• Mass Spectrometry Letters
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• 제12권3호
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• pp.60-65
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• 2021

As a part of the Chromosome-centric Human Proteome Project (C-HPP), we have developed a few algorithms for accurate identification of missing proteins, alternative splicing variants, single amino acid variants, and characterization of function unannotated proteins. We have found missing proteins, novel and known ASVs, and SAAVs using LC-MS/MS data from human brain and olfactory epithelial tissue, where we validated their existence using synthetic peptides. According to the neXtProt database, the number of missing proteins in chromosome 11 shows a decreasing pattern. The development of genomic and transcriptomic sequencing techniques make the number of protein variants in chromosome 11 tremendously increase. We developed a web solution named as SAAvpedia for identification and function annotation of SAAVs, and the SAAV information is automatically transformed into the neXtProt web page using REST API service. For the 73 uPE1 in chromosome 11, we have studied the function annotaion of CCDC90B (NX_Q9GZT6), SMAP (NX_O00193), and C11orf52 (NX_Q96A22).

• 한국전기전자재료학회논문지
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• 제32권2호
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• pp.104-109
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• 2019

An analytical threshold voltage model is proposed to analyze the threshold voltage roll-off and drain-induced barrier lowering (DIBL) for a junction-based double-gate (JBDG) MOSFET and a junction-less double-gate (JLDG) MOSFET. We used the series-type potential distribution function derived from the Poisson equation, and observed that it is sufficient to use n=1 due to the drastic decrease in eigenvalues when increasing the n of the series-type potential function. The threshold voltage derived from this threshold voltage model was in good agreement with the result of TCAD simulation. The threshold voltage roll-off of the JBDG MOSFET was about 57% better than that of the JLDG MOSFET for a channel length of 25 nm, channel thickness of 10 nm, and oxide thickness of 2 nm. The DIBL of the JBDG MOSFET was about 12% better than that of the JLDG MOSFET, at a gate metal work-function of 5 eV. It was also found that decreasing the work-function of the gate metal significantly reduces the DIBL.

• 국제물리치료학회지
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• 제1권2호
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• pp.126-135
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• 2010

The purpose of this study is to investigate the effects of closed and open kinetic chain exercise for increasing knee joint function on the knee position sense in the normal adults. Thirty normal adults(male 15, female 15; mean age: $22.13{\pm}2.58$ years) were participated in this study into two groups, each with 15 people. The group I was trained that closed kinetic chain exercise on the knee joint and the group II was trained that open kinetic chain exercise on the knee joint. Exercise programs performed for 4 weeks, 3 times a week were using Shuttle 2000-1 closed kinetic chain exercise and Knee Extensor open kinetic chain exercise(HUR, Filand). The results of this study were as follows: 1) There were statistically significant decreasing of measuring error degree in $0-20^{\circ}$ were found between before and after training in closed kinetic chain exercise(p<.05). 2) There were statistically significant decreasing of measuring error degree in $21-40^{\circ}$ were found between before and after training in closed kinetic chain exercise(p<.05). 3) There were statistically significant decreasing of measuring error degree in $41-60^{\circ}$ were found between before and after training in closed kinetic chain exercise(p<.05). 4) There were statistically significant decreasing of measuring error degree in $0-20^{\circ}$ were found between before and after training in open kinetic chain exercise(p<.05). 5) There were statistically significant decreasing of measuring error degree in $21-40^{\circ}$ were found between before and after training in open kinetic chain exercise(p<.05). 6) There were statistically significant decreasing of measuring error degree in $41-60^{\circ}$ were found between before and after training in open kinetic chain exercise(p<.05). In conclusion, these results suggest that closed and open kinetic chain exercise has increased in the knee joint proprioception between before and after training. Especially, closed kinetic chain exercise could be more useful intervention than open kinetic chain exercise for increasing proprioceptive sense.

• 품질경영학회지
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• 제31권1호
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• pp.142-147
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• 2003

Burn-in is a widely used method to eliminate the initial failures. Preventive maintenance policy such as block replacement with minimal repair at failure is often used in field operation. In this, paper burn-in and maintenance policy are taken into consideration at the same time. The cost of a minimal repair is assumed to be a non-decreasing function of its age. The problems of determining optimal burn-in times and optimal maintenance policy are considered.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2007년도 추계학술대회 및 정기총회
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• pp.309-312
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• 2007

We consider a proportionate flow shop problem with controllable processing times. The objective is to minimize the sum of total completion time and total compression cost, in which the cost function of compressing the processing times is non-decreasing concave. We show that the problem can be solved in polynomial time by reducing it to a polynomially solvable 0-1 unconstrained quadratic program.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2002년도 추계 학술발표회 논문집
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• pp.147-151
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• 2002

Burn-in is a widely used method to eliminate initial failures. Preventive maintenance policy such as block replacement with minimal repair at failure is often used in field operation. In this paper burn-in and maintenance policy are taken into consideration at the same time. The cost of a minimal repair is assumed to be a non-decreasing function of its age. The problems of determining optimal burn-in times and optimal maintenance policy are considered.

• International Journal of Reliability and Applications
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• 제16권2호
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• pp.123-133
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• 2015

In this paper, the problem of testing exponentiality against net decreasing variance residual lifetime (NDVRL) classes of life distributions is investigated. For this property a nonparametric test is presented based on kernel method. The test is presented for complete and right censored data. Furthermore, Pitman's asymptotic relative efficiency (PARE) is discussed to assess the performance of the test with respect to other tests. Selected critical values are tabulated. Some numerical simulations on the power estimates are presented for proposed test. Finally, numerical examples are presented for the purpose of illustrating our test.

• 대한수학회논문집
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• 제14권2호
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• pp.329-336
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• 1999

We construct the Gelfand triple based on the space \ulcorner, introduced by Sato and di Silva, of analytic and exponentially decreasing function. This space denoted by(\ulcorner) of white noise test functionals are defined by the operator cosh \ulcorner, A=-(\ulcorner)\ulcorner+x\ulcorner+1. We also note that many properties like generalizations of the Paley-Wiener theorem and the Bochner-Schwartz theorem hold in this space as in the space of Hida distributions.

• Communications for Statistical Applications and Methods
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• 제2권2호
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• pp.52-62
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• 1995

Consider an estimation problem under squared error loss in a family of non-regular densities with both terminals of the support being decreasing functions of an unknown parameter. Using Karlin's(1958) technique, sufficient conditions are given for generalized Bayes estimators to be admissible for estimating an arbitrarily positive, monotone parametric function and then treat some examples which illustrate our results.

• Communications for Statistical Applications and Methods
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• 제14권3호
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• pp.577-582
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• 2007

A continuum structure function (CSF) is a non-decreasing mapping from the unit hypercube to the unit interval. A B-type CSF, defined in the text, is a CSF whose behaviour is modeled by its underlying binary structures. As the measure of importance of a system component for a B-type CSF, the structural and reliability importance of a component at a system level ${\alpha}$(0 < ${\alpha}$ < 1) are defined and their properties are deduced.