• Asian-Australasian Journal of Animal Sciences
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• 제21권1호
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• pp.29-34
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• 2008

The aim of the study was to investigate the effect of dietary fish oil supplementation on the semen characteristics of the Markhoz buck. Sixteen bucks were randomly allocated into 4 groups and received four different diets: unsupplemented control diet, supplemented with fish oil at 2.50% dry matter (DM), supplemented with fish oil (2.50% DM) and vitamin E (0.30 g/kg DM), and supplemented with vitamin E (0.30 g/kg DM). All experimental diets were formulated according to AFRC (1998). Semen was collected at 14 d intervals from June 17, 2006 to September 2, 2006. Semen characteristics were evaluated. Significant effects (p<0.05) of the week (sampling time) were observed for all parameters except semen volume. Also a significant effect (p<0.05) of dietary treatment was observed for all parameters except for percent sperm with normal morphologies and semen volume. Fish oil supplementation with excess vitamin E had a significant effect (p<0.05) on total number and sperm density, motility and progressive motility, percentage viability and dead sperm. The interaction between fish oil feeding and sampling time was significant (p<0.05) for all of the parameters. The bucks that received fish oil in association with vitamin E, effect fish oil showed the greatest improvement in semen characteristics compared with the other groups (p<0.05). This study showed that fish oil supplementation with vitamin E may have a beneficial effect on the semen quality and fertility of Markhoz bucks.

• Archives of Plastic Surgery
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• 제39권4호
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• pp.345-351
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• 2012

Background Cranial base defects are challenging to reconstruct without serious complications. Although free tissue transfer has been used widely and efficiently, it still has the limitation of requiring a long operation time along with the burden of microanastomosis and donor site morbidity. We propose using a reverse temporalis muscle flap and calvarial bone graft as an alternative option to a free flap for anterior cranial base reconstruction. Methods Between April 2009 and February 2012, cranial base reconstructions using an autologous calvarial split bone graft combined with a reverse temporalis muscle flap were performed in five patients. Medical records were retrospectively analyzed and postoperative computed tomography scans, magnetic resonance imaging, and angiography findings were examined to evaluate graft survival and flap viability. Results The mean follow-up period was 11.8 months and the mean operation time for reconstruction was $8.4{\pm}3.36$ hours. The defects involved the anterior cranial base, including the orbital roof and the frontal and ethmoidal sinus. All reconstructions were successful. Viable flap vascularity and bone survival were observed. There were no serious complications except for acceptable donor site depressions, which were easily corrected with minor procedures. Conclusions The reverse temporalis muscle flap could provide sufficient bulkiness to fill dead space and sufficient vascularity to endure infection. The calvarial bone graft provides a rigid framework, which is critical for maintaining the cranial base structure. Combined anterior cranial base reconstruction with a reverse temporalis muscle flap and calvarial bone graft could be a viable alternative to free tissue transfer.

• 미생물학회지
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• 제33권1호
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• pp.7-14
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• 1997

성장인자가 포함되지 않은 무기염 액체배지(ISP-4)에서 Streptomyces coelicolor A3(2)의 포자가 발아할 때, 성장인자의 주기적인 요구성이(양 등,1993_ 단백질과 RNA 합성과 어떤 관계를 가지고 있는지를 규명하고자 하ㅣ였다. 발아는 10시간 정도 걸렸으며 이때 성장인자의 요구성이 2시간 주기로 반복되는 것을 재입증하였다. 포자의 크기는 시간에 따라 증가하였으나, 포자수는 표준 평판계수법에서 감소하였다. 포자 집단은 생리적으로 살아있거나, 휴면 중인 포자와 죽은 포자로 구분될 수 있었다. 이러한 발아과정에서 포자를 acridine orange(AO)와 iodonitrotetrazolium chloride(INT)로 염색하여 형광현미경으로 관찰하였을 때 RNA와 단백질도 일정한 주기를 갖고 합성되었으며, 이 주기성은 성장인자의 요구 주기와 거의 일치하였다. 이로써 발아 초기에 포자 집단은 성장인자 중에서 특히 단백질 합성과 관련된 물질인 아미노산이 주기적으로 요구되고 있음을 토론하였다.

• 한국임상약학회지
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• 제28권2호
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• pp.131-137
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• 2018

Background: In South Korea, 22.3% of women ${\geq}50years$ of age and 37% of women ${\geq}70years$ of age visit the doctor to obtain treatment for osteoporosis. According to the analysis of the National Health Insurance Services claim data between 2008 and 2012, the number and incidence of hip and vertebral fractures increased during the same period. Denosumab, a newly marketed medicine in Korea, is the first RANK inhibitor. Methods: A cost-utility analysis was conducted from a societal perspective to prove the superiority of denosumab to alendronate. A Markov cohort model was used to investigate the cost-effectiveness of denosumab. A 6-month cycle length was used in the model, and all patients were individually followed up through the model, from their age at treatment initiation to their time of death or until 100 years of age. The model consisted of eight health states: well; hip fracture; vertebral fracture; wrist fracture; other osteoporotic fracture; post-hip fracture; post-vertebral fracture; and dead. All patients began in the well-health state. In this model, 5% discounted rate, two-year maximum offset time, and persistence were adopted. Results: The total lifetime costs for alendronate and denosumab were USD 5,587 and USD 6,534, respectively. The incremental cost-effectiveness ratio (ICER) for denosumab versus alendronate was USD 20,600/QALY. Given the ICER threshold in Korea, the results indicated that denosumab was remarkably superior to alendronate. Conclusion: Denosumab is a cost-effective alternative to the oral anti-osteoporotic treatment, alendronate, in South Korea.

• 한국전산구조공학회논문집
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• 제29권6호
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• pp.539-545
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• 2016

천연가스 생산기지 내의 UPS시스템은 지진 시에도 기능성을 유지해야 하는 주요 설비 중 하나이다. 이 연구에서는 IEEE Std 693-2005 기준을 토대로 대형 진동대를 이용한 UPS시스템의 동특성 탐색시험을 수행하고 기기의 고유진동수와 모드감쇠, 모드형상 등을 도출하였다. 또한, 3축 시간이력시험을 통해 지진 시 기기의 거동 및 부재의 발생응력을 확인하였다. 유한요소모델을 생성하여 고유치해석을 수행하고 이를 동특성 탐색시험의 시험값과 비교, 분석하여 해석모델을 개선하고 자중해석과 응답스펙트럼 해석을 수행하여 조합응력을 3축 시간이력시험의 시험값과 비교하였다. 개선된 유한요소 해석모델의 동특성과 조합응력이 시험 결과와 유사함을 입증하여 개선된 UPS시스템 해석모델의 적합성을 제시하였다.

• Steel and Composite Structures
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• 제39권1호
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• pp.65-80
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• 2021

Irregularities of a building in plan and elevation, which results in the change in stiffness on different floors highly affect the seismic performance and resistance of a structure. This study motivated to investigate the seismic responses of high-rise steel-frame buildings of twelve stories with various stiffness irregularities. The building has five spans of 3200 mm distance in both X- and Z-directions in the plan. The design package SAP2000 was adopted for the design of beams and columns and resulted in the profile IPE500 for the beams of all floors and box sections for columns. The column cross-section dimensions vary concerning the number of the story; one to three: 0.50×0.50×0.05m, four to seven: 0.45×0.45×0.05 m, and eight to twelve: 0.40×0.40×0.05 m. Real recorded ground accelerations obtained from the Vrancea earthquake in Romania together with dead and live loads corresponding to each story were considered for the applied load. The model was validated by comparing the results of the current method and literature considering a three-bay steel moment-resisting frame of eight-story height subject to seismic load. To investigate the seismic performance of the buildings, the time-history analysis was performed using ABAQUS. Deformed shapes corresponding to negative and positive peaks were provided followed by the story drifts and fragility curves which were used to examine the probability of collapse of the building. From the results, it was concluded that regular buildings provided a seismic performance much better than irregular buildings. Furthermore, it was observed that building with torsional irregularity was more vulnerable to seismic failure.

• 산업진흥연구
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• 제7권4호
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• pp.85-95
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• 2022

본 연구는 전통사회와 현대를 이어주는 제례(祭禮)가 의례(儀禮)의 전승(傳乘)이라는 관점에서 제례진설에 나타난 상징성의 의미를 분석하고자 한다. 전통의례의 삶과 죽음에 대한 유교적 생사관과 사상적 바탕이 되었던 음양오행론, 우주구조의 이해와 사시(四時)의 변화로 나타난다. 제사상의 진설이 조상의 존재를 인정하고 상징체계를 통해 산 자와 죽은 자가 시간과 공간적으로 소통하는 의례적 도구로 이해하였다. 또한 사계절과 하늘·땅·지하의 공간을 제수(祭需)의 선정과 배열을 통해 상징화하고 구체화하였다. 현대 제례진설에서 위치를 결정하는 요인은 대상에 대한 시·공간적 분석을 필요로 한다. 이는 제물이 기능적 역할 뿐만 아니라 제물을 통해 표현하고자 하는 시·공간적 상징성으로 이해되기 때문이다. 본 연구에서는 제례진설에 나타난 사상적 배경과 상징체계에 대한 논의를 통해 제례문화의 계승이라는 관점에서 고찰하는데 의의가 있다.

• Journal of Microbiology and Biotechnology
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• 제33권1호
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• pp.106-113
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• 2023

The supply of microbiological risk-free water is essential to keep food safety and public hygiene. And removal, inactivation, and destruction of microorganisms in drinking water are key for ensuring safety in the food industry. Ultraviolet-C (UV-C) irradiation is an attractive method for efficient disinfection of water without generating toxicity and adversely affecting human health. In this study, the disinfection efficiencies of UV-C irradiation on Shigella flexneri (Gram negative) and Listeria monocytogenes (Gram positive) at various concentrations in drinking water were evaluated using a water purifier. Their morphological and physiological characteristics after UV-C irradiation were observed using fluorescence microscopy and flow cytometry combined with live/dead staining. UV-C irradiation (254 nm wavelength, irradiation dose: 40 mJ/cm²) at a water flow velocity of 3.4 L/min showed disinfection ability on both bacteria up to 10⁸ CFU/4 L. And flow cytometric analysis showed different physiological shift between S. flexneri and L. monocytogenes after UV-C irradiation, but no significant shift of morphology in both bacteria. In addition, each bacterium revealed different characteristics with time-course observation after UV-C irradiation: L. monocytogenes dramatically changed its physiological feature and seemed to reach maximum damage at 4 h and then recovered, whereas S. flexneri seemed to gradually die over time. This study revealed that UV-C irradiation of water purifiers is effective in disinfecting microbial contaminants in drinking water and provides basic information on bacterial features/responses after UV-C irradiation.

• 영어영문학
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• 제56권5호
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• pp.797-821
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• 2010

This paper aims to explore how Millay's love sonnets rewrite the carpe diem tradition in the complicated ways. This paper redirects critical attention away from Millay's individual experience and inner self toward the scene of literary history, suggesting that there may be more historical consciousness in Millay's sentimental and feminine "gesture." Rewriting the carpe diem tradition, Millay's sonnets reveal an awareness of the dependence of the carpe diem poems' discursive logic on the woman's coyness, its inability to accomplish its triumph over woman or time (death) without her posited reluctance. Contrary to Andrew Marvel's "To His Coy Mistress," the speakers of Millay's sonnets could never be accused of the sexual coyness; they are outspoken in their defiance of both death and lovers whose possessiveness resembles death's embrace. Moreover, as Stacy Carson Hubbard points out, by converting female sexual experience from its status as a onetime closural event to repeatable one, hence an opportunity for the general and emotional irritability productive of narrative, Millay seizes for the woman the power of "dilation" in both its sexual and its verbal forms. Furthermore, this paper argues that the woman's sex no longer invites analogies to things secret and sealed, preserved or ruined in Millay's sonnets. The woman's promiscuity implies a rejection of monumentalizing love, as well as a refusal of the fixing inherent in the carpe diem's fearful invocation of the movement of time. Throughout the love sonnets, the speaker's sexualized body produces nothing but ephemera. For Millay, this body spends its powers in hopes of having them, and the force of this spending is a perpetual and willful forgetting, which makes possible the repetition of love's story. Ultimately, Milly disturbs our critical categories by rendering permeable boundaries between modern literature and dead form of classic literature, the female speaker and male speaker.

• 한국어병학회지
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• 제36권2호
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• pp.229-238
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• 2023

In this study, the correlation between clinical changes and RSIV genome copy number was investigated to determine the quantitative criteria for the characteristics of RSIV infection. The rock bream (Oplegnathus fasciatus) was intraperitoneally injected with three different doses (1.0×10¹, 1.0×10³ and 1.0×10⁵ viral genome copies/fish) as low, medium, and high doses, respectively. The clinical signs (spleen enlargement, death) observation and real-time PCR were conducted at 5, 10 and 14 days post-injection. During the experiment, spleen index as a quantitative indicator for spleen enlargement was continuously increased in the medium- (up to 2.26) and high-dose (up to 4.99) challenge groups, respectively. Notably, when the spleen index was over 1.5, 2.0, 2.5 and 3.0, a positive correlation was revealed with average viral genome copy numbers of 2.51, 3.37, 4.97 and 5.43×10⁷ viral genome copies/mg, respectively. Moreover, the threshold of spleen index over 1.5 was 1.0×10⁶ viral genome copies/mg, while the thresholds of spleen index over 2.0 and dead was 2.51×10⁷ viral genome copies/mg and the thresholds of spleen index over 2.5 and 3 was 3.98×10⁷ viral genome copies/mg. These findings suggest the possibility of quantitatively analyzing the characteristics and development process of RSIV infection.