp.1-15
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• 2018

Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin $(IL)-1{\beta}$ and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SS). Since rheumatic diseases are inflammatory/autoimmune disorders, it is reasonable to hypothesize that inflammasomes activated during the inflammatory response play a pivotal role in development and progression of these diseases. Indeed, previous studies have provided important observations that inflammasomes are actively involved in the pathogenesis of inflammatory/autoimmune rheumatic diseases. In this review, we summarize the current knowledge on several types of inflammasomes during macrophage-mediated inflammatory responses and discuss recent research regarding the role of inflammasomes in the pathogenesis of inflammatory/autoimmune rheumatic diseases. This avenue of research could provide new insights for the development of promising therapeutics to treat inflammatory/autoimmune rheumatic diseases.

• 한국전산유체공학회:학술대회논문집
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• 2006.05a
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• pp.292-295
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• 2006

The terrorist attack of September $11^{th}$ 2001 has enforced a new examination of the response of modern steel structures, such as those found in large warehouses, auditoriums and airport terminals, to terrorist bomb attack. The effort described in this paper assesses the potential damage to such a newly designed structure form a medium-size car bomb. The structure is mostly composed of a lightweight complex beam structure with large windows and skylights piercing through a corrugated roof. The structural response to the terrorist attack requires the modelling of various physics phenomena including bomb detonation, blast wave propagation, reflections, and refractions and resulting blast impact on the structure. Hence, a fluid/structure coupled methodology is used to perform the assessment.

• Journal of the Society of Naval Architects of Korea
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• v.45 no.6
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• pp.688-694
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• 2008

The reduction of the structure-borne noise is very important in order to reduce the noise of a ship. The noise at the high frequency range usually comes from the fluid flowing. The noise from the sea-water conveying pipe is one of the main source on these high frequency range. Therefore, the transmissibility variations are evaluated according to the shape of the rubber mount. The evaluations are performed with the frequency response function numerically and experimentally.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.10a
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• pp.11-11
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• 2017

• Journal of the Korea Institute of Military Science and Technology
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• v.20 no.5
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• pp.639-646
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• 2017

This paper describes the sound insulation and structural safety of the shelter which may be used for shooters. The noise level of the shelter should be less than 100 dB on the basis of the Industrial Safety and Act, the World Health Organization and the MIL-STD. The sound insulation design was designed for the shelter structure. The designed shelter performance was verified by the real measurement after completing the construction of the shelter. The system was also designed using the finite element method with data of sound pressure measured in the test. Its response was obtained numerically. It is proved that the shelter structure is sufficiently safe considering the calculated maximum stress level with the allowable stress of structural property.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.81-83
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• 2005

The Plant Signaling Network Research Center (SigNet) is a government-funded (by Korea's Ministry of Science and Technology (MOST)/ Korea Science and Engineering Foundation (KOSEF)) research center established at the School of Life Sciences and Biotechnology of Korea University in 2003. The SigNet conducts plant biological studies, especially in the field of developmental and defense biology. The research purpose of SigNet is dissection and analysis of plant development and defense signaling network through multiscientific approaches. Knowledge acquired from SigNet research scientists will provide new integrated view of understanding and potential application of plant development and defense mechanism. The other important mission of the SigNet is nurturing Center of Excellence for future outstanding research scientists of Korea. The SigNet will continue to expend every effort to achieve the goals for the future. Through passionate research endeavor of each laboratory and partnerships within inside and outside laboratories, we will continue to develop world-leading plant research group and to educate new generations of innovative researchers. As the SigNet looks toward the future, the SigNet will try to achieve its mission of research, education and service to the community. And the defense response research of our lab will be presented at later part.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.24 no.12
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• pp.992-998
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• 2014

Acoustic radiation efficiency is one of the important factors in the prediction of underwater radiated noise of ships. A ship has much equipment to operate successful mission in a ship. Most of equipment is running simultaneously as multi-excitation and becomes the source of underwater radiated noise. In many cases of multi-excitation, phase difference between multi-excitation is not considered. Because vibration response under multi-excitation is the vector sum of each single excitation, acoustic radiation efficiency based on surface velocity field can be affected by phase of excitation. In this study, acoustic radiation efficiency of a plate on air and a stiffened cylindrical model in water under multi-excitation with phase difference is investigated.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.7
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• pp.691-698
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• 2015

Inertial Navigation Systems (INS) are widely used as the main navigation device for aircraft. To get the initial attitude, the INS requires the initial alignment before navigation starts. An aircraft also needs an engine test procedure that causes some vibrations before flight. An INS can't be aligned in a vibration environment so the initial alignment is performed before the aircraft engine test. Therefore, the initial alignment time of an INS has been a major factor in limiting an aircraft's takeoff response time. In this paper, we designed an initial alignment algorithm that can be executed even in disturbances such as aircraft run-up. We demonstrated verification of the algorithm that is embedded on the real INS and testing methods to evaluate the alignment of the INS. We also analyzed the test results of the proposed initial alignment algorithm that is performed during a real aircraft run-up.

• The Plant Pathology Journal
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• v.37 no.5
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• pp.415-427
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• 2021

A plethora of compounds stimulate protective mechanisms in plants against microbial pathogens and abiotic stresses. Some defense activators are synthetic compounds and trigger responses only in certain protective pathways, such as activation of defenses under regulation by the plant regulator, salicylic acid (SA). This review discusses the potential of naturally occurring plant metabolites as primers for defense responses in the plant. The production of the metabolites, hexanoic acid and melatonin, in plants means they are consumed when plants are eaten as foods. Both metabolites prime stronger and more rapid activation of plant defense upon subsequent stress. Because these metabolites trigger protective measures in the plant they can be considered as "vaccines" to promote plant vigor. Hexanoic acid and melatonin instigate systemic changes in plant metabolism associated with both of the major defense pathways, those regulated by SA- and jasmonic acid (JA). These two pathways are well studied because of their induction by different microbial triggers: necrosis-causing microbial pathogens induce the SA pathway whereas colonization by beneficial microbes stimulates the JA pathway. The plant's responses to the two metabolites, however, are not identical with a major difference being a characterized growth response with melatonin but not hexanoic acid. As primers for plant defense, hexanoic acid and melatonin have the potential to be successfully integrated into vaccination-like strategies to protect plants against diseases and abiotic stresses that do not involve man-made chemicals.

• Journal of the Korean Society of Industry Convergence
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• v.22 no.2
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• pp.71-79
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• 2019

Since the announcement of President Klaus Schwab's fourth industrial revolution at the World Economic Forum in Davos, Switzerland in January 2016, the fourth industrial revolution has emerged as a hot topic in our society. The United States, Japan, China, and Germany, which are major advanced nations, are preparing and implementing a strategy and system for responding to the Fourth Industrial Revolution, focusing on information and communication technology (ICT) and manufacturing convergence in response to the fourth industrial revolution era. Korea is announcing the expansion of financial support for R & D investment budget and related industries for major technology related to revolution. In this paper, we analyze the defense R & D project procedure of the Defense Improvement Project, which is responsible for the development of the defense weapon system, and present the development direction of the defense weapon system in accordance with the 4th world industrial revolution trend.