• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.3
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• pp.437-443
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• 2003

Epidemiological data suggest that lycopene has anticancer activities in humans. Insulin-like growth factor-I receptor (IGF-IR) is a transmembrane tyrosine kinase that mediates the biological actions of IGFs and may play an active role in cancer progression. Because our previous in vitro studies have indicated lycopene inhibits HT-29 cell growth, the aim of this study was to determine whether lycopene induces apoptotic cell death and the inhibitory effect of lycopene on HT-29 cell growth is related to changes in IGF-IR levels and the receptor's intracellular signalling pathways. HT-29 cells were incubated for 4 days in serum-free medium in the presence of 0, 25, 50, or 100 $\mu$M lycopene, and the DNA fragmentation assay was performed. Cells treated with lycopene produced a distinct oligonucleosomal ladder with different sizes of DNA fragments, a typical characteristic of cells undergoing apoptosis. HT-29 cells were cultured for 4 days in serum-free medium in the presence of 0~100 $\mu$M lycopene and IGF-I (10nM) was added for 0~60 minutes immediately prior to lysate preparations. Western blot analysis of total lysates revealed that lycopene decreased the levels of IRS-1, Akt, phosphatidylinositol 3-kinase (PI3K), and IGF-IR $\beta$-subunit, and increased the levels of the IGF-IR precursor dose dependently. Lycopene also decreased IGF-I-induced phosphorylation of IGF-IR$\beta$, IRS-1 and Akt, which were, at least in part, due to decreased expression of these proteins. These results suggest that lycopene induces apoptosis of HT-29 cells by inhibiting IGF-IR signaling thereby interfering with an IGF-II-driven autocrine growth loop, which is known to exist in this cell line.

• Journal of Distribution Science
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• v.13 no.10
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• pp.83-91
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• 2015

Purpose - The purpose of this study is to identify whether the operation of cultural centers in discount stores contributes to their profitability. Thus, this study is aimed at exploring how the lifestyles of customers who use the cultural centers influence their intention to use the discount stores. Specifically, the effect of shopping value on the correlation between the lifestyle types and usage intention of the customers were examined through a structured research model. To verify the effect, a survey on 139 customers of the Cultural Center of Nonghyup Hanaro Club's S branch was conducted and the valid questionnaires were used for analysis. Research design, data, and methodology - The findings are as follows. First, the lifestyles seeking self-realization had a positive effect on utilitarian value, and lifestyles seeking pop cultures had a positive effect on hedonic value. Second, the mediating effect of shopping value on the correlation between the lifestyle types and usage intention of the customers is as follows. Utilitarian value had a mediating effect only on the lifestyles seeking self-realization. In case of lifestyles seeking pop cultures, the use of Cultural Center had no effect on the intention to use the discount store. Third, an analysis of a revised research model revealed that the store usage intention of lifestyles seeking pop cultures can be enhanced by boosting the utilitarian value through hedonic value. Results - The findings suggest the following. Customers with lifestyles seeking self-realization, who value what is beneficial to them with little attention to the perceptions of others, are highly interested in the benefits they can gain from shopping. As for customers with lifestyles seeking pop cultures, they are highly likely to consume products popular in a particular culture such as new products and sports, based on financial stability they pursue. Thus, they prefer more subjective, personal experience, unlike consumers pursuing utilitarian value. Conclusions - As a result, the former pursues hedonic value gained in the process of shopping with fun and joy, rather than doing shopping with a particular purpose in mind. Therefore, Cultural Centers need to offer information that fits the lifestyles of the users so that they are more likely to use the discount stores. However, if the Cultural Centers offer unified, profit-driven products and information, just to increase their store sales, it can backfire, which occurred in the past. On the other hand, if they provide information that fits the lifestyles of the users, it can actually increase the sales. Also, the findings suggest that sophisticated marketing strategies that can boost the hedonic value of customers by linking the educational contents of Cultural Centers to actual shopping, which is beneficial to consumers, should be set and operated by discount stores. In particular, customers with lifestyles seeking self-realization can be encouraged to use the stores by making them recognize the utilitarian value. However, the use of Cultural Centers doesn't necessarily lead to higher sales among customers with lifestyles seeking pop cultures. As mentioned previously, unified marketing strategy is not as effective for Cultural Centers of large discount stores.

• Molecules and Cells
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• v.28 no.4
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• pp.383-388
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• 2009

The dehydration responsive element binding protein 2C (DREB2C) is a dehydration responsive element/C-repeat (DRE/CRT)-motif binding transcription factor that induced by mild heat stress. Previous experiments established that overexpression of DREB2C cDNA driven by the cauliflower mosaic virus 35S promoter (35S:DREB2C) resulted in increased heat tolerance in Arabidopsis. We first analyzed the proteomic profiles in wild-type and 35S:DREB2C plants at a normal temperature ($22^{\circ}C$), but could not detect any differences between the proteomes of wild-type and 35S: DREB2C plants. The transcript level of DREB2C in 35S: DREB2C plants after treatment with mild heat stress was increased more than two times compared with expression in 35S:DREB2C plants under unstressed condition. A proteomic approach was used to decipher the molecular mechanisms underlying thermotolerance in 35S:DREB2C Arabidopsis plants. Eleven protein spots were identified as being differentially regulated in 35S:DREB2C plants. Moreover, in silico motif analysis showed that peptidyl-prolyl isomerase ROC4, glutathione transferase 8, pyridoxal biosynthesis protein PDX1, and elongation factor Tu contained one or more DRE/CRT motifs. To our knowledge, this study is the first to identify possible targets of DREB2C transcription factors at the protein level. The proteomic results were in agreement with transcriptional data.

• Journal of Korean Society of Transportation
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• v.35 no.6
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• pp.545-556
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• 2017

Various assessment indexes have been developed and utilized to evaluate the driver workload. However, existing workload assessment indexes do not fully reflect driving habits and driving patterns of individual drivers. In addition, there exists significant differences in the amount of workload experienced by a driver and the ability to overcome the driver's workload. To overcome these limitations associated with existing indexes, this study has developed a novel workload assessment index to reflect an individual driver's driving pattern. An average of the absolute values of the steering velocity for each driver are set as a threshold value in order to reflect the driving patterns of individual drivers. Further, the sum of the areas of the steering velocities exceeding the threshold value, which is defined as erratic steering area (ESA) in this study, was quantified. The developed ESA index is applied in evaluating the driver workload of manually driven vehicles in automated vehicle platooning environments. Driving simulation experiments are conducted to collect drivers' responsive behavior data which are used for exploring the relationship between the NASA-TLX score and the ESA by the correlation analysis. As a result, ESA is found to have the greatest correlation with the NASA-TLX score among the various driver workload evaluation indexes in the lane change scenario, confirming the usefulness of ESA.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.532-536
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• 2007

급속한 도시화 및 지구온난화로 인한 집중호우로 홍수피해가 해마다 증가하고 있다. 홍수피해를 최소화하기 위하여 4대강 중심의 홍수예경보시스템이 구축되는 등 다양한 제도적 장치가 마련되고 있으나 중소하천이 분포되어 있는 도시유역에서의 홍수예측기능은 부족한 실정이다. 본 연구에서는 중소 도시하천에 적용 가능한 실시간 도시홍수예측서비스 시스템(Realtime Urban Flood Forecasting Service, U-FFS)을 개발하였다. 경기도 성남에 위치한 탄천을 대상유역으로 선정하고 실시간 강우 및 수위관측소를 설치하여 수문데이타를 수집하였으며 이를 바탕으로 수위예측모형을 구축하였다. 모형구축에는 이미 국내외 학계에서 그 정확도가 입증된 바 있는 Data-driven 모델의 일종인 ANFIS(Adaptive Neuro-Fuzzy Inference System)를 이용하였다. 개발된 수위예측모형은 지정된 시간에 자동으로 작동 가능한 실행파일로 프로그래밍되어 최종적으로 홍수예측 웹서비스와 연동된다. U-FFS는 집중호우 발생 시 최종 유출구의 30분, 1시간, 2시간 후의 수위 예측값을 웹 상을 통해 제공함으로써 언제 어디서나 홍수예측 정보를 누구나 손쉽게 획득할 수 있는 장점이 있다. 시범운영 결과, 30분 및 1시간 후의 수위 예측은 정확도가 매우 뛰어났으며 2시간 후의 수위 예측의 정확성은 다소 떨어지는 것으로 확인되었으나 전반적인 홍수예측 판단에는 무리가 없을 것으로 예상된다. 본 시스템의 홍수예측모형은 생성 및 수정이 간편하여 그 활용성이 매우 높을 것으로 기대된다. 특히 안전함을 지향하는 각종 U-City나 홍수피해가 빈번한 도시유역에 적용하면 기존 시스템과 차별화된 실시간 홍수예측 서비스가 가능해져 홍수피해를 최소화할 수 있을 것이다. 취수구 직경 D의 3.3배를 벗어나지 않는다는 결과를 도출할 수 있었다.링 목적으로 사용될 수 있다. 본 연구에서 개발한 영상수위계는 한강홍수통제소 관할의 전류, 청담대교 등 4개소 낙동강 홍수통제소 2개소, 지자체 등에 적용되었으며, 적용 결과 비교적 안정적이면서 정확하게 수위를 측정하는 것으로 나타났다. 한편 기존 CCD 카메라 이외에 CCTV를 이용한 영상수위계를 개발하여 영상의 화질 개선뿐 아니라 하천화상 감시 기능을 강화하였다.소류의 섭취율은 높았다. 집단간의 상관도를 보면 교육별로 김치, 장아찌, 콩이 각각 p>0.5 수준에서 유의한 차가 없었고, 나머지는 유의한 차가 있었다. 연령별로는 멸치가 유의한 차가 없었고(p>0.5), 수입별로는 콩이 유의한 차가 없었다(p>0.5). 4. 영양지식(營養知識) 검토 가정생활(家庭生活)에 필요(必要)한 일반적(一般的)인 영양지식(營養知識)은 대체적으로 낮은 편이었다. 어린이 영양, 편식의 해로움, 비만증의 해로움, 임신부 그리고 수유부 영양에 대하여는 일반적으로 알고 있다고 하였으며, 그다음으로 이유기 영양, 어린이 발육에 필요한 식품, 식품과 영양소와의 관계, 우유의 성분, 노인영양에 대하여 잘 알고 있는 비율이 낮았으며, 인체의 영양소, 식단작성여부, 간식의 이론, 식품감별법에 대하여는 가장 낮은 비율을 나타냈다. 각 영양지식은 교육정도가 높을수록 영양지식이 높았고, 교육별 집단간의 유의한 차가 나타났다. (0.001

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.27-27
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• 2011

For the design of real applicable molecular devices, current-voltage properties through molecular nanostructures such as metal-molecule-metal junctions (molecular junctions) have been studied extensively. In thiolate monolayers on the gold electrode, the chemical bonding of sulfur to gold and the van der Waals interactions between the alkyl chains of neighboring molecules are important factors in the formation of well-defined monolayers and in the control of the electron transport rate. Charge transport through the molecular junctions depends significantly on the energy levels of molecules relative to the Fermi levels of the contacts and the electronic structure of the molecule. It is important to understand the interfacial electron transport in accordance with the increased film thickness of alkyl chains that are known as an insulating layer, but are required for molecular device fabrication. Thiol-tethered RuII terpyridine complexes were synthesized for a voltage-driven molecular switch and used to understand the switch-on mechanism of the molecular switches of single metal complexes in the solid-state molecular junction in a vacuum. Electrochemical voltammetry and current-voltage (I-V) characteristics are measured to elucidate electron transport processes in the bistable conducting states of single molecular junctions of a molecular switch, Ru(II) terpyridine complexes. (1) On the basis of the Ru-centered electrochemical reaction data, the electron transport rate increases in the mixed self-assembled monolayer (SAM) of Ru(II) terpyridine complexes, indicating strong electronic coupling between the redox center and the substrate, along the molecules. (2) In a low-conducting state before switch-on, I-V characteristics are fitted to a direct tunneling model, and the estimated tunneling decay constant across the Ru(II) terpyridine complex is found to be smaller than that of alkanethiol. (3) The threshold voltages for the switch-on from low- to high-conducting states are identical, corresponding to the electron affinity of the molecules. (4) A high-conducting state after switch-on remains in the reverse voltage sweep, and a linear relationship of the current to the voltage is obtained. These results reveal electron transport paths via the redox centers of the Ru(II) terpyridine complexes, a molecular switch.

• Journal of the Korean association of regional geographers
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• v.19 no.3
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• pp.384-400
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• 2013

In this study, spatio-temporal patterns of extreme precipitation events caused by typhoons are examined based on observational daily precipitation data at approximately 340 weather stations of Korea Meterological Administration's ASOS (Automated Synoptic Observation System) and AWS (Automatic Weather System) networks for the recent 10 year period (2002~2011). Generally, extreme precipitation events by typhoons exceeding 80mm of daily precipitation commonly appear in Jeju Island, Gyeongsangnam-do, and the eastern coastal regions of the Korean Peninsula. However, the frequency, intensity and spatial extent of typhoon-driven extreme precipitation events can be modified depending on the topography of major mountain ridges as well as the pathway of and proximity to typhoons accompanying the anti-clockwise circulation of low-level moisture with hundreds of kilometers of radius. Yellow Sea-passing type of typhoons in July cause more frequent extreme precipitation events in the northern region of Gyeonggi-do, while East Sea-passing type or southern-region-landfall type of typhoons in August-early September do in the interior regions of Gyeongsangnam-do. These results suggest that when local governments develop optimal mitigation strategies against potential damages by typhoons, the pathway of and proximity to typhoons are key factors.

• The Journal of Engineering Geology
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• v.25 no.3
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• pp.413-420
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• 2015

Streambed hydraulic conductivity along the upper reaches of the Gongdo stage of Anseong Stream was estimated through measurements of stream-aquifer exchange rates (using a seepage meter) and vertical hydraulic gradients (using a manually driven piezometer). From the measured data, it was found out that the stream-aquifer exchange rates varied from -1.55 × 10^-6 to 1.77 × 10^-5 m/s, the corresponding vertical hydraulic gradient varied from -0.122 to 0.030, and the values of the streambed vertical hydraulic conductivity were estimated from 1.77 × 10^-5 to 1.97 × 10^-3 m/s, with variations representing local differences. The results are within the general range of streambed hydraulic conductivity values suggested by Calver (2001) and are slightly higher than values previously measured at other stream sites in Korea. The combined use of a drive-point piezometer and seepage meter (both constructed of high-strength stainless steel) is expected to be of practical use in the estimation of streambed hydraulic conductance, given the durability and portability of the instruments.

• Economic and Environmental Geology
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• v.53 no.3
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• pp.245-258
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• 2020

In this study, a data-driven response surface method using the results acquired from the numerical simulation is developed to evaluate the potential storage capacity of groundwater due to the construction of a groundwater dam. The hydraulic conductivities of alluvium and basement rock, depth and slope of the channel are considered as the natural conditions of the location for groundwater dam construction. In particular, the probability models of the hydraulic conductivities and the various types of geometry of the channel are considered to ensure the reliability of the numerical simulation and the generality of the developed estimation model. As the results of multiple simulations, it can be seen that the hydraulic conductivity of basement rock and the depth of the channel greatly influence to the groundwater storage capacity. In contrast, the slope of the channel along the groundwater flow direction shows a relatively lower impact on the storage capacity. Based on the considered natural conditions and the corresponding numerical simulation results, the storage capacity estimation model is developed applying an artificial neural network as the nonlinear regression model for training. The developed estimation model shows a high correlation coefficient (>0.9) between the simulated and the estimated storage amount. This result indicates the superiority of the developed model in evaluating the storage capacity of the potential location for groundwater dam construction without the numerical simulation. Therefore, a more objective and efficient comparison for the storage capacity between the different potential locations can be possibly made based on the developed estimation model. In line with this, the proposed method can be an effective tool to assess the optimal location of groundwater dam construction across Korea.

• Journal of the Korean GEO-environmental Society
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• v.9 no.5
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• pp.45-52
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• 2008

The present study has extended OpenSees, which is an open-source software framework DOS program for developing applications to idealize geotechnical and structural problems, for the static analysis of axial load capacity and settlement of single piles in MS Windows environment. The Windows version of OpenSees as improved by this study has enhanced the DOS version from a general purpose software program to a special purpose program for driven and bored pile analysis with additional features of pre-processing and post-processing and a user friendly graphical interface. The method used in the load capacity analysis is the numerical methods based on load transfer functions combined with finite elements. The use of empirical nonlinear T-z and Q-z load transfer curves to model soil-pile interaction in skin friction and end bearing, respectively, has been shown to capture the nonlinear soil-pile response under settlement due to load. Validation studies have shown the static load capacity and settlement predictions implemented in this study are in fair agreement with reference data from the static loading tests.