• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.11
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• pp.2031-2038
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• 2008

A small-area and high-speed authentication/security processor (WUSB_Sec) IP is designed, which performs the 4-way handshake protocol for authentication between host and device, and data encryption/decryption of wireless USB system. The PRF-256 and PRF-64 are implemented by CCM (Counter mode with CBC-MAC) operation, and the CCM is designed with two AES (Advanced Encryption Standard) encryption coles working concurrently for parallel processing of CBC mode and CTR mode operations. The AES core that is an essential block of the WUSB_Sec processor is designed by applying composite field arithmetic on AF$(((2^2)^2)^2)$. Also, S-Box sharing between SubByte block and key scheduler block reduces the gate count by 10%. The designed WUSB_Sec processor has 25,000 gates and the estimated throughput rate is about 480Mbps at 120MHz clock frequency.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.529-537
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• 2019

Lung cancer is the most common cause of cancer deaths worldwide and several molecular signatures have been developed to predict survival in lung cancer. Increasing evidence suggests that proliferation and migration to promote tumor growth are associated with dysregulated ion channel expression. In this study, by analyzing high-throughput gene expression data, we identify the differentially expressed $K^+$ channel genes in lung cancer. In total, we prioritize ten dysregulated $K^+$ channel genes (5 up-regulated and 5 down-regulated genes, which were designated as K-10) in lung tumor tissue compared with normal tissue. A risk scoring system combined with the K-10 signature accurately predicts clinical outcome in lung cancer, which is independent of standard clinical and pathological prognostic factors including patient age, lymph node involvement, tumor size, and tumor grade. We further indicate that the K-10 potentially predicts clinical outcome in breast and colon cancers. Molecular signature discovered through $K^+$ gene expression profiling may serve as a novel biomarker to assess the risk in lung cancer.

• Korean Journal of Optics and Photonics
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• v.32 no.5
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• pp.215-219
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• 2021

Recently a system for nondestructive measurement of seedling plants in real time has been attracting attention as an essential element in fields such as the "smart farm". This study reports the simultaneous measurement of anthocyanin accumulations in leaf tissues in a large number of bok choy, using a hyperspectral imaging system. To measure many seedlings simultaneously, an existing hyperspectral imaging system is modified. In this paper, a total of 96 seedlings are measured: 24 each of 4 cultivars. Using the hyperspectral data-acquisition system, 12 seedlings can be analyzed simultaneously within 3 minutes. The hyperspectral imaging technology proposed in this paper is shown to provide an analytic system comparable to destructive chemical analysis. This hyperspectral imaging technology can be applied to a high-throughput plant-phenotyping system, owing to its capability of measuring a large number of specimens at the same time.

• Genomics & Informatics
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• v.18 no.4
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• pp.42.1-42.9
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• 2020

Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-Seq) is a powerful technology to profile the location of proteins of interest on a whole-genome scale. To identify the enrichment location of proteins, many programs and algorithms have been proposed. However, none of the commonly used peak calling programs could accurately explain the binding features of target proteins detected by ChIP-Seq. Here, publicly available data on 12 histone modifications, including H3K4ac/me1/me2/me3, H3K9ac/me3, H3K27ac/me3, H3K36me3, H3K56ac, and H3K79me1/me2, generated from a human embryonic stem cell line (H1), were profiled with five peak callers (CisGenome, MACS1, MACS2, PeakSeq, and SISSRs). The performance of the peak calling programs was compared in terms of reproducibility between replicates, examination of enriched regions to variable sequencing depths, the specificity-to-noise signal, and sensitivity of peak prediction. There were no major differences among peak callers when analyzing point source histone modifications. The peak calling results from histone modifications with low fidelity, such as H3K4ac, H3K56ac, and H3K79me1/me2, showed low performance in all parameters, which indicates that their peak positions might not be located accurately. Our comparative results could provide a helpful guide to choose a suitable peak calling program for specific histone modifications.

• Mycobiology
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• v.46 no.4
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• pp.421-428
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• 2018

The white button mushroom (Agaricus bisporus) is one of the most widely cultivated species of edible mushroom. Despite its economic importance, relatively little is known about the genetic diversity of this species. Illumina paired-end sequencing produced 43,871,558 clean reads and 69,174 contigs were generated from five offspring. These contigs were subsequently assembled into 57,594 unigenes. The unigenes were annotated with reference genome in which 6,559 unigenes were associated with clusters, indicating orthologous genes. Gene ontology classification assigned many unigenes. Based on genome data of the five offspring, 44 polymorphic simple sequence repeat (SSR) markers were developed. The major allele frequency ranged from 0.42 to 0.92. The number of genotypes and the number of alleles ranged from 1 to 4, and from 2 to 4, respectively. The observed heterozygosity and the expected heterozygosity ranged from 0.00 to 1.00, and from 0.15 to 0.64, respectively. The polymorphic information content value ranged from 0.14 to 0.57. The genetic distances and UPGMA clustering discriminated offspring strains. The SSR markers developed in this study can be applied in polymorphism analyses of button mushroom and for cultivar discrimination.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.401-404
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• 2016

This paper proposes entropy coding method of HEVC CABAC Encoder for efficient hardware architecture. The Binary Arithmetic Encoder requires data dependency at each step, which is difficult to be operated in a fast. Proposed Binary Arithmetic Encoder is designed 4 stage pipeline to quickly process the input value bin. According to bin approach, either MPS or LPS is selected and the binary arithmetic encoding is performed. Critical path caused by repeated operation is reduced by using the LUT and designed as a shift operation which decreases hardware size and not using memory. The proposed Binary Arithmetic Encoder of CABAC is designed using Verilog-HDL and it was implemented in 65nm technology. Its gate count is 3.17k and operating speed is 1.53GHz.

• Molecules and Cells
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• v.42 no.1
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• pp.87-95
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• 2019

Long interspersed element-1 (LINE-1 or L1) is an autonomous retrotransposon, which is capable of inserting into a new region of genome. Previous studies have reported that these elements lead to genomic variations and altered functions by affecting gene expression and genetic networks. Mounting evidence strongly indicates that genetic diseases or various cancers can occur as a result of retrotransposition events that involve L1s. Therefore, the development of methodologies to study the structural variations and interpersonal insertion polymorphisms by L1 element-associated changes in an individual genome is invaluable. In this study, we applied a systematic approach to identify human-specific L1s (i.e., L1Hs) through the bioinformatics analysis of high-throughput next-generation sequencing data. We identified 525 candidates that could be inferred to carry non-reference L1Hs in a Korean individual genome (KPGP9). Among them, we randomly selected 40 candidates and validated that approximately 92.5% of non-reference L1Hs were inserted into a KPGP9 genome. In addition, unlike conventional methods, our relatively simple and expedited approach was highly reproducible in confirming the L1 insertions. Taken together, our findings strongly support that the identification of non-reference L1Hs by our novel target enrichment method demonstrates its future application to genomic variation studies on the risk of cancer and genetic disorders.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.4
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• pp.431-437
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• 2019

PLC(Power Line Communication) is being used in various ways in smart grid system because of the advantages of low cost and high data throughput. However, power line channel has many problems due to impulse noise and various studies have been conducted to solve the problem. Recently, ACDL(Adaptive Cannonical Differential Limiter) which is based on an adaptive clipping with analog nonlinear filter, has been proposed and performs better than the others. In this paper, we show that ACDL is similar to the detection of slew rate with oversampled digital signal by simplification and analysis. Through the simulation under the PRIME standard it is shown that the proposed performs equal to or better than that of ACDL, but significantly reduce the complexity to implement. The BER performance is equal but the complexity is reduced to less than 10%.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.5
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• pp.581-588
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• 2019

In this paper, I propose an modified back-off algorithm to improve the fairness for slotted ALOHA sensor networks. In hierarchical networks, the performance degradation of a specific node can cause degradation of the overall network performance in case the data transmitted by lower nodes is needed to be synthesized and processed by an upper node. Therefore it is important to ensure the fairness of transmission performance to all nodes. The proposed scheme choose a back-off time of a node considering the previous transmission results as well as the current transmission result. Moreover a node that failed to transmit consecutively is given gradually shorter back-off time but a node that is success to transmit consecutively is given gradually longer back-off time. Through simulations, I compare and analyze the performance of the proposed scheme with the binary exponential back-off algorithm(BEB). The results show that the proposed scheme reduces the throughput slightly compared to BEB but improves the fairness significantly.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.294-298
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• 2021

Recently, many electronic devices have been integrated with various kinds of wireless sensor network technologies that have been enabled with wireless network connections. These wireless sensor network devices have adopted various kinds of wireless network technologies. On the other hand, because each wireless network technology has its advantages and disadvantages, the target and purposes should be considered carefully at the beginning of the development. In particular, the approach to the magnetic sensor should be considered carefully because it has its own characteristic compared to general sensors. The magnetic field generates nonlinear data. This paper introduces the design aspects to reflect low cost and wearable devices to use in a wireless sensor network. In addition, this paper addresses how to select proper sensor network technology. As a result, wireless sensor network devices were integrated using Zigbee and showed the performance of the throughput.